ATE435922T1 - Selex-verfahren ohne transkription - Google Patents
Selex-verfahren ohne transkriptionInfo
- Publication number
- ATE435922T1 ATE435922T1 AT00947549T AT00947549T ATE435922T1 AT E435922 T1 ATE435922 T1 AT E435922T1 AT 00947549 T AT00947549 T AT 00947549T AT 00947549 T AT00947549 T AT 00947549T AT E435922 T1 ATE435922 T1 AT E435922T1
- Authority
- AT
- Austria
- Prior art keywords
- transcription
- fragments
- free
- nucleic acid
- ligands
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 4
- 238000013518 transcription Methods 0.000 title 1
- 230000035897 transcription Effects 0.000 title 1
- 239000012634 fragment Substances 0.000 abstract 3
- 239000003446 ligand Substances 0.000 abstract 3
- 150000007523 nucleic acids Chemical class 0.000 abstract 3
- 102000039446 nucleic acids Human genes 0.000 abstract 3
- 108020004707 nucleic acids Proteins 0.000 abstract 3
- 238000000137 annealing Methods 0.000 abstract 1
- 230000000295 complement effect Effects 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 230000009897 systematic effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6811—Selection methods for production or design of target specific oligonucleotides or binding molecules
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2537/00—Reactions characterised by the reaction format or use of a specific feature
- C12Q2537/10—Reactions characterised by the reaction format or use of a specific feature the purpose or use of
- C12Q2537/155—Cyclic reactions
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- Physics & Mathematics (AREA)
- Molecular Biology (AREA)
- Biotechnology (AREA)
- Biophysics (AREA)
- Analytical Chemistry (AREA)
- Immunology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Saccharide Compounds (AREA)
- Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US09/362,578 US6387620B1 (en) | 1999-07-28 | 1999-07-28 | Transcription-free selex |
| PCT/US2000/019725 WO2001009380A1 (en) | 1999-07-28 | 2000-07-19 | Transcription-free selex |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE435922T1 true ATE435922T1 (de) | 2009-07-15 |
Family
ID=23426653
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT00947549T ATE435922T1 (de) | 1999-07-28 | 2000-07-19 | Selex-verfahren ohne transkription |
Country Status (8)
| Country | Link |
|---|---|
| US (2) | US6387620B1 (de) |
| EP (1) | EP1206575B1 (de) |
| JP (1) | JP2003505108A (de) |
| AT (1) | ATE435922T1 (de) |
| AU (1) | AU782673B2 (de) |
| CA (1) | CA2391351A1 (de) |
| DE (1) | DE60042526D1 (de) |
| WO (1) | WO2001009380A1 (de) |
Families Citing this family (67)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6716580B2 (en) * | 1990-06-11 | 2004-04-06 | Somalogic, Inc. | Method for the automated generation of nucleic acid ligands |
| US6951719B1 (en) * | 1999-08-11 | 2005-10-04 | Proteus S.A. | Process for obtaining recombined nucleotide sequences in vitro, libraries of sequences and sequences thus obtained |
| US20030104417A1 (en) * | 1998-08-12 | 2003-06-05 | Proteus S.A. | Template-mediated, ligation-oriented method of nonrandomly shuffling polynucleotides |
| US6387620B1 (en) * | 1999-07-28 | 2002-05-14 | Gilead Sciences, Inc. | Transcription-free selex |
| US7645743B2 (en) * | 1999-12-22 | 2010-01-12 | Altermune, Llc | Chemically programmable immunity |
| CA2328356A1 (en) * | 1999-12-22 | 2001-06-22 | Itty Atcravi | Recreational vehicles |
| EP2070939B1 (de) | 2001-05-25 | 2014-04-02 | Duke University | Modulatoren von pharmakologischen Wirkstoffen |
| US8030465B2 (en) | 2001-06-29 | 2011-10-04 | Medimolecular Pty Ltd | Nucleic acid ligands to complex targets |
| WO2003093504A1 (de) * | 2002-05-06 | 2003-11-13 | Noxxon Pharma Ag | Verfahren zur amplifikation von nukleinsäuren |
| US7727969B2 (en) * | 2003-06-06 | 2010-06-01 | Massachusetts Institute Of Technology | Controlled release nanoparticle having bound oligonucleotide for targeted delivery |
| KR20090088852A (ko) | 2006-09-05 | 2009-08-20 | 메다렉스, 인코포레이티드 | 골형성 단백질의 항체와 이의 수용체 및 이의 사용방법 |
| ES2625798T3 (es) | 2006-10-02 | 2017-07-20 | E. R. Squibb & Sons, L.L.C. | Anticuerpos humanos que se unen a CXCR4 y usos de los mismos |
| EP2097097B1 (de) | 2006-12-01 | 2018-05-30 | E. R. Squibb & Sons, L.L.C. | Antikörper, insbesondere menschliche antikörper, die an cd22 binden und deren verwendung |
| CL2007003622A1 (es) | 2006-12-13 | 2009-08-07 | Medarex Inc | Anticuerpo monoclonal humano anti-cd19; composicion que lo comprende; y metodo de inhibicion del crecimiento de celulas tumorales. |
| AU2007333098A1 (en) | 2006-12-14 | 2008-06-19 | Medarex, Inc. | Human antibodies that bind CD70 and uses thereof |
| AU2008262384B9 (en) | 2007-06-05 | 2014-11-27 | Yale University | Inhibitors of receptor tyrosine kinases and methods of use thereof |
| PT2403878T (pt) | 2009-03-05 | 2017-09-01 | Squibb & Sons Llc | Anticorpos completamente humanos específicos a cadm1 |
| EP3009454A3 (de) | 2009-04-20 | 2016-10-19 | Oxford Bio Therapeutics Limited | Antikörper spezifisch gegen cadherin-17 |
| JP2012526130A (ja) * | 2009-05-05 | 2012-10-25 | アルテルムネ テクフノロジエス,エルエルシー | 化学的にプログラム可能な免疫 |
| EP2470569A1 (de) | 2009-10-13 | 2012-07-04 | Oxford Biotherapeutics Ltd. | Antikörper gegen epha10 |
| US8236570B2 (en) | 2009-11-03 | 2012-08-07 | Infoscitex | Methods for identifying nucleic acid ligands |
| US8841429B2 (en) | 2009-11-03 | 2014-09-23 | Vivonics, Inc. | Nucleic acid ligands against infectious prions |
| WO2011072266A2 (en) | 2009-12-11 | 2011-06-16 | Atyr Pharma, Inc. | Aminoacyl trna synthetases for modulating hematopoiesis |
| AU2011214465A1 (en) | 2010-02-10 | 2012-08-30 | Novartis Ag | Methods and compounds for muscle growth |
| AU2011248625B2 (en) | 2010-04-26 | 2017-01-05 | Pangu Biopharma Limited | Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of cysteinyl-tRNA synthetase |
| JP6294074B2 (ja) | 2010-04-27 | 2018-03-14 | エータイアー ファーマ, インコーポレイテッド | イソロイシルtRNA合成酵素のタンパク質フラグメントに関連した治療用、診断用および抗体組成物の革新的発見 |
| CN103097524B (zh) | 2010-04-28 | 2016-08-03 | Atyr医药公司 | 与丙氨酰-tRNA合成酶的蛋白片段相关的治疗、诊断和抗体组合物的创新发现 |
| CA2797374C (en) | 2010-04-29 | 2021-02-16 | Pangu Biopharma Limited | Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of asparaginyl trna synthetases |
| AU2011248457B2 (en) | 2010-04-29 | 2017-02-16 | Pangu Biopharma Limited | Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of valyl tRNA synthetases |
| WO2011150279A2 (en) | 2010-05-27 | 2011-12-01 | Atyr Pharma, Inc. | Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of glutaminyl-trna synthetases |
| WO2011140135A2 (en) | 2010-05-03 | 2011-11-10 | Atyr Pharma, Inc. | Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of methionyl-trna synthetases |
| CA2797977C (en) | 2010-05-03 | 2019-08-20 | Atyr Pharma, Inc. | Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of phenylalanyl-alpha-trna synthetases |
| WO2011139986A2 (en) | 2010-05-03 | 2011-11-10 | Atyr Pharma, Inc. | Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of arginyl-trna synthetases |
| CA2798139C (en) | 2010-05-04 | 2019-09-24 | Atyr Pharma, Inc. | Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of p38 multi-trna synthetase complex |
| ES2816898T3 (es) | 2010-05-13 | 2021-04-06 | Sarepta Therapeutics Inc | Compuestos que modulan la actividad de señalización de las interleucinas 17 y 23 |
| CN103200953B (zh) | 2010-05-14 | 2017-02-15 | Atyr 医药公司 | 与苯丙氨酰‑β‑tRNA合成酶的蛋白片段相关的治疗、诊断和抗体组合物的创新发现 |
| AU2011289831C1 (en) | 2010-07-12 | 2017-06-15 | Pangu Biopharma Limited | Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of glycyl-tRNA synthetases |
| CN103108650A (zh) | 2010-08-25 | 2013-05-15 | Atyr医药公司 | 与酪氨酰-tRNA合成酶的蛋白片段相关的治疗、诊断和抗体组合物的创新发现 |
| CN103649121B (zh) | 2011-06-28 | 2016-10-19 | 牛津生物疗法有限公司 | 针对adp-核糖基环化酶2的抗体 |
| CN103890174B9 (zh) * | 2011-08-24 | 2026-04-03 | 大塚化学株式会社 | IgG结合性肽及利用其检测和纯化IgG的方法 |
| GB201114662D0 (en) | 2011-08-24 | 2011-10-12 | Altermune Technologies Llc | Chemically programmable immunity |
| IN2014MN01642A (de) | 2012-02-16 | 2015-07-03 | Atyr Pharma Inc | |
| KR20150090072A (ko) | 2012-10-23 | 2015-08-05 | 카리스 라이프 사이언스 스위스 홀딩스 게엠베하 | 압타머 및 이의 용도 |
| US10942184B2 (en) | 2012-10-23 | 2021-03-09 | Caris Science, Inc. | Aptamers and uses thereof |
| EP2935628B1 (de) | 2012-12-19 | 2018-03-21 | Caris Life Sciences Switzerland Holdings GmbH | Zusammensetzungen und verfahren für aptamer-screening |
| EP2970433B1 (de) | 2013-03-13 | 2019-09-18 | Bioasis Technologies Inc. | Fragmente von p97 und verwendungen davon |
| WO2014144744A1 (en) | 2013-03-15 | 2014-09-18 | The Trustees Of Columbia University In The City Of New York | Aptamer methods and compositions |
| KR101809072B1 (ko) | 2013-08-02 | 2017-12-14 | 화이자 인코포레이티드 | 항-cxcr4 항체 및 항체-약물 접합체 |
| AU2015301491A1 (en) | 2014-08-15 | 2017-02-02 | Adynxx, Inc. | Oligonucleotide decoys for the treatment of pain |
| EP3589654A1 (de) | 2017-03-02 | 2020-01-08 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Antikörper mit spezifität gegen nectin-4 und verwendungen davon |
| US11505610B2 (en) | 2018-04-06 | 2022-11-22 | Atyr Pharma, Inc. | Compositions and methods comprising anti-NRP2 antibodies |
| US20220162336A1 (en) | 2018-07-22 | 2022-05-26 | Bioasis Technologies, Inc. | Treatment of lymphatic metastases |
| US12577324B2 (en) | 2019-12-09 | 2026-03-17 | Inserm (Institut National De La Sante Et De La Recherche Medicale) | Antibodies having specificity to HER4 and uses thereof |
| KR20230008751A (ko) | 2020-05-12 | 2023-01-16 | 인쎄름 (엥스띠뛰 나씨오날 드 라 쌍떼 에 드 라 흐쉐르슈 메디깔) | 피부 t-세포 림프종 및 tfh 유래된 림프종을 치료하는 신규한 방법 |
| US20210355468A1 (en) | 2020-05-18 | 2021-11-18 | Bioasis Technologies, Inc. | Compositions and methods for treating lewy body dementia |
| US20210393787A1 (en) | 2020-06-17 | 2021-12-23 | Bioasis Technologies, Inc. | Compositions and methods for treating frontotemporal dementia |
| WO2023034809A1 (en) | 2021-08-30 | 2023-03-09 | Lassen Therapeutics 1, Inc. | Anti-il-11rα antibodies |
| JP2025510588A (ja) | 2022-03-11 | 2025-04-15 | アンスティチュ ナショナル ドゥ ラ サンテ エ ドゥ ラ ルシェルシュ メディカル | B細胞及びt細胞を特異的に初期化するための核酸系及びその使用 |
| WO2023183873A1 (en) | 2022-03-24 | 2023-09-28 | Mensura Health Inc. | Aptamers and uses thereof |
| US20260078376A1 (en) | 2022-08-26 | 2026-03-19 | Core Biotherapeutics, Inc. | Oligonucleotides for the treatment of breast cancer |
| JP2025531832A (ja) | 2022-09-08 | 2025-09-25 | アンスティチュ ナショナル ドゥ ラ サンテ エ ドゥ ラ ルシェルシュ メディカル | LTBP2(潜在的形質転換増殖因子β結合タンパク質2)に対する特異性を有する抗体及びその使用 |
| TW202430560A (zh) | 2023-01-06 | 2024-08-01 | 美商拉森醫療公司 | 抗il-18bp抗體 |
| CN120787238A (zh) | 2023-01-06 | 2025-10-14 | 拉森医疗公司 | 用于治疗甲状腺眼病的抗IL-11Rα抗体 |
| JP2026503273A (ja) | 2023-01-06 | 2026-01-28 | ラッセン・セラピューティクス・インコーポレイテッド | 抗il-18bp抗体 |
| WO2025224297A1 (en) | 2024-04-26 | 2025-10-30 | Institut National de la Santé et de la Recherche Médicale | Antibodies having specificity to tgfbi and uses thereof |
| WO2025242732A1 (en) | 2024-05-21 | 2025-11-27 | Institut National de la Santé et de la Recherche Médicale | Pan antibodies against sars-cov-2 spike protein and uses thereof for therapeutical purposes |
| WO2025257181A1 (en) | 2024-06-11 | 2025-12-18 | Institut National de la Santé et de la Recherche Médicale | Antibodies targeting trans-active response dna-binding protein-43 (tdp-43) |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3546807C2 (de) | 1985-03-30 | 1991-03-28 | Marc Genf/Geneve Ch Ballivet | |
| WO1989006694A1 (en) | 1988-01-15 | 1989-07-27 | Trustees Of The University Of Pennsylvania | Process for selection of proteinaceous substances which mimic growth-inducing molecules |
| US5637459A (en) * | 1990-06-11 | 1997-06-10 | Nexstar Pharmaceuticals, Inc. | Systematic evolution of ligands by exponential enrichment: chimeric selex |
| US5660985A (en) * | 1990-06-11 | 1997-08-26 | Nexstar Pharmaceuticals, Inc. | High affinity nucleic acid ligands containing modified nucleotides |
| US5707796A (en) * | 1990-06-11 | 1998-01-13 | Nexstar Pharmaceuticals, Inc. | Method for selecting nucleic acids on the basis of structure |
| US5496938A (en) * | 1990-06-11 | 1996-03-05 | Nexstar Pharmaceuticals, Inc. | Nucleic acid ligands to HIV-RT and HIV-1 rev |
| KR970002255B1 (ko) | 1990-06-11 | 1997-02-26 | 넥스스타 파아마슈티컬드, 인크. | 핵산 리간드 |
| WO1992014843A1 (en) | 1991-02-21 | 1992-09-03 | Gilead Sciences, Inc. | Aptamer specific for biomolecules and method of making |
| US5582981A (en) * | 1991-08-14 | 1996-12-10 | Gilead Sciences, Inc. | Method for identifying an oligonucleotide aptamer specific for a target |
| US5698391A (en) | 1991-08-23 | 1997-12-16 | Isis Pharmaceuticals, Inc. | Methods for synthetic unrandomization of oligomer fragments |
| US5605793A (en) * | 1994-02-17 | 1997-02-25 | Affymax Technologies N.V. | Methods for in vitro recombination |
| US5706796A (en) * | 1996-08-16 | 1998-01-13 | Genero; Nivardo Blasoni | Heat diffusion ovens |
| US6387620B1 (en) * | 1999-07-28 | 2002-05-14 | Gilead Sciences, Inc. | Transcription-free selex |
-
1999
- 1999-07-28 US US09/362,578 patent/US6387620B1/en not_active Expired - Fee Related
-
2000
- 2000-07-19 WO PCT/US2000/019725 patent/WO2001009380A1/en not_active Ceased
- 2000-07-19 DE DE60042526T patent/DE60042526D1/de not_active Expired - Lifetime
- 2000-07-19 JP JP2001513635A patent/JP2003505108A/ja active Pending
- 2000-07-19 AT AT00947549T patent/ATE435922T1/de not_active IP Right Cessation
- 2000-07-19 AU AU61133/00A patent/AU782673B2/en not_active Ceased
- 2000-07-19 CA CA002391351A patent/CA2391351A1/en not_active Abandoned
- 2000-07-19 EP EP00947549A patent/EP1206575B1/de not_active Expired - Lifetime
-
2002
- 2002-03-22 US US10/103,944 patent/US20020102599A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| AU782673B2 (en) | 2005-08-18 |
| EP1206575A1 (de) | 2002-05-22 |
| EP1206575A4 (de) | 2004-12-01 |
| AU6113300A (en) | 2001-02-19 |
| DE60042526D1 (de) | 2009-08-20 |
| CA2391351A1 (en) | 2001-02-08 |
| US20020102599A1 (en) | 2002-08-01 |
| EP1206575B1 (de) | 2009-07-08 |
| WO2001009380A1 (en) | 2001-02-08 |
| JP2003505108A (ja) | 2003-02-12 |
| US6387620B1 (en) | 2002-05-14 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |