ATE437366T1 - Verfahren zur direkten auswahl von antigen- spezifischen t-zellen - Google Patents

Verfahren zur direkten auswahl von antigen- spezifischen t-zellen

Info

Publication number
ATE437366T1
ATE437366T1 AT99924167T AT99924167T ATE437366T1 AT E437366 T1 ATE437366 T1 AT E437366T1 AT 99924167 T AT99924167 T AT 99924167T AT 99924167 T AT99924167 T AT 99924167T AT E437366 T1 ATE437366 T1 AT E437366T1
Authority
AT
Austria
Prior art keywords
cells
antigen
product
labeled
specific
Prior art date
Application number
AT99924167T
Other languages
English (en)
Inventor
Mario Assenmacher
Stefan Miltenyi
Jurgen Schmitz
Original Assignee
Miltenyi Biotec Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Miltenyi Biotec Gmbh filed Critical Miltenyi Biotec Gmbh
Application granted granted Critical
Publication of ATE437366T1 publication Critical patent/ATE437366T1/de

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
    • G01N33/56966—Animal cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/10—Cellular immunotherapy characterised by the cell type used
    • A61K40/11—T-cells, e.g. tumour infiltrating lymphocytes [TIL] or regulatory T [Treg] cells; Lymphokine-activated killer [LAK] cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/40—Cellular immunotherapy characterised by antigens that are targeted or presented by cells of the immune system
    • A61K40/46—Viral antigens
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0634—Cells from the blood or the immune system
    • C12N5/0636—T lymphocytes
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/5044—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics involving specific cell types
    • G01N33/5047—Cells of the immune system
    • G01N33/505—Cells of the immune system involving T-cells

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Hematology (AREA)
  • Cell Biology (AREA)
  • Molecular Biology (AREA)
  • Urology & Nephrology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Food Science & Technology (AREA)
  • Pathology (AREA)
  • Zoology (AREA)
  • General Physics & Mathematics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Analytical Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Genetics & Genomics (AREA)
  • Veterinary Medicine (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Wood Science & Technology (AREA)
  • Virology (AREA)
  • General Engineering & Computer Science (AREA)
  • Toxicology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
AT99924167T 1998-05-11 1999-05-10 Verfahren zur direkten auswahl von antigen- spezifischen t-zellen ATE437366T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US8513698P 1998-05-11 1998-05-11
PCT/US1999/010200 WO1999058977A1 (en) 1998-05-11 1999-05-10 Method of direct selection of antigen-specific t cells

Publications (1)

Publication Number Publication Date
ATE437366T1 true ATE437366T1 (de) 2009-08-15

Family

ID=22189678

Family Applications (1)

Application Number Title Priority Date Filing Date
AT99924167T ATE437366T1 (de) 1998-05-11 1999-05-10 Verfahren zur direkten auswahl von antigen- spezifischen t-zellen

Country Status (10)

Country Link
US (2) US6576428B1 (de)
EP (1) EP1078263B1 (de)
JP (1) JP4601166B2 (de)
AT (1) ATE437366T1 (de)
AU (1) AU765085B2 (de)
CA (1) CA2330678C (de)
DE (1) DE69941150D1 (de)
DK (1) DK1078263T3 (de)
ES (1) ES2328650T3 (de)
WO (1) WO1999058977A1 (de)

Families Citing this family (71)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7166423B1 (en) 1992-10-21 2007-01-23 Miltenyi Biotec Gmbh Direct selection of cells by secretion product
AU679949B2 (en) * 1992-10-21 1997-07-17 Stefan Miltenyi Direct selection of cells by secretion product
IL141627A0 (en) * 1998-08-24 2002-03-10 Maxim Pharm Inc Activation and protection of t-cells (cd4+and cd8+) using an h2 receptor agonist and other t-cell activating agents
US7807377B2 (en) * 1998-10-20 2010-10-05 Salvatore Albani Method of isolating antigen-specific T cells employing artificial antigen presenting cells
US20020044656A1 (en) * 1999-10-13 2002-04-18 Brant L. Candelore Interfacing a conditional access circuit to a digital device using input and output stream switching
US7541184B2 (en) * 2000-02-24 2009-06-02 Invitrogen Corporation Activation and expansion of cells
US7572631B2 (en) 2000-02-24 2009-08-11 Invitrogen Corporation Activation and expansion of T cells
US7462486B2 (en) 2000-05-12 2008-12-09 Oregon Health & Science University Methods of selecting T cell receptor V peptides for therapeutic use
US7371385B2 (en) 2000-05-12 2008-05-13 Oregon Health & Science University Method of treating immune pathologies with low dose estrogen
JP2002365286A (ja) * 2000-11-13 2002-12-18 Kyogo Ito 細胞性免疫検出法およびその医薬への応用
US20090137416A1 (en) 2001-01-16 2009-05-28 Regeneron Pharmaceuticals, Inc. Isolating Cells Expressing Secreted Proteins
ATE325865T1 (de) 2001-01-16 2006-06-15 Regeneron Pharma Isolierung von sezernierte proteine exprimierenden zellen
GB0118337D0 (en) * 2001-07-27 2001-09-19 Lonza Biologics Plc Method for selecting antibody expressing cells
US20060035291A1 (en) * 2001-09-18 2006-02-16 Kyogo Itoh Method of detecting cellular immunity and application thereof to drugs
US20040175373A1 (en) * 2002-06-28 2004-09-09 Xcyte Therapies, Inc. Compositions and methods for eliminating undesired subpopulations of T cells in patients with immunological defects related to autoimmunity and organ or hematopoietic stem cell transplantation
US20050084967A1 (en) * 2002-06-28 2005-04-21 Xcyte Therapies, Inc. Compositions and methods for eliminating undesired subpopulations of T cells in patients with immunological defects related to autoimmunity and organ or hematopoietic stem cell transplantation
ES2422193T3 (es) * 2002-06-28 2013-09-09 Life Technologies Corp Métodos para restaurar el repertorio inmune en pacientes con defectos inmunológicos relacionados con la autoinmunidad y trasplante de órganos o de células madre hematopoyéticas
ES2267937T3 (es) * 2002-08-23 2007-03-16 Deutsches Rheuma-Forschungszentrum Berlin Procedimiento de deteccion y aislamiento de linfocitos t que reconocen un antigeno definido.
WO2004051268A1 (en) 2002-12-03 2004-06-17 Celltech R & D Limited Assay for identifying antibody producing cells
US20040248205A1 (en) * 2003-04-16 2004-12-09 Stern Lawrence J. Major histocompatibility complex (MHC)-peptide arrays
WO2004104185A1 (en) * 2003-05-08 2004-12-02 Xcyte Therapies, Inc. Generation and isolation of antigen-specific t cells
US7771969B2 (en) 2003-08-20 2010-08-10 Celltech R&D Limited Methods for obtaining antibodies
WO2005031357A2 (en) * 2003-09-24 2005-04-07 Ucl Biomedica Plc. Cell sample analysis
JP2008507259A (ja) * 2004-05-24 2008-03-13 ベイラー・リサーチ・インスチチユート 免疫応答の評価方法
WO2005118884A1 (en) * 2004-05-28 2005-12-15 The United States Of America As Represented By The Secretary Of The Navy A method for the rapid diagnosis of infectious disease by detection and quantitation of microorganism induced cytokines
GB0412973D0 (en) * 2004-06-10 2004-07-14 Celltech R&D Ltd Identification of antibody producing cells
CA2575604A1 (en) 2004-07-30 2006-02-02 Oregon Health And Science University Methods for detecting and treating autoimmune disorders
CA2585462A1 (en) * 2004-10-29 2006-05-11 Benaroya Research Institute At Virginia Mason Methods of generating antigen-specific cd4+cd25+ regulatory t cells, compositions and methods of use
WO2006124356A2 (en) * 2005-05-16 2006-11-23 The Rockefeller University Method for isolating dermal papilla cells and uses thereof
EP1996931B1 (de) 2005-12-28 2013-11-27 The General Hospital Corporation Blutzellen-sortierungsverfahren und -systeme
EP1878744A1 (de) * 2006-07-13 2008-01-16 Max-Delbrück-Centrum für Molekulare Medizin (MDC) Epitope-Tag für an der Oberfläche exprimierte T-Zell Rezeptor Proteine, deren Anwendung und Verfahren zur Selection von Wirtszellen, die sie exprimieren
WO2008016431A2 (en) * 2006-07-29 2008-02-07 Robert Lamar Bjork Bi-specific monoclonal antibody (specific for both cd3 and cd11b) therapeutic drug
CN101221171B (zh) * 2007-12-11 2011-07-20 广州益善生物技术有限公司 用于骨代谢生化标志物检测的液相芯片及其制备方法
WO2009103753A1 (en) * 2008-02-20 2009-08-27 Ablynx Nv Methods for identifying and/or sorting cells by secreted molecule and kits for performing such methods
EP2306959A2 (de) * 2008-07-11 2011-04-13 The General Hospital Corporation Magnetvorrichtung für bluttrennung
US8309306B2 (en) * 2008-11-12 2012-11-13 Nodality, Inc. Detection composition
GB0823553D0 (en) * 2008-12-24 2009-01-28 Immunosolv Ltd Cell separation technique
US20120045827A1 (en) * 2009-03-09 2012-02-23 Biofactura, Inc. Separation of antigen-specific memory b cells with a conjugated biopolymer surface
US8790916B2 (en) 2009-05-14 2014-07-29 Genestream, Inc. Microfluidic method and system for isolating particles from biological fluid
CN102033129A (zh) * 2009-09-29 2011-04-27 上海英伯肯医学生物技术有限公司 用抗原刺激的细胞免疫反应来检测病原微生物的方法及测试笔
EP2390661B1 (de) * 2010-05-02 2015-06-24 Miltenyi Biotec GmbH Verankerungs-/Erfassungsmittel zum Auswählen oder Analysieren einer CHO-Zelle entsprechend einem Produkt, das von der CHO-Zelle sezerniert wird
US9725689B2 (en) 2010-10-08 2017-08-08 Terumo Bct, Inc. Configurable methods and systems of growing and harvesting cells in a hollow fiber bioreactor system
EP2518504A1 (de) * 2011-04-29 2012-10-31 Miltenyi Biotec GmbH Verfahren zur quantitativen und qualitativen Charakterisierung von antigenspezifischen T-Zellen, die ein spezifischen Antigen erkennen
HK1199404A1 (en) 2011-05-26 2015-07-03 Geneius Biotechnology Investments, Llc Modulated immunodominance therapy
RU2657758C2 (ru) * 2011-12-22 2018-06-15 Иеда Рисеч Энд Девелопмент Ко. Лтд. Комбинированная терапия для стабильного и долговременного приживления трансплантата
EP4006550B1 (de) 2012-08-29 2026-06-17 Inguran, LLC Zusammensetzung für die magnetische entfernung oder identifizierung von beschädigten oder beeinträchtigten zellen oder zellstrukturen
US10379026B2 (en) 2012-08-29 2019-08-13 Inguran, Llc Cell processing using magnetic particles
TWI864338B (zh) 2012-11-14 2024-12-01 美商再生元醫藥公司 重組細胞表面捕捉蛋白質
EP3068867B1 (de) 2013-11-16 2018-04-18 Terumo BCT, Inc. Zellenexpansion in einem bioreaktor
US11008547B2 (en) 2014-03-25 2021-05-18 Terumo Bct, Inc. Passive replacement of media
CN103901188B (zh) * 2014-04-11 2016-08-24 苏州浩欧博生物医药有限公司 一种吸入过敏原的化学发光定量检测试剂盒及其制备方法和检测方法
EP3198006B1 (de) 2014-09-26 2021-03-24 Terumo BCT, Inc. Geplante fütterung
WO2017004592A1 (en) 2015-07-02 2017-01-05 Terumo Bct, Inc. Cell growth with mechanical stimuli
CA3009852A1 (en) * 2015-12-28 2017-07-06 Novartis Ag Methods of making chimeric antigen receptor-expressing cells
WO2017205667A1 (en) 2016-05-25 2017-11-30 Terumo Bct, Inc. Cell expansion
US11104874B2 (en) 2016-06-07 2021-08-31 Terumo Bct, Inc. Coating a bioreactor
US11685883B2 (en) 2016-06-07 2023-06-27 Terumo Bct, Inc. Methods and systems for coating a cell growth surface
AU2017290119A1 (en) * 2016-06-28 2019-01-24 Geneius Biotechnology, Inc. T cell compositions for immunotherapy
US11624046B2 (en) 2017-03-31 2023-04-11 Terumo Bct, Inc. Cell expansion
US12234441B2 (en) 2017-03-31 2025-02-25 Terumo Bct, Inc. Cell expansion
JP7393945B2 (ja) 2017-03-31 2023-12-07 テルモ ビーシーティー、インコーポレーテッド 細胞増殖
WO2019028028A1 (en) * 2017-08-01 2019-02-07 Benaroya Research Institute At Virgina Mason METHODS OF IDENTIFICATION AND SEPARATION OF PRO-ALLERGIC SPECIFIC T LYMPHOCYTES
CN110857948B (zh) * 2018-08-24 2025-01-21 武汉纳达康生物科技有限公司 H7禽流感病毒抗体磁免疫化学发光检测试剂盒及其应用
WO2020079264A1 (en) * 2018-10-19 2020-04-23 ETH Zürich Chimeric molecules
WO2021030606A1 (en) * 2019-08-14 2021-02-18 Sanford Burnham Prebys Medical Discovery Institute Methods and devices for rare cell capture
JP2022093945A (ja) * 2020-12-14 2022-06-24 株式会社山田養蜂場本社 Ｂ細胞数増加剤
EP4314244B1 (de) 2021-03-23 2025-07-23 Terumo BCT, Inc. Zellerfassung und -erweiterung
US12152699B2 (en) 2022-02-28 2024-11-26 Terumo Bct, Inc. Multiple-tube pinch valve assembly
USD1099116S1 (en) 2022-09-01 2025-10-21 Terumo Bct, Inc. Display screen or portion thereof with a graphical user interface for displaying cell culture process steps and measurements of an associated bioreactor device
CN117433867A (zh) * 2023-10-24 2024-01-23 深圳联合医学科技有限公司 阴道微生物的荧光染色液及检测阴道微生物的方法
WO2025151270A2 (en) * 2024-01-08 2025-07-17 Board Of Regents, The University Of Texas System Microfluidic device for rapid enrichment of anti-tumor t-cells and methods of use thereof

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4230685A (en) 1979-02-28 1980-10-28 Northwestern University Method of magnetic separation of cells and the like, and microspheres for use therein
US4452773A (en) 1982-04-05 1984-06-05 Canadian Patents And Development Limited Magnetic iron-dextran microspheres
GB8408127D0 (en) 1984-03-29 1984-05-10 Nyegaard & Co As Contrast agents
US4770183A (en) 1986-07-03 1988-09-13 Advanced Magnetics Incorporated Biologically degradable superparamagnetic particles for use as nuclear magnetic resonance imaging agents
IL91414A0 (en) 1988-08-31 1990-04-29 Zynaxis Technologies Inc Reagents and methods for the determination of analytes
ATE114507T1 (de) 1988-12-28 1994-12-15 Stefan Miltenyi Verfahren sowie materialien zur hochgraduierten magnetischen abspaltung biologischer materialien.
US5385707A (en) 1988-12-28 1995-01-31 Stefan Miltenyi Metal matrices for use in high gradient magnetic separation of biological materials and method for coating the same
AU679949B2 (en) * 1992-10-21 1997-07-17 Stefan Miltenyi Direct selection of cells by secretion product
US5635363A (en) 1995-02-28 1997-06-03 The Board Of Trustees Of The Leland Stanford Junior University Compositions and methods for the detection, quantitation and purification of antigen-specific T cells
US6143292A (en) 1995-05-25 2000-11-07 Baxter International Inc. Allogeneic cell therapy for cancer following allogeneic stem cell transplantation
EP0852618A1 (de) 1995-07-25 1998-07-15 Celltherapy Inc. Autologe immunzellentherapie, zellzusammensetzungen, verfahren und verwendung zur behandlung menschlicher krankheiten
EP0954601A4 (de) 1996-03-20 2004-08-18 Genzyme Corp Verfahren zur erkennung von zytotoxischen t-zell epitopen
IL126843A (en) 1996-05-23 2007-06-17 Scripps Research Inst Mhc class ii antigen-presenting systems and methods for activating cd4+t cells in vitro
US5750356A (en) * 1996-05-31 1998-05-12 Anergen, Inc. Method for monitoring T cell reactivity

Also Published As

Publication number Publication date
AU4073699A (en) 1999-11-29
EP1078263A1 (de) 2001-02-28
US20040023377A1 (en) 2004-02-05
JP4601166B2 (ja) 2010-12-22
WO1999058977A1 (en) 1999-11-18
CA2330678A1 (en) 1999-11-18
EP1078263B1 (de) 2009-07-22
AU765085B2 (en) 2003-09-11
US6576428B1 (en) 2003-06-10
DE69941150D1 (de) 2009-09-03
CA2330678C (en) 2009-04-07
DK1078263T3 (da) 2009-11-02
ES2328650T3 (es) 2009-11-16
JP2002514765A (ja) 2002-05-21

Similar Documents

Publication Publication Date Title
DE69941150D1 (de) Verfahren zur direkten auswahl von antigen-spezifischen t-zellen
KR950704475A (ko) 분비 생성물에 의한 직접적인 세포 선별(direct selection of cells by se-cretion product)
PL316209A1 (en) Method of and apparatus for detecting specific target cells in specialised or mixed cell populations and solutions containing moxed populations of cells
ATE292282T1 (de) Verfahren zur zellseparation unter verwendung von immunorosetten
ATE97500T1 (de) Verfahren zur unterscheidung zwischen intakten und beschaedigten zellen in einer probe.
PL328272A1 (en) Methods of and compositions for detecting ligand pair bonds using non-fluoroscent labelling
EP0850417A4 (de) Effiziente anreicherung und detektion von ausgesäten tumorzellen
DE69626418D1 (de) Verfahren zur bulk-anreicherung von einer zellpopulation oder zellsubpopulation
DE69721258T2 (de) Markierung und auswahl von molekülen
Laghmouchi et al. Long‐term in vitro persistence of magnetic properties after magnetic bead‐based cell separation of T cells
WO2002087792A8 (en) Methods and apparatus for use of optical forces for identification, characterization and/or sorting of particles
Peters et al. A leucine-rich repeat variant with a novel repetitive protein structural motif
ATE366801T1 (de) Zusammensetzungen und verfahren zur trennung von zellen
ATE320314T1 (de) Verfahren zur modifikation von ausgewählten zellen in einer magnetischen zelltrennungsäule
DE69633740D1 (de) Verfahren zur auswahl einer population oder subpopulation einer probe unter verwendung von partikel-und schwerkraft -sedimentation
ATE120796T1 (de) Trennungsverfahren zum trennen von hämatopoeitischen vorläuferzellen.
TW215898B (de)
WO1993020103A3 (en) Peptides of an antigen, capable of recognition by or induction of cytotoxic t lymphocytes, and method of their identification
SE8603312L (sv) Sett att overvaka fermentering

Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties