ATE437643T1 - Pharmazeutische zusammensetzung mit einem benzodiazepin-derivat und einem hemmer des rsv- fusionsproteins - Google Patents

Pharmazeutische zusammensetzung mit einem benzodiazepin-derivat und einem hemmer des rsv- fusionsproteins

Info

Publication number
ATE437643T1
ATE437643T1 AT05718061T AT05718061T ATE437643T1 AT E437643 T1 ATE437643 T1 AT E437643T1 AT 05718061 T AT05718061 T AT 05718061T AT 05718061 T AT05718061 T AT 05718061T AT E437643 T1 ATE437643 T1 AT E437643T1
Authority
AT
Austria
Prior art keywords
pharmaceutical composition
fusion protein
composition containing
benzodiazepine derivative
protein inhibitor
Prior art date
Application number
AT05718061T
Other languages
English (en)
Inventor
Kenneth Powell
Richard Kelsey
Malcolm Carter
Dagmar Alber
Lara Wilson
Elisa Henderson
Phil Chambers
Debra Taylor
Stan Tyms
Verity Dowdell
Original Assignee
Arrow Therapeutics Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Arrow Therapeutics Ltd filed Critical Arrow Therapeutics Ltd
Application granted granted Critical
Publication of ATE437643T1 publication Critical patent/ATE437643T1/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
    • A61K31/5513—1,4-Benzodiazepines, e.g. diazepam or clozapine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
    • C07D243/06—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
    • C07D243/10—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
    • C07D243/14—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines
    • C07D243/16—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals
    • C07D243/18—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals substituted in position 2 by nitrogen, oxygen or sulfur atoms
    • C07D243/24—Oxygen atoms

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Pulmonology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Virology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
AT05718061T 2004-03-19 2005-03-18 Pharmazeutische zusammensetzung mit einem benzodiazepin-derivat und einem hemmer des rsv- fusionsproteins ATE437643T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB0406282.4A GB0406282D0 (en) 2004-03-19 2004-03-19 Therapeutic compounds
PCT/GB2005/001018 WO2005089769A1 (en) 2004-03-19 2005-03-18 Pharmaceutical composition comprising a benzodiazepine derivative and an inhibit or of the rsv fusion protein

Publications (1)

Publication Number Publication Date
ATE437643T1 true ATE437643T1 (de) 2009-08-15

Family

ID=32118068

Family Applications (1)

Application Number Title Priority Date Filing Date
AT05718061T ATE437643T1 (de) 2004-03-19 2005-03-18 Pharmazeutische zusammensetzung mit einem benzodiazepin-derivat und einem hemmer des rsv- fusionsproteins

Country Status (18)

Country Link
US (1) US8853204B2 (de)
EP (1) EP1727550B1 (de)
JP (1) JP4940128B2 (de)
KR (2) KR101292431B1 (de)
CN (1) CN1933842A (de)
AT (1) ATE437643T1 (de)
AU (2) AU2005224157B2 (de)
BR (1) BRPI0507654A (de)
CA (1) CA2558112C (de)
CY (1) CY1109523T1 (de)
DE (1) DE602005015686D1 (de)
DK (1) DK1727550T3 (de)
ES (1) ES2327757T3 (de)
GB (1) GB0406282D0 (de)
PL (1) PL1727550T3 (de)
PT (1) PT1727550E (de)
RU (1) RU2388476C2 (de)
WO (1) WO2005089769A1 (de)

Families Citing this family (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0406279D0 (en) * 2004-03-19 2004-04-21 Arrow Therapeutics Ltd Therapeutic compounds
PL2094308T3 (pl) * 2006-11-21 2011-06-30 Novartis Ag Trwały preparat pozajelitowy zawierający inhibitor RSV o strukturze benzodiazepiny
GB201506448D0 (en) 2015-04-16 2015-06-03 Univ Durham An antimicrobial compound
DK3324977T3 (da) * 2015-07-22 2022-10-17 Enanta Pharm Inc Benzodiazepinderivater som rsv-inhibitorer
EP3402799B1 (de) 2016-01-15 2022-05-04 Enanta Pharmaceuticals, Inc. Heterocyclische verbindungen als rsv-inhibitoren
GB201613942D0 (en) * 2016-08-15 2016-09-28 Univ Of Durham The An antimicrobial compound
US10398706B2 (en) 2017-01-06 2019-09-03 Enanta Pharmaceuticals, Inc. Heteroaryldiazepine derivatives as RSV inhibitors
CN110809472B (zh) 2017-02-16 2023-05-23 英安塔制药有限公司 用于制备苯二氮䓬衍生物的方法
WO2018226801A1 (en) 2017-06-07 2018-12-13 Enanta Pharmaceuticals, Inc. Aryldiazepine derivatives as rsv inhibitors
WO2019006291A1 (en) 2017-06-30 2019-01-03 Enanta Pharmaceuticals, Inc. HETEROCYCLIC COMPOUNDS AS RSV INHIBITORS
US11091501B2 (en) 2017-06-30 2021-08-17 Enanta Pharmaceuticals, Inc. Heterocyclic compounds as RSV inhibitors
BR112020006334A2 (pt) * 2017-09-29 2020-09-24 Enanta Pharmaceuticals, Inc. combinação de agentes farmacêuticos como inibidores de rsv
US10647711B2 (en) 2017-11-13 2020-05-12 Enanta Pharmaceuticals, Inc. Azepin-2-one derivatives as RSV inhibitors
CA3080138A1 (en) * 2017-11-13 2019-05-16 Enanta Pharmaceuticals, Inc. Processes for the resolution of benzodiazepin-2-one and benzoazepin-2-one derivatives
WO2019199908A1 (en) 2018-04-11 2019-10-17 Enanta Pharmaceuticals, Inc. Heterocyclic compounds as rsv inhibitors
BR112021018335A2 (pt) 2019-03-18 2021-11-23 Enanta Pharm Inc Derivados de benzodiazepina como inibidores de rsv
WO2020210246A1 (en) 2019-04-09 2020-10-15 Enanta Pharmaceuticals, Inc, Heterocyclic compounds as rsv inhibitors
GB201911944D0 (en) 2019-08-20 2019-10-02 Reviral Ltd Pharmaceutical compounds
AU2020357452B2 (en) 2019-10-04 2026-01-29 Enanta Pharmaceuticals, Inc Antiviral heterocyclic compounds
US11505558B1 (en) 2019-10-04 2022-11-22 Enanta Pharmaceuticals, Inc. Antiviral heterocyclic compounds
GB201915273D0 (en) * 2019-10-22 2019-12-04 Reviral Ltd Pharmaceutical compounds
GB201915932D0 (en) 2019-11-01 2019-12-18 Reviral Ltd Pharmaceutical compounds
UY39032A (es) 2020-01-24 2021-07-30 Enanta Pharm Inc Compuestos heterocíclicos como agentes antivirales
WO2022010882A1 (en) 2020-07-07 2022-01-13 Enanta Pharmaceuticals, Inc, Dihydroquinoxaline and dihydropyridopyrazine derivatives as rsv inhibitors
GB202010409D0 (en) * 2020-07-07 2020-08-19 Reviral Ltd Pharmaceutical compounds
US11945824B2 (en) 2020-10-19 2024-04-02 Enanta Pharmaceuticals, Inc. Heterocyclic compounds as anti-viral agents
WO2022182861A1 (en) 2021-02-26 2022-09-01 Enanta Pharmaceuticals, Inc. Antiviral heterocyclic compounds
US12612412B2 (en) 2021-02-26 2026-04-28 Enanta Pharmaceuticals, Inc. Antiviral heterocyclic compounds
US12080039B2 (en) 2021-06-08 2024-09-03 Kyndryl, Inc. Contextual policy-based computer vision control
AR129003A1 (es) 2022-04-07 2024-07-03 Enanta Pharm Inc Compuestos heterocíclicos antivirales
WO2023211997A1 (en) 2022-04-27 2023-11-02 Enanta Pharmaceuticals, Inc. Antiviral compounds

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4324794A (en) * 1980-08-26 1982-04-13 Research Triangle Institute Inhibition of respiratory syncytial virus-induced cell fusion by amidino compounds
EP0491218A1 (de) * 1990-12-17 1992-06-24 F. Hoffmann-La Roche Ag Benzodiazepinone
JP2001519806A (ja) * 1997-04-07 2001-10-23 アクシス ファーマシューティカルズ，インコーポレイティド セリンプロテアーゼ活性、特にトリプターゼ活性に関連する疾病を処理するための化合物及び組成物
EP1098644A1 (de) * 1998-07-20 2001-05-16 Bristol-Myers Squibb Company Antivirale substituierte benzimidazole
US6489338B2 (en) * 2000-06-13 2002-12-03 Bristol-Myers Squibb Company Imidazopyridine and imidazopyrimidine antiviral agents
US6506738B1 (en) * 2000-09-27 2003-01-14 Bristol-Myers Squibb Company Benzimidazolone antiviral agents
WO2003049688A2 (en) * 2001-12-10 2003-06-19 Bristol-Myers Squibb Company Bis hydrochloride monohydrate salt of rsv fusion inhibitor
US6919331B2 (en) * 2001-12-10 2005-07-19 Bristol-Myers Squibb Company Substituted 2-methyl-benzimidazole respiratory syncytial virus antiviral agents
JP2004107494A (ja) * 2002-09-18 2004-04-08 National Institute For Materials Science 熱可塑性層状アルキルシロキサンとその製造方法
NZ538870A (en) * 2002-09-20 2007-04-27 Arrow Therapeutics Ltd Benzodiazepine derivatives and pharmaceutical compositions containing them
GB0406279D0 (en) * 2004-03-19 2004-04-21 Arrow Therapeutics Ltd Therapeutic compounds

Also Published As

Publication number Publication date
AU2009212826A1 (en) 2009-09-17
CY1109523T1 (el) 2014-08-13
CN1933842A (zh) 2007-03-21
PT1727550E (pt) 2009-08-28
ES2327757T3 (es) 2009-11-03
DK1727550T3 (da) 2009-10-19
US20070142403A1 (en) 2007-06-21
RU2388476C2 (ru) 2010-05-10
JP2007529489A (ja) 2007-10-25
GB0406282D0 (en) 2004-04-21
RU2006136880A (ru) 2008-04-27
DE602005015686D1 (de) 2009-09-10
JP4940128B2 (ja) 2012-05-30
AU2005224157A1 (en) 2005-09-29
WO2005089769A1 (en) 2005-09-29
BRPI0507654A (pt) 2007-07-10
EP1727550B1 (de) 2009-07-29
KR101292431B1 (ko) 2013-07-31
CA2558112A1 (en) 2005-09-29
HK1098372A1 (en) 2007-07-20
KR20070009629A (ko) 2007-01-18
EP1727550A1 (de) 2006-12-06
PL1727550T3 (pl) 2010-01-29
AU2005224157B2 (en) 2009-05-28
KR20130042593A (ko) 2013-04-26
US8853204B2 (en) 2014-10-07
CA2558112C (en) 2014-07-29

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