ATE437954T1 - Verfahren zur herstellung optisch aktiver 5- substituierter 2-oxazolidinone aus racemischen epoxiden und cyanat unter einsatz einer halohydrin-dehalogenase - Google Patents

Verfahren zur herstellung optisch aktiver 5- substituierter 2-oxazolidinone aus racemischen epoxiden und cyanat unter einsatz einer halohydrin-dehalogenase

Info

Publication number: ATE437954T1
Authority: AT; Austria
Prior art keywords: cyanate; oxazolidinones; substituted; optically active; producing optically
Prior art date: 2006-03-03

Application number

AT07712350T

Other languages

English (en)

Inventor

Bernhard Hauer

Elenkov Maja Majeric

Dirk Barend Janssen

Original Assignee

Basf Se

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2006-03-03

Filing date

2007-02-28

Publication date

2009-08-15

2007-02-28 Application filed by Basf Se filed Critical Basf Se

2009-08-15 Application granted granted Critical

2009-08-15 Publication of ATE437954T1 publication Critical patent/ATE437954T1/de

Links

XLJMAIOERFSOGZ-UHFFFAOYSA-M cyanate Chemical compound [O-]C#N XLJMAIOERFSOGZ-UHFFFAOYSA-M 0.000 title abstract 2
150000002118 epoxides Chemical class 0.000 title abstract 2
108010013164 halohydrin dehalogenase Proteins 0.000 title abstract 2
238000004519 manufacturing process Methods 0.000 title abstract 2
IZXIZTKNFFYFOF-UHFFFAOYSA-N 2-Oxazolidone Chemical compound O=C1NCCO1 IZXIZTKNFFYFOF-UHFFFAOYSA-N 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
- C12P17/14—Nitrogen or oxygen as hetero atom and at least one other diverse hetero ring atom in the same ring
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P41/00—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture
- C12P41/006—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture by reactions involving C-N bonds, e.g. nitriles, amides, hydantoins, carbamates, lactames, transamination reactions, or keto group formation from racemic mixtures

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Engineering & Computer Science (AREA)
Life Sciences & Earth Sciences (AREA)
Zoology (AREA)
Wood Science & Technology (AREA)
Health & Medical Sciences (AREA)
General Engineering & Computer Science (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Biotechnology (AREA)
Biochemistry (AREA)
Bioinformatics & Cheminformatics (AREA)
Microbiology (AREA)
General Health & Medical Sciences (AREA)
Genetics & Genomics (AREA)
Analytical Chemistry (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Enzymes And Modification Thereof (AREA)

AT07712350T 2006-03-03 2007-02-28 Verfahren zur herstellung optisch aktiver 5- substituierter 2-oxazolidinone aus racemischen epoxiden und cyanat unter einsatz einer halohydrin-dehalogenase ATE437954T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
EP06110638		2006-03-03
PCT/EP2007/051861 WO2007099107A1 (en)	2006-03-03	2007-02-28	Process for the preparation of optically active 5-substituted 2-oxazolidinones from racemic epoxides and cyanate employing a halohydrin dehalogenase

Publications (1)

Publication Number	Publication Date
ATE437954T1 true ATE437954T1 (de)	2009-08-15

Family

ID=38008312

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT07712350T ATE437954T1 (de)	2006-03-03	2007-02-28	Verfahren zur herstellung optisch aktiver 5- substituierter 2-oxazolidinone aus racemischen epoxiden und cyanat unter einsatz einer halohydrin-dehalogenase

Country Status (8)

Country	Link
US (1)	US7993904B2 (de)
EP (1)	EP1994162B1 (de)
JP (1)	JP5191399B2 (de)
CN (1)	CN101437955B (de)
AT (1)	ATE437954T1 (de)
DE (1)	DE602007001794D1 (de)
ES (1)	ES2328183T3 (de)
WO (1)	WO2007099107A1 (de)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
WO2007071599A2 (en) *	2005-12-21	2007-06-28	Basf Se	A process for the production of an optically enriched tertiary alcohol
WO2010080635A2 (en) *	2008-12-18	2010-07-15	Codexis, Inc.	Recombinant halohydrin dehalogenase polypeptides
CN104745556B (zh) *	2015-03-05	2017-09-22	浙江工业大学	一种重组卤醇脱卤酶、突变体、工程菌及其应用
CN105838700A (zh) *	2016-03-25	2016-08-10	浙江工业大学	一种固定化卤醇脱卤酶及其应用
CN112251479B (zh) *	2020-10-27	2023-05-16	遵义医科大学	一种双酶级联催化合成手性噁唑烷酮类化合物的方法
CN115927276B (zh) *	2022-08-31	2024-08-27	中国科学院天津工业生物技术研究所	卤醇脱卤酶突变体及其合成手性噁唑烷酮的应用
CN118222538B (zh) *	2024-05-23	2024-09-20	南京工业大学	一种卤醇脱卤酶突变体及其应用

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP1158054A1 (de) *	2000-05-25	2001-11-28	Rijksuniversiteit te Groningen	Enzymatische Umwandlung von Epoxiden
CA2535255A1 (en)	2003-08-11	2005-02-24	Codexis, Inc.	Improved halohydrin dehalogenases and related polynucleotides
JP2007520460A (ja) *	2003-12-18	2007-07-26	ジーイー・ヘルスケア・リミテッド	アジド及び炭素同位体一酸化物を使用しイソシアネートを経由する、ロジウムで促進されたカルボニル化による炭素同位体標識合成の方法

2007
- 2007-02-28 AT AT07712350T patent/ATE437954T1/de not_active IP Right Cessation
- 2007-02-28 DE DE602007001794T patent/DE602007001794D1/de active Active
- 2007-02-28 CN CN2007800074997A patent/CN101437955B/zh not_active Expired - Fee Related
- 2007-02-28 ES ES07712350T patent/ES2328183T3/es active Active
- 2007-02-28 EP EP07712350A patent/EP1994162B1/de not_active Not-in-force
- 2007-02-28 JP JP2008556772A patent/JP5191399B2/ja not_active Expired - Fee Related
- 2007-02-28 US US12/279,786 patent/US7993904B2/en not_active Expired - Fee Related
- 2007-02-28 WO PCT/EP2007/051861 patent/WO2007099107A1/en not_active Ceased

Also Published As

Publication number	Publication date
JP5191399B2 (ja)	2013-05-08
JP2009528039A (ja)	2009-08-06
US20090042261A1 (en)	2009-02-12
EP1994162A1 (de)	2008-11-26
DE602007001794D1 (de)	2009-09-10
ES2328183T3 (es)	2009-11-10
WO2007099107A1 (en)	2007-09-07
US7993904B2 (en)	2011-08-09
CN101437955A (zh)	2009-05-20
CN101437955B (zh)	2012-10-31
EP1994162B1 (de)	2009-07-29

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Legal Events

Date	Code	Title	Description
2010-01-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties