ATE438621T1 - 3-(substitutierte amino)-1h-indole-2- carbonsäureester und 3-(substitutierte amino)- benzoäbüthiophen-2-carbonsäureester verbindungen als inhibitoren der interleukin-4 genexpression - Google Patents
3-(substitutierte amino)-1h-indole-2- carbonsäureester und 3-(substitutierte amino)- benzoäbüthiophen-2-carbonsäureester verbindungen als inhibitoren der interleukin-4 genexpressionInfo
- Publication number
- ATE438621T1 ATE438621T1 AT03733867T AT03733867T ATE438621T1 AT E438621 T1 ATE438621 T1 AT E438621T1 AT 03733867 T AT03733867 T AT 03733867T AT 03733867 T AT03733867 T AT 03733867T AT E438621 T1 ATE438621 T1 AT E438621T1
- Authority
- AT
- Austria
- Prior art keywords
- carboxylic acid
- acid esters
- substituted amino
- interleukin
- indole
- Prior art date
Links
- 102000004388 Interleukin-4 Human genes 0.000 title abstract 4
- 108090000978 Interleukin-4 Proteins 0.000 title abstract 4
- 229940028885 interleukin-4 Drugs 0.000 title abstract 4
- -1 3-(SUBSTITUTED AMINO)-1H-INDOLE-2- CARBOXYLIC ACID Chemical class 0.000 title 1
- 230000014509 gene expression Effects 0.000 title 1
- 239000003112 inhibitor Substances 0.000 title 1
- 241000725643 Respiratory syncytial virus Species 0.000 abstract 2
- 208000003950 B-cell lymphoma Diseases 0.000 abstract 1
- 201000004624 Dermatitis Diseases 0.000 abstract 1
- 241000709661 Enterovirus Species 0.000 abstract 1
- 206010020751 Hypersensitivity Diseases 0.000 abstract 1
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- 208000026935 allergic disease Diseases 0.000 abstract 1
- 230000007815 allergy Effects 0.000 abstract 1
- 208000006673 asthma Diseases 0.000 abstract 1
- 230000001580 bacterial effect Effects 0.000 abstract 1
- 125000005605 benzo group Chemical group 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 210000002443 helper t lymphocyte Anatomy 0.000 abstract 1
- 150000002475 indoles Chemical class 0.000 abstract 1
- 208000015181 infectious disease Diseases 0.000 abstract 1
- 230000002401 inhibitory effect Effects 0.000 abstract 1
- 230000017307 interleukin-4 production Effects 0.000 abstract 1
- 206010039083 rhinitis Diseases 0.000 abstract 1
- 230000035897 transcription Effects 0.000 abstract 1
- 238000013518 transcription Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
- A61K31/404—Indoles, e.g. pindolol
- A61K31/405—Indole-alkanecarboxylic acids; Derivatives thereof, e.g. tryptophan, indomethacin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/02—Nasal agents, e.g. decongestants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/16—Otologicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C07D209/42—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pulmonology (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Epidemiology (AREA)
- Virology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Immunology (AREA)
- Otolaryngology (AREA)
- Dermatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Indole Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US37530402P | 2002-04-23 | 2002-04-23 | |
| GBGB0217920.8A GB0217920D0 (en) | 2002-04-23 | 2002-08-02 | Interleukin-4 Gene Expression inhibitors |
| PCT/US2003/012189 WO2003091214A1 (en) | 2002-04-23 | 2003-04-23 | 3-substituted amino-1h-indole-2-carboxylic acid and 3-substituted amino-benzo |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE438621T1 true ATE438621T1 (de) | 2009-08-15 |
Family
ID=29272010
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT03733867T ATE438621T1 (de) | 2002-04-23 | 2003-04-23 | 3-(substitutierte amino)-1h-indole-2- carbonsäureester und 3-(substitutierte amino)- benzoäbüthiophen-2-carbonsäureester verbindungen als inhibitoren der interleukin-4 genexpression |
| AT03721841T ATE361910T1 (de) | 2002-04-23 | 2003-04-23 | 3-(pyridinyl-amino)-1h-indol-2-carbonsäure- verbindungen als inhibitoren der interleukin-4 genexpression |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT03721841T ATE361910T1 (de) | 2002-04-23 | 2003-04-23 | 3-(pyridinyl-amino)-1h-indol-2-carbonsäure- verbindungen als inhibitoren der interleukin-4 genexpression |
Country Status (8)
| Country | Link |
|---|---|
| EP (3) | EP1834947A3 (de) |
| JP (1) | JP4497930B2 (de) |
| AT (2) | ATE438621T1 (de) |
| AU (2) | AU2003225131A1 (de) |
| CA (2) | CA2483091A1 (de) |
| DE (2) | DE60328675D1 (de) |
| ES (1) | ES2330628T3 (de) |
| WO (2) | WO2003091214A1 (de) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20050215640A1 (en) | 2004-03-26 | 2005-09-29 | Baxter Jeffrey H | HMB compositions and uses thereof |
| JP2008519034A (ja) | 2004-11-03 | 2008-06-05 | バーテックス ファーマシューティカルズ インコーポレイテッド | イオンチャネル調節剤としてのピリミジン誘導体および使用方法 |
| WO2006090817A1 (ja) * | 2005-02-25 | 2006-08-31 | Ono Pharmaceutical Co., Ltd. | インドール化合物およびその用途 |
| NZ568611A (en) * | 2005-12-19 | 2011-11-25 | Abbott Lab | Use of beta-hydroxy-beta-methylbutyrate to modulate the imbalance in type 1 and type 2 cytokine production |
| PL2099796T3 (pl) | 2006-11-30 | 2011-10-31 | Genentech Inc | Związki azaindolilowe i sposoby ich zastosowania |
| CA2682354C (en) | 2007-04-16 | 2016-12-13 | Abbott Laboratories | 7-nonsubstituted indole mcl-1 inhibitors |
| RU2426540C1 (ru) * | 2009-11-19 | 2011-08-20 | Закрытое Акционерное Общество "Мастерклон" | Противовоспалительное и противоаллергическое лекарственное средство и фармацевтическая композиция на его основе |
| TWI469965B (zh) | 2008-12-22 | 2015-01-21 | Ono Pharmaceutical Co | 乙炔基吲哚化合物 |
| US9693577B2 (en) | 2010-01-29 | 2017-07-04 | Abbott Laboratories | Method of preparing a nutritional powder comprising spray dried HMB |
| EP2461704B1 (de) | 2010-01-29 | 2013-10-09 | Abbott Laboratories | Aseptisch verpackte nahrungsflüssigkeiten mit hmb |
| WO2011094557A1 (en) | 2010-01-29 | 2011-08-04 | Abbott Laboratories | Nutritional emulsions comprising calcium hmb |
| TWI526161B (zh) | 2010-06-10 | 2016-03-21 | 亞培公司 | 包含鈣ｈｍｂ及可溶性蛋白質之實質上透明營養液 |
| WO2011162222A1 (ja) | 2010-06-21 | 2011-12-29 | 小野薬品工業株式会社 | ４，４'－［４－フルオロ－７－（｛４－［４－（３－フルオロ－２－メチルフェニル）ブトキシ］フェニル｝エチニル）－２－メチル－１ｈ－インドール－１，３－ジイル］ジブタン酸、４，４'－［２－メチル－７－（｛４－［４－（ペンタフルオロフェニル）ブトキシ］フェニル｝エチニル）－１ｈ－インドール－１，３－ジイル］ジブタン酸および４，４'－［４－フルオロ－２－メチル－７－（｛４－［４－（２，３，４，６－テトラフルオロフェニル）ブトキシ］フェニル｝エチニル）－１ｈ－インドール－１，３－ジイル］ジブタン酸の新規結晶形 |
| WO2016199172A2 (en) | 2015-06-10 | 2016-12-15 | Council Of Scientific & Industrial Research | Novel compounds and uses thereof |
| CN106632076B (zh) * | 2016-09-20 | 2019-04-30 | 中国药科大学 | 4,6-二苯基嘧啶类化合物、其制备方法和医药用途 |
| CN114773302B (zh) * | 2022-04-29 | 2024-04-02 | 中国药科大学 | 一种苯并呋喃衍生物及其医药用途 |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4675332A (en) * | 1984-12-10 | 1987-06-23 | Warner-Lambert Company | Acidic tetrazolyl substituted indole compounds and their use as antiallergy agents |
| US5189054A (en) * | 1990-11-02 | 1993-02-23 | Merrell Dow Pharmaceuticals Inc. | 3-amidoindolyl derivatives and pharmaceutical compositions thereof |
| US5328920A (en) * | 1991-04-17 | 1994-07-12 | Hoechst-Roussel Pharmaceuticals Incorporated | Substituted (pyridinylamino)-indoles |
| US5489586A (en) * | 1994-03-07 | 1996-02-06 | Warner-Lambert Company | Method for treating inflammatory disease in humans |
| PE32296A1 (es) * | 1994-07-28 | 1996-08-07 | Hoffmann La Roche | Ester de l-monovalina derivado de 2-(2-amino-1,6-dihidro-6-oxo-purin-9-il) metoxi-1,3-propandiol y sus sales farmaceuticamente aceptables |
| WO1997013768A1 (fr) * | 1995-10-11 | 1997-04-17 | Synthelabo | Composes derives d'oxazolidin-2-one, leur procede de preparation et leur application en therapeutique |
| GB9902455D0 (en) * | 1999-02-05 | 1999-03-24 | Zeneca Ltd | Chemical compounds |
-
2003
- 2003-04-23 AT AT03733867T patent/ATE438621T1/de not_active IP Right Cessation
- 2003-04-23 WO PCT/US2003/012189 patent/WO2003091214A1/en not_active Ceased
- 2003-04-23 JP JP2003587780A patent/JP4497930B2/ja not_active Expired - Fee Related
- 2003-04-23 EP EP06026815A patent/EP1834947A3/de not_active Withdrawn
- 2003-04-23 DE DE60328675T patent/DE60328675D1/de not_active Expired - Lifetime
- 2003-04-23 AU AU2003225131A patent/AU2003225131A1/en not_active Abandoned
- 2003-04-23 AU AU2003239150A patent/AU2003239150A1/en not_active Abandoned
- 2003-04-23 AT AT03721841T patent/ATE361910T1/de not_active IP Right Cessation
- 2003-04-23 DE DE60313769T patent/DE60313769T2/de not_active Expired - Lifetime
- 2003-04-23 CA CA002483091A patent/CA2483091A1/en not_active Abandoned
- 2003-04-23 WO PCT/US2003/012661 patent/WO2003091215A1/en not_active Ceased
- 2003-04-23 CA CA2483162A patent/CA2483162C/en not_active Expired - Fee Related
- 2003-04-23 ES ES03733867T patent/ES2330628T3/es not_active Expired - Lifetime
- 2003-04-23 EP EP03721841A patent/EP1501796B1/de not_active Expired - Lifetime
- 2003-04-23 EP EP03733867A patent/EP1501797B1/de not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| WO2003091214A1 (en) | 2003-11-06 |
| DE60313769T2 (de) | 2008-03-06 |
| DE60313769D1 (de) | 2007-06-21 |
| AU2003225131A1 (en) | 2003-11-10 |
| WO2003091215A1 (en) | 2003-11-06 |
| ES2330628T3 (es) | 2009-12-14 |
| JP2005529135A (ja) | 2005-09-29 |
| EP1501796A1 (de) | 2005-02-02 |
| DE60328675D1 (de) | 2009-09-17 |
| EP1501797B1 (de) | 2009-08-05 |
| EP1834947A2 (de) | 2007-09-19 |
| EP1501796B1 (de) | 2007-05-09 |
| CA2483091A1 (en) | 2003-11-06 |
| CA2483162A1 (en) | 2003-11-06 |
| ATE361910T1 (de) | 2007-06-15 |
| AU2003239150A1 (en) | 2003-11-10 |
| JP4497930B2 (ja) | 2010-07-07 |
| EP1501797A1 (de) | 2005-02-02 |
| CA2483162C (en) | 2011-08-23 |
| EP1834947A3 (de) | 2008-05-28 |
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