PE32296A1 - Ester de l-monovalina derivado de 2-(2-amino-1,6-dihidro-6-oxo-purin-9-il) metoxi-1,3-propandiol y sus sales farmaceuticamente aceptables - Google Patents

Ester de l-monovalina derivado de 2-(2-amino-1,6-dihidro-6-oxo-purin-9-il) metoxi-1,3-propandiol y sus sales farmaceuticamente aceptables

Info

Publication number
PE32296A1
PE32296A1 PE1995273436A PE27343695A PE32296A1 PE 32296 A1 PE32296 A1 PE 32296A1 PE 1995273436 A PE1995273436 A PE 1995273436A PE 27343695 A PE27343695 A PE 27343695A PE 32296 A1 PE32296 A1 PE 32296A1
Authority
PE
Peru
Prior art keywords
metoxi
purin
oxo
amino
pharmaceutically acceptable
Prior art date
Application number
PE1995273436A
Other languages
English (en)
Inventor
Scott W Womble
John J Nestor
Hans Maag
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=23079211&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PE32296(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of PE32296A1 publication Critical patent/PE32296A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
    • C07D473/18—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 one oxygen and one nitrogen atom, e.g. guanine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A61P31/22—Antivirals for DNA viruses for herpes viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Virology (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Communicable Diseases (AREA)
  • Engineering & Computer Science (AREA)
  • Oncology (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Saccharide Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Hydrogenated Pyridines (AREA)

Abstract

SE REFIERE AL COMPUESTO 2-(2-AMINO-1,6-DIHIDRO-6-OXO-PURIN-9-IL)METOXI-3-HIDROXI-1-PROPANIL-L-VALINATO o MONO-L-VALINA GANCICLOVIR O UNA SAL RESPECTIVA TAL COMO CLORHIDRATO O ACETATO EN FORMA DE SUS DIASTEREOMEROS R(-) o S(-), O EN FORMA DE MEZCLAS DE LOS DOS DIASTEREOMEROS EN IGUALES PROPORCIONES, EN DONDE EL (R)- ES 2-(2-AMINO-1,6-DIHIDRO-6-OXO-PURIN-9-IL )METOXI-3-HIDROXI-1-PROPANIL-L-VALINATO Y EL (S)- ES 2-(2-AMINO-1,6-DIHIDRO-6-OXO-PURIN-9-IL)METOXI-3-HIDROXI-1-PROPANIL-L-VALINATO. ESTOS COMPUESTOS OPCIONALMENTE TIENE UN EXCIPIENTE O VEHICULO FARMACEUTICAMENTE ACEPTABLE PARA ADMINISTRACION ORAL, TOPICA O COMO IMPLANTE INTRAVITREAL Y SON UTILIZADOS EN EL TRATAMIENTO DE INFECCIONES HERPETICAS EN PACIENTES INMUNOCOMPROMETIDOS
PE1995273436A 1994-07-28 1995-07-10 Ester de l-monovalina derivado de 2-(2-amino-1,6-dihidro-6-oxo-purin-9-il) metoxi-1,3-propandiol y sus sales farmaceuticamente aceptables PE32296A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US28189394A 1994-07-28 1994-07-28

Publications (1)

Publication Number Publication Date
PE32296A1 true PE32296A1 (es) 1996-08-07

Family

ID=23079211

Family Applications (1)

Application Number Title Priority Date Filing Date
PE1995273436A PE32296A1 (es) 1994-07-28 1995-07-10 Ester de l-monovalina derivado de 2-(2-amino-1,6-dihidro-6-oxo-purin-9-il) metoxi-1,3-propandiol y sus sales farmaceuticamente aceptables

Country Status (32)

Country Link
EP (1) EP0694547B1 (es)
JP (1) JP3090305B2 (es)
KR (1) KR100358626B1 (es)
CN (1) CN1045089C (es)
AT (1) ATE179173T1 (es)
AU (1) AU697107B2 (es)
BR (1) BR9503468A (es)
CA (1) CA2154721C (es)
CO (1) CO4410181A1 (es)
CY (2) CY2180B1 (es)
CZ (1) CZ290511B6 (es)
DE (3) DE694547T1 (es)
DK (1) DK0694547T3 (es)
ES (1) ES2083348T3 (es)
FI (1) FI112080B (es)
GR (2) GR960300021T1 (es)
HU (1) HU216867B (es)
IL (1) IL114735A (es)
LU (1) LU91136I2 (es)
MA (1) MA23631A1 (es)
MY (1) MY114393A (es)
NL (1) NL300071I2 (es)
NO (2) NO312899B1 (es)
NZ (1) NZ272652A (es)
PE (1) PE32296A1 (es)
PL (1) PL180609B1 (es)
RU (1) RU2133749C1 (es)
SA (1) SA95160158B1 (es)
TR (1) TR199500895A2 (es)
TW (1) TW434242B (es)
UY (1) UY24006A1 (es)
ZA (1) ZA956228B (es)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6458772B1 (en) 1909-10-07 2002-10-01 Medivir Ab Prodrugs
US5700936A (en) * 1996-01-26 1997-12-23 Syntex (U.S.A.) Inc. Process for preparing a 2-(2-amino-1,6-dihydro-6-oxo-purin-9-yl) methoxy-1,3-propanediol valinate
US5756736A (en) * 1996-01-26 1998-05-26 Syntex (U.S.A.) Inc. Process for preparing a 2-(2-amino-1,6-dihydro-6-oxo-purin-9-yl)methoxy-1,3-propanediol derivative
WO1997027194A1 (en) * 1996-01-26 1997-07-31 F. Hoffmann-La Roche Ag Process for preparing purine derivatives
US5840890A (en) * 1996-01-26 1998-11-24 Syntex (U.S.A.) Inc. Process for preparing a 2-(2-amino-1,6-dihydro-6-oxo-purin-9-yl)methoxy-1,3-propanediol derivative
DE69714971T3 (de) * 1996-01-26 2005-12-15 F. Hoffmann-La Roche Ag Verfahren zur herstellung von purin-derivaten
US5869493A (en) * 1996-02-16 1999-02-09 Medivir Ab Acyclic nucleoside derivatives
US6703394B2 (en) 1996-02-16 2004-03-09 Medivir Ab Acyclic nucleoside derivatives
CA2572577C (en) * 1997-02-10 2011-04-05 Medivir Ab Synthesis of acyclic nucleoside derivatives
US6184376B1 (en) 1997-02-10 2001-02-06 Mediver Ab Synthesis of acyclic nucleoside derivatives
PT988304E (pt) * 1997-08-15 2001-10-31 Medivir Ab Analogos de nucleosidos tais como os antivirais que contem inibidores de transcritase reversa retroviral e de adn-polimerase do virus da hepatite b (hbv)
AU1711599A (en) * 1997-12-19 1999-07-12 Bristol-Myers Squibb Company Prodrugs of lobucavir and methods of use
WO1999051613A1 (en) * 1998-04-03 1999-10-14 Medivir Ab Prodrugs of phosphorous-containing pharmaceuticals
JP2000256359A (ja) * 1999-03-11 2000-09-19 Japan Science & Technology Corp 面性キラリティーを有する分子群の高選択的不斉変換法
KR20030015655A (ko) * 2001-08-17 2003-02-25 한미약품공업 주식회사 항암제의 경구흡수율을 증가시키는 인단계 화합물의결정성 산부가염, 이의 제조방법 및 이를 함유하는 약학적조성물
DE60328675D1 (de) * 2002-04-23 2009-09-17 Aventis Pharma Inc 3-(substitutierte amino)-1h-indole-2-carbonsäureester und 3-(substitutierte amino)-benzoäbüthiophen-2-carbonsäureester verbindungen als inhibitoren der interleukin-4 genexpression
WO2004035052A1 (ja) 2002-10-16 2004-04-29 Takeda Pharmaceutical Company Limited 安定な固形製剤
DK1583542T3 (da) 2003-01-14 2008-09-22 Gilead Sciences Inc Sammensætninger og fremgangsmåder til antiviral kombinationsterapi
US20070129385A1 (en) * 2003-08-28 2007-06-07 Sharma Mukesh K Amorphous valganciclovir hydrochloride
US8461187B2 (en) 2004-06-16 2013-06-11 Takeda Pharmaceuticals U.S.A., Inc. Multiple PPI dosage form
RU2527893C2 (ru) * 2004-07-19 2014-09-10 Биокон Лимитед Инсулин-олигомерные конъюгаты, их препараты и применения
TWI375560B (en) 2005-06-13 2012-11-01 Gilead Sciences Inc Composition comprising dry granulated emtricitabine and tenofovir df and method for making the same
TWI471145B (zh) 2005-06-13 2015-02-01 Bristol Myers Squibb & Gilead Sciences Llc 單一式藥學劑量型
ZA200702234B (en) * 2006-03-21 2008-07-30 Cipla Ltd Preparation of ester of purine derivatives
WO2009049160A1 (en) 2007-10-12 2009-04-16 Takeda Pharmaceuticals North America Methods of treating gastrointestinal disorders independent of the intake of food
EP2714691B1 (en) * 2011-05-31 2016-09-07 Pharmathen S.A. Process for the preparation of 2-amino-9-((2-phenyl-1,3-dioxan-5-yloxy)methyl)-1h-purin-6(9h)-one compound useful in the preparation of valganciclovir
KR102312533B1 (ko) 2021-02-24 2021-10-15 주식회사 이웅 자동 스패너

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL8202626A (nl) * 1982-06-29 1984-01-16 Stichting Rega V Z W Derivaten van 9-(2-hydroxyethoxymethyl)guanine.
US4897479A (en) * 1983-09-30 1990-01-30 Merck & Co., Inc. Arylsulfonyloxy purine intermediates
IE842642L (en) * 1983-10-31 1985-04-30 Harvard College Purine Derivatives
KR910000198B1 (ko) * 1984-12-12 1991-01-23 신텍스(유.에스.에이.) 인코포레이티드 글리세롤의 알콕시메틸 에테르 및 알콕시메틸 에스테르의 제조방법
AP160A (en) * 1987-08-15 1991-11-18 The Wellcome Foundation Ltd Therapeutic acyclic nucleosides.
DE68922903T2 (de) * 1988-12-19 1995-11-23 Wellcome Found Antivirale Pyrimidin- und Purinverbindungen, Verfahren zu ihrer Herstellung und sie enthaltende pharmazeutische Präparate.

Also Published As

Publication number Publication date
TR199500895A2 (tr) 1996-06-21
BR9503468A (pt) 1996-02-27
PL309812A1 (en) 1996-02-05
CZ193995A3 (en) 1996-02-14
FI953592A0 (fi) 1995-07-27
DK0694547T3 (da) 2000-01-03
CY2004003I1 (el) 2009-11-04
UY24006A1 (es) 2001-07-31
NO2003001I2 (no) 2007-06-11
NL300071I1 (nl) 2002-02-01
RU95113148A (ru) 1997-06-27
MA23631A1 (fr) 1996-04-01
CA2154721C (en) 2001-01-02
ZA956228B (en) 1996-02-22
FI953592L (fi) 1996-01-29
NO312899B1 (no) 2002-07-15
TW434242B (en) 2001-05-16
HUT73246A (en) 1996-07-29
IL114735A (en) 1998-06-15
DE10299032I1 (de) 2003-01-23
NO952977L (no) 1996-01-29
KR960004345A (ko) 1996-02-23
NZ272652A (en) 1996-12-20
SA95160158B1 (ar) 2006-05-20
EP0694547A2 (en) 1996-01-31
CY2004003I2 (el) 2009-11-04
AU697107B2 (en) 1998-09-24
CZ290511B6 (cs) 2002-08-14
ES2083348T3 (es) 1999-08-01
GR960300021T1 (en) 1996-04-30
HU216867B (hu) 1999-09-28
JPH0841061A (ja) 1996-02-13
NL300071I2 (nl) 2002-03-01
LU91136I2 (fr) 2005-07-06
GR3030678T3 (en) 1999-11-30
RU2133749C1 (ru) 1999-07-27
HK1012339A1 (en) 1999-07-30
CA2154721A1 (en) 1996-01-29
EP0694547A3 (en) 1996-06-05
JP3090305B2 (ja) 2000-09-18
ES2083348T1 (es) 1996-04-16
AU2719595A (en) 1996-02-08
DE694547T1 (de) 1996-10-24
DE69509173D1 (de) 1999-05-27
HU9502238D0 (en) 1995-09-28
MY114393A (en) 2002-10-31
PL180609B1 (pl) 2001-03-30
EP0694547B1 (en) 1999-04-21
ATE179173T1 (de) 1999-05-15
DE69509173T2 (de) 1999-10-21
KR100358626B1 (ko) 2003-01-14
DE10299032I2 (de) 2006-06-14
CY2180B1 (en) 2002-08-23
CN1122804A (zh) 1996-05-22
CN1045089C (zh) 1999-09-15
NO952977D0 (no) 1995-07-27
CO4410181A1 (es) 1997-01-09
IL114735A0 (en) 1995-11-27
FI112080B (fi) 2003-10-31

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