ATE439438T1 - Durch rna-interferenz vermittelte hemmung der genexpression unter verwendung von chemisch modifizierter sina (short interfering nucleic acid) - Google Patents

Durch rna-interferenz vermittelte hemmung der genexpression unter verwendung von chemisch modifizierter sina (short interfering nucleic acid)

Info

Publication number
ATE439438T1
ATE439438T1 AT04776102T AT04776102T ATE439438T1 AT E439438 T1 ATE439438 T1 AT E439438T1 AT 04776102 T AT04776102 T AT 04776102T AT 04776102 T AT04776102 T AT 04776102T AT E439438 T1 ATE439438 T1 AT E439438T1
Authority
AT
Austria
Prior art keywords
nucleic acid
gene expression
chemically modified
rna interference
short interfering
Prior art date
Application number
AT04776102T
Other languages
English (en)
Inventor
James Mcswiggen
David Morrissey
Shawn Zinnen
Vasant Jadhav
Narendra Vaish
Original Assignee
Sirna Therapeutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US10/444,853 external-priority patent/US8202979B2/en
Priority claimed from US10/693,059 external-priority patent/US20080039414A1/en
Priority claimed from US10/720,448 external-priority patent/US8273866B2/en
Priority claimed from US10/727,780 external-priority patent/US20050233329A1/en
Priority claimed from US10/757,803 external-priority patent/US20050020525A1/en
Priority claimed from US10/780,447 external-priority patent/US7491805B2/en
Priority claimed from US10/826,966 external-priority patent/US20050032733A1/en
Application filed by Sirna Therapeutics Inc filed Critical Sirna Therapeutics Inc
Priority claimed from PCT/US2004/016390 external-priority patent/WO2005019453A2/en
Application granted granted Critical
Publication of ATE439438T1 publication Critical patent/ATE439438T1/de

Links

AT04776102T 2003-05-23 2004-05-24 Durch rna-interferenz vermittelte hemmung der genexpression unter verwendung von chemisch modifizierter sina (short interfering nucleic acid) ATE439438T1 (de)

Applications Claiming Priority (10)

Application Number Priority Date Filing Date Title
US10/444,853 US8202979B2 (en) 2002-02-20 2003-05-23 RNA interference mediated inhibition of gene expression using chemically modified short interfering nucleic acid
US10/652,791 US20050106726A1 (en) 2002-02-20 2003-08-29 RNA interference mediated inhibition of platelet-derived endothelial cell growth factor (ECGF1) gene expression using short interfering nucleic acid (siNA)
US10/693,059 US20080039414A1 (en) 2002-02-20 2003-10-23 RNA interference mediated inhibition of gene expression using chemically modified short interfering nucleic acid (siNA)
US10/720,448 US8273866B2 (en) 2002-02-20 2003-11-24 RNA interference mediated inhibition of gene expression using chemically modified short interfering nucleic acid (SINA)
US10/727,780 US20050233329A1 (en) 2002-02-20 2003-12-03 Inhibition of gene expression using duplex forming oligonucleotides
US10/757,803 US20050020525A1 (en) 2002-02-20 2004-01-14 RNA interference mediated inhibition of gene expression using chemically modified short interfering nucleic acid (siNA)
US54348004P 2004-02-10 2004-02-10
US10/780,447 US7491805B2 (en) 2001-05-18 2004-02-13 Conjugates and compositions for cellular delivery
US10/826,966 US20050032733A1 (en) 2001-05-18 2004-04-16 RNA interference mediated inhibition of gene expression using chemically modified short interfering nucleic acid (SiNA)
PCT/US2004/016390 WO2005019453A2 (en) 2001-05-18 2004-05-24 RNA INTERFERENCE MEDIATED INHIBITION OF GENE EXPRESSION USING CHEMICALLY MODIFIED SHORT INTERFERING NUCLEIC ACID (siNA)

Publications (1)

Publication Number Publication Date
ATE439438T1 true ATE439438T1 (de) 2009-08-15

Family

ID=38556364

Family Applications (1)

Application Number Title Priority Date Filing Date
AT04776102T ATE439438T1 (de) 2003-05-23 2004-05-24 Durch rna-interferenz vermittelte hemmung der genexpression unter verwendung von chemisch modifizierter sina (short interfering nucleic acid)

Country Status (2)

Country Link
JP (1) JP4948163B2 (de)
AT (1) ATE439438T1 (de)

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JP2011251912A (ja) * 2008-09-22 2011-12-15 Gifu Prefecture Kenkyu Kaihatsu Zaidan マイクロｒｎａ―１４３誘導体を含有する医薬
JP2012505657A (ja) * 2008-10-15 2012-03-08 ソマジェニックス インク． 遺伝子発現の阻害のためのショートヘアピンｒｎａ
JP5575593B2 (ja) 2010-09-17 2014-08-20 株式会社ダイセル 注射器
JP5559647B2 (ja) 2010-09-24 2014-07-23 株式会社ダイセル 注射器
WO2012074038A1 (ja) * 2010-12-02 2012-06-07 第一三共株式会社 修飾１本鎖ポリヌクレオチド
JP5794786B2 (ja) 2011-02-04 2015-10-14 株式会社ダイセル 無針注射器
JP2013059424A (ja) 2011-09-12 2013-04-04 Daicel Corp 無針注射器
SI3366775T2 (sl) * 2011-11-18 2025-12-31 Alnylam Pharmaceuticals, Inc. Modificirana sredstva RNAI
JP5973228B2 (ja) 2012-05-11 2016-08-23 株式会社ダイセル 注射器
JP6297794B2 (ja) 2013-06-12 2018-03-20 株式会社ダイセル 注射器
JP2016049246A (ja) 2014-08-29 2016-04-11 株式会社ダイセル 無針注射器
JP6471029B2 (ja) 2015-04-10 2019-02-13 株式会社ダイセル 注射器
WO2017029703A1 (ja) 2015-08-18 2017-02-23 株式会社ダイセル 無針注射器
WO2017115867A1 (ja) 2015-12-28 2017-07-06 株式会社ダイセル 投与装置の設計システム、投与システム、投与装置の設計方法、投与装置の設計プログラム、及び医療装置の設計システム
JP6954521B2 (ja) 2015-12-28 2021-10-27 株式会社ダイセル 射出装置
WO2017131124A1 (ja) 2016-01-26 2017-08-03 日産化学工業株式会社 一本鎖オリゴヌクレオチド
WO2017217463A1 (ja) 2016-06-17 2017-12-21 株式会社ダイセル 注射器
WO2018038116A1 (ja) 2016-08-23 2018-03-01 株式会社ダイセル 無針注射器
CN109564838B (zh) 2016-08-23 2020-11-17 株式会社大赛璐 致动器
WO2018038118A1 (ja) 2016-08-23 2018-03-01 株式会社ダイセル 投与装置
AU2018215440B2 (en) 2017-02-06 2024-10-24 Nissan Chemical Corporation Single-stranded oligonucleotide
JP7329307B2 (ja) 2017-06-27 2023-08-18 株式会社ダイセル 無針注射器の製造方法、無針注射器における点火薬及びガス発生剤の量を設定する方法、および無針注射器の射出パラメータ算出プログラム
JP6973778B2 (ja) 2017-06-27 2021-12-01 株式会社ダイセル 注入器
US10549038B2 (en) 2017-06-29 2020-02-04 Daicel Corporation Syringe
US12115352B2 (en) 2018-08-03 2024-10-15 Daicel Corporation Needleless injector

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2546853C (en) * 2003-11-21 2020-04-21 Revivicor, Inc. Use of interfering rna in the production of transgenic animals

Also Published As

Publication number Publication date
JP2007525192A (ja) 2007-09-06
JP4948163B2 (ja) 2012-06-06
HK1086036A1 (en) 2006-09-08

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