ATE439439T1 - Disulfid-vernetzte glycoprotein-hormone, ihre herstellung und verwendung - Google Patents

Disulfid-vernetzte glycoprotein-hormone, ihre herstellung und verwendung

Info

Publication number
ATE439439T1
ATE439439T1 AT06015992T AT06015992T ATE439439T1 AT E439439 T1 ATE439439 T1 AT E439439T1 AT 06015992 T AT06015992 T AT 06015992T AT 06015992 T AT06015992 T AT 06015992T AT E439439 T1 ATE439439 T1 AT E439439T1
Authority
AT
Austria
Prior art keywords
disulfide
production
cross
glycoprotein hormones
linked glycoprotein
Prior art date
Application number
AT06015992T
Other languages
English (en)
Inventor
William R Moyle
Original Assignee
Merck Serono Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=21967404&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ATE439439(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Merck Serono Sa filed Critical Merck Serono Sa
Application granted granted Critical
Publication of ATE439439T1 publication Critical patent/ATE439439T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/59—Follicle-stimulating hormone [FSH]; Chorionic gonadotropins, e.g.hCG [human chorionic gonadotropin]; Luteinising hormone [LH]; Thyroid-stimulating hormone [TSH]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/27—Growth hormone [GH], i.e. somatotropin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/18—Feminine contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/06—Drugs for disorders of the endocrine system of the anterior pituitary hormones, e.g. TSH, ACTH, FSH, LH, PRL, GH
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Endocrinology (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Reproductive Health (AREA)
  • Zoology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Molecular Biology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Toxicology (AREA)
  • Biotechnology (AREA)
  • Gynecology & Obstetrics (AREA)
  • Wood Science & Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Plant Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Pregnancy & Childbirth (AREA)
  • Microbiology (AREA)
  • Diabetes (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
AT06015992T 1997-06-25 1998-06-25 Disulfid-vernetzte glycoprotein-hormone, ihre herstellung und verwendung ATE439439T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US5078497P 1997-06-25 1997-06-25

Publications (1)

Publication Number Publication Date
ATE439439T1 true ATE439439T1 (de) 2009-08-15

Family

ID=21967404

Family Applications (2)

Application Number Title Priority Date Filing Date
AT06015992T ATE439439T1 (de) 1997-06-25 1998-06-25 Disulfid-vernetzte glycoprotein-hormone, ihre herstellung und verwendung
AT98930477T ATE335000T1 (de) 1997-06-25 1998-06-25 Disulfid-vernetzte glycoprotein-hormone, ihre herstellung und verwendung

Family Applications After (1)

Application Number Title Priority Date Filing Date
AT98930477T ATE335000T1 (de) 1997-06-25 1998-06-25 Disulfid-vernetzte glycoprotein-hormone, ihre herstellung und verwendung

Country Status (20)

Country Link
US (1) US8530190B1 (de)
EP (2) EP1775346B1 (de)
JP (3) JP3950484B2 (de)
KR (2) KR100560279B1 (de)
CN (3) CN1197968C (de)
AR (1) AR013139A1 (de)
AT (2) ATE439439T1 (de)
AU (1) AU747179B2 (de)
BR (1) BR9810478A (de)
CA (1) CA2293731C (de)
CY (2) CY1105763T1 (de)
DE (2) DE69835433T2 (de)
DK (2) DK0996629T3 (de)
ES (2) ES2332931T3 (de)
HU (1) HU227908B1 (de)
IL (2) IL133686A0 (de)
PT (2) PT1775346E (de)
SI (2) SI1775346T1 (de)
WO (1) WO1998058957A2 (de)
ZA (1) ZA985545B (de)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6716428B1 (en) * 1999-10-06 2004-04-06 The Ohio State University Research Foundation Antigenic modification of polypeptides
HRP20020651B1 (en) * 2000-02-22 2011-01-31 Laboratoires Serono Sa Purified lh
WO2002030978A1 (en) * 2000-10-06 2002-04-18 Regeneron Pharmaceuticals, Inc. Polypeptides, methods of making, and uses thereof
IL161804A0 (en) * 2001-11-08 2005-11-20 Yongna Xing Protein knobs
PL1951395T3 (pl) 2005-09-14 2012-08-31 Ares Trading Sa Sposób ilościowego oznaczania poloksamerów
ZA200805194B (en) * 2006-01-17 2009-10-28 Serono Lab Novel FSH glycosylation variant D3N
CN101250531B (zh) * 2006-11-27 2013-04-24 株式会社Lg生命科学 一核苷酸序列、包含该序列的表达载体、该载体转化的动物细胞及利用该细胞生产人fsh的方法
RS52106B (sr) 2008-02-08 2012-08-31 Biogenerix Ag Tečni preparat fsh
CN101347613B (zh) * 2008-09-17 2011-10-26 上海天伟生物制药有限公司 几乎不含亚基的糖蛋白的组合物及其制备方法
JP5816097B2 (ja) * 2009-01-22 2015-11-18 ノヴォ・ノルディスク・ヘルス・ケア・アーゲー 安定な成長ホルモン化合物
JP5845170B2 (ja) 2009-04-01 2016-01-20 ラティオファーム ゲーエムベーハー 組換えｆｓｈを精製する方法
TWI532495B (zh) 2009-10-05 2016-05-11 菲瑞茵國際中心股份有限公司 藥學製劑
EP2325194A1 (de) 2009-11-24 2011-05-25 Glycotope GmbH Verfahren zur Reinigung von Glykoproteinen
PL2525834T3 (pl) 2010-01-22 2020-10-19 Novo Nordisk Health Care Ag Hormony wzrostu o przedłużonej skuteczności in-vivo
RU2012134974A (ru) 2010-01-22 2014-02-27 Ново Нордиск Хелс Кеа Аг Стабилизированное соединение гормона роста
CA3163525A1 (en) 2011-03-31 2012-10-04 Ferring Bv. Pharmaceutical preparation
JP6429774B2 (ja) * 2012-07-30 2018-11-28 トロホジェン・インコーポレーテッド 糖タンパク質ホルモン長期作用性スーパーアゴニスト
ES2841123T3 (es) 2013-04-05 2021-07-07 Formulacion Del Compuesto De La Hormona De Crecimiento Formulación del compuesto de la hormona de crecimiento
US20230365944A1 (en) * 2020-09-30 2023-11-16 The University Of North Carolina At Chapel Hill Engineered stable lactate oxidoreductases, compositions, devices, kits and uses thereof
WO2022150878A1 (en) * 2021-01-13 2022-07-21 University Of Newcastle Compositions and methods of using targeting peptides and nanopharmaceuticals for the sterilization of cats and dogs
WO2024099445A1 (zh) * 2022-11-10 2024-05-16 康立泰生物医药(青岛)有限公司 聚乙二醇定点修饰异源聚体蛋白或多肽及其制备方法与应用

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5079230A (en) * 1988-09-12 1992-01-07 Pitman-Moore, Inc. Stable bioactive somatotropins
US5691455A (en) * 1995-10-24 1997-11-25 Akzo Nobel N.V. Gonadotropins with non-native disulfide bridges
US20090209453A1 (en) * 2005-04-13 2009-08-20 University Of Medicine And Dentistry Of New Jersey Glycoprotein Hormone Analogs

Also Published As

Publication number Publication date
KR100560279B1 (ko) 2006-03-10
EP1775346B1 (de) 2009-08-12
CN1548459A (zh) 2004-11-24
EP1775346A1 (de) 2007-04-18
ES2332931T3 (es) 2010-02-15
DE69835433T2 (de) 2007-03-08
CY1105763T1 (el) 2011-02-02
DK1775346T3 (da) 2009-09-28
US8530190B1 (en) 2013-09-10
KR100706469B1 (ko) 2007-04-10
WO1998058957A3 (en) 1999-04-22
CN1302010C (zh) 2007-02-28
HUP0100681A3 (en) 2004-03-01
SI0996629T1 (sl) 2006-12-31
HU227908B1 (en) 2012-05-29
CY1109439T1 (el) 2014-08-13
WO1998058957A9 (en) 1999-06-03
JP2005162734A (ja) 2005-06-23
DK0996629T3 (da) 2006-12-04
DE69841063D1 (de) 2009-09-24
JP2001521402A (ja) 2001-11-06
ZA985545B (en) 1999-04-01
AU7986198A (en) 1999-01-04
WO1998058957A2 (en) 1998-12-30
DE69835433D1 (de) 2006-09-14
EP0996629B1 (de) 2006-08-02
AR013139A1 (es) 2000-12-13
JP3950484B2 (ja) 2007-08-01
CA2293731A1 (en) 1998-12-30
JP4278668B2 (ja) 2009-06-17
KR20020006720A (ko) 2002-01-26
CN100404551C (zh) 2008-07-23
CA2293731C (en) 2010-01-12
ES2268781T3 (es) 2007-03-16
HUP0100681A1 (hu) 2001-06-28
IL133686A0 (en) 2001-04-30
PT996629E (pt) 2006-12-29
IL133686A (en) 2007-07-24
HK1033149A1 (en) 2001-08-17
JP2007016040A (ja) 2007-01-25
PT1775346E (pt) 2009-08-25
BR9810478A (pt) 2000-09-12
AU747179B2 (en) 2002-05-09
SI1775346T1 (sl) 2009-10-31
CN1269833A (zh) 2000-10-11
JP4279768B2 (ja) 2009-06-17
CN1548458A (zh) 2004-11-24
EP0996629A2 (de) 2000-05-03
KR20040039421A (ko) 2004-05-10
ATE335000T1 (de) 2006-08-15
CN1197968C (zh) 2005-04-20

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