ATE335000T1 - Disulfid-vernetzte glycoprotein-hormone, ihre herstellung und verwendung - Google Patents

Disulfid-vernetzte glycoprotein-hormone, ihre herstellung und verwendung

Info

Publication number
ATE335000T1
ATE335000T1 AT98930477T AT98930477T ATE335000T1 AT E335000 T1 ATE335000 T1 AT E335000T1 AT 98930477 T AT98930477 T AT 98930477T AT 98930477 T AT98930477 T AT 98930477T AT E335000 T1 ATE335000 T1 AT E335000T1
Authority
AT
Austria
Prior art keywords
disulfide
production
cross
glycoprotein hormones
linked glycoprotein
Prior art date
Application number
AT98930477T
Other languages
English (en)
Inventor
William R Moyle
Original Assignee
Applied Research Systems
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=21967404&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ATE335000(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Applied Research Systems filed Critical Applied Research Systems
Application granted granted Critical
Publication of ATE335000T1 publication Critical patent/ATE335000T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/59—Follicle-stimulating hormone [FSH]; Chorionic gonadotropins, e.g.hCG [human chorionic gonadotropin]; Luteinising hormone [LH]; Thyroid-stimulating hormone [TSH]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/27—Growth hormone [GH], i.e. somatotropin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/18—Feminine contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/06—Drugs for disorders of the endocrine system of the anterior pituitary hormones, e.g. TSH, ACTH, FSH, LH, PRL, GH
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Endocrinology (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Zoology (AREA)
  • Reproductive Health (AREA)
  • Molecular Biology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Toxicology (AREA)
  • Wood Science & Technology (AREA)
  • Gynecology & Obstetrics (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Physics & Mathematics (AREA)
  • Pregnancy & Childbirth (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Plant Pathology (AREA)
  • Microbiology (AREA)
  • Diabetes (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
AT98930477T 1997-06-25 1998-06-25 Disulfid-vernetzte glycoprotein-hormone, ihre herstellung und verwendung ATE335000T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US5078497P 1997-06-25 1997-06-25

Publications (1)

Publication Number Publication Date
ATE335000T1 true ATE335000T1 (de) 2006-08-15

Family

ID=21967404

Family Applications (2)

Application Number Title Priority Date Filing Date
AT98930477T ATE335000T1 (de) 1997-06-25 1998-06-25 Disulfid-vernetzte glycoprotein-hormone, ihre herstellung und verwendung
AT06015992T ATE439439T1 (de) 1997-06-25 1998-06-25 Disulfid-vernetzte glycoprotein-hormone, ihre herstellung und verwendung

Family Applications After (1)

Application Number Title Priority Date Filing Date
AT06015992T ATE439439T1 (de) 1997-06-25 1998-06-25 Disulfid-vernetzte glycoprotein-hormone, ihre herstellung und verwendung

Country Status (20)

Country Link
US (1) US8530190B1 (de)
EP (2) EP0996629B1 (de)
JP (3) JP3950484B2 (de)
KR (2) KR100560279B1 (de)
CN (3) CN1197968C (de)
AR (1) AR013139A1 (de)
AT (2) ATE335000T1 (de)
AU (1) AU747179B2 (de)
BR (1) BR9810478A (de)
CA (1) CA2293731C (de)
CY (2) CY1105763T1 (de)
DE (2) DE69835433T2 (de)
DK (2) DK1775346T3 (de)
ES (2) ES2332931T3 (de)
HU (1) HU227908B1 (de)
IL (2) IL133686A0 (de)
PT (2) PT996629E (de)
SI (2) SI1775346T1 (de)
WO (1) WO1998058957A2 (de)
ZA (1) ZA985545B (de)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6716428B1 (en) * 1999-10-06 2004-04-06 The Ohio State University Research Foundation Antigenic modification of polypeptides
CZ303274B6 (cs) * 2000-02-22 2012-07-11 Merck Serono Sa Zpusob vycištení luteinizacního hormonu
AU2000280019A1 (en) * 2000-10-06 2002-04-22 Regeneron Pharmaceuticals, Inc. Polypeptides, methods of making, and uses thereof
KR20040063928A (ko) * 2001-11-08 2004-07-14 윌리암 알. 모일 단백질 노브
AU2006290662B2 (en) 2005-09-14 2010-12-23 Ares Trading S.A. Method for the quantitative determination of poloxamers
PL1981908T3 (pl) * 2006-01-17 2011-04-29 Merck Serono Sa Nowe D3N warianty glikolizacji FSH
CN101250531B (zh) * 2006-11-27 2013-04-24 株式会社Lg生命科学 一核苷酸序列、包含该序列的表达载体、该载体转化的动物细胞及利用该细胞生产人fsh的方法
NZ586588A (en) 2008-02-08 2012-10-26 Biogenerix Ag Formulation of ( follice stimulating hormone) fsh and varients with benzalkonium chloride and benzyl alcohol
CN101347613B (zh) * 2008-09-17 2011-10-26 上海天伟生物制药有限公司 几乎不含亚基的糖蛋白的组合物及其制备方法
MX2011007736A (es) * 2009-01-22 2011-09-06 Novo Nordisk Healthcare Ag Compuestos de hormona del crecimiento estables.
JP5845170B2 (ja) 2009-04-01 2016-01-20 ラティオファーム ゲーエムベーハー 組換えｆｓｈを精製する方法
TWI532495B (zh) 2009-10-05 2016-05-11 菲瑞茵國際中心股份有限公司 藥學製劑
EP2325194A1 (de) 2009-11-24 2011-05-25 Glycotope GmbH Verfahren zur Reinigung von Glykoproteinen
RS59459B1 (sr) 2010-01-22 2019-11-29 Novo Nordisk Healthcare Ag Hormoni rasta sa produženom in-vivo efikasnošću
MX338357B (es) 2010-01-22 2016-04-13 Novo Nordisk Healthcare Ag Compuestos estables de la hormona de crecimiento.
PL2691119T3 (pl) 2011-03-31 2019-01-31 Ferring B.V. Preparat farmaceutyczny
RU2668174C2 (ru) * 2012-07-30 2018-09-26 Трофоген Инк. Суперагонисты гликопротеинового гормона длительного действия
US11045523B2 (en) 2013-04-05 2021-06-29 Novo Nordisk Healthcare Ag Formulation of growth hormone albumin-binder conjugate
US20230365944A1 (en) * 2020-09-30 2023-11-16 The University Of North Carolina At Chapel Hill Engineered stable lactate oxidoreductases, compositions, devices, kits and uses thereof
WO2022150878A1 (en) * 2021-01-13 2022-07-21 University Of Newcastle Compositions and methods of using targeting peptides and nanopharmaceuticals for the sterilization of cats and dogs
EP4617281A1 (de) * 2022-11-10 2025-09-17 Kanglitai Biomedical (Qingdao) Co., Ltd. Ortsspezifisches pegyliertes heteromeres protein oder polypeptid sowie herstellungsverfahren dafür und verwendung davon

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5079230A (en) * 1988-09-12 1992-01-07 Pitman-Moore, Inc. Stable bioactive somatotropins
US5691455A (en) * 1995-10-24 1997-11-25 Akzo Nobel N.V. Gonadotropins with non-native disulfide bridges
US20090209453A1 (en) * 2005-04-13 2009-08-20 University Of Medicine And Dentistry Of New Jersey Glycoprotein Hormone Analogs

Also Published As

Publication number Publication date
KR20040039421A (ko) 2004-05-10
CN100404551C (zh) 2008-07-23
EP1775346B1 (de) 2009-08-12
ATE439439T1 (de) 2009-08-15
ZA985545B (en) 1999-04-01
JP2007016040A (ja) 2007-01-25
WO1998058957A2 (en) 1998-12-30
CN1197968C (zh) 2005-04-20
HU227908B1 (en) 2012-05-29
JP2001521402A (ja) 2001-11-06
DK1775346T3 (da) 2009-09-28
KR20020006720A (ko) 2002-01-26
DK0996629T3 (da) 2006-12-04
AU747179B2 (en) 2002-05-09
PT996629E (pt) 2006-12-29
JP3950484B2 (ja) 2007-08-01
WO1998058957A9 (en) 1999-06-03
SI0996629T1 (sl) 2006-12-31
US8530190B1 (en) 2013-09-10
WO1998058957A3 (en) 1999-04-22
KR100706469B1 (ko) 2007-04-10
AU7986198A (en) 1999-01-04
JP4279768B2 (ja) 2009-06-17
ES2332931T3 (es) 2010-02-15
DE69835433D1 (de) 2006-09-14
CY1109439T1 (el) 2014-08-13
CA2293731A1 (en) 1998-12-30
DE69835433T2 (de) 2007-03-08
CA2293731C (en) 2010-01-12
KR100560279B1 (ko) 2006-03-10
CN1548458A (zh) 2004-11-24
HUP0100681A3 (en) 2004-03-01
HUP0100681A1 (hu) 2001-06-28
HK1033149A1 (en) 2001-08-17
JP4278668B2 (ja) 2009-06-17
IL133686A0 (en) 2001-04-30
BR9810478A (pt) 2000-09-12
CN1269833A (zh) 2000-10-11
SI1775346T1 (sl) 2009-10-31
CN1302010C (zh) 2007-02-28
CN1548459A (zh) 2004-11-24
AR013139A1 (es) 2000-12-13
EP1775346A1 (de) 2007-04-18
JP2005162734A (ja) 2005-06-23
PT1775346E (pt) 2009-08-25
ES2268781T3 (es) 2007-03-16
IL133686A (en) 2007-07-24
CY1105763T1 (el) 2011-02-02
EP0996629B1 (de) 2006-08-02
EP0996629A2 (de) 2000-05-03
DE69841063D1 (de) 2009-09-24

Similar Documents

Publication Publication Date Title
DE69529026D1 (de) Trehalose, ihre Herstellung und ihre Verwendung
DE69814431D1 (de) 3,3-diarylpropylamine , ihre verwendung und herstellung
ATE335000T1 (de) Disulfid-vernetzte glycoprotein-hormone, ihre herstellung und verwendung
DE69627411D1 (de) Triazinderivate, ihre Herstellung und Verwendung
DE69812710D1 (de) Löslicher magnesiumhalogenidkomplex, herstellung und verwendung
ATE258549T1 (de) Oxazolidindion-derivate, ihre herstellung und verwendung
DE69817611D1 (de) 2-aryl-8-oxodihydropurin-derivate, ihre herstellung, ihre verwendung als medikamentenkomponente und deren intermediate
DE59709806D1 (de) Cycloolefincopolymere, ihre verwendung und daraus hergestellte formkörper
DE60038200D1 (de) ren Herstellung und Verwendung
ATA189691A (de) Hpth-peptide, ihre herstellung und verwendung
ATE286021T1 (de) Substituierte phenylderivate, ihre herstellung und verwendung
DE10084441T1 (de) Koalinton-Pigmente, ihre Herstellung und Verwendung
DE69625857D1 (de) Siliconderivate, ihre Herstellung und Verwendung
DE59703980D1 (de) Reaktivfarbstoffe, ihre Herstellung und Verwendung
DE59802590D1 (de) Cyclische Cedren-Acetale, ihre Herstellung und ihre Verwendung
DE59702018D1 (de) Azofarbstoffe, ihre Herstellung und Verwendung
DE59710272D1 (de) Neue alpha-hydroxysäurederivate, ihre herstellung und verwendung
DE69810521D1 (de) Abbeizzusammensetzungen, ihre Herstellung und Verwendung
DE59409541D1 (de) Bicyclen-derivate, ihre herstellung und verwendung
DE69521595D1 (de) Optisch-aktives Benzothiepin-Derivate, ihre Herstellung und Verwendung
DE59802922D1 (de) 3-substituierte tetrahydropyridopyrimidinon-derivate, ihre herstellung und verwendung
ATE268760T1 (de) Neue carbonsäurederivate, ihre herstellung und verwendung
DE69723463D1 (de) Cyclische organoselenderivate, ihre herstellung und verwendung
DE59703086D1 (de) Faserreaktive Farbstoffe, ihre Herstellung und Verwendung
DE69911243D1 (de) Benzofuranderivate, ihre herstellung und verwendung

Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification

Ref document number: 0996629

Country of ref document: EP

EEFA Change of the company name