ATE439834T1 - Kombination von r,r-glycopyrrolat, rolipram und budesonid zur behandlung von entzündungskrankheiten - Google Patents
Kombination von r,r-glycopyrrolat, rolipram und budesonid zur behandlung von entzündungskrankheitenInfo
- Publication number
- ATE439834T1 ATE439834T1 AT06829226T AT06829226T ATE439834T1 AT E439834 T1 ATE439834 T1 AT E439834T1 AT 06829226 T AT06829226 T AT 06829226T AT 06829226 T AT06829226 T AT 06829226T AT E439834 T1 ATE439834 T1 AT E439834T1
- Authority
- AT
- Austria
- Prior art keywords
- treatment
- inflammatory diseases
- glycopyrrolate
- rolipram
- budesonide
- Prior art date
Links
- 208000027866 inflammatory disease Diseases 0.000 title abstract 2
- VOVIALXJUBGFJZ-KWVAZRHASA-N Budesonide Chemical compound C1CC2=CC(=O)C=C[C@]2(C)[C@@H]2[C@@H]1[C@@H]1C[C@H]3OC(CCC)O[C@@]3(C(=O)CO)[C@@]1(C)C[C@@H]2O VOVIALXJUBGFJZ-KWVAZRHASA-N 0.000 title 1
- 229960004436 budesonide Drugs 0.000 title 1
- 229940015042 glycopyrrolate Drugs 0.000 title 1
- HJORMJIFDVBMOB-UHFFFAOYSA-N rolipram Chemical compound COC1=CC=C(C2CC(=O)NC2)C=C1OC1CCCC1 HJORMJIFDVBMOB-UHFFFAOYSA-N 0.000 title 1
- 229950005741 rolipram Drugs 0.000 title 1
- 208000006545 Chronic Obstructive Pulmonary Disease Diseases 0.000 abstract 2
- 208000023275 Autoimmune disease Diseases 0.000 abstract 1
- 208000025747 Rheumatic disease Diseases 0.000 abstract 1
- 239000000556 agonist Substances 0.000 abstract 1
- 229940065524 anticholinergics inhalants for obstructive airway diseases Drugs 0.000 abstract 1
- 208000006673 asthma Diseases 0.000 abstract 1
- 239000000812 cholinergic antagonist Substances 0.000 abstract 1
- 239000003862 glucocorticoid Substances 0.000 abstract 1
- 208000030603 inherited susceptibility to asthma Diseases 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 208000023504 respiratory system disease Diseases 0.000 abstract 1
- 230000000552 rheumatic effect Effects 0.000 abstract 1
- 229940037128 systemic glucocorticoids Drugs 0.000 abstract 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
- A61K31/167—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the nitrogen of a carboxamide group directly attached to the aromatic ring, e.g. lidocaine, paracetamol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/4015—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil having oxo groups directly attached to the heterocyclic ring, e.g. piracetam, ethosuximide
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/58—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin
-
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
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- A—HUMAN NECESSITIES
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- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P13/12—Drugs for disorders of the urinary system of the kidneys
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A61P17/06—Antipsoriatics
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- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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- A61P37/02—Immunomodulators
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- A61P37/08—Antiallergic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/007—Pulmonary tract; Aromatherapy
- A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
- A61K9/0075—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a dry powder inhaler [DPI], e.g. comprising micronized drug mixed with lactose carrier particles
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/007—Pulmonary tract; Aromatherapy
- A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
- A61K9/008—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy comprising drug dissolved or suspended in liquid propellant for inhalation via a pressurized metered dose inhaler [MDI]
Landscapes
- Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Immunology (AREA)
- Pulmonology (AREA)
- Neurology (AREA)
- Pain & Pain Management (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Rheumatology (AREA)
- Urology & Nephrology (AREA)
- Dermatology (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Transplantation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US75205805P | 2005-12-21 | 2005-12-21 | |
| PCT/EP2006/011536 WO2007071313A2 (en) | 2005-12-21 | 2006-12-01 | Combination of anticholinergics, glucocorticoids, beta2-ag0nists, pde4 inhibitor and antileukotriene for the treatment of inflammatory diseases |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE439834T1 true ATE439834T1 (de) | 2009-09-15 |
Family
ID=37872413
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT06829226T ATE439834T1 (de) | 2005-12-21 | 2006-12-01 | Kombination von r,r-glycopyrrolat, rolipram und budesonid zur behandlung von entzündungskrankheiten |
Country Status (19)
| Country | Link |
|---|---|
| US (2) | US8048910B2 (de) |
| EP (2) | EP2098248B1 (de) |
| JP (1) | JP5107933B2 (de) |
| CN (1) | CN101321539B (de) |
| AT (1) | ATE439834T1 (de) |
| AU (1) | AU2006329042B2 (de) |
| CA (2) | CA2824075C (de) |
| CY (2) | CY1110519T1 (de) |
| DE (1) | DE602006008665D1 (de) |
| DK (2) | DK1971369T3 (de) |
| ES (2) | ES2330047T3 (de) |
| HR (2) | HRP20090498T1 (de) |
| NO (1) | NO20083090L (de) |
| NZ (2) | NZ591969A (de) |
| PL (2) | PL1971369T3 (de) |
| PT (2) | PT2098248E (de) |
| RU (1) | RU2465915C2 (de) |
| SI (2) | SI1971369T1 (de) |
| WO (1) | WO2007071313A2 (de) |
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|---|---|---|---|---|
| ES2413011T3 (es) * | 2004-02-06 | 2013-07-15 | Meda Pharma Gmbh & Co. Kg | Combinación de anticolinérgicos y glucocorticoides para el tratamiento a largo plazo de asma y EPOC |
| PT2068889T (pt) * | 2006-08-10 | 2020-01-30 | Roy C Levitt | Anakinra para uso no tratamento da síndrome da bronquiolite obliterante |
| EP1894568A1 (de) * | 2006-08-31 | 2008-03-05 | Novartis AG | Pharmazeutische Zusammensetzungen zur Behandlung von entzündlichen oder obstruktiven Atemwegserkrankungen |
| EP2309858A4 (de) * | 2008-07-31 | 2011-09-14 | Dekel Pharmaceuticals Ltd | Zusammensetzungen und verfahren zur behandlung von entzündungserkrankungen |
| CN101474191B (zh) * | 2009-01-21 | 2011-03-23 | 李虎山 | 一种治疗哮喘和慢性阻塞性肺病的药物组合物 |
| US8815258B2 (en) | 2009-05-29 | 2014-08-26 | Pearl Therapeutics, Inc. | Compositions, methods and systems for respiratory delivery of two or more active agents |
| PT2435025T (pt) * | 2009-05-29 | 2016-11-11 | Pearl Therapeutics Inc | Administração, por via respiratória, de agentes activos |
| CA2764867C (en) * | 2009-06-09 | 2016-05-17 | Elevation Pharmaceuticals, Inc. | Treatment of chronic obstructive pulmonary disease with nebulized beta 2-agonist or combined nebulized beta 2-agonist and anticholinergic administration |
| HRP20140582T4 (hr) | 2009-12-23 | 2023-06-09 | Chiesi Farmaceutici S.P.A. | Kombinacijska terapija za copd |
| ES2705244T3 (es) | 2010-06-16 | 2019-03-22 | Inflammatory Response Res Inc | Levocetirizina y montelukast para el tratamiento de la gripe y del resfriado común |
| US20120077786A1 (en) * | 2010-09-27 | 2012-03-29 | Byron David A | Methods and compositions for disease treatment using inhalation |
| CN102416179B (zh) | 2010-09-28 | 2014-05-07 | 益得生物科技股份有限公司 | 用于哮喘的吸入性复方组合物 |
| KR20180028563A (ko) | 2010-10-12 | 2018-03-16 | 시플라 리미티드 | 약학 조성물 |
| WO2012107364A1 (en) * | 2011-02-07 | 2012-08-16 | Scipharm Sàrl | Novel composition for the treatment of cystic fibrosis |
| CN102247380A (zh) * | 2011-08-19 | 2011-11-23 | 北京阜康仁生物制药科技有限公司 | 一种以布地奈德与茚达特罗为活性成分的复方制剂 |
| CN110464724A (zh) * | 2013-01-28 | 2019-11-19 | 理森制药股份公司 | 通过吸入罗氟司特n-氧化物治疗自身免疫、呼吸和/或炎性病症的方法 |
| CN105228700A (zh) * | 2013-03-13 | 2016-01-06 | 炎症反应研究公司 | 左西替利嗪和孟鲁司特在治疗自身免疫病中的用途 |
| EP2968309A4 (de) | 2013-03-13 | 2016-08-31 | Inflammatory Response Res Inc | Verwendung von levocetirizin und montelukast bei der behandlung von vaskulitis |
| ES2660494T3 (es) | 2013-03-13 | 2018-03-22 | 14779507 | Uso de levocetirizina y montelukast en el tratamiento de una lesión traumática |
| JP6454323B2 (ja) | 2013-03-15 | 2019-01-16 | パール セラピューティクス,インコーポレイテッド | 粒子状結晶性材料のコンディショニングのための方法及びシステム |
| JP2017526728A (ja) | 2014-09-15 | 2017-09-14 | インフラマトリー・レスポンス・リサーチ・インコーポレイテッド | 炎症介在性状態の治療におけるレボセチリジン及びモンテルカスト |
| US10058661B2 (en) | 2014-12-04 | 2018-08-28 | Norton (Waterford) Limited | Inhalation monitoring system and method |
| JP6528314B2 (ja) * | 2015-03-20 | 2019-06-12 | 国立大学法人山口大学 | A(H1N1)pdm09インフルエンザウイルス感染による気管支喘息の予防又は改善剤 |
| JP6674748B2 (ja) * | 2015-05-27 | 2020-04-01 | 花王株式会社 | Glp−1分泌促進剤 |
| WO2019060595A1 (en) | 2017-09-20 | 2019-03-28 | Teva Branded Pharmaceutical Products R&D, Inc. | INHALABLE DRY POWDER MEDICINAL PRODUCT COMPRISING GLYCOPYRRONIUM |
| CN111228257A (zh) * | 2020-03-03 | 2020-06-05 | 中国人民解放军南部战区总医院 | 咯利普兰在制备治疗脓毒症心功能障碍的药物中的应用 |
| US11160814B1 (en) * | 2020-05-07 | 2021-11-02 | Ensemlble Group Holdings | Methods of treatment for disease from coronavirus exposure |
| WO2021236518A1 (en) | 2020-05-19 | 2021-11-25 | IRR, Inc. | Levocetirizine and montelukast in the treatment of sepsis and symptoms thereof |
| EP4209219A1 (de) * | 2022-01-07 | 2023-07-12 | MetrioPharm AG | Kombination von budesonid und 5-amino-2,3-dihydro-1,4-phtalazindion |
| CN118105342A (zh) * | 2023-09-28 | 2024-05-31 | 立生医药(苏州)有限公司 | 一种含pde-4抑制剂的无菌吸入用混悬液及其制备方法和应用 |
| CN121910722A (zh) * | 2026-03-20 | 2026-04-24 | 中国人民解放军海军军医大学 | 一种格隆溴铵在制备治疗神经系统疾病药物上的应用 |
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|---|---|---|---|---|
| CZ290266B6 (cs) | 1993-07-02 | 2002-06-12 | Byk Gulden Lomberg Chemische Fabrik Gmbh | Substituované benzamidy, způsob jejich výroby a farmaceutické prostředky s jejich obsahem |
| EP0932401A1 (de) | 1996-07-01 | 1999-08-04 | Sepracor, Inc. | Methoden und zusammensetzungen zur behandlung von harninkontiniez mittels enantiomerishc angereichertem (r,r)-glycopyrrolat |
| SI0937041T1 (en) * | 1996-11-11 | 2003-10-31 | Christian R. Noe | Use of a pharmaceutically acceptable salt of (3R,2'R)-3-((Cyclopently-hydroxyphenylacetyl)oxy)-1,1-dimethyl-pyrrolidinium for the preparation of a medicament |
| US6384038B1 (en) | 1998-04-14 | 2002-05-07 | Sepracor Inc. | Methods and compositions using cetirizine in combination with leukotriene inhibitors or decongestants |
| US6402285B1 (en) * | 1998-05-29 | 2002-06-11 | Citizen Watch Co., Ltd. | Method of subjecting ink jet printer to preuse treatment |
| ATE234604T1 (de) | 1998-08-04 | 2003-04-15 | Jago Res Ag | Medizinische aerosolformulierungen |
| CN1150895C (zh) | 1998-11-13 | 2004-05-26 | 杰格研究股份公司 | 用于吸入给药的干粉 |
| US6745467B1 (en) * | 1999-02-10 | 2004-06-08 | Canon Kabushiki Kaisha | Method of producing a liquid discharge head |
| US6086914A (en) | 1999-03-12 | 2000-07-11 | Weinstein; Robert E. | Nonsedating formulations for allergic rhinitis which possess antihistaminic and anticholinergic activity |
| DE19921693A1 (de) | 1999-05-12 | 2000-11-16 | Boehringer Ingelheim Pharma | Neuartige Arzneimittelkompositionen auf der Basis von anticholinergisch wirksamen Verbindungen und ß-Mimetika |
| US20040002548A1 (en) | 1999-05-12 | 2004-01-01 | Boehringer Ingelheim Pharma Kg | Medicament compositions containing anticholinergically-effective compounds and betamimetics |
| GB9918760D0 (en) * | 1999-08-09 | 1999-10-13 | Darwin Discovery Ltd | Topical treatment |
| US20040028958A1 (en) | 2002-06-18 | 2004-02-12 | Total Innovative Manufacturing Llc | Recyclable fire-resistant moldable batt and panels formed therefrom |
| DE19961300A1 (de) | 1999-12-18 | 2001-06-21 | Asta Medica Ag | Vorratssystem für Arzneimittel in Pulverform und damit ausgestatteter Inhalator |
| DE10007203A1 (de) | 2000-02-17 | 2001-08-23 | Asta Medica Ag | Neue Kombination nichtsedierender Antihistaminika mit Substanzen, die die Leukotrienwirkung beeinflussen, zur Behandlung der Rhinitis/Konjunktivitis |
| GB0008660D0 (en) | 2000-04-07 | 2000-05-31 | Arakis Ltd | The treatment of respiratory diseases |
| GB0009584D0 (en) * | 2000-04-18 | 2000-06-07 | Glaxo Group Ltd | Pharmaceutical compositions |
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- 2006-12-01 JP JP2008546173A patent/JP5107933B2/ja not_active Expired - Fee Related
- 2006-12-01 CA CA2632780A patent/CA2632780C/en not_active Expired - Fee Related
- 2006-12-01 SI SI200630435T patent/SI1971369T1/sl unknown
- 2006-12-01 PT PT09006788T patent/PT2098248E/pt unknown
- 2006-12-01 DE DE602006008665T patent/DE602006008665D1/de active Active
- 2006-12-01 WO PCT/EP2006/011536 patent/WO2007071313A2/en not_active Ceased
- 2006-12-01 NZ NZ591969A patent/NZ591969A/en unknown
- 2006-12-01 HR HR20090498T patent/HRP20090498T1/xx unknown
- 2006-12-01 ES ES06829226T patent/ES2330047T3/es active Active
- 2006-12-01 DK DK06829226T patent/DK1971369T3/da active
- 2006-12-01 PL PL09006788T patent/PL2098248T3/pl unknown
- 2006-12-01 DK DK09006788.5T patent/DK2098248T3/da active
- 2006-12-01 ES ES09006788T patent/ES2389231T3/es active Active
- 2006-12-01 AT AT06829226T patent/ATE439834T1/de active
- 2006-12-01 SI SI200631387T patent/SI2098248T1/sl unknown
- 2006-12-01 RU RU2008129600/15A patent/RU2465915C2/ru not_active Application Discontinuation
- 2006-12-01 EP EP09006788A patent/EP2098248B1/de not_active Revoked
- 2006-12-01 PT PT06829226T patent/PT1971369E/pt unknown
- 2006-12-01 NZ NZ568349A patent/NZ568349A/en unknown
- 2006-12-01 EP EP06829226A patent/EP1971369B1/de not_active Not-in-force
- 2006-12-01 AU AU2006329042A patent/AU2006329042B2/en not_active Ceased
- 2006-12-01 CN CN2006800455833A patent/CN101321539B/zh not_active Expired - Fee Related
- 2006-12-21 US US11/642,967 patent/US8048910B2/en active Active
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