ATE439866T1 - Kontrastmittel für die magnetresonanzbildgebung mit cest-aktivem paramagnetischem komplex - Google Patents

Kontrastmittel für die magnetresonanzbildgebung mit cest-aktivem paramagnetischem komplex

Info

Publication number
ATE439866T1
ATE439866T1 AT06727994T AT06727994T ATE439866T1 AT E439866 T1 ATE439866 T1 AT E439866T1 AT 06727994 T AT06727994 T AT 06727994T AT 06727994 T AT06727994 T AT 06727994T AT E439866 T1 ATE439866 T1 AT E439866T1
Authority
AT
Austria
Prior art keywords
cest
contrast agents
magnetic resonance
resonance imaging
paramagnetic complex
Prior art date
Application number
AT06727994T
Other languages
English (en)
Inventor
Nicolaas Willard
Rene Wegh
Jeroen Pikkemaat
Holger Gruell
Original Assignee
Koninkl Philips Electronics Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Koninkl Philips Electronics Nv filed Critical Koninkl Philips Electronics Nv
Application granted granted Critical
Publication of ATE439866T1 publication Critical patent/ATE439866T1/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
    • A61K49/10—Organic compounds
    • A61K49/12—Macromolecular compounds
    • A61K49/124—Macromolecular compounds dendrimers, dendrons, hyperbranched compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/18—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes
    • A61K49/1806—Suspensions, emulsions, colloids, dispersions
    • A61K49/1812—Suspensions, emulsions, colloids, dispersions liposomes, polymersomes, e.g. immunoliposomes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/18—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes
    • A61K49/1818—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes particles, e.g. uncoated or non-functionalised microparticles or nanoparticles
    • A61K49/1821—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes particles, e.g. uncoated or non-functionalised microparticles or nanoparticles coated or functionalised microparticles or nanoparticles

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Radiology & Medical Imaging (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Nanotechnology (AREA)
  • Dispersion Chemistry (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Magnetic Resonance Imaging Apparatus (AREA)
  • Medicinal Preparation (AREA)
AT06727994T 2005-04-26 2006-04-21 Kontrastmittel für die magnetresonanzbildgebung mit cest-aktivem paramagnetischem komplex ATE439866T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP05103356 2005-04-26
PCT/IB2006/051235 WO2006114738A2 (en) 2005-04-26 2006-04-21 Mri contrast agents comprising cest active paramagnetic complex

Publications (1)

Publication Number Publication Date
ATE439866T1 true ATE439866T1 (de) 2009-09-15

Family

ID=37215130

Family Applications (1)

Application Number Title Priority Date Filing Date
AT06727994T ATE439866T1 (de) 2005-04-26 2006-04-21 Kontrastmittel für die magnetresonanzbildgebung mit cest-aktivem paramagnetischem komplex

Country Status (7)

Country Link
US (1) US8734761B2 (de)
EP (1) EP1881852B1 (de)
JP (1) JP5638752B2 (de)
CN (1) CN101166547B (de)
AT (1) ATE439866T1 (de)
DE (1) DE602006008604D1 (de)
WO (1) WO2006114738A2 (de)

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* Cited by examiner, † Cited by third party
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WO2006032705A2 (en) * 2004-09-23 2006-03-30 Guerbet Contrast agents encapsulating systems for cest imaging
WO2006114765A2 (en) * 2005-04-26 2006-11-02 Koninklijke Philips Electronics N.V. Mri involving contrast agent with time modulated contrast enhancement
EP2065058A1 (de) * 2007-11-28 2009-06-03 Koninklijke Philips Electronics N.V. Nicht kugelförmige Kontrastmittel für CEST-MRI auf der Basis des magnetischen Bulk-Suszeptibilitätseffekts
WO2010040117A2 (en) 2008-10-03 2010-04-08 California Institute Of Technology Extraction of anions from solutions and mixtures using hyperbranched macromolecules
US9815712B2 (en) 2008-10-03 2017-11-14 California Institute Of Technology High capacity perchlorate-selective resins from hyperbranched macromolecules
US8658702B2 (en) 2009-12-17 2014-02-25 Mamadou Diallo Soluble anion exchangers from hyperbranched macromolecules
WO2012024396A2 (en) * 2010-08-17 2012-02-23 Rutgers, The State University Of New Jersey Compositions and methods for delivering nucleic acid molecules and treating cancer
WO2012070681A1 (ja) * 2010-11-26 2012-05-31 国立大学法人九州大学 常磁性を有する水溶性ハイパーブランチポリマー
EP3925625A1 (de) * 2011-01-09 2021-12-22 ANP Technologies, Inc. Hydrophobe, molekülinduzierte und verzweigte polymeraggregate und ihre verwendung
US11931740B2 (en) 2012-02-13 2024-03-19 Neumodx Molecular, Inc. System and method for processing and detecting nucleic acids
US9637775B2 (en) 2012-02-13 2017-05-02 Neumodx Molecular, Inc. System and method for processing biological samples
US11485968B2 (en) 2012-02-13 2022-11-01 Neumodx Molecular, Inc. Microfluidic cartridge for processing and detecting nucleic acids
EP2814942B1 (de) 2012-02-13 2024-07-03 Neumodx Molecular, Inc. Mikrofluidische kartusche zur verarbeitung und zum nachweis von nucleinsäuren
US9604213B2 (en) 2012-02-13 2017-03-28 Neumodx Molecular, Inc. System and method for processing and detecting nucleic acids
ES2741749T3 (es) 2012-10-25 2020-02-12 Neumodx Molecular Inc Método y materiales para el aislamiento de materiales de ácido nucleico
JP6297440B2 (ja) * 2013-07-31 2018-03-20 キヤノンメディカルシステムズ株式会社 造影剤
JP6411117B2 (ja) 2013-07-31 2018-10-24 キヤノンメディカルシステムズ株式会社 医用画像診断装置及び超音波診断装置
CN104623697B (zh) * 2015-02-08 2017-03-22 中国科学院武汉物理与数学研究所 一种基于人体生理温度响应的聚合物胶束型磁共振造影剂的制备方法
US9890187B2 (en) 2015-06-26 2018-02-13 Epos-Iasis Research And Development, Ltd. Prototype systems of theranostic biomarkers for in vivo molecular management of cancer
CN108369266B (zh) * 2015-12-23 2021-08-06 伯拉考成像股份公司 比率计量的脉冲cest成像
WO2017147418A1 (en) 2016-02-24 2017-08-31 Ohio State Innovation Foundation Methods and devices for contrast agent magnetic resonance imaging
CN105963718A (zh) * 2016-04-28 2016-09-28 东华大学 一种麦芽糖修饰的钆基螯合物mr造影剂的制备方法
WO2018053460A1 (en) * 2016-09-19 2018-03-22 The Regents Of The University Of California Paramagnetic polymers
RU2755181C2 (ru) * 2016-11-28 2021-09-14 Байер Фарма Акциенгезельшафт Новые хелатные соединения гадолиния с высокой релаксивностью для применения в магнитно-резонансной визуализации
CN108743977B (zh) * 2018-04-03 2021-03-02 中国科学院武汉物理与数学研究所 一种无重金属离子卟啉化合物造影剂及其在磁共振成像中的应用
EP4556031A3 (de) * 2018-04-27 2025-06-25 University of Iowa Research Foundation Zusammensetzungen zur chelatbildung von metallen bei niedrigen temperaturen
CN120609858B (zh) * 2025-05-30 2026-07-31 中国科学院精密测量科学与技术创新研究院 镧系金属配合物作为31p cest高场造影剂在识别atp中的应用
CN120668710A (zh) * 2025-05-30 2025-09-19 中国科学院精密测量科学与技术创新研究院 一种基于高场（≥5.0t）31p cest的磷酸根识别方法

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US6693190B1 (en) * 1994-05-11 2004-02-17 Bracco International B.V. Enhanced relaxivity monomeric and multimeric compounds
WO2000047111A1 (en) 1999-02-09 2000-08-17 Board Of Regents The University Of Texas System Ph sensitive mri contrast agents
US6746662B1 (en) * 1999-02-09 2004-06-08 Board Of Regents The University Of Texas System pH sensitive MRI contrast agents
AU4656400A (en) 1999-04-21 2000-11-17 Government of The United States of America, as represented by The Secretary Department of Health & Human Services, The National Institutes of Health, The Method for enhancing contrast produced by mri
CA2425508A1 (en) * 2000-10-11 2002-04-18 John S. Pease Targeted therapeutic agents
US6875419B2 (en) * 2000-11-20 2005-04-05 Board Of Regents The University Of Texas System Paramagnetic metal ion-based macrocyclic magnetization transfer contrast agents and method of use
DE10135356C1 (de) * 2001-07-20 2003-04-17 Schering Ag Makrocyclische Metallkomplexe und deren Verwendung zur Herstellung von Konjugaten mit Biomolekülen
DE10135355C1 (de) * 2001-07-20 2003-04-17 Schering Ag Konjugate makrocyclischer Metallkomplexe mit Biomolekülen und deren Verwendung zur Herstellung von Mitteln für die NMR- und Radiodiagnostik sowie die Radiotherapie
US20040030239A1 (en) * 2001-12-13 2004-02-12 The Johns Hopkins University School Of Medicine Method for MR/NMR imaging
EP1331012A1 (de) 2002-01-29 2003-07-30 BRACCO IMAGING S.p.A. Magnetisch beeinflussbare paramagnetische Kontrastmittel für Magnetresonanzbildgebung
JP4355144B2 (ja) 2003-01-21 2009-10-28 学校法人日本大学 新規含窒素環状化合物
EP1466629A1 (de) * 2003-04-11 2004-10-13 BRACCO IMAGING S.p.A. Adducte zwischen NMR Vershibungsreagenzen und Substraten mit austauschbaren Protonen für die "CEST" Anwendung
US20040258614A1 (en) * 2003-06-20 2004-12-23 University Of Maryland, Baltimore Microparticles for microarterial imaging and radiotherapy
WO2006032705A2 (en) * 2004-09-23 2006-03-30 Guerbet Contrast agents encapsulating systems for cest imaging

Also Published As

Publication number Publication date
US8734761B2 (en) 2014-05-27
CN101166547A (zh) 2008-04-23
WO2006114738A3 (en) 2007-06-21
EP1881852A2 (de) 2008-01-30
US20080193384A1 (en) 2008-08-14
WO2006114738A2 (en) 2006-11-02
JP2008539223A (ja) 2008-11-13
DE602006008604D1 (de) 2009-10-01
CN101166547B (zh) 2013-02-06
EP1881852B1 (de) 2009-08-19
JP5638752B2 (ja) 2014-12-10

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