ATE519505T1 - Reaktive paramagnetische kontrastmittel für magnetresonanzbildgebung - Google Patents

Reaktive paramagnetische kontrastmittel für magnetresonanzbildgebung

Info

Publication number: ATE519505T1
Authority: AT; Austria
Prior art keywords: magnetic resonance; resonance imaging; contrast agents; paramagnetic contrast; reactive
Prior art date: 2002-01-29

Application number

AT03702538T

Other languages

English (en)

Inventor

Silvio Aime

Castelli Daniela Delli

Franco Fedeli

Enzo Terreno

Original Assignee

Bracco Imaging Spa

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2002-01-29

Filing date

2003-01-27

Publication date

2011-08-15

2003-01-27 Application filed by Bracco Imaging Spa filed Critical Bracco Imaging Spa

2011-08-15 Application granted granted Critical

2011-08-15 Publication of ATE519505T1 publication Critical patent/ATE519505T1/de

Links

239000002872 contrast media Substances 0.000 title abstract 2
230000005298 paramagnetic effect Effects 0.000 title abstract 2
238000002595 magnetic resonance imaging Methods 0.000 title 1
238000000034 method Methods 0.000 abstract 2
238000000338 in vitro Methods 0.000 abstract 1
238000001727 in vivo Methods 0.000 abstract 1
239000000126 substance Substances 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/0002—General or multifunctional contrast agents, e.g. chelated agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
- A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
- A61K49/10—Organic compounds
- A61K49/101—Organic compounds the carrier being a complex-forming compound able to form MRI-active complexes with paramagnetic metals
- A61K49/106—Organic compounds the carrier being a complex-forming compound able to form MRI-active complexes with paramagnetic metals the complex-forming compound being cyclic, e.g. DOTA

Landscapes

Health & Medical Sciences (AREA)
Public Health (AREA)
Epidemiology (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Veterinary Medicine (AREA)
Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Radiology & Medical Imaging (AREA)
Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Magnetic Resonance Imaging Apparatus (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)

AT03702538T 2002-01-29 2003-01-27 Reaktive paramagnetische kontrastmittel für magnetresonanzbildgebung ATE519505T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
EP20020001178 EP1331012A1 (de)	2002-01-29	2002-01-29	Magnetisch beeinflussbare paramagnetische Kontrastmittel für Magnetresonanzbildgebung
PCT/EP2003/000796 WO2003063912A1 (en)	2002-01-29	2003-01-27	Responsive paramagnetic mri contrast agents

Publications (1)

Publication Number	Publication Date
ATE519505T1 true ATE519505T1 (de)	2011-08-15

Family

ID=8185284

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT03702538T ATE519505T1 (de)	2002-01-29	2003-01-27	Reaktive paramagnetische kontrastmittel für magnetresonanzbildgebung

Country Status (6)

Country	Link
US (2)	US7524483B2 (de)
EP (3)	EP1331012A1 (de)
JP (3)	JP4850391B2 (de)
AT (1)	ATE519505T1 (de)
DK (2)	DK1469890T3 (de)
WO (1)	WO2003063912A1 (de)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
WO2000066180A2 (en)	1999-04-21	2000-11-09	The Government Of The United States Of America, As Represented By The Secretary, Department Of Health And Human Services, The National Institutes Of Health	Method for enhancing contrast produced by mri
EP1331012A1 (de) *	2002-01-29	2003-07-30	BRACCO IMAGING S.p.A.	Magnetisch beeinflussbare paramagnetische Kontrastmittel für Magnetresonanzbildgebung
EP1466629A1 (de) *	2003-04-11	2004-10-13	BRACCO IMAGING S.p.A.	Adducte zwischen NMR Vershibungsreagenzen und Substraten mit austauschbaren Protonen für die "CEST" Anwendung
DE602005025659D1 (de) *	2004-09-23	2011-02-10	Guerbet Sa
WO2006114765A2 (en) *	2005-04-26	2006-11-02	Koninklijke Philips Electronics N.V.	Mri involving contrast agent with time modulated contrast enhancement
WO2006114739A2 (en) *	2005-04-26	2006-11-02	Koninklijke Philips Electronics N.V.	Method for using cest contrast agents in mri
CN101166547B (zh)	2005-04-26	2013-02-06	皇家飞利浦电子股份有限公司	包含cest活性的顺磁性配合物的mri造影剂
WO2006121889A2 (en) *	2005-05-06	2006-11-16	Epix Pharmaceuticals, Inc.	Chemical exchange saturation transfer contrast agents
US7610077B2 (en) *	2005-12-08	2009-10-27	General Electric Compnay	Quantitation of sample properties using contrast enhancement from saturation transfer
US8003078B2 (en) *	2006-03-29	2011-08-23	Barnes-Jewish Hospital	Targeted MR imaging agents
WO2007141767A2 (en) *	2006-06-09	2007-12-13	Koninklijke Philips Electronics N.V.	Elimination of contrast agent concentration dependency in mri
WO2009042881A1 (en) *	2007-09-26	2009-04-02	The Johns Hopkins University	Frequency referencing for chemical exchange saturation transfer (cest) mri
ES2712881T3 (es)	2008-12-02	2019-05-16	Univ Melbourne	Conjugados macrocíclicos que contienen nitrógeno como radiofármacos
US20120330132A1 (en)	2009-12-07	2012-12-27	Paul Sorajja	Device for the Delineation of Cardiovascular or Other Anatomical Structures
EP2752677B1 (de) *	2010-01-06	2015-07-22	Shiseido Company, Ltd.	Probenröhrchen für NMR-Messungen
WO2012006038A2 (en) *	2010-06-28	2012-01-12	The Board Of Regents, The University Of Texas System	Agents and compounds for imaging and other applications, and methods of use and synthesis thereof
EP2457594A1 (de) *	2010-11-05	2012-05-30	Bracco Imaging S.p.A	CEST-Systeme mit konzentrationsunabhängiger Ansprechempfindlichkeit
US11246949B2 (en)	2011-05-11	2022-02-15	The Research Foundation For The State University Of New York	Imaging contrast agents and uses thereof
EP2788353B1 (de)	2011-12-06	2022-05-18	Clarity Pharmaceuticals Ltd	Käfig-aminliganden für metallo-radiopharmazeutika
US10551455B2 (en)	2015-05-04	2020-02-04	Duke University	Magnetic resonance imaging (MRI) systems and methods using adiabatic tip-down and matched adiabatic flip-back pulses
WO2017109111A1 (en) *	2015-12-23	2017-06-29	Bracco Imaging Spa	Ratiometric pulsed cest imaging

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5190744A (en) *	1990-03-09	1993-03-02	Salutar	Methods for detecting blood perfusion variations by magnetic resonance imaging
CN1148812A (zh)	1994-03-28	1997-04-30	尼科梅德成像有限公司	“脂质体”
JP3759765B2 (ja) *	1994-03-28	2006-03-29	第一製薬株式会社	リポソーム
WO2000066180A2 (en) *	1999-04-21	2000-11-09	The Government Of The United States Of America, As Represented By The Secretary, Department Of Health And Human Services, The National Institutes Of Health	Method for enhancing contrast produced by mri
EP1390079A2 (de)	2000-11-20	2004-02-25	Board of Regents University of Texas System	Paramagnetischen metallion-basierte makrozyklische kontrastmitteln
EP1302465A1 (de)	2001-10-11	2003-04-16	BRACCO IMAGING S.p.A.	Verbesserte MRI-Bildgebung mittels umkehrbares binding zu einem paramagnetischen Komplex
EP1331012A1 (de) *	2002-01-29	2003-07-30	BRACCO IMAGING S.p.A.	Magnetisch beeinflussbare paramagnetische Kontrastmittel für Magnetresonanzbildgebung

2002
- 2002-01-29 EP EP20020001178 patent/EP1331012A1/de not_active Withdrawn
2003
- 2003-01-27 AT AT03702538T patent/ATE519505T1/de not_active IP Right Cessation
- 2003-01-27 EP EP10176761A patent/EP2298362B1/de not_active Expired - Lifetime
- 2003-01-27 DK DK03702538.4T patent/DK1469890T3/da active
- 2003-01-27 WO PCT/EP2003/000796 patent/WO2003063912A1/en not_active Ceased
- 2003-01-27 US US10/502,701 patent/US7524483B2/en not_active Expired - Lifetime
- 2003-01-27 DK DK10176761.4T patent/DK2298362T3/da active
- 2003-01-27 EP EP03702538A patent/EP1469890B1/de not_active Expired - Lifetime
- 2003-01-27 JP JP2003563601A patent/JP4850391B2/ja not_active Expired - Fee Related
2009
- 2009-04-03 US US12/418,155 patent/US8318134B2/en not_active Expired - Fee Related
- 2009-11-19 JP JP2009264106A patent/JP4796643B2/ja not_active Expired - Fee Related
2011
- 2011-07-08 JP JP2011151981A patent/JP2011235125A/ja not_active Withdrawn

Also Published As

Publication number	Publication date
JP2011235125A (ja)	2011-11-24
US8318134B2 (en)	2012-11-27
JP2010088901A (ja)	2010-04-22
JP4850391B2 (ja)	2012-01-11
EP1469890A1 (de)	2004-10-27
WO2003063912A1 (en)	2003-08-07
DK1469890T3 (da)	2011-11-14
JP2005515842A (ja)	2005-06-02
US20090234221A1 (en)	2009-09-17
US7524483B2 (en)	2009-04-28
EP1469890B1 (de)	2011-08-10
DK2298362T3 (da)	2013-06-10
US20050191243A1 (en)	2005-09-01
EP2298362B1 (de)	2013-03-13
EP2298362A1 (de)	2011-03-23
JP4796643B2 (ja)	2011-10-19
EP1331012A1 (de)	2003-07-30

Legal Events

Date	Code	Title	Description
2012-02-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties

Publication	Publication Date	Title
ATE519505T1 (de)	2011-08-15	Reaktive paramagnetische kontrastmittel für magnetresonanzbildgebung
ATE470470T1 (de)	2010-06-15	Medizinische geräte mit kontrastmittel und verfahren zu dessen herstellung
SE9903185D0 (sv)	1999-09-08	Terapeutisk metod och anordning baserad på magnetism
DE602006008604D1 (de)	2009-10-01	Kontrastmittel für die magnetresonanzbildgebung mit cest-aktivem paramagnetischem komplex
IL180896A0 (en)	2007-07-04	Method of tumour imaging
ATE460753T1 (de)	2010-03-15	Gewölbtes gehäuse für eine implantierbare medizinische vorrichtung
ATE552768T1 (de)	2012-04-15	Vorrichtung für in-vivo-verfahren
FI20000417A0 (fi)	2000-02-23	Ihmiseen liittyvä mittausarviointi
DE60223176D1 (de)	2007-12-06	Metallkomplexverbindungen
ATE400813T1 (de)	2008-07-15	Tumormarker für frühes krebsstadium
ATE295203T1 (de)	2005-05-15	Patientenpositionierungssystem für die radiotherapie
ATE269524T1 (de)	2004-07-15	Kühlgerät und verfahren zur verkeimungsindikation
WO2008017879A3 (en)	2008-04-03	Imaging magnet with illuminated bore
ATE452655T1 (de)	2010-01-15	Verwendung von l-polynukleotiden zur diagnostischen bilderzeugung
HU9401166D0 (en)	1994-07-28	Method for the in vivo measurement of the concentration of nmr-detectable xenobiotic compounds
DE60234821D1 (de)	2010-02-04	Messverfahren für vollblut
DE60207288D1 (de)	2005-12-15	Gewebespezifische fluoreszierende chelate
TW200712534A (en)	2007-04-01	Wireless device
WO2003084384A3 (en)	2004-02-26	Diagnosis of flavivirus infection
DE60332791D1 (de)	2010-07-15	NMR-Magnet für Lösungsanalyse und NMR-Gerät
BR0312552A (pt)	2005-04-26	Aplicação de complexos de metais contendo perfluoralquila como agente de contraste na imagem de ressonância magnética para a representação de trombos intravasculares
DE60026743D1 (de)	2006-05-11	Verwendung von kontrastmitteln zur herstellung eines diagnostischen mittels für die darm-lumenbildgebung
WO2003086563A3 (en)	2004-03-18	Diabetes imaging probes
DE502004004456D1 (de)	2007-09-06	Kanülenhalter
DE60135918D1 (de)	2008-11-06	Gerät für prostatekrebsdiagnose