ATE519505T1 - Reaktive paramagnetische kontrastmittel für magnetresonanzbildgebung - Google Patents

Reaktive paramagnetische kontrastmittel für magnetresonanzbildgebung

Info

Publication number
ATE519505T1
ATE519505T1 AT03702538T AT03702538T ATE519505T1 AT E519505 T1 ATE519505 T1 AT E519505T1 AT 03702538 T AT03702538 T AT 03702538T AT 03702538 T AT03702538 T AT 03702538T AT E519505 T1 ATE519505 T1 AT E519505T1
Authority
AT
Austria
Prior art keywords
magnetic resonance
resonance imaging
contrast agents
paramagnetic contrast
reactive
Prior art date
Application number
AT03702538T
Other languages
English (en)
Inventor
Silvio Aime
Castelli Daniela Delli
Franco Fedeli
Enzo Terreno
Original Assignee
Bracco Imaging Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bracco Imaging Spa filed Critical Bracco Imaging Spa
Application granted granted Critical
Publication of ATE519505T1 publication Critical patent/ATE519505T1/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/0002—General or multifunctional contrast agents, e.g. chelated agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
    • A61K49/10—Organic compounds
    • A61K49/101—Organic compounds the carrier being a complex-forming compound able to form MRI-active complexes with paramagnetic metals
    • A61K49/106—Organic compounds the carrier being a complex-forming compound able to form MRI-active complexes with paramagnetic metals the complex-forming compound being cyclic, e.g. DOTA

Landscapes

  • Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Radiology & Medical Imaging (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Magnetic Resonance Imaging Apparatus (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
AT03702538T 2002-01-29 2003-01-27 Reaktive paramagnetische kontrastmittel für magnetresonanzbildgebung ATE519505T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP20020001178 EP1331012A1 (de) 2002-01-29 2002-01-29 Magnetisch beeinflussbare paramagnetische Kontrastmittel für Magnetresonanzbildgebung
PCT/EP2003/000796 WO2003063912A1 (en) 2002-01-29 2003-01-27 Responsive paramagnetic mri contrast agents

Publications (1)

Publication Number Publication Date
ATE519505T1 true ATE519505T1 (de) 2011-08-15

Family

ID=8185284

Family Applications (1)

Application Number Title Priority Date Filing Date
AT03702538T ATE519505T1 (de) 2002-01-29 2003-01-27 Reaktive paramagnetische kontrastmittel für magnetresonanzbildgebung

Country Status (6)

Country Link
US (2) US7524483B2 (de)
EP (3) EP1331012A1 (de)
JP (3) JP4850391B2 (de)
AT (1) ATE519505T1 (de)
DK (2) DK1469890T3 (de)
WO (1) WO2003063912A1 (de)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU4656400A (en) * 1999-04-21 2000-11-17 Government of The United States of America, as represented by The Secretary Department of Health & Human Services, The National Institutes of Health, The Method for enhancing contrast produced by mri
EP1331012A1 (de) * 2002-01-29 2003-07-30 BRACCO IMAGING S.p.A. Magnetisch beeinflussbare paramagnetische Kontrastmittel für Magnetresonanzbildgebung
EP1466629A1 (de) * 2003-04-11 2004-10-13 BRACCO IMAGING S.p.A. Adducte zwischen NMR Vershibungsreagenzen und Substraten mit austauschbaren Protonen für die "CEST" Anwendung
WO2006032705A2 (en) * 2004-09-23 2006-03-30 Guerbet Contrast agents encapsulating systems for cest imaging
WO2006114765A2 (en) * 2005-04-26 2006-11-02 Koninklijke Philips Electronics N.V. Mri involving contrast agent with time modulated contrast enhancement
ATE439866T1 (de) 2005-04-26 2009-09-15 Koninkl Philips Electronics Nv Kontrastmittel für die magnetresonanzbildgebung mit cest-aktivem paramagnetischem komplex
EP1889086B1 (de) * 2005-04-26 2010-01-13 Koninklijke Philips Electronics N.V. Verfahren zur verwendung von cest-kontrastmitteln bei der magnetresonanztomographie
US20060275217A1 (en) * 2005-05-06 2006-12-07 Caravan Peter D Chemical exchange saturation transfer contrast agents
US7610077B2 (en) * 2005-12-08 2009-10-27 General Electric Compnay Quantitation of sample properties using contrast enhancement from saturation transfer
US8003078B2 (en) * 2006-03-29 2011-08-23 Barnes-Jewish Hospital Targeted MR imaging agents
EP2035044B1 (de) * 2006-06-09 2013-10-16 Koninklijke Philips N.V. Eliminierung der kontrastmittelkonzentrationsabhängigkeit in der kernspintomographie
EP2205986B1 (de) * 2007-09-26 2013-07-03 The Johns Hopkins University Frequenzreferenzierung für mri mit cest (chemical exchange saturation transfer)
ES2712881T3 (es) 2008-12-02 2019-05-16 Univ Melbourne Conjugados macrocíclicos que contienen nitrógeno como radiofármacos
US20120330132A1 (en) 2009-12-07 2012-12-27 Paul Sorajja Device for the Delineation of Cardiovascular or Other Anatomical Structures
CN102741700A (zh) 2010-01-06 2012-10-17 株式会社资生堂 Nmr用的标准物质、nmr用的试样管、nmr用的毛细管、及测定试样的nmr的方法
WO2012006038A2 (en) * 2010-06-28 2012-01-12 The Board Of Regents, The University Of Texas System Agents and compounds for imaging and other applications, and methods of use and synthesis thereof
EP2457594A1 (de) * 2010-11-05 2012-05-30 Bracco Imaging S.p.A CEST-Systeme mit konzentrationsunabhängiger Ansprechempfindlichkeit
WO2012155076A2 (en) * 2011-05-11 2012-11-15 The Research Foundation Of State University Of New York Imaging contrast agents and uses thereof
DK2788353T3 (da) 2011-12-06 2022-08-15 Clarity Pharmaceuticals Ltd Bur-aminligander til metallo-radiofarmaceutika
WO2016179264A1 (en) * 2015-05-04 2016-11-10 Duke University Magnetic resonance imaging (mri) systems and methods using adiabatic tip-down and matched adiabatic flip-back pulses
CN108369266B (zh) * 2015-12-23 2021-08-06 伯拉考成像股份公司 比率计量的脉冲cest成像

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5190744A (en) * 1990-03-09 1993-03-02 Salutar Methods for detecting blood perfusion variations by magnetic resonance imaging
JP3759765B2 (ja) * 1994-03-28 2006-03-29 第一製薬株式会社 リポソーム
CN1148812A (zh) 1994-03-28 1997-04-30 尼科梅德成像有限公司 “脂质体”
AU4656400A (en) * 1999-04-21 2000-11-17 Government of The United States of America, as represented by The Secretary Department of Health & Human Services, The National Institutes of Health, The Method for enhancing contrast produced by mri
US6875419B2 (en) 2000-11-20 2005-04-05 Board Of Regents The University Of Texas System Paramagnetic metal ion-based macrocyclic magnetization transfer contrast agents and method of use
EP1302465A1 (de) 2001-10-11 2003-04-16 BRACCO IMAGING S.p.A. Verbesserte MRI-Bildgebung mittels umkehrbares binding zu einem paramagnetischen Komplex
EP1331012A1 (de) * 2002-01-29 2003-07-30 BRACCO IMAGING S.p.A. Magnetisch beeinflussbare paramagnetische Kontrastmittel für Magnetresonanzbildgebung

Also Published As

Publication number Publication date
JP4850391B2 (ja) 2012-01-11
US8318134B2 (en) 2012-11-27
JP4796643B2 (ja) 2011-10-19
DK2298362T3 (da) 2013-06-10
EP1331012A1 (de) 2003-07-30
JP2010088901A (ja) 2010-04-22
US20050191243A1 (en) 2005-09-01
JP2005515842A (ja) 2005-06-02
US7524483B2 (en) 2009-04-28
DK1469890T3 (da) 2011-11-14
EP1469890B1 (de) 2011-08-10
US20090234221A1 (en) 2009-09-17
JP2011235125A (ja) 2011-11-24
EP2298362A1 (de) 2011-03-23
EP1469890A1 (de) 2004-10-27
WO2003063912A1 (en) 2003-08-07
EP2298362B1 (de) 2013-03-13

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