ATE440089T1 - Peptid-nukleinsäure-oligomere aus 1-benzol sulfonyl-3-amino säure seitenkette-4-(2-nukleo base(acetyl))piperazin-2-onen - Google Patents
Peptid-nukleinsäure-oligomere aus 1-benzol sulfonyl-3-amino säure seitenkette-4-(2-nukleo base(acetyl))piperazin-2-onenInfo
- Publication number
- ATE440089T1 ATE440089T1 AT03700408T AT03700408T ATE440089T1 AT E440089 T1 ATE440089 T1 AT E440089T1 AT 03700408 T AT03700408 T AT 03700408T AT 03700408 T AT03700408 T AT 03700408T AT E440089 T1 ATE440089 T1 AT E440089T1
- Authority
- AT
- Austria
- Prior art keywords
- sub
- side chain
- oligomers
- amino acid
- peptide
- Prior art date
Links
- 239000002253 acid Substances 0.000 title abstract 2
- 125000002777 acetyl group Chemical class [H]C([H])([H])C(*)=O 0.000 title 1
- UHOVQNZJYSORNB-UHFFFAOYSA-N benzene Substances C1=CC=CC=C1 UHOVQNZJYSORNB-UHFFFAOYSA-N 0.000 title 1
- 108091093037 Peptide nucleic acid Proteins 0.000 abstract 4
- 125000003545 alkoxy group Chemical group 0.000 abstract 2
- 125000000217 alkyl group Chemical group 0.000 abstract 2
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 2
- 150000007513 acids Chemical class 0.000 abstract 1
- 150000001370 alpha-amino acid derivatives Chemical class 0.000 abstract 1
- 235000008206 alpha-amino acids Nutrition 0.000 abstract 1
- 230000015572 biosynthetic process Effects 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 239000000178 monomer Substances 0.000 abstract 1
- 150000002825 nitriles Chemical class 0.000 abstract 1
- 238000002360 preparation method Methods 0.000 abstract 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 1
- 125000006239 protecting group Chemical group 0.000 abstract 1
- 238000003786 synthesis reaction Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
- C07D473/18—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 one oxygen and one nitrogen atom, e.g. guanine
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- C07D473/26—Heterocyclic compounds containing purine ring systems with an oxygen, sulphur, or nitrogen atom directly attached in position 2 or 6, but not in both
- C07D473/28—Oxygen atom
- C07D473/30—Oxygen atom attached in position 6, e.g. hypoxanthine
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- C07D473/26—Heterocyclic compounds containing purine ring systems with an oxygen, sulphur, or nitrogen atom directly attached in position 2 or 6, but not in both
- C07D473/32—Nitrogen atom
- C07D473/34—Nitrogen atom attached in position 6, e.g. adenine
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/001—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof by chemical synthesis
- C07K14/003—Peptide-nucleic acids (PNAs)
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biochemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- General Chemical & Material Sciences (AREA)
- Biophysics (AREA)
- Gastroenterology & Hepatology (AREA)
- Medicinal Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Peptides Or Proteins (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Plural Heterocyclic Compounds (AREA)
- Polyamides (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| KR10-2002-0004194A KR100464261B1 (ko) | 2002-01-24 | 2002-01-24 | Ｐｎａ 올리고머를 합성하기 위한 신규한 단량체 및 그의제조방법 |
| PCT/IB2003/000164 WO2003062212A1 (en) | 2002-01-24 | 2003-01-23 | Peptide nucleic acid oligomers from 1-benzenesulfonyl-3-amino acid side chain-4-(2-nucleobase(acetyl))-piperazin-2-ones |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE440089T1 true ATE440089T1 (de) | 2009-09-15 |
Family
ID=27607011
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT03700408T ATE440089T1 (de) | 2002-01-24 | 2003-01-23 | Peptid-nukleinsäure-oligomere aus 1-benzol sulfonyl-3-amino säure seitenkette-4-(2-nukleo base(acetyl))piperazin-2-onen |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US7022851B2 (de) |
| EP (1) | EP1470114B1 (de) |
| JP (1) | JP4394952B2 (de) |
| KR (1) | KR100464261B1 (de) |
| CN (1) | CN100351243C (de) |
| AT (1) | ATE440089T1 (de) |
| DE (1) | DE60328866D1 (de) |
| DK (1) | DK1470114T3 (de) |
| WO (1) | WO2003062212A1 (de) |
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| JP2025539043A (ja) | 2022-11-14 | 2025-12-03 | バイオンテック・エスイー | Ｒｎａキャッピング効率アッセイ |
| TW202442246A (zh) | 2023-04-27 | 2024-11-01 | 美商薩羅塔治療公司 | 用於治療慢性腎病之反義寡聚物 |
| WO2024231285A1 (en) | 2023-05-05 | 2024-11-14 | BioNTech SE | Method of analysing contaminants in rna products by ion-pair chromatography |
| AU2024362420A1 (en) | 2023-10-18 | 2026-04-23 | Murdoch University | Antisense oligomers for treatment of centronuclear myopathies |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4204870A (en) * | 1978-07-25 | 1980-05-27 | Eastman Kodak Company | Photographic products and processes employing novel nondiffusible heterocyclyazonaphthol dye-releasing compounds |
| DK51092D0 (da) | 1991-05-24 | 1992-04-15 | Ole Buchardt | Oligonucleotid-analoge betegnet pna, monomere synthoner og fremgangsmaade til fremstilling deraf samt anvendelser deraf |
| US5294713A (en) * | 1991-08-23 | 1994-03-15 | Takeda Chemical Industries, Ltd. | 2-piperazinone compounds and their use |
| US6133444A (en) * | 1993-12-22 | 2000-10-17 | Perseptive Biosystems, Inc. | Synthons for the synthesis and deprotection of peptide nucleic acids under mild conditions |
| US5539083A (en) * | 1994-02-23 | 1996-07-23 | Isis Pharmaceuticals, Inc. | Peptide nucleic acid combinatorial libraries and improved methods of synthesis |
| WO1996040709A1 (en) * | 1995-06-07 | 1996-12-19 | Perseptive Biosystems, Inc. | Pna-dna chimeras and pna synthons for their preparation |
| DE19620170A1 (de) * | 1996-05-20 | 1997-11-27 | Wolfgang Prof Dr Dr Pfleiderer | Nucleosid-Derivate mit photolabilen Schutzgruppen |
| AUPO008396A0 (en) * | 1996-05-27 | 1996-06-20 | Fujisawa Pharmaceutical Co., Ltd. | New piperazine compounds |
| US6403595B1 (en) * | 1998-02-05 | 2002-06-11 | Takeda Chemical Industries, Ltd. | Sulfonamide derivatives, processes for producing the same and utilization thereof |
| DE69933770D1 (de) | 1998-07-09 | 2006-12-07 | Biocept Inc | Verfahren zur verwendung einer universellen bibliothek von peptid-nukleinsäuren zur optimierung der dns-hybridisierung |
| KR20030009903A (ko) * | 2001-07-24 | 2003-02-05 | 삼성정밀화학 주식회사 | 주쇄 ２－아미노에틸글리신의 １차 아미노기가ｐ－니트로페닐설포닐에톡시카르보닐기로 보호된 펩타이드핵산 단량체의 제조방법 |
| KR20030042180A (ko) * | 2001-11-21 | 2003-05-28 | 주식회사 파나진 | 펩타이드 핵산의 골격을 제조하는 방법 |
| KR20030084444A (ko) * | 2002-04-26 | 2003-11-01 | 주식회사 파나진 | Ｐｎａ 올리고머를 합성하기 위한 신규한 단량체 및 그의제조방법 |
-
2002
- 2002-01-24 KR KR10-2002-0004194A patent/KR100464261B1/ko not_active Expired - Fee Related
-
2003
- 2003-01-23 EP EP03700408A patent/EP1470114B1/de not_active Expired - Lifetime
- 2003-01-23 DE DE60328866T patent/DE60328866D1/de not_active Expired - Lifetime
- 2003-01-23 JP JP2003562092A patent/JP4394952B2/ja not_active Expired - Lifetime
- 2003-01-23 DK DK03700408T patent/DK1470114T3/da active
- 2003-01-23 AT AT03700408T patent/ATE440089T1/de not_active IP Right Cessation
- 2003-01-23 WO PCT/IB2003/000164 patent/WO2003062212A1/en not_active Ceased
- 2003-01-23 CN CNB038064944A patent/CN100351243C/zh not_active Expired - Lifetime
- 2003-01-24 US US10/351,173 patent/US7022851B2/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| KR100464261B1 (ko) | 2005-01-03 |
| JP2005538928A (ja) | 2005-12-22 |
| EP1470114B1 (de) | 2009-08-19 |
| KR20030063848A (ko) | 2003-07-31 |
| US20030195332A1 (en) | 2003-10-16 |
| JP4394952B2 (ja) | 2010-01-06 |
| US7022851B2 (en) | 2006-04-04 |
| WO2003062212A1 (en) | 2003-07-31 |
| EP1470114A4 (de) | 2005-05-11 |
| DK1470114T3 (da) | 2009-11-02 |
| CN100351243C (zh) | 2007-11-28 |
| DE60328866D1 (de) | 2009-10-01 |
| EP1470114A1 (de) | 2004-10-27 |
| CN1642923A (zh) | 2005-07-20 |
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