ATE440857T1 - Verfahren zum eliminieren von n-terminalem methionin - Google Patents

Verfahren zum eliminieren von n-terminalem methionin

Info

Publication number: ATE440857T1
Authority: AT; Austria
Prior art keywords: terminal methionine; salt; eliminating; methionine residue; diketone
Prior art date: 1998-10-05

Application number

AT99969949T

Other languages

English (en)

Inventor

Osamu Nishimura

Tsuneo Asano

Masato Suenaga

Hiroaki Ohmae

Norio Okutani

Original Assignee

Takeda Pharmaceutical

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1998-10-05

Filing date

1999-10-04

Publication date

2009-09-15

1999-10-04 Application filed by Takeda Pharmaceutical filed Critical Takeda Pharmaceutical

2009-09-15 Application granted granted Critical

2009-09-15 Publication of ATE440857T1 publication Critical patent/ATE440857T1/de

Links

238000000034 method Methods 0.000 title abstract 3
FFEARJCKVFRZRR-BYPYZUCNSA-N L-methionine Chemical group CSCC[C@H](N)C(O)=O FFEARJCKVFRZRR-BYPYZUCNSA-N 0.000 title 1
229930182817 methionine Natural products 0.000 title 1
BDAGIHXWWSANSR-UHFFFAOYSA-N methanoic acid Natural products OC=O BDAGIHXWWSANSR-UHFFFAOYSA-N 0.000 abstract 4
QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 abstract 3
125000001360 methionine group Chemical group N[C@@H](CCSC)C(=O)* 0.000 abstract 3
150000003839 salts Chemical class 0.000 abstract 3
OSWFIVFLDKOXQC-UHFFFAOYSA-N 4-(3-methoxyphenyl)aniline Chemical compound COC1=CC=CC(C=2C=CC(N)=CC=2)=C1 OSWFIVFLDKOXQC-UHFFFAOYSA-N 0.000 abstract 2
239000004280 Sodium formate Substances 0.000 abstract 2
125000005594 diketone group Chemical group 0.000 abstract 2
235000019253 formic acid Nutrition 0.000 abstract 2
108090000765 processed proteins & peptides Proteins 0.000 abstract 2
HLBBKKJFGFRGMU-UHFFFAOYSA-M sodium formate Chemical compound [Na+].[O-]C=O HLBBKKJFGFRGMU-UHFFFAOYSA-M 0.000 abstract 2
235000019254 sodium formate Nutrition 0.000 abstract 2
HEMGYNNCNNODNX-UHFFFAOYSA-N 3,4-diaminobenzoic acid Chemical compound NC1=CC=C(C(O)=O)C=C1N HEMGYNNCNNODNX-UHFFFAOYSA-N 0.000 abstract 1
VMHLLURERBWHNL-UHFFFAOYSA-M Sodium acetate Chemical compound [Na+].CC([O-])=O VMHLLURERBWHNL-UHFFFAOYSA-M 0.000 abstract 1
235000011054 acetic acid Nutrition 0.000 abstract 1
238000004519 manufacturing process Methods 0.000 abstract 1
239000001632 sodium acetate Substances 0.000 abstract 1
235000017281 sodium acetate Nutrition 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/12—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by hydrolysis, i.e. solvolysis in general

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Medicinal Chemistry (AREA)
Molecular Biology (AREA)
Biochemistry (AREA)
Biophysics (AREA)
General Health & Medical Sciences (AREA)
Genetics & Genomics (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Analytical Chemistry (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Peptides Or Proteins (AREA)
Saccharide Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

AT99969949T 1998-10-05 1999-10-04 Verfahren zum eliminieren von n-terminalem methionin ATE440857T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
JP28247698		1998-10-05
PCT/JP1999/005456 WO2000020439A1 (fr)	1998-10-05	1999-10-04	Procede d'elimination de methionine n-terminale

Publications (1)

Publication Number	Publication Date
ATE440857T1 true ATE440857T1 (de)	2009-09-15

Family

ID=17652941

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT99969949T ATE440857T1 (de)	1998-10-05	1999-10-04	Verfahren zum eliminieren von n-terminalem methionin

Country Status (9)

Country	Link
US (1)	US6774221B1 (de)
EP (1)	EP1120425B1 (de)
KR (1)	KR20010080015A (de)
CN (1)	CN1322211A (de)
AT (1)	ATE440857T1 (de)
AU (1)	AU6002199A (de)
CA (1)	CA2346064A1 (de)
DE (1)	DE69941337D1 (de)
WO (1)	WO2000020439A1 (de)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US7538188B2 (en) *	1998-04-08	2009-05-26	Industrial Technology Research Institute	Method for fabricating an olfactory receptor-based biosensor
EP1306430A4 (de) *	2000-07-31	2004-09-08	Takeda Chemical Industries Ltd	Verfahren zur herstellung eines rekombinanten proteins
US8673848B2 (en)	2012-01-27	2014-03-18	Novartis Ag	Synthetic apelin mimetics for the treatment of heart failure
UY35144A (es)	2012-11-20	2014-06-30	Novartis Ag	Miméticos lineales sintéticos de apelina para el tratamiento de insuficiencia cardiaca
US8921307B2 (en)	2012-11-20	2014-12-30	Novartis Ag	Synthetic linear apelin mimetics for the treatment of heart failure
HK1218252A1 (zh)	2013-07-25	2017-02-10	Novartis Ag	合成apelin多肽之生物结合物
KR20160031551A (ko)	2013-07-25	2016-03-22	노파르티스 아게	심부전의 치료를 위한 시클릭 폴리펩티드
SG11201811478TA (en) *	2016-01-12	2019-01-30	Intron Biotechnology Inc	Freeze-dried formulations of antibacterial protein
CN115806946B (zh) *	2022-12-20	2025-09-16	深圳瑞德林生物技术有限公司	京都啡肽及其衍生物的制备方法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
WO1986001229A1 (en) *	1984-08-16	1986-02-27	Bio-Technology General Corp.	Method of removing n-terminal amino acid residues from eucaryotic polypetide analogs and polypeptides produced thereby
US5037806A (en)	1985-02-22	1991-08-06	Monsanto Company	Biologically active method using somatotropins
EP0812856B1 (de) *	1996-06-14	1999-09-29	Takeda Chemical Industries, Ltd.	Verfahren zur Entfernung von N-Terminalem Methionin

1999
- 1999-10-04 DE DE69941337T patent/DE69941337D1/de not_active Expired - Lifetime
- 1999-10-04 EP EP99969949A patent/EP1120425B1/de not_active Expired - Lifetime
- 1999-10-04 US US09/806,871 patent/US6774221B1/en not_active Expired - Fee Related
- 1999-10-04 AU AU60021/99A patent/AU6002199A/en not_active Abandoned
- 1999-10-04 CN CN99811785A patent/CN1322211A/zh active Pending
- 1999-10-04 CA CA002346064A patent/CA2346064A1/en not_active Abandoned
- 1999-10-04 AT AT99969949T patent/ATE440857T1/de not_active IP Right Cessation
- 1999-10-04 KR KR1020017004342A patent/KR20010080015A/ko not_active Withdrawn
- 1999-10-04 WO PCT/JP1999/005456 patent/WO2000020439A1/ja not_active Ceased

Also Published As

Publication number	Publication date
AU6002199A (en)	2000-04-26
WO2000020439A1 (fr)	2000-04-13
EP1120425A1 (de)	2001-08-01
EP1120425A4 (de)	2002-01-02
KR20010080015A (ko)	2001-08-22
US6774221B1 (en)	2004-08-10
DE69941337D1 (de)	2009-10-08
CA2346064A1 (en)	2000-04-13
EP1120425B1 (de)	2009-08-26
CN1322211A (zh)	2001-11-14

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Legal Events

Date	Code	Title	Description
2010-02-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties