ES2136458T3 - Metodo para separar la metionina n-terminal. - Google Patents

Metodo para separar la metionina n-terminal.

Info

Publication number
ES2136458T3
ES2136458T3 ES97303856T ES97303856T ES2136458T3 ES 2136458 T3 ES2136458 T3 ES 2136458T3 ES 97303856 T ES97303856 T ES 97303856T ES 97303856 T ES97303856 T ES 97303856T ES 2136458 T3 ES2136458 T3 ES 2136458T3
Authority
ES
Spain
Prior art keywords
terminal
metionin
separating
methionine residue
peptide
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES97303856T
Other languages
English (en)
Inventor
Osamu Nishimura
Masato Suenaga
Mae Hiroaki Oh
Shinji Tsuji
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Takeda Pharmaceutical Co Ltd
Original Assignee
Takeda Chemical Industries Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Takeda Chemical Industries Ltd filed Critical Takeda Chemical Industries Ltd
Application granted granted Critical
Publication of ES2136458T3 publication Critical patent/ES2136458T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/12—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by hydrolysis, i.e. solvolysis in general
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/61—Growth hormone [GH], i.e. somatotropin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/635—Parathyroid hormone, i.e. parathormone; Parathyroid hormone-related peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • C07K16/244—Interleukins [IL]
    • C07K16/246—IL-2

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Analytical Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • External Artificial Organs (AREA)
  • Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
  • Forging (AREA)

Abstract

LA PRESENTE INVENCION PROPORCIONA UN METODO PARA ELIMINAR QUIMICAMENTE UN RESIDUO DE METIONINA N TERMINAL SELECTIVAMENTE, ESPECIFICAMENTE Y EFICAZMENTE A PARTIR DE UN PEPTIDO O UNA SAL DEL MISMO QUE TIENE UN RESIDUO DE METIONINA OPCIONALMENTE OXIDADO EN SU EXTREMO N TERMINAL. EN EL METODO REACCIONA UN PEPTIDO O UNA SAL DEL MISMO QUE TIENE UN RESIDUO DE METIONINA OPCIONALMENTE OXIDADO EN SU EXTREMO N TERMINAL CON UN DERIVADO {AL} - DICETONA, SEGUIDO DE HIDROLISIS.
ES97303856T 1996-06-14 1997-06-05 Metodo para separar la metionina n-terminal. Expired - Lifetime ES2136458T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP15463496 1996-06-14

Publications (1)

Publication Number Publication Date
ES2136458T3 true ES2136458T3 (es) 1999-11-16

Family

ID=15588495

Family Applications (1)

Application Number Title Priority Date Filing Date
ES97303856T Expired - Lifetime ES2136458T3 (es) 1996-06-14 1997-06-05 Metodo para separar la metionina n-terminal.

Country Status (11)

Country Link
US (2) US6066470A (es)
EP (1) EP0812856B1 (es)
KR (1) KR100478747B1 (es)
CN (1) CN1158303C (es)
AT (1) ATE185146T1 (es)
CA (1) CA2207723C (es)
DE (1) DE69700561T2 (es)
DK (1) DK0812856T3 (es)
ES (1) ES2136458T3 (es)
GR (1) GR3032139T3 (es)
IL (1) IL121053A (es)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2768743B1 (fr) * 1997-09-23 2001-09-14 Bio Merieux Procede de lyse de micro-organisme
ATE440857T1 (de) 1998-10-05 2009-09-15 Takeda Pharmaceutical Verfahren zum eliminieren von n-terminalem methionin
AU1797100A (en) * 1998-12-11 2000-07-03 Takeda Chemical Industries Ltd. Process for producing apelin
EP1347053A4 (en) * 2000-12-07 2004-11-24 Takeda Chemical Industries Ltd METHOD FOR PRODUCING RFRP
WO2002052027A1 (en) * 2000-12-22 2002-07-04 Nippon Soda Co., Ltd. Process for producing substance by using microbial catalyst
DK1581251T3 (da) * 2002-12-31 2016-06-27 Althea Tech Inc Krystaller af humant væksthormon og fremgangsmåder til fremstilling deraf
DE10353973B4 (de) * 2003-11-19 2006-08-17 Beru Ag Verfahren zum Herstellen eines keramischen Glühstiftes für eine keramische Glühkerze
EP1976551A4 (en) * 2005-12-23 2009-12-30 Altus Pharmaceuticals Inc COMPOSITIONS COMPRISING COMPLEX PROTEIN CRYSTALS BY POLYCATIONS AND PROCESSING METHOD THEREOF
US8889632B2 (en) 2007-01-31 2014-11-18 Dana-Farber Cancer Institute, Inc. Stabilized p53 peptides and uses thereof
EP2508531B1 (en) 2007-03-28 2016-10-19 President and Fellows of Harvard College Stitched polypeptides
SI2603600T1 (sl) 2010-08-13 2019-04-30 Aileron Therapeutics, Inc. Peptidomimetični makrocikli
TW201806968A (zh) 2011-10-18 2018-03-01 艾利倫治療公司 擬肽巨環化合物
HK1205454A1 (en) 2012-02-15 2015-12-18 Aileron Therapeutics, Inc. Triazole-crosslinked and thioether-crosslinked peptidomimetic macrocycles
KR102112373B1 (ko) 2012-02-15 2020-05-18 에일러론 테라퓨틱스 인코포레이티드 펩티드모방체 마크로사이클
WO2014071241A1 (en) 2012-11-01 2014-05-08 Aileron Therapeutics, Inc. Disubstituted amino acids and methods of preparation and use thereof
EP3036252A1 (en) * 2013-08-21 2016-06-29 Cadila Healthcare Limited Purification process for pth
BR112017005598A2 (pt) 2014-09-24 2017-12-12 Aileron Therapeutics Inc macrociclos peptidomiméticos e usos dos mesmos
WO2016154058A1 (en) 2015-03-20 2016-09-29 Aileron Therapeutics, Inc. Peptidomimetic macrocycles and uses thereof
CN115806946B (zh) * 2022-12-20 2025-09-16 深圳瑞德林生物技术有限公司 京都啡肽及其衍生物的制备方法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1986007380A1 (fr) 1985-06-04 1986-12-18 Takeda Chemical Industries, Ltd. Procede de preparation de polypeptides
IT1219454B (it) * 1988-02-17 1990-05-18 Serono Cesare Ist Ricerca Metodo di rottura alla metionina di polipeptidi contenenti pontidisolfuro
JPH06316557A (ja) * 1993-03-06 1994-11-15 Fuji Kagaku Kogyo Kk アルキルチオ脂肪酸誘導体、製造法及びその肝臓疾患、腎臓疾患、膵臓疾患及び脳疾患用剤

Also Published As

Publication number Publication date
EP0812856A1 (en) 1997-12-17
US6309859B1 (en) 2001-10-30
ATE185146T1 (de) 1999-10-15
GR3032139T3 (en) 2000-04-27
IL121053A0 (en) 1997-11-20
IL121053A (en) 2000-12-06
CA2207723A1 (en) 1997-12-14
KR980002062A (ko) 1998-03-30
DE69700561T2 (de) 2000-05-04
DK0812856T3 (da) 2000-01-03
CN1178798A (zh) 1998-04-15
CA2207723C (en) 2006-12-12
DE69700561D1 (de) 1999-11-04
EP0812856B1 (en) 1999-09-29
KR100478747B1 (ko) 2005-09-08
US6066470A (en) 2000-05-23
CN1158303C (zh) 2004-07-21

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