ATE440868T1 - Monoklonaler antikírper gegen ein prion protein und dessen verwendung zum nachweis von prionen - Google Patents

Monoklonaler antikírper gegen ein prion protein und dessen verwendung zum nachweis von prionen

Info

Publication number
ATE440868T1
ATE440868T1 AT98910699T AT98910699T ATE440868T1 AT E440868 T1 ATE440868 T1 AT E440868T1 AT 98910699 T AT98910699 T AT 98910699T AT 98910699 T AT98910699 T AT 98910699T AT E440868 T1 ATE440868 T1 AT E440868T1
Authority
AT
Austria
Prior art keywords
prion protein
monoclonal antibodies
antibodies against
detecting prions
antibody
Prior art date
Application number
AT98910699T
Other languages
English (en)
Inventor
Carsten Korth
Beat Stierli
Peter Streit
Bruno Oesch
Markus Moser
Original Assignee
Universitaet Zurich
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Universitaet Zurich filed Critical Universitaet Zurich
Application granted granted Critical
Publication of ATE440868T1 publication Critical patent/ATE440868T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2872—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against prion molecules, e.g. CD230
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Immunology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
AT98910699T 1997-02-21 1998-02-18 Monoklonaler antikírper gegen ein prion protein und dessen verwendung zum nachweis von prionen ATE440868T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP97102837A EP0861900A1 (de) 1997-02-21 1997-02-21 Immunologischer Nachweis von Prionen
PCT/EP1998/000917 WO1998037210A1 (en) 1997-02-21 1998-02-18 Immunological detection of prions

Publications (1)

Publication Number Publication Date
ATE440868T1 true ATE440868T1 (de) 2009-09-15

Family

ID=8226511

Family Applications (1)

Application Number Title Priority Date Filing Date
AT98910699T ATE440868T1 (de) 1997-02-21 1998-02-18 Monoklonaler antikírper gegen ein prion protein und dessen verwendung zum nachweis von prionen

Country Status (8)

Country Link
US (2) US6765088B1 (de)
EP (3) EP0861900A1 (de)
AT (1) ATE440868T1 (de)
AU (1) AU742838B2 (de)
CA (1) CA2280791C (de)
DE (1) DE69841102D1 (de)
NZ (1) NZ336656A (de)
WO (1) WO1998037210A1 (de)

Families Citing this family (85)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5891641A (en) * 1997-02-21 1999-04-06 The Regents Of The University Of California Assay for disease related conformation of a protein
US6617119B2 (en) 1997-02-21 2003-09-09 The Regents Of The University Of California Assay for specific strains of multiple disease related conformations of a protein
US6221614B1 (en) 1997-02-21 2001-04-24 The Regents Of The University Of California Removal of prions from blood, plasma and other liquids
US6620629B1 (en) 1997-02-21 2003-09-16 The Regents Of The University Of California Method for detecting prions
DE19741607A1 (de) * 1997-09-20 1999-03-25 Prionics Ag Synthetische Polypeptide zur Diagnose und Therapie von Prionerkrankungen
US6214565B1 (en) 1998-10-09 2001-04-10 The Regents Of The University Of California Assay for disease related conformation of a protein and isolating same
GB2371049B (en) * 1998-11-04 2003-06-04 Imp College Innovations Ltd Methods of making antibodies against ß-forms of prion proteins and their uses
GB2362385B (en) * 1998-11-04 2002-06-19 Imp College Innovations Ltd Non-aggregated ß-forms of prion proteins
GB2348203B (en) 1998-11-04 2002-06-19 Imp College Innovations Ltd Solube beta-forms of prion proteins, methods of preparation and use
FI982481A0 (fi) * 1998-11-17 1998-11-17 Wallac Oy Immunomääritys nautaeläinten tarttuvan spongiomuotoisen aivotaudin määrittämiseksi
FI982480A0 (fi) * 1998-11-17 1998-11-17 Wallac Oy Immunomääritys nisäkkäiden tarttuvan spongiomuotoisen aivotaudin määrittämiseksi
CA2361013A1 (en) 1999-01-25 2000-07-27 Minerva Biotechnologies Corporation Rapid and sensitive detection of aberrant protein aggregation in neurodegenerative diseases
GB2346971B (en) * 1999-02-19 2004-07-21 Audrey Ann Coop Blood test for infectious prion protein using antibodies raised to eye lens crystallin proteins
DE19918141A1 (de) * 1999-04-21 2000-10-26 Boehringer Ingelheim Vetmed Verfahren zur Diagnose von übertragbaren Spongiformen Enzephalopathien
MXPA01013186A (es) * 1999-06-23 2002-08-12 Caprion Pharmaceuticals Inc Peptidos de la proteina prion y sus usos.
US7041807B1 (en) 1999-06-23 2006-05-09 Caprion Pharmaceuticals, Inc. Antibodies to a YYX epitope of a mammalian prion protein
CA2379237A1 (en) * 1999-07-27 2001-02-01 Imperial College Innovations Limited Fragments of cellular prion protein and methods useful in the diagnosis and treatment of prion diseases
CA2385743A1 (en) * 1999-09-28 2001-04-05 Universitat Zurich Factors having prion-binding activity in serum and plasma and agents to detect transmissible spongiform encephalopathitis
FR2801106B1 (fr) 1999-11-12 2007-10-05 Commissariat Energie Atomique Procede de diagnostic d'une esst provoquee par une souche d'atnc dans un echantillon biologique et son utilisation dans le diagnostic differentiel des differentes souches d'atnc
JP2003517313A (ja) 1999-12-15 2003-05-27 ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア コンフォメーションおよびトポロジータンパク質の調節
GB2360089A (en) * 2000-03-10 2001-09-12 Univ Geneve Diagnostic assay for transmisible spongiform encephalopathies
ATE368858T1 (de) 2000-03-10 2007-08-15 Univ Geneve Verfahren zur diagnose von transmissiblen spongiformen encephalopathien
FR2808278A1 (fr) * 2000-04-28 2001-11-02 Inst Nat Sante Rech Med Proteines a prions et leurs utilisations
DK1158003T4 (da) * 2000-05-23 2013-04-08 Blood Transfusion Ct Of Slovenia Antistoffer, som er i stand til selektivt at detektere prion PrP Sc-isoformer
US7098317B1 (en) * 2000-05-23 2006-08-29 Blood Transfusion Center Of Slovenia Antibodies capable to selectively detect prion PrPSc isoforms
IL141950A0 (en) * 2000-10-22 2002-03-10 Hadasit Med Res Service Diagnosis of prion diseases
NZ515982A (en) * 2000-12-08 2003-09-26 Fujirebio Kk Method and monoclonal antibodies for differentiation between abnormal and normal prions
US7303907B2 (en) 2001-01-08 2007-12-04 Health Protection Agency Degradation and detection of TSE infectivity
IES20010042A2 (en) * 2001-01-19 2002-12-11 Enfer Technology Ltd Test for transmissible spongiform encephalopathies
US20020137114A1 (en) * 2001-01-19 2002-09-26 Dirk Voelkel Method of detecting PrP protein and kits therefor
DE10104480A1 (de) * 2001-01-31 2002-08-14 November Ag Molekulare Medizin Verfahren, Verwendung und Kit zum Auffinden von Wirkstoffen gegen mit spezifischen Proteinen assoziierte Krankheiten
DE10106835A1 (de) * 2001-02-14 2002-09-05 Basf Lynx Bioscience Ag Signaltransduktionsproteine 15B3, 15B3-1 und 15B3-2 und zugrundeliegende DNA-Sequenzen
DE10120562C2 (de) * 2001-04-26 2003-04-10 Horst Messer Verfahren zur Diagnose von übertragbaren spongiformen Enzephalopathien
ES2279869T3 (es) * 2001-06-20 2007-09-01 Ramot At Tel Aviv University Ltd. Peptido antigenico comprendido por mulitples copias de un epitope de un polipeptido implicado en enfermedades de formacion de placas y los procedimientos de uso correspondientes.
DE10143647A1 (de) * 2001-09-05 2003-03-27 Prionics Ag Zuerich DNA-Sequenzen codierend für variable Bereiche von Antikörpern, die an das Prion-Protein (PrP) binden sowie PrP-bindende Polypeptide
US20040241877A1 (en) * 2001-09-25 2004-12-02 Paul Price Test strips for the detection of prion proteins
US20030092090A1 (en) * 2001-11-14 2003-05-15 Kiamars Hajizadeh Rapid prion-detection device, system, and test kit
US7045297B2 (en) * 2001-11-14 2006-05-16 Prion Developmental Laboratories, Inc. Rapid prion-detection assay
US20030092199A1 (en) * 2001-11-14 2003-05-15 Kiamars Hajizadeh Prion-detection business methods
EP1312617A1 (de) 2001-11-14 2003-05-21 ATOFINA Research Schlagzähes Polypropen
WO2004003505A2 (en) * 2002-06-27 2004-01-08 University Of Marlyland, Baltimore Methods for detecting and inactivating a prion
EP1382971A1 (de) * 2002-07-17 2004-01-21 Pepscan Systems B.V. Nachweis von Prion Erkrankung
US20040072236A1 (en) 2002-09-27 2004-04-15 Neil Cashman PrPSc -interacting molecules and uses thereof
WO2004046728A1 (en) * 2002-11-18 2004-06-03 Prionics Ag Method for the detection of prpsc
GB0227886D0 (en) * 2002-11-29 2003-01-08 Medical Res Council Prion inhibition
AU2003266801B2 (en) * 2002-12-19 2010-02-25 Ortho-Clinical Diagnostics, Inc Detection and diagnosis of transmissable spongiform encephalopathies
US7399603B2 (en) 2002-12-19 2008-07-15 Ortho-Clinical Diagnostics, Inc. Antibodies for discrimination of prions
FR2849204B1 (fr) * 2002-12-20 2005-02-11 Afssa Procede de detection de la prpsc utilisant un antibiotique d de la famille des aminoglycosides pour l'elimination et la detection de la prpsc dans des echantillons biologiques
EP1445615A1 (de) * 2003-02-10 2004-08-11 Ortho-Clinical Diagnostics, Inc. Methode zur unterscheidung zwischen infektiösen und nicht-infektiösen prionen
EP1457500A1 (de) * 2003-03-14 2004-09-15 University of Zurich Lösliche Prionen-Hybrid-Proteine und deren Verwendung zur Diagnose, Behandlung und Prevention von transmissibler spongiformer Encephalopathie
US20060035242A1 (en) * 2004-08-13 2006-02-16 Michelitsch Melissa D Prion-specific peptide reagents
NZ580256A (en) 2003-08-13 2011-07-29 Novartis Vaccines & Diagnostic Prion-specific peptide reagents comprising the sequence KKRPKPGG
EP1668369B1 (de) * 2003-08-20 2016-01-06 ProMIS Neurosciences Inc. Epitopschutztest und verfahren zum nachweis von proteinkonformationen
US20060199194A1 (en) * 2003-11-10 2006-09-07 Q-Rna, Inc. Methods of detection using immuno-Q-Amp technology
US20050214805A1 (en) * 2003-11-10 2005-09-29 Q-Rna, Inc. Methods of detection employing immuno-Q-Amp technology
EP1596199A1 (de) * 2004-05-14 2005-11-16 Prionics AG Verfahren zum Nachweis von pathogenen Prionenproteinen.
AU2005209592B2 (en) 2004-09-30 2012-07-12 Ortho-Clinical Diagnostics, Inc. Peptides for discrimination of prions
WO2006076683A2 (en) * 2005-01-13 2006-07-20 Novartis Vaccines And Diagnostics Inc. Isolation and detection of pathogenic prions
US20090099343A1 (en) * 2005-01-13 2009-04-16 David Peretz Isolation of pathogenic prions
JP5162250B2 (ja) * 2005-01-13 2013-03-13 ノバルティス バクシンズ アンド ダイアグノスティックス，インコーポレーテッド プリオン特異的ペプチド試薬を使用するｅｌｉｓａアッセイ
GB0501564D0 (en) * 2005-01-25 2005-03-02 Univ Cambridge Tech Test for prion disease
WO2006102099A2 (en) * 2005-03-18 2006-09-28 The Regents Of The University Of California ANTIBODIES SPECIFIC FOR HUMAN AND BOVINE PrP
RU2281510C1 (ru) * 2005-03-23 2006-08-10 Общество С Ограниченной Ответственностью "Биохарт" АНТИТЕЛА, СПЕЦИФИЧЕСКИ РЕАГИРУЮЩИЕ С ПРИОННЫМ ПРОТЕИНОМ PrP ИЛИ ЕГО ФРАГМЕНТОМ, И ИХ ПРИМЕНЕНИЕ
US20070015211A1 (en) * 2005-06-22 2007-01-18 Prosetta Corporation Conformer-specific antibodies and method of use, thereof
EP1931695B1 (de) 2005-09-09 2013-04-10 Novartis AG Prionspezifische Peptoidreagentien
US7794692B2 (en) * 2005-12-02 2010-09-14 Amorfix Life Sciences Ltd. Methods and compositions for detecting amyotrophic lateral sclerosis
US7887803B2 (en) 2005-12-02 2011-02-15 Amorfix Life Sciences Methods and compositions to treat misfolded-SOD1 mediated diseases
DK2514823T3 (en) 2006-03-03 2018-07-23 Promis Neurosciences Inc Methods and compositions for treating and detecting failed SOD1-mediated diseases
JP5164971B2 (ja) * 2006-04-21 2013-03-21 ピープルバイオ，アイ エヌ シー 三次元的相互作用を用いてマルチマー形成ポリペプチドのモノマーからマルチマーを分別検出する方法
US8492097B2 (en) 2006-04-24 2013-07-23 Diagnostic Hybrids, Inc. Compositions and methods for human metapneumovirus monoclonal antibodies
WO2008029965A1 (en) * 2006-09-08 2008-03-13 Peoplebio, Inc. Simultaneous reaction assay for differentially detecting multimeric form
US8013122B2 (en) 2006-12-20 2011-09-06 Kieu Hoang Method of purifying apolipoprotein A-1
BRPI0910550A2 (pt) * 2008-04-30 2015-09-29 Novartis Ag ensaio para confôrmeros patogênicos
TWI560197B (en) * 2009-05-05 2016-12-01 Amgen Inc Fgf21 mutants and uses thereof
JP5868955B2 (ja) 2010-04-30 2016-02-24 プロセッタ アンチバイラル インコーポレイテッド 抗ウイルス化合物
US8759336B2 (en) 2011-03-17 2014-06-24 Prosetta Antiviral Inc. Antiviral compounds
EP2699241B1 (de) 2011-04-20 2016-07-27 Prosetta Antiviral Inc. Antivirale verbindungen
US20120301904A1 (en) 2011-04-26 2012-11-29 Prosetta Antiviral, Inc Multiprotein assemblies
CN103044546B (zh) * 2011-11-24 2015-09-30 上海转基因研究中心 一种朊蛋白抗体及其制备方法和应用
CN102565410B (zh) * 2012-01-12 2014-08-06 吉林大学 一种梅花鹿朊蛋白免疫学检测方法
CN102558349B (zh) * 2012-01-12 2013-12-11 吉林大学 一种识别天然结构梅花鹿朊蛋白的单克隆抗体及制备方法
US9226038B2 (en) 2012-11-12 2015-12-29 Roger B. and Ann K. McNamee Trust U/T/A/D Systems and methods for communicating a live event to users using the internet
FR2998373B1 (fr) 2012-11-20 2015-01-09 Franklab Sas Procede de mesure de l'aptitude d'une formulation a inactiver un atnc.
WO2016149537A1 (en) 2015-03-17 2016-09-22 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Bank vole prion protein as a broad-spectrum substrate for rt-quic-based detection and discrimination of prion strains
JP6716799B1 (ja) * 2020-02-07 2020-07-01 三菱日立パワーシステムズ株式会社 温度計保護筒、温度計測器具及び蒸気配管構造物並びに温度計保護筒の設置方法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ246059A (en) * 1991-12-03 1995-08-28 Proteus Molecular Design Synthetic polypeptides with at least one antigenic site of a prion protein, methods of their use and manufacture, antibodies thereto, compositions and kits
AU4376093A (en) * 1992-05-15 1993-12-13 Instituto Nazionale Neurologico C. Besta Soluble prion polypeptides, and methods for detecting and purifying thereof
EP1416280A3 (de) * 1995-09-14 2005-08-10 The Regents of the University of California Antikörper spezifisch für natives PrPsc

Also Published As

Publication number Publication date
EP0861900A1 (de) 1998-09-02
EP2172486A2 (de) 2010-04-07
EP2172486A3 (de) 2012-02-29
EP1007700B1 (de) 2009-08-26
US20060025575A1 (en) 2006-02-02
US7259246B2 (en) 2007-08-21
EP2172486B1 (de) 2014-11-05
NZ336656A (en) 2002-05-31
AU742838B2 (en) 2002-01-10
AU6498698A (en) 1998-09-09
DE69841102D1 (de) 2009-10-08
EP1007700A1 (de) 2000-06-14
US6765088B1 (en) 2004-07-20
CA2280791C (en) 2011-06-21
WO1998037210A1 (en) 1998-08-27
CA2280791A1 (en) 1998-08-27

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