ATE441434T1 - Nichtkovalente biokonjugate für diagnose und therapie - Google Patents

Nichtkovalente biokonjugate für diagnose und therapie

Info

Publication number
ATE441434T1
ATE441434T1 AT99915152T AT99915152T ATE441434T1 AT E441434 T1 ATE441434 T1 AT E441434T1 AT 99915152 T AT99915152 T AT 99915152T AT 99915152 T AT99915152 T AT 99915152T AT E441434 T1 ATE441434 T1 AT E441434T1
Authority
AT
Austria
Prior art keywords
bioconjugates
hapten
carrier
molecule
covalent
Prior art date
Application number
AT99915152T
Other languages
English (en)
Inventor
Raghavan Rajagopalan
Joseph Bugaj
Richard Dorshow
Samuel Achilefu
Original Assignee
Mallinckrodt Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Mallinckrodt Inc filed Critical Mallinckrodt Inc
Application granted granted Critical
Publication of ATE441434T1 publication Critical patent/ATE441434T1/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/001—Preparation for luminescence or biological staining
    • A61K49/0013—Luminescence
    • A61K49/0017—Fluorescence in vivo
    • A61K49/0019—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules
    • A61K49/0021—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules the fluorescent group being a small organic molecule
    • A61K49/0032—Methine dyes, e.g. cyanine dyes
    • A61K49/0034—Indocyanine green, i.e. ICG, cardiogreen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
    • A61K41/0057—Photodynamic therapy with a photosensitizer, i.e. agent able to produce reactive oxygen species upon exposure to light or radiation, e.g. UV or visible light; photocleavage of nucleic acids with an agent
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/001—Preparation for luminescence or biological staining
    • A61K49/0013—Luminescence
    • A61K49/0017—Fluorescence in vivo
    • A61K49/0019—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules
    • A61K49/0021—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules the fluorescent group being a small organic molecule
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/001—Preparation for luminescence or biological staining
    • A61K49/0013—Luminescence
    • A61K49/0017—Fluorescence in vivo
    • A61K49/0019—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules
    • A61K49/0021—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules the fluorescent group being a small organic molecule
    • A61K49/0032—Methine dyes, e.g. cyanine dyes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/001—Preparation for luminescence or biological staining
    • A61K49/0013—Luminescence
    • A61K49/0017—Fluorescence in vivo
    • A61K49/005—Fluorescence in vivo characterised by the carrier molecule carrying the fluorescent agent
    • A61K49/0052—Small organic molecules
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/001—Preparation for luminescence or biological staining
    • A61K49/0013—Luminescence
    • A61K49/0017—Fluorescence in vivo
    • A61K49/005—Fluorescence in vivo characterised by the carrier molecule carrying the fluorescent agent
    • A61K49/0054—Macromolecular compounds, i.e. oligomers, polymers, dendrimers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/001—Preparation for luminescence or biological staining
    • A61K49/0013—Luminescence
    • A61K49/0017—Fluorescence in vivo
    • A61K49/005—Fluorescence in vivo characterised by the carrier molecule carrying the fluorescent agent
    • A61K49/0056—Peptides, proteins, polyamino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicinal Preparation (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
AT99915152T 1998-04-03 1999-03-31 Nichtkovalente biokonjugate für diagnose und therapie ATE441434T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US8065898P 1998-04-03 1998-04-03
PCT/US1999/007061 WO1999051284A2 (en) 1998-04-03 1999-03-31 Non-covalent bioconjugates useful for diagnosis and therapy

Publications (1)

Publication Number Publication Date
ATE441434T1 true ATE441434T1 (de) 2009-09-15

Family

ID=22158792

Family Applications (1)

Application Number Title Priority Date Filing Date
AT99915152T ATE441434T1 (de) 1998-04-03 1999-03-31 Nichtkovalente biokonjugate für diagnose und therapie

Country Status (9)

Country Link
US (1) US6423547B1 (de)
EP (3) EP2108378A3 (de)
JP (1) JP4560209B2 (de)
AT (1) ATE441434T1 (de)
AU (1) AU766290B2 (de)
CA (1) CA2326650A1 (de)
DE (1) DE69941371D1 (de)
ES (1) ES2331671T3 (de)
WO (1) WO1999051284A2 (de)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6228344B1 (en) * 1997-03-13 2001-05-08 Mallinckrodt Inc. Method of measuring physiological function
CA2326650A1 (en) * 1998-04-03 1999-10-14 Mallinckrodt Inc. Azo and diaza dericatives and uses thereof in phototherapy
US6844425B1 (en) 1999-02-24 2005-01-18 Mallinckrodt Inc. Combination of intercalating organometallic complexes and tumor seeking biomolecules for DNA cleavage and radiotherapy
US6217848B1 (en) * 1999-05-20 2001-04-17 Mallinckrodt Inc. Cyanine and indocyanine dye bioconjugates for biomedical applications
CA2322344A1 (en) * 1999-12-08 2001-06-08 Mallinckrodt Inc. Non-covalent bioconjugates useful for magnetic resonance imaging
US20080233050A1 (en) * 2000-01-18 2008-09-25 Mallinckrodt Inc. Diagnostic and therapeutic optical agents
US7790144B2 (en) * 2000-01-18 2010-09-07 Mallinckrodt Inc. Receptor-avid exogenous optical contrast and therapeutic agents
US6180085B1 (en) * 2000-01-18 2001-01-30 Mallinckrodt Inc. Dyes
WO2001085212A2 (en) * 2000-05-08 2001-11-15 The University Of British Columbia Drug delivery systems for photodynamic therapy
US6617136B2 (en) 2001-04-24 2003-09-09 3M Innovative Properties Company Biological sample processing methods and compositions that include surfactants
EP1293248B1 (de) * 2001-09-17 2008-04-09 Central P BV Neue dispergierbare kolloidale Calixarene-Systeme in Form von Nanoteilchen
US7226577B2 (en) 2003-01-13 2007-06-05 Bracco Imaging, S. P. A. Gastrin releasing peptide compounds
DE10324710A1 (de) * 2003-05-30 2004-12-16 Supramol Parenteral Colloids Gmbh Stärkederivatkomplexe
US20060207881A1 (en) * 2005-02-01 2006-09-21 Sigma-Aldrich Co. Detection of polyamino acids using trimethincyanine dyes
WO2008076467A2 (en) * 2006-07-03 2008-06-26 Beth Israel Deaconess Medical Center, Inc. Intraoperative imaging methods
DE102007007738A1 (de) * 2007-02-09 2008-08-14 Südzucker AG Mannheim/Ochsenfurt Farbmarkierte Oligo- oder Polysaccharide
WO2010129258A2 (en) 2009-04-27 2010-11-11 Mallinckrodt Inc. Tissue sealant compositions, vascular closure devices, and uses thereof
US8343463B2 (en) * 2009-07-31 2013-01-01 Numira Biosciences Inc. Optical imaging agent
KR101117209B1 (ko) 2009-10-12 2012-03-19 경북대학교 산학협력단 벤조티아졸계 세미스쿠아릴리움 염료 및 이를 이용한 수은 금속 이온 검출방법
HUE041616T2 (hu) 2010-01-28 2019-05-28 National Univ Corporation Mie Univ Indocianin vegyület, szintézisének eljárása, tisztítási eljárása, indocianin vegyületet alkalmazó diagnosztikai készítmény, és készülék in vivo kinetika mérésére és készülék keringés megjelenítésére a diagnosztikai készítmény alkalmazásával
JP5817073B2 (ja) * 2010-01-28 2015-11-18 国立大学法人三重大学 新規インドシアニン化合物を用いた診断用組成物及び分析方法
AU2012305327B2 (en) * 2011-09-05 2016-07-14 Hiroshi Maeda Polymer-type fluorescent molecule probe
CN104491863A (zh) * 2014-11-20 2015-04-08 浙江大学 基于聚谷氨酸与四氯四碘荧光素键合物的抗肿瘤药物及其制备方法和应用
CN113307863B (zh) * 2021-05-25 2022-12-16 华南农业大学 一种聚天冬氨酸及其盐类抗体的制备方法和应用

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2155935B (en) * 1984-02-16 1988-10-12 Antibioticos Sa Novel e. coli hybrid plasmid vector conferring sucrose fermenting capacity
US4806488A (en) * 1985-09-06 1989-02-21 Syntex (U.S.A.) Inc. Ligand-receptor assays employing squarate dye compositions
US5110794A (en) * 1987-01-30 1992-05-05 Abbott Laboratories Method of immunization with partially cationized substances and said partially cationized substances
DE3828360A1 (de) * 1988-08-20 1990-02-22 Stanowsky Alexander Dr Farbstoff-markierter antitumor-antikoerper und verfahren zu seiner herstellung
ES2163393T3 (es) * 1990-05-15 2002-02-01 Hyperion Inc Porfirina fluorescente y ftalocianina fluorescente - derivados de polietilenglicol, poliol y sacaridos como sondas fluorescentes.
DE4445065A1 (de) * 1994-12-07 1996-06-13 Diagnostikforschung Inst Verfahren zur In-vivo-Diagnostik mittels NIR-Strahlung
CA2326650A1 (en) * 1998-04-03 1999-10-14 Mallinckrodt Inc. Azo and diaza dericatives and uses thereof in phototherapy

Also Published As

Publication number Publication date
ES2331671T3 (es) 2010-01-12
WO1999051284A2 (en) 1999-10-14
EP2283872A2 (de) 2011-02-16
EP1189645A4 (de) 2004-10-13
AU766290B2 (en) 2003-10-16
CA2326650A1 (en) 1999-10-14
EP2283872A3 (de) 2011-02-23
EP1189645A2 (de) 2002-03-27
DE69941371D1 (de) 2009-10-15
EP2108378A3 (de) 2010-10-27
AU3373899A (en) 1999-10-25
EP1189645B1 (de) 2009-09-02
EP2108378A2 (de) 2009-10-14
JP4560209B2 (ja) 2010-10-13
JP2002531377A (ja) 2002-09-24
WO1999051284A3 (en) 2002-01-17
US6423547B1 (en) 2002-07-23

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