ATE441722T1 - Enzymatische umwandlung eines prostaglandin (bimatoprost)-zwischenproduktes - Google Patents

Enzymatische umwandlung eines prostaglandin (bimatoprost)-zwischenproduktes

Info

Publication number: ATE441722T1
Authority: AT; Austria
Prior art keywords: bimatoprost; prostaglandin; enzymatic conversion; enzymatic; conversion
Prior art date: 2005-03-04

Application number

AT06737313T

Other languages

English (en)

Inventor

Reinhard Effenberger

Ayelet Fishman

Original Assignee

Teva Pharma

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2005-03-04

Filing date

2006-03-06

Publication date

2009-09-15

2006-03-06 Application filed by Teva Pharma filed Critical Teva Pharma

2009-09-15 Application granted granted Critical

2009-09-15 Publication of ATE441722T1 publication Critical patent/ATE441722T1/de

Links

AQOKCDNYWBIDND-FTOWTWDKSA-N bimatoprost Chemical compound CCNC(=O)CCC\C=C/C[C@H]1[C@@H](O)C[C@@H](O)[C@@H]1\C=C\[C@@H](O)CCC1=CC=CC=C1 AQOKCDNYWBIDND-FTOWTWDKSA-N 0.000 title abstract 2
229960002470 bimatoprost Drugs 0.000 title abstract 2
230000002255 enzymatic effect Effects 0.000 title abstract 2
238000006243 chemical reaction Methods 0.000 title 1
150000003180 prostaglandins Chemical class 0.000 title 1
230000021736 acetylation Effects 0.000 abstract 1
238000006640 acetylation reaction Methods 0.000 abstract 1
238000000034 method Methods 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P31/00—Preparation of compounds containing a five-membered ring having two side-chains in ortho position to each other, and having at least one oxygen atom directly bound to the ring in ortho position to one of the side-chains, one side-chain containing, not directly bound to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having at least one oxygen atom bound in gamma-position to the ring, e.g. prostaglandins
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P41/00—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture
- C12P41/003—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture by ester formation, lactone formation or the inverse reactions
- C12P41/004—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture by ester formation, lactone formation or the inverse reactions by esterification of alcohol- or thiol groups in the enantiomers or the inverse reaction

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Engineering & Computer Science (AREA)
Life Sciences & Earth Sciences (AREA)
Zoology (AREA)
Wood Science & Technology (AREA)
Health & Medical Sciences (AREA)
General Engineering & Computer Science (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Biotechnology (AREA)
Biochemistry (AREA)
Bioinformatics & Cheminformatics (AREA)
Microbiology (AREA)
General Health & Medical Sciences (AREA)
Genetics & Genomics (AREA)
Analytical Chemistry (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Enzymes And Modification Thereof (AREA)
Furan Compounds (AREA)

AT06737313T 2005-03-04 2006-03-06 Enzymatische umwandlung eines prostaglandin (bimatoprost)-zwischenproduktes ATE441722T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US65900905P	2005-03-04	2005-03-04
PCT/US2006/008129 WO2006094294A2 (en)	2005-03-04	2006-03-06	Enzymatic transformation of a prostaglandin (bimatoprost) intermediate

Publications (1)

Publication Number	Publication Date
ATE441722T1 true ATE441722T1 (de)	2009-09-15

Family

ID=36659921

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT06737313T ATE441722T1 (de)	2005-03-04	2006-03-06	Enzymatische umwandlung eines prostaglandin (bimatoprost)-zwischenproduktes

Country Status (10)

Country	Link
US (1)	US7611886B2 (de)
EP (1)	EP1853719B1 (de)
JP (1)	JP2007537733A (de)
CN (1)	CN101198704A (de)
AT (1)	ATE441722T1 (de)
CA (1)	CA2600436A1 (de)
DE (1)	DE602006008895D1 (de)
ES (1)	ES2331205T3 (de)
IL (1)	IL184041A0 (de)
WO (1)	WO2006094294A2 (de)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP2135860A1 (de)	2008-06-20	2009-12-23	Sandoz AG	Verbesserter Herstellungsverfahren für Bimatoprost
EP2143712A1 (de)	2008-07-10	2010-01-13	Sandoz AG	Verbessertes Verfahren zur Herstellung von Prostaglandinen und Prostaglandin-Analogen
RU2652063C2 (ru)	2012-10-26	2018-04-24	Форсайт Вижн5, Инк.	Офтальмологическая система для замедленного высвобождения лекарственного средства в глазу
US20160296532A1 (en)	2015-04-13	2016-10-13	Forsight Vision5, Inc.	Ocular Insert Composition of a Semi-Crystalline or Crystalline Pharmaceutically Active Agent
CN112481313B (zh) *	2020-11-23	2022-08-12	江苏阿尔法药业股份有限公司	一种贝美前列素中间体的酶催化合成方法
CN114921507B (zh) *	2022-05-30	2024-01-30	南京工业大学	前列腺素手性中间体2-氧杂双环-[3.3.0]辛-6-烯-3-酮的拆分方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3969396A (en) *	1972-09-15	1976-07-13	The Upjohn Company	8β, 11β, 12α-PGE2 compounds
LU87593A1 (de)	1989-09-25	1991-05-07	Europ Communities	Enantioselektive enzymatische synthese von s(-)-und r(+)-estern des 4-hydroxy-cyclopenten-1-ons und seines 2',2'-dimethylpropan-1',3'-diol-ketals
JP3097145B2 (ja)	1991-02-27	2000-10-10	日産化学工業株式会社	コーリーラクトンジオールの光学分割方法
IL134241A (en) *	2000-01-27	2006-06-11	Finetech Pharmaceutical Ltd	Process for the preparation of latanoprost

2006
- 2006-03-06 CA CA002600436A patent/CA2600436A1/en not_active Abandoned
- 2006-03-06 ES ES06737313T patent/ES2331205T3/es not_active Expired - Lifetime
- 2006-03-06 JP JP2007511732A patent/JP2007537733A/ja active Pending
- 2006-03-06 DE DE602006008895T patent/DE602006008895D1/de not_active Expired - Lifetime
- 2006-03-06 CN CNA2006800151293A patent/CN101198704A/zh active Pending
- 2006-03-06 EP EP06737313A patent/EP1853719B1/de not_active Expired - Lifetime
- 2006-03-06 US US11/369,518 patent/US7611886B2/en not_active Expired - Fee Related
- 2006-03-06 WO PCT/US2006/008129 patent/WO2006094294A2/en not_active Ceased
- 2006-03-06 AT AT06737313T patent/ATE441722T1/de not_active IP Right Cessation
2007
- 2007-06-19 IL IL184041A patent/IL184041A0/en unknown

Also Published As

Publication number	Publication date
WO2006094294A3 (en)	2006-11-30
ES2331205T3 (es)	2009-12-23
CA2600436A1 (en)	2006-09-08
US7611886B2 (en)	2009-11-03
DE602006008895D1 (de)	2009-10-15
WO2006094294A2 (en)	2006-09-08
JP2007537733A (ja)	2007-12-27
US20060247453A1 (en)	2006-11-02
IL184041A0 (en)	2007-10-31
CN101198704A (zh)	2008-06-11
EP1853719B1 (de)	2009-09-02
EP1853719A2 (de)	2007-11-14

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Legal Events

Date	Code	Title	Description
2010-03-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties