ATE442347T1 - Biphenylderivate als selektive agonisten des gamma-rar-rezeptors - Google Patents

Biphenylderivate als selektive agonisten des gamma-rar-rezeptors

Info

Publication number
ATE442347T1
ATE442347T1 AT06807841T AT06807841T ATE442347T1 AT E442347 T1 ATE442347 T1 AT E442347T1 AT 06807841 T AT06807841 T AT 06807841T AT 06807841 T AT06807841 T AT 06807841T AT E442347 T1 ATE442347 T1 AT E442347T1
Authority
AT
Austria
Prior art keywords
gamma
selective agonists
treating
biphenyl derivatives
rar receptor
Prior art date
Application number
AT06807841T
Other languages
English (en)
Inventor
Thibaud Biadatti
Etienne Thoreau
Original Assignee
Galderma Res & Dev
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Galderma Res & Dev filed Critical Galderma Res & Dev
Application granted granted Critical
Publication of ATE442347T1 publication Critical patent/ATE442347T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C65/00—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C65/21—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups containing ether groups, groups, groups, or groups
    • C07C65/24—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups containing ether groups, groups, groups, or groups polycyclic
    • C07C65/26—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups containing ether groups, groups, groups, or groups polycyclic containing rings other than six-membered aromatic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/10—Anti-acne agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
    • C07C51/09—Preparation of carboxylic acids or their salts, halides or anhydrides from carboxylic acid esters or lactones

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Dermatology (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Glass Compositions (AREA)
  • Materials For Medical Uses (AREA)
  • Sorting Of Articles (AREA)
AT06807841T 2005-12-15 2006-11-28 Biphenylderivate als selektive agonisten des gamma-rar-rezeptors ATE442347T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR0512760A FR2894959B1 (fr) 2005-12-15 2005-12-15 Derives biphenyliques agonistes selectifs du recepteur rar-gamma
PCT/EP2006/068976 WO2007068580A1 (fr) 2005-12-15 2006-11-28 Derives biphenyliques agonistes selectifs du recepteur rar-gamma

Publications (1)

Publication Number Publication Date
ATE442347T1 true ATE442347T1 (de) 2009-09-15

Family

ID=36954941

Family Applications (1)

Application Number Title Priority Date Filing Date
AT06807841T ATE442347T1 (de) 2005-12-15 2006-11-28 Biphenylderivate als selektive agonisten des gamma-rar-rezeptors

Country Status (9)

Country Link
US (2) US8049034B2 (de)
EP (1) EP1963250B1 (de)
AT (1) ATE442347T1 (de)
BR (1) BRPI0620660A2 (de)
CA (1) CA2632910C (de)
DE (1) DE602006009142D1 (de)
ES (1) ES2331431T3 (de)
FR (1) FR2894959B1 (de)
WO (1) WO2007068580A1 (de)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE414689T1 (de) * 2003-12-08 2008-12-15 Galderma Res & Dev Biphenylderivate, die sich als rar-rezeptor- aktivierende liganden eignen, verfahren zu deren herstellung und deren verwendung in der humanmedizin und in kosmetika
FR2894959B1 (fr) * 2005-12-15 2008-02-29 Galderma Res & Dev Derives biphenyliques agonistes selectifs du recepteur rar-gamma
US20090162359A1 (en) 2007-12-21 2009-06-25 Christian Klein Bivalent, bispecific antibodies
US9266967B2 (en) 2007-12-21 2016-02-23 Hoffmann-La Roche, Inc. Bivalent, bispecific antibodies
CA2756244A1 (en) * 2009-04-02 2010-10-07 Roche Glycart Ag Multispecific antibodies comprising full length antibodies and single chain fab fragments
SG175077A1 (en) 2009-04-07 2011-11-28 Roche Glycart Ag Trivalent, bispecific antibodies
US9676845B2 (en) 2009-06-16 2017-06-13 Hoffmann-La Roche, Inc. Bispecific antigen binding proteins
US8703132B2 (en) 2009-06-18 2014-04-22 Hoffmann-La Roche, Inc. Bispecific, tetravalent antigen binding proteins
EP2478013B1 (de) 2009-09-16 2018-10-24 F.Hoffmann-La Roche Ag Coiled-coil- und/oder tether-haltige proteinkomplexe und verwendungen davon
TW201138821A (en) 2010-03-26 2011-11-16 Roche Glycart Ag Bispecific antibodies
CN103068846B9 (zh) 2010-08-24 2016-09-28 弗·哈夫曼-拉罗切有限公司 包含二硫键稳定性Fv片段的双特异性抗体
EP3721880B1 (de) 2010-09-01 2022-02-02 Thomas Jefferson University Zusammensetzungen und verfahren zur muskelreparatur und -regeneration
KR101758152B1 (ko) * 2010-10-22 2017-07-14 삼성전자주식회사 무선 접속 시스템에서 망 장애 처리 장치 및 방법
SG191153A1 (en) 2010-12-23 2013-07-31 Hoffmann La Roche Polypeptide-polynucleotide-complex and its use in targeted effector moiety delivery
MX342034B (es) 2011-02-28 2016-09-12 Hoffmann La Roche Proteinas monovalentes que se unen a antigenos.
AR085404A1 (es) 2011-02-28 2013-09-25 Hoffmann La Roche Proteinas de union a antigeno
US8772273B2 (en) * 2011-10-04 2014-07-08 Quretino Therapeutics, Inc. Formulations and uses of retinoic acid receptor selective agonists
CA2861124A1 (en) 2012-02-10 2013-08-15 Genentech, Inc. Single-chain antibodies and other heteromultimers
RU2639287C2 (ru) 2012-06-27 2017-12-20 Ф. Хоффманн-Ля Рош Аг Способ отбора и получения высокоселективных и мультиспецифичных нацеливающих групп с заданными свойствами, включающих по меньшей мере две различные связывающие группировки, и их применения
KR20150030744A (ko) 2012-06-27 2015-03-20 에프. 호프만-라 로슈 아게 표적에 특이적으로 결합하는 하나 이상의 결합 단위를 포함하는 항체 Ｆｃ－영역 접합체의 제조 방법 및 그의 용도
BR112016006929A2 (pt) 2013-10-11 2017-09-19 Hoffmann La Roche Anticorpo, ácido nucleico, vetor de expressão, célula hospedeira, métodos de preparação de anticorpo, de tratamento de pacientes e de geração de um anticorpo, composição farmacêutica e uso do anticorpo
EP3227332B1 (de) 2014-12-03 2019-11-06 F.Hoffmann-La Roche Ag Multispezifische antikörper
TW201906816A (zh) 2017-07-06 2019-02-16 大陸商江蘇恆瑞醫藥股份有限公司 吲哚甲醯胺類衍生物、其製備方法及其在醫藥上的應用
EP3683206A4 (de) 2017-09-12 2021-01-13 Jiangsu Hengrui Medicine Co., Ltd. Deuteriumatom-substituiertes indolformamidderivat, herstellungsverfahren dafür und medizinische anwendungen davon
US11135236B2 (en) 2018-04-10 2021-10-05 Northwestern University Retinoic acid receptor gamma agonists to attenuate anthracycline-induced cardiotoxicity
US20240217992A1 (en) * 2021-04-27 2024-07-04 Jiangxi Kerui Pharmaceutical Co., Ltd. Retinoic acid receptor agonist, preparation method therefor, intermediate, pharmaceutical composition and use
CN120289357A (zh) * 2024-01-09 2025-07-11 江西科睿药业有限公司 联苯类化合物、其制备方法、中间体、药物组合物和应用

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2767525B1 (fr) * 1997-08-21 1999-11-12 Cird Galderma Derives biphenyliques substitues par un radical aromatique ou heteroaromatique et compositions pharmaceutiques et cosmetiques les contenant
ATE414689T1 (de) * 2003-12-08 2008-12-15 Galderma Res & Dev Biphenylderivate, die sich als rar-rezeptor- aktivierende liganden eignen, verfahren zu deren herstellung und deren verwendung in der humanmedizin und in kosmetika
FR2894959B1 (fr) * 2005-12-15 2008-02-29 Galderma Res & Dev Derives biphenyliques agonistes selectifs du recepteur rar-gamma

Also Published As

Publication number Publication date
US20090023811A1 (en) 2009-01-22
US20120016031A1 (en) 2012-01-19
BRPI0620660A2 (pt) 2011-11-22
DE602006009142D1 (de) 2009-10-22
FR2894959A1 (fr) 2007-06-22
US8049034B2 (en) 2011-11-01
CA2632910C (fr) 2014-07-22
FR2894959B1 (fr) 2008-02-29
US8362082B2 (en) 2013-01-29
CA2632910A1 (fr) 2007-06-21
EP1963250A1 (de) 2008-09-03
WO2007068580A1 (fr) 2007-06-21
ES2331431T3 (es) 2010-01-04
EP1963250B1 (de) 2009-09-09

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