ATE442347T1 - Biphenylderivate als selektive agonisten des gamma-rar-rezeptors - Google Patents

Biphenylderivate als selektive agonisten des gamma-rar-rezeptors

Info

Publication number
ATE442347T1
ATE442347T1 AT06807841T AT06807841T ATE442347T1 AT E442347 T1 ATE442347 T1 AT E442347T1 AT 06807841 T AT06807841 T AT 06807841T AT 06807841 T AT06807841 T AT 06807841T AT E442347 T1 ATE442347 T1 AT E442347T1
Authority
AT
Austria
Prior art keywords
gamma
selective agonists
treating
biphenyl derivatives
rar receptor
Prior art date
Application number
AT06807841T
Other languages
English (en)
Inventor
Thibaud Biadatti
Etienne Thoreau
Original Assignee
Galderma Res & Dev
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Galderma Res & Dev filed Critical Galderma Res & Dev
Application granted granted Critical
Publication of ATE442347T1 publication Critical patent/ATE442347T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C65/00—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C65/21—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups containing ether groups, groups, groups, or groups
    • C07C65/24—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups containing ether groups, groups, groups, or groups polycyclic
    • C07C65/26—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups containing ether groups, groups, groups, or groups polycyclic containing rings other than six-membered aromatic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/10—Anti-acne agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
    • C07C51/09—Preparation of carboxylic acids or their salts, halides or anhydrides from carboxylic acid esters or lactones

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Dermatology (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Glass Compositions (AREA)
  • Materials For Medical Uses (AREA)
  • Sorting Of Articles (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
AT06807841T 2005-12-15 2006-11-28 Biphenylderivate als selektive agonisten des gamma-rar-rezeptors ATE442347T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR0512760A FR2894959B1 (fr) 2005-12-15 2005-12-15 Derives biphenyliques agonistes selectifs du recepteur rar-gamma
PCT/EP2006/068976 WO2007068580A1 (fr) 2005-12-15 2006-11-28 Derives biphenyliques agonistes selectifs du recepteur rar-gamma

Publications (1)

Publication Number Publication Date
ATE442347T1 true ATE442347T1 (de) 2009-09-15

Family

ID=36954941

Family Applications (1)

Application Number Title Priority Date Filing Date
AT06807841T ATE442347T1 (de) 2005-12-15 2006-11-28 Biphenylderivate als selektive agonisten des gamma-rar-rezeptors

Country Status (9)

Country Link
US (2) US8049034B2 (de)
EP (1) EP1963250B1 (de)
AT (1) ATE442347T1 (de)
BR (1) BRPI0620660A2 (de)
CA (1) CA2632910C (de)
DE (1) DE602006009142D1 (de)
ES (1) ES2331431T3 (de)
FR (1) FR2894959B1 (de)
WO (1) WO2007068580A1 (de)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2545296C (en) * 2003-12-08 2012-10-16 Galderma Research & Development, S.N.C. Biphenyl derivatives useful as ligands that activate the rar receptors, process for preparing them and use thereof in human medicine and in cosmetics
FR2894959B1 (fr) * 2005-12-15 2008-02-29 Galderma Res & Dev Derives biphenyliques agonistes selectifs du recepteur rar-gamma
US9266967B2 (en) 2007-12-21 2016-02-23 Hoffmann-La Roche, Inc. Bivalent, bispecific antibodies
US20090162359A1 (en) 2007-12-21 2009-06-25 Christian Klein Bivalent, bispecific antibodies
BRPI1014089A2 (pt) * 2009-04-02 2016-04-19 Roche Glycart Ag anticorpos multiespecíficos que compreendem anticorpos de comprimento completo e fragmentos fab de cadeia simples
PT2417156E (pt) 2009-04-07 2015-04-29 Roche Glycart Ag Anticorpos trivalentes, biespecíficos
US9676845B2 (en) 2009-06-16 2017-06-13 Hoffmann-La Roche, Inc. Bispecific antigen binding proteins
US8703132B2 (en) 2009-06-18 2014-04-22 Hoffmann-La Roche, Inc. Bispecific, tetravalent antigen binding proteins
MX2012003396A (es) 2009-09-16 2012-04-10 Genentech Inc Complejos de proteina conteniendo helice super-enrollada y/o enlazador tether y usos de los mismos.
TW201138821A (en) 2010-03-26 2011-11-16 Roche Glycart Ag Bispecific antibodies
RU2013110875A (ru) 2010-08-24 2014-09-27 Ф.Хоффманн-Ля Рош Аг БИСПЕЦИФИЧЕСКИЕ АНТИТЕЛА, СОДЕРЖАЩИЕ СТАБИЛИЗИРОВАННЫЙ ДИСУЛЬФИДОМ ФРАГМЕНТ Fv
PL2613776T3 (pl) 2010-09-01 2021-01-11 Thomas Jefferson University Kompozycja oraz sposób naprawy i regeneracji mięśni
KR101758152B1 (ko) * 2010-10-22 2017-07-14 삼성전자주식회사 무선 접속 시스템에서 망 장애 처리 장치 및 방법
JP5766296B2 (ja) 2010-12-23 2015-08-19 エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ ポリペプチド−ポリヌクレオチド複合体、およびエフェクター成分の標的化された送達におけるその使用
EP2681239B8 (de) 2011-02-28 2015-09-09 F. Hoffmann-La Roche AG Antigenbindende proteine
AR085403A1 (es) 2011-02-28 2013-09-25 Hoffmann La Roche Proteinas monovalentes que se unen a antigenos
US8772273B2 (en) * 2011-10-04 2014-07-08 Quretino Therapeutics, Inc. Formulations and uses of retinoic acid receptor selective agonists
CN104105711B (zh) 2012-02-10 2018-11-30 弗·哈夫曼-拉罗切有限公司 单链抗体及其他异多聚体
MX2014014804A (es) 2012-06-27 2015-02-12 Hoffmann La Roche Metodo para la elaboracion de conjugados de la region fc de anticuerpos que comprenden por lo menos una entidad de union que se une especificamente a un objetivo y usos del mismo.
EP2867253B1 (de) 2012-06-27 2016-09-14 F. Hoffmann-La Roche AG Verfahren zur auswahl und herstellung massgeschneiderter, hochselektiver und multispezifischer targeting-einheiten mit mindestens zwei verschiedenen bindungseinheiten sowie verwendungen davon
RU2016115866A (ru) 2013-10-11 2017-11-16 Ф. Хоффманн-Ля Рош Аг Мультиспецифические антитела с обменянными доменами и одинаковыми вариабельными доменами легкой цепи
CN107001482B (zh) 2014-12-03 2021-06-15 豪夫迈·罗氏有限公司 多特异性抗体
CN109952298B (zh) 2017-07-06 2021-09-03 江苏恒瑞医药股份有限公司 吲哚甲酰胺类衍生物、其制备方法及其在医药上的应用
EP3683206A4 (de) 2017-09-12 2021-01-13 Jiangsu Hengrui Medicine Co., Ltd. Deuteriumatom-substituiertes indolformamidderivat, herstellungsverfahren dafür und medizinische anwendungen davon
US11135236B2 (en) 2018-04-10 2021-10-05 Northwestern University Retinoic acid receptor gamma agonists to attenuate anthracycline-induced cardiotoxicity
KR20240000600A (ko) * 2021-04-27 2024-01-02 지앙시 커루이 파마슈티컬 컴퍼니 리미티드 레티노산 수용체 작용제, 이의 제조 방법, 중간체, 약학 조성물 및 용도
CN120289357A (zh) * 2024-01-09 2025-07-11 江西科睿药业有限公司 联苯类化合物、其制备方法、中间体、药物组合物和应用

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2767525B1 (fr) * 1997-08-21 1999-11-12 Cird Galderma Derives biphenyliques substitues par un radical aromatique ou heteroaromatique et compositions pharmaceutiques et cosmetiques les contenant
CA2545296C (en) * 2003-12-08 2012-10-16 Galderma Research & Development, S.N.C. Biphenyl derivatives useful as ligands that activate the rar receptors, process for preparing them and use thereof in human medicine and in cosmetics
FR2894959B1 (fr) * 2005-12-15 2008-02-29 Galderma Res & Dev Derives biphenyliques agonistes selectifs du recepteur rar-gamma

Also Published As

Publication number Publication date
EP1963250A1 (de) 2008-09-03
US20090023811A1 (en) 2009-01-22
FR2894959B1 (fr) 2008-02-29
WO2007068580A1 (fr) 2007-06-21
US8362082B2 (en) 2013-01-29
CA2632910A1 (fr) 2007-06-21
ES2331431T3 (es) 2010-01-04
DE602006009142D1 (de) 2009-10-22
US20120016031A1 (en) 2012-01-19
US8049034B2 (en) 2011-11-01
CA2632910C (fr) 2014-07-22
FR2894959A1 (fr) 2007-06-22
EP1963250B1 (de) 2009-09-09
BRPI0620660A2 (pt) 2011-11-22

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