ATE442379T1 - Bildgebende agentien auf basis bizyklischer peptide - Google Patents
Bildgebende agentien auf basis bizyklischer peptideInfo
- Publication number
- ATE442379T1 ATE442379T1 AT04743485T AT04743485T ATE442379T1 AT E442379 T1 ATE442379 T1 AT E442379T1 AT 04743485 T AT04743485 T AT 04743485T AT 04743485 T AT04743485 T AT 04743485T AT E442379 T1 ATE442379 T1 AT E442379T1
- Authority
- AT
- Austria
- Prior art keywords
- bizyclic
- peptides
- imaging agents
- agents based
- compounds
- Prior art date
Links
- 239000012216 imaging agent Substances 0.000 title 1
- 102000004196 processed proteins & peptides Human genes 0.000 title 1
- 108090000765 processed proteins & peptides Proteins 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 2
- 201000010099 disease Diseases 0.000 abstract 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 2
- 201000009273 Endometriosis Diseases 0.000 abstract 1
- 206010061218 Inflammation Diseases 0.000 abstract 1
- 208000007766 Kaposi sarcoma Diseases 0.000 abstract 1
- 230000033115 angiogenesis Effects 0.000 abstract 1
- 238000003745 diagnosis Methods 0.000 abstract 1
- 208000019622 heart disease Diseases 0.000 abstract 1
- 230000004054 inflammatory process Effects 0.000 abstract 1
- 230000003211 malignant effect Effects 0.000 abstract 1
- 206010039073 rheumatoid arthritis Diseases 0.000 abstract 1
- 230000008685 targeting Effects 0.000 abstract 1
- 238000002560 therapeutic procedure Methods 0.000 abstract 1
- 239000013598 vector Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
- A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
- A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
- A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
- A61K47/6425—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent the peptide or protein in the drug conjugate being a receptor, e.g. CD4, a cell surface antigen, i.e. not a peptide ligand targeting the antigen, or a cell surface determinant, i.e. a part of the surface of a cell
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Molecular Biology (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Epidemiology (AREA)
- Cell Biology (AREA)
- Immunology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Light Receiving Elements (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nuclear Medicine (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB0317815.9A GB0317815D0 (en) | 2003-07-30 | 2003-07-30 | Imaging agents |
| PCT/GB2004/003150 WO2005012335A1 (en) | 2003-07-30 | 2004-07-21 | Imaging agents |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE442379T1 true ATE442379T1 (de) | 2009-09-15 |
Family
ID=27799463
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT04743485T ATE442379T1 (de) | 2003-07-30 | 2004-07-21 | Bildgebende agentien auf basis bizyklischer peptide |
Country Status (23)
| Country | Link |
|---|---|
| US (2) | US7410943B2 (de) |
| EP (1) | EP1648925B1 (de) |
| JP (1) | JP4625002B2 (de) |
| KR (1) | KR101153529B1 (de) |
| CN (1) | CN1829735B (de) |
| AT (1) | ATE442379T1 (de) |
| BR (1) | BRPI0412986A (de) |
| CA (1) | CA2533321C (de) |
| CY (1) | CY1109522T1 (de) |
| DE (1) | DE602004023092D1 (de) |
| DK (1) | DK1648925T3 (de) |
| ES (1) | ES2332722T3 (de) |
| GB (1) | GB0317815D0 (de) |
| HU (1) | HUP0600230A3 (de) |
| IL (1) | IL173029A0 (de) |
| MX (1) | MXPA06001090A (de) |
| NO (1) | NO20060825L (de) |
| NZ (1) | NZ544583A (de) |
| PL (2) | PL1648925T3 (de) |
| PT (1) | PT1648925E (de) |
| RU (2) | RU2355702C2 (de) |
| SI (1) | SI1648925T1 (de) |
| WO (1) | WO2005012335A1 (de) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113000001A (zh) * | 2021-03-22 | 2021-06-22 | 洛阳海惠新材料股份有限公司 | 一种用于制备pbat的增粘连体反应器 |
| CN113750923A (zh) * | 2021-08-30 | 2021-12-07 | 桐昆集团浙江恒腾差别化纤维有限公司 | 一种酯化反应回收系统 |
Families Citing this family (40)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| HU230901B1 (hu) * | 2001-07-10 | 2019-01-28 | Ge Healthcare Limited | Peptidalapú vegyületek és ezeket tartalmazó gyógyszerkészítmények |
| GB0206750D0 (en) * | 2002-03-22 | 2002-05-01 | Amersham Plc | Radiofluorination methods |
| NO20033115D0 (no) * | 2003-07-08 | 2003-07-08 | Amersham Health As | Peptid-baserte forbindelser |
| HRP20140361T1 (hr) * | 2003-12-16 | 2014-05-23 | Nektar Therapeutics | Monodisperzne smjese pegiliranog naloksola |
| US20060182692A1 (en) | 2003-12-16 | 2006-08-17 | Fishburn C S | Chemically modified small molecules |
| CN102532264A (zh) * | 2004-06-16 | 2012-07-04 | 通用电气医疗集团股份有限公司 | 基于肽的化合物 |
| GB0420344D0 (en) * | 2004-09-14 | 2004-10-13 | Amersham Plc | Diagnostic compounds |
| JP5116480B2 (ja) | 2004-11-22 | 2013-01-09 | ジーイー・ヘルスケア・アクスイェ・セルスカプ | 造影剤 |
| CA2625196C (fr) | 2005-10-07 | 2016-04-05 | Guerbet | Composes comprenant une partie de reconnaissance d'une cible biologique, couplee a une partie de signal capable de complexer le gallium |
| US8986650B2 (en) | 2005-10-07 | 2015-03-24 | Guerbet | Complex folate-NOTA-Ga68 |
| WO2007122488A2 (en) * | 2006-04-20 | 2007-11-01 | Hammersmith Imanet Limited | Radiofluorinated compounds and their preparation |
| BRPI0720306A2 (pt) | 2006-12-14 | 2014-02-04 | Aileron Therapeutics Inc | Sistemas de macrociclização da bis-sufidrila |
| PL2118123T3 (pl) | 2007-01-31 | 2016-06-30 | Dana Farber Cancer Inst Inc | Stabilizowane peptydy p53 i ich zastosowania |
| CA2678941C (en) | 2007-02-23 | 2018-11-27 | Aileron Therapeutics, Inc. | Triazole macrocycle systems |
| JP5631201B2 (ja) | 2007-03-28 | 2014-11-26 | プレジデント アンド フェローズ オブ ハーバード カレッジ | ステッチングされたポリペプチド |
| GB0722650D0 (en) * | 2007-11-19 | 2007-12-27 | Ge Healthcare Ltd | Novel imaging method |
| AU2009204133B2 (en) * | 2008-01-09 | 2014-04-10 | Molecular Insight Pharmaceuticals, Inc. | Inhibitors of carbonic anhydrase IX |
| JP5399422B2 (ja) * | 2008-02-28 | 2014-01-29 | ジーイー・ヘルスケア・リミテッド | 市販の安価な化学薬品からのｐｅｇ−６成分の合成 |
| GB0814722D0 (en) * | 2008-08-12 | 2008-09-17 | Ge Healthcare Ltd | Treatment monitoring |
| EP2344145A1 (de) * | 2008-09-29 | 2011-07-20 | Gilead Sciences, Inc. | Kombinationen eines ratenkontrollierenden mittels und eines a-2-alpha-rezeptor-antagonisten zur verwendung in multidetektor-computertomographie-verfahren |
| AU2010204648B2 (en) | 2009-01-14 | 2016-09-01 | Aileron Therapeutics, Inc. | Peptidomimetic macrocycles |
| GB0905438D0 (en) | 2009-03-30 | 2009-05-13 | Ge Healthcare Ltd | Radiolabelling reagents and methods |
| GB0910013D0 (en) * | 2009-06-10 | 2009-07-22 | Ge Healthcare Ltd | PET imaging of fibogenesis |
| JP2013505300A (ja) | 2009-09-22 | 2013-02-14 | エルロン・セラピューティクス・インコーポレイテッド | ペプチド模倣大環状分子 |
| WO2011084763A1 (en) | 2009-12-21 | 2011-07-14 | Ge Healthcare Limited | Borosilicate glassware and silica based qma's in 18f nucleophilic substitution: influence of aluminum, boron and silicon on the reactivity of the 18f ion |
| KR102104762B1 (ko) | 2010-08-13 | 2020-04-24 | 에일러론 테라퓨틱스 인코포레이티드 | 펩티도미메틱 거대고리 |
| PE20140636A1 (es) | 2010-09-30 | 2014-06-18 | Astrazeneca Ab | Conjugado de naloxol-peg cristalino |
| FR2967671A1 (fr) * | 2010-11-24 | 2012-05-25 | Pf Medicament | Complexe de technetium 99m en tant qu'outil de diagnostic in vivo des tumeurs cancereuses |
| EP2768518A4 (de) | 2011-10-18 | 2015-05-27 | Aileron Therapeutics Inc | Peptidomimetische makrozyklen |
| RU2642299C2 (ru) | 2012-02-15 | 2018-01-24 | Эйлерон Терапьютикс, Инк. | P53 пептидомиметические макроциклы |
| CA2864120A1 (en) | 2012-02-15 | 2013-08-22 | Aileron Therapeutics, Inc. | Triazole-crosslinked and thioether-crosslinked peptidomimetic macrocycles |
| BR112015009470A2 (pt) | 2012-11-01 | 2019-12-17 | Aileron Therapeutics Inc | aminoácidos dissubstituídos e seus métodos de preparação e uso |
| CN107106642B (zh) | 2014-09-24 | 2021-02-26 | 艾瑞朗医疗公司 | 拟肽大环化合物及其制剂 |
| EP3197478A4 (de) | 2014-09-24 | 2018-05-30 | Aileron Therapeutics, Inc. | Peptidomimetische makrozyklen und verwendungen davon |
| WO2016061142A1 (en) | 2014-10-14 | 2016-04-21 | Novartis Ag | Antibody molecules to pd-l1 and uses thereof |
| JP2018516844A (ja) | 2015-03-20 | 2018-06-28 | エルロン・セラピューティクス・インコーポレイテッドＡｉｌｅｒｏｎ Ｔｈｅｒａｐｅｕｔｉｃｓ，Ｉｎｃ． | ペプチド模倣大環状分子およびその使用 |
| GB201511036D0 (en) | 2015-06-23 | 2015-08-05 | Guy S And St Thomas Hospital Nhs Foundation Trust | Imaging method |
| US10059741B2 (en) | 2015-07-01 | 2018-08-28 | Aileron Therapeutics, Inc. | Peptidomimetic macrocycles |
| EP3347372A4 (de) | 2015-09-10 | 2019-09-04 | Aileron Therapeutics, Inc. | Peptidomimetische makrocyclen als modulatoren von mcl-1 |
| GB201621864D0 (en) * | 2016-12-21 | 2017-02-01 | Ge Healthcare Ltd | Solid phase conditioning |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ATE188387T1 (de) * | 1991-02-08 | 2000-01-15 | Diatide Inc | Technetium-99m markierte polypeptide zur bildformung |
| US5981478A (en) * | 1993-11-24 | 1999-11-09 | La Jolla Cancer Research Foundation | Integrin-binding peptides |
| KR100866666B1 (ko) * | 2000-04-12 | 2008-11-04 | 지이 헬스케어 에이에스 | 펩티드 기재 화합물 |
| RU2165266C1 (ru) * | 2000-06-28 | 2001-04-20 | Центральный научно-исследовательский рентгенорадиологический институт | Способ получения [2-18f]-2-дезоксиглюкозы |
| WO2002020610A2 (en) | 2000-09-07 | 2002-03-14 | Biosynthema Inc. | Conformationally constrained labeled peptides for imaging and therapy |
| IL141276A0 (en) * | 2001-02-05 | 2002-03-10 | Peptor Ltd | Backbone cyclized radiolabelled somatostatin analogs |
| HU230901B1 (hu) | 2001-07-10 | 2019-01-28 | Ge Healthcare Limited | Peptidalapú vegyületek és ezeket tartalmazó gyógyszerkészítmények |
-
2003
- 2003-07-30 GB GBGB0317815.9A patent/GB0317815D0/en not_active Ceased
-
2004
- 2004-07-21 BR BRPI0412986-5A patent/BRPI0412986A/pt not_active IP Right Cessation
- 2004-07-21 SI SI200431293T patent/SI1648925T1/sl unknown
- 2004-07-21 PL PL04743485T patent/PL1648925T3/pl unknown
- 2004-07-21 CN CN2004800220449A patent/CN1829735B/zh not_active Expired - Fee Related
- 2004-07-21 RU RU2006102324/04A patent/RU2355702C2/ru not_active IP Right Cessation
- 2004-07-21 DE DE602004023092T patent/DE602004023092D1/de not_active Expired - Lifetime
- 2004-07-21 PT PT04743485T patent/PT1648925E/pt unknown
- 2004-07-21 US US10/566,487 patent/US7410943B2/en not_active Expired - Fee Related
- 2004-07-21 CA CA2533321A patent/CA2533321C/en not_active Expired - Fee Related
- 2004-07-21 JP JP2006521646A patent/JP4625002B2/ja not_active Expired - Fee Related
- 2004-07-21 AT AT04743485T patent/ATE442379T1/de active
- 2004-07-21 DK DK04743485T patent/DK1648925T3/da active
- 2004-07-21 PL PL379705A patent/PL210122B1/pl not_active IP Right Cessation
- 2004-07-21 ES ES04743485T patent/ES2332722T3/es not_active Expired - Lifetime
- 2004-07-21 KR KR1020067001968A patent/KR101153529B1/ko not_active Expired - Fee Related
- 2004-07-21 HU HU0600230A patent/HUP0600230A3/hu unknown
- 2004-07-21 MX MXPA06001090A patent/MXPA06001090A/es active IP Right Grant
- 2004-07-21 WO PCT/GB2004/003150 patent/WO2005012335A1/en not_active Ceased
- 2004-07-21 NZ NZ544583A patent/NZ544583A/xx not_active IP Right Cessation
- 2004-07-21 EP EP04743485A patent/EP1648925B1/de not_active Expired - Lifetime
-
2006
- 2006-01-09 IL IL173029A patent/IL173029A0/en unknown
- 2006-02-21 NO NO20060825A patent/NO20060825L/no not_active Application Discontinuation
-
2008
- 2008-06-18 US US12/141,123 patent/US7811551B2/en not_active Expired - Fee Related
-
2009
- 2009-02-19 RU RU2009105640/04A patent/RU2009105640A/ru not_active Application Discontinuation
- 2009-12-01 CY CY20091101253T patent/CY1109522T1/el unknown
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113000001A (zh) * | 2021-03-22 | 2021-06-22 | 洛阳海惠新材料股份有限公司 | 一种用于制备pbat的增粘连体反应器 |
| CN113750923A (zh) * | 2021-08-30 | 2021-12-07 | 桐昆集团浙江恒腾差别化纤维有限公司 | 一种酯化反应回收系统 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification |
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