BRPI0412986A - composto, método para o diagnóstico ou formação de imagem in vivo de uma doença ou condição associadas com a angiogênese, formulação radiofarmacêutica, método para a preparação de um composto, e, kit para a preparação de um peptìdeo radiofluorado - Google Patents

composto, método para o diagnóstico ou formação de imagem in vivo de uma doença ou condição associadas com a angiogênese, formulação radiofarmacêutica, método para a preparação de um composto, e, kit para a preparação de um peptìdeo radiofluorado

Info

Publication number
BRPI0412986A
BRPI0412986A BRPI0412986-5A BRPI0412986A BRPI0412986A BR PI0412986 A BRPI0412986 A BR PI0412986A BR PI0412986 A BRPI0412986 A BR PI0412986A BR PI0412986 A BRPI0412986 A BR PI0412986A
Authority
BR
Brazil
Prior art keywords
compound
preparing
angiogenesis
disease
kit
Prior art date
Application number
BRPI0412986-5A
Other languages
English (en)
Inventor
Alan Cuthbertson
Magne Solbakken
Original Assignee
Amersham Health As
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Amersham Health As filed Critical Amersham Health As
Publication of BRPI0412986A publication Critical patent/BRPI0412986A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
    • A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
    • A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
    • A61K47/6425—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent the peptide or protein in the drug conjugate being a receptor, e.g. CD4, a cell surface antigen, i.e. not a peptide ligand targeting the antigen, or a cell surface determinant, i.e. a part of the surface of a cell
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Epidemiology (AREA)
  • Cell Biology (AREA)
  • Immunology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Light Receiving Elements (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nuclear Medicine (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

"COMPOSTO, MéTODO PARA O DIAGNóSTICO OU FORMAçãO DE IMAGEM IN VIVO DE UMA DOENçA OU CONDIçãO ASSOCIADAS COM A ANGIOGêNESE, FORMULAçãO RADIOFARMACêUTICA, MéTODO PARA A PREPARAçãO DE UM COMPOSTO, E, KIT PARA A PREPARAçãO DE UM PEPTìDEO RADIOFLUORADO". A invenção diz respeito a compostos de fórmula (I): e seu uso como vetores de alvejamento que se ligam aos receptores associados com a angiogênese. Tais compostos podem, assim, ser usados para o diagnóstico ou a terapia de, por exemplo, doenças malignas, doenças do coração, endometriose, doenças relacionadas à inflamação, artrite reumatóide e sarcoma de Kaposi.
BRPI0412986-5A 2003-07-30 2004-07-21 composto, método para o diagnóstico ou formação de imagem in vivo de uma doença ou condição associadas com a angiogênese, formulação radiofarmacêutica, método para a preparação de um composto, e, kit para a preparação de um peptìdeo radiofluorado BRPI0412986A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB0317815.9A GB0317815D0 (en) 2003-07-30 2003-07-30 Imaging agents
PCT/GB2004/003150 WO2005012335A1 (en) 2003-07-30 2004-07-21 Imaging agents

Publications (1)

Publication Number Publication Date
BRPI0412986A true BRPI0412986A (pt) 2006-10-03

Family

ID=27799463

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0412986-5A BRPI0412986A (pt) 2003-07-30 2004-07-21 composto, método para o diagnóstico ou formação de imagem in vivo de uma doença ou condição associadas com a angiogênese, formulação radiofarmacêutica, método para a preparação de um composto, e, kit para a preparação de um peptìdeo radiofluorado

Country Status (23)

Country Link
US (2) US7410943B2 (pt)
EP (1) EP1648925B1 (pt)
JP (1) JP4625002B2 (pt)
KR (1) KR101153529B1 (pt)
CN (1) CN1829735B (pt)
AT (1) ATE442379T1 (pt)
BR (1) BRPI0412986A (pt)
CA (1) CA2533321C (pt)
CY (1) CY1109522T1 (pt)
DE (1) DE602004023092D1 (pt)
DK (1) DK1648925T3 (pt)
ES (1) ES2332722T3 (pt)
GB (1) GB0317815D0 (pt)
HU (1) HUP0600230A3 (pt)
IL (1) IL173029A0 (pt)
MX (1) MXPA06001090A (pt)
NO (1) NO20060825L (pt)
NZ (1) NZ544583A (pt)
PL (2) PL1648925T3 (pt)
PT (1) PT1648925E (pt)
RU (2) RU2355702C2 (pt)
SI (1) SI1648925T1 (pt)
WO (1) WO2005012335A1 (pt)

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JP5116480B2 (ja) 2004-11-22 2013-01-09 ジーイー・ヘルスケア・アクスイェ・セルスカプ 造影剤
CA2625196C (fr) 2005-10-07 2016-04-05 Guerbet Composes comprenant une partie de reconnaissance d'une cible biologique, couplee a une partie de signal capable de complexer le gallium
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PL2118123T3 (pl) 2007-01-31 2016-06-30 Dana Farber Cancer Inst Inc Stabilizowane peptydy p53 i ich zastosowania
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KR102104762B1 (ko) 2010-08-13 2020-04-24 에일러론 테라퓨틱스 인코포레이티드 펩티도미메틱 거대고리
PE20140636A1 (es) 2010-09-30 2014-06-18 Astrazeneca Ab Conjugado de naloxol-peg cristalino
FR2967671A1 (fr) * 2010-11-24 2012-05-25 Pf Medicament Complexe de technetium 99m en tant qu'outil de diagnostic in vivo des tumeurs cancereuses
EP2768518A4 (en) 2011-10-18 2015-05-27 Aileron Therapeutics Inc PEPTIDOMIMETIC MACROCYCLES
RU2642299C2 (ru) 2012-02-15 2018-01-24 Эйлерон Терапьютикс, Инк. P53 пептидомиметические макроциклы
CA2864120A1 (en) 2012-02-15 2013-08-22 Aileron Therapeutics, Inc. Triazole-crosslinked and thioether-crosslinked peptidomimetic macrocycles
BR112015009470A2 (pt) 2012-11-01 2019-12-17 Aileron Therapeutics Inc aminoácidos dissubstituídos e seus métodos de preparação e uso
CN107106642B (zh) 2014-09-24 2021-02-26 艾瑞朗医疗公司 拟肽大环化合物及其制剂
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Also Published As

Publication number Publication date
NZ544583A (en) 2009-12-24
PL1648925T3 (pl) 2010-02-26
HUP0600230A2 (en) 2007-01-29
EP1648925B1 (en) 2009-09-09
DK1648925T3 (da) 2010-01-04
SI1648925T1 (sl) 2010-01-29
NO20060825L (no) 2006-03-29
PL210122B1 (pl) 2011-12-30
CY1109522T1 (el) 2014-08-13
RU2006102324A (ru) 2007-09-20
GB0317815D0 (en) 2003-09-03
IL173029A0 (en) 2006-06-11
KR20060090795A (ko) 2006-08-16
CA2533321A1 (en) 2005-02-10
EP1648925A1 (en) 2006-04-26
KR101153529B1 (ko) 2012-06-11
HUP0600230A3 (en) 2009-09-28
JP4625002B2 (ja) 2011-02-02
US7410943B2 (en) 2008-08-12
ES2332722T3 (es) 2010-02-11
MXPA06001090A (es) 2006-04-24
DE602004023092D1 (de) 2009-10-22
PT1648925E (pt) 2009-12-10
US20060193773A1 (en) 2006-08-31
RU2355702C2 (ru) 2009-05-20
ATE442379T1 (de) 2009-09-15
CN1829735A (zh) 2006-09-06
US7811551B2 (en) 2010-10-12
US20080267881A1 (en) 2008-10-30
PL379705A1 (pl) 2006-11-13
CN1829735B (zh) 2010-05-26
CA2533321C (en) 2012-09-18
WO2005012335A1 (en) 2005-02-10
JP2007523880A (ja) 2007-08-23
HK1097278A1 (en) 2007-06-22
RU2009105640A (ru) 2010-08-27

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B25D Requested change of name of applicant approved

Owner name: GE HEALTHCARE AS (NO)

Free format text: ALTERADO DE: AMERSHAM HEALTH AS

B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE A 10A ANUIDADE.

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2264 DE 27/05/2014.

B15K Others concerning applications: alteration of classification

Ipc: C07K 7/06 (2006.01), A61K 47/60 (2017.01), A61K 47