ATE443038T1 - Verfahren zur herstellung von cinacalcet hydrochlorid - Google Patents
Verfahren zur herstellung von cinacalcet hydrochloridInfo
- Publication number
- ATE443038T1 ATE443038T1 AT06760041T AT06760041T ATE443038T1 AT E443038 T1 ATE443038 T1 AT E443038T1 AT 06760041 T AT06760041 T AT 06760041T AT 06760041 T AT06760041 T AT 06760041T AT E443038 T1 ATE443038 T1 AT E443038T1
- Authority
- AT
- Austria
- Prior art keywords
- cinacalcet hydrochloride
- producing cinacalcet
- producing
- hydrochloride
- processes
- Prior art date
Links
- 229960000478 cinacalcet hydrochloride Drugs 0.000 title 1
- QANQWUQOEJZMLL-PKLMIRHRSA-N cinacalcet hydrochloride Chemical compound Cl.N([C@H](C)C=1C2=CC=CC=C2C=CC=1)CCCC1=CC=CC(C(F)(F)F)=C1 QANQWUQOEJZMLL-PKLMIRHRSA-N 0.000 title 1
- 238000004519 manufacturing process Methods 0.000 title 1
- VDHAWDNDOKGFTD-MRXNPFEDSA-N cinacalcet Chemical compound N([C@H](C)C=1C2=CC=CC=C2C=CC=1)CCCC1=CC=CC(C(F)(F)F)=C1 VDHAWDNDOKGFTD-MRXNPFEDSA-N 0.000 abstract 1
- 229960003315 cinacalcet Drugs 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C209/00—Preparation of compounds containing amino groups bound to a carbon skeleton
- C07C209/04—Preparation of compounds containing amino groups bound to a carbon skeleton by substitution of functional groups by amino groups
- C07C209/22—Preparation of compounds containing amino groups bound to a carbon skeleton by substitution of functional groups by amino groups by substitution of other functional groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C209/00—Preparation of compounds containing amino groups bound to a carbon skeleton
- C07C209/04—Preparation of compounds containing amino groups bound to a carbon skeleton by substitution of functional groups by amino groups
- C07C209/06—Preparation of compounds containing amino groups bound to a carbon skeleton by substitution of functional groups by amino groups by substitution of halogen atoms
- C07C209/08—Preparation of compounds containing amino groups bound to a carbon skeleton by substitution of functional groups by amino groups by substitution of halogen atoms with formation of amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C209/00—Preparation of compounds containing amino groups bound to a carbon skeleton
- C07C209/04—Preparation of compounds containing amino groups bound to a carbon skeleton by substitution of functional groups by amino groups
- C07C209/14—Preparation of compounds containing amino groups bound to a carbon skeleton by substitution of functional groups by amino groups by substitution of hydroxy groups or of etherified or esterified hydroxy groups
- C07C209/16—Preparation of compounds containing amino groups bound to a carbon skeleton by substitution of functional groups by amino groups by substitution of hydroxy groups or of etherified or esterified hydroxy groups with formation of amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C211/00—Compounds containing amino groups bound to a carbon skeleton
- C07C211/01—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms
- C07C211/26—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing at least one six-membered aromatic ring
- C07C211/30—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing at least one six-membered aromatic ring the six-membered aromatic ring being part of a condensed ring system formed by two rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/07—Optical isomers
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (20)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US68167105P | 2005-05-16 | 2005-05-16 | |
| US68415205P | 2005-05-23 | 2005-05-23 | |
| US69698105P | 2005-07-05 | 2005-07-05 | |
| US69711105P | 2005-07-06 | 2005-07-06 | |
| US69861305P | 2005-07-11 | 2005-07-11 | |
| US70123205P | 2005-07-20 | 2005-07-20 | |
| US70291805P | 2005-07-26 | 2005-07-26 | |
| US70691005P | 2005-08-09 | 2005-08-09 | |
| US73005005P | 2005-10-24 | 2005-10-24 | |
| US73208305P | 2005-10-31 | 2005-10-31 | |
| US73300805P | 2005-11-02 | 2005-11-02 | |
| US73466905P | 2005-11-07 | 2005-11-07 | |
| US73512605P | 2005-11-08 | 2005-11-08 | |
| US73882705P | 2005-11-21 | 2005-11-21 | |
| US73921505P | 2005-11-22 | 2005-11-22 | |
| US74178705P | 2005-12-01 | 2005-12-01 | |
| US74262605P | 2005-12-05 | 2005-12-05 | |
| US75091005P | 2005-12-15 | 2005-12-15 | |
| US79480406P | 2006-04-24 | 2006-04-24 | |
| PCT/US2006/019131 WO2006125026A2 (en) | 2005-05-16 | 2006-05-16 | Process for preparing cinacalcet hydrochloride |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE443038T1 true ATE443038T1 (de) | 2009-10-15 |
Family
ID=36950075
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT06760041T ATE443038T1 (de) | 2005-05-16 | 2006-05-16 | Verfahren zur herstellung von cinacalcet hydrochlorid |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US7250533B2 (de) |
| EP (1) | EP1881954B1 (de) |
| JP (1) | JP4773436B2 (de) |
| KR (1) | KR20070116286A (de) |
| AT (1) | ATE443038T1 (de) |
| CA (1) | CA2603145A1 (de) |
| ES (1) | ES2332016T3 (de) |
| IL (1) | IL185107A0 (de) |
| WO (1) | WO2006125026A2 (de) |
Families Citing this family (35)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2605764A1 (en) | 2005-05-23 | 2006-11-30 | Teva Pharmaceutical Industries Ltd. | Amorphous cinacalcet hydrochloride and preparation thereof |
| US7563930B2 (en) | 2005-11-22 | 2009-07-21 | Teva Pharmaceutical Industries Ltd | Crystal forms of Cinacalcet HCI and processes for their preparation |
| US8415501B2 (en) | 2006-03-23 | 2013-04-09 | Amgen, Inc. | Methods and compositions for making and using polymorphs of cinacalcet |
| JP5027214B2 (ja) | 2006-04-27 | 2012-09-19 | テバ ファーマシューティカル インダストリーズ リミティド | シナカルセット塩基の調製法 |
| US7393967B2 (en) | 2006-04-27 | 2008-07-01 | Teva Pharmaceutical Industries Ltd. | Process for the preparation of cinacalcet base |
| MX2009002335A (es) * | 2006-09-01 | 2009-03-20 | Teva Pharma | Composiciones solidas de un compuesto activo receptor de calcio. |
| WO2008058236A2 (en) * | 2006-11-08 | 2008-05-15 | Dr. Reddy's Labortories, Ltd. | Methods for preparing cinacalcet hydrochloride |
| US20080146845A1 (en) * | 2006-11-20 | 2008-06-19 | Boaz Gome | Process for preparing Cinacalcet |
| WO2008122010A1 (en) * | 2007-04-02 | 2008-10-09 | Concert Pharmaceuticals, Inc. | Pharmaceutical calcimimetics |
| EP1990333A1 (de) * | 2007-05-11 | 2008-11-12 | Sandoz AG | Verfahren zur Herstellung von Cinacalcethydrochlorid |
| EP2170805B1 (de) | 2007-06-21 | 2016-03-16 | Amgen Inc. | Verfahren zur synthese von cinacalcet und salzen davon |
| ITMI20071261A1 (it) | 2007-06-22 | 2008-12-23 | Dipharma Francis Srl | Procedimento per la preparazione di cinacalcet |
| WO2009025792A2 (en) * | 2007-08-16 | 2009-02-26 | Teva Pharmaceutical Industries Ltd. | Crystalline forms cinacalcet fumarate and cinacalcet succinate and processes for preparation thereof |
| EP2321256B1 (de) * | 2008-06-18 | 2014-11-12 | ERREGIERRE S.p.A. | Verfahren zur synthese von cinacalcet hydrochlorid |
| KR20110028647A (ko) * | 2008-07-08 | 2011-03-21 | 인드-스위프트 래버러토리즈 리미티드 | 시나칼셋 및 약학적으로 허용되는 그의 염의 제조 방법 |
| WO2010010359A2 (en) * | 2008-07-24 | 2010-01-28 | Cilpa Limited | A process for the preparation of cinacalcet and its salts |
| CN102112423A (zh) * | 2008-08-01 | 2011-06-29 | 巴斯夫欧洲公司 | 制备苯基链烷-1-醇的方法 |
| WO2010015935A2 (en) * | 2008-08-06 | 2010-02-11 | Actavis Group Ptc Ehf | Unsaturated cinacalcet salts and processes for preparing cinacalcet hydrochloride |
| US20110318417A1 (en) | 2008-12-08 | 2011-12-29 | Actavis Group Ptc Ehf | Highly pure cinacalcet or a pharmaceutically acceptable salt thereof |
| EP2398763A2 (de) * | 2009-02-19 | 2011-12-28 | ZaCh System S.p.A. | Verfahren zur herstellung von cinacalcet-hydrochlorid |
| US8575393B2 (en) | 2009-03-05 | 2013-11-05 | Cipla Limited | Process for the preparation of cinacalcet and salts thereof, and intermediates for use in the process |
| WO2010103531A2 (en) * | 2009-03-09 | 2010-09-16 | Megafine Pharma (P) Ltd. | A new method for the preparation of cinacalcet and new intermediates thereof |
| WO2010128388A2 (en) | 2009-05-08 | 2010-11-11 | Aurobindo Pharma Limited | An improved process for the preparation of intermediate compounds useful for the preparation of cinacalcet |
| CA2769659C (en) | 2009-09-10 | 2017-10-24 | Zach System S.P.A. | Process for preparing cinacalcet |
| AU2010315805B2 (en) | 2009-09-29 | 2015-09-17 | Nektar Therapeutics | Oligomer-calcimimetic conjugates and related compounds |
| US8722732B2 (en) | 2009-09-29 | 2014-05-13 | Nektar Therapeutics | Oligomer-calcimimetic conjugates and related compounds |
| IT1396623B1 (it) | 2009-11-26 | 2012-12-14 | Dipharma Francis Srl | Procedimento per la preparazione di cinacalcet e suoi intermedi |
| US8921606B2 (en) * | 2010-07-16 | 2014-12-30 | Hetero Research Foundation | Process for cinacalcet hydrochloride |
| CN101941911A (zh) * | 2010-09-21 | 2011-01-12 | 上海应用技术学院 | 一种西纳卡塞的绿色合成方法 |
| CZ303627B6 (cs) | 2011-11-25 | 2013-01-16 | Zentiva, K.S. | Zpusob výroby Cinacalcetu |
| CN103450027B (zh) * | 2012-05-29 | 2015-07-29 | 上海京新生物医药有限公司 | 盐酸西那卡塞的制备方法 |
| FR2995307A1 (fr) | 2012-09-07 | 2014-03-14 | Prod Chim Auxiliaires Et De Synthese | Procede de preparation du cinacalcet et de ses sels pharmaceutiquement acceptables |
| CN103044267A (zh) * | 2012-12-06 | 2013-04-17 | 华润赛科药业有限责任公司 | 一种高纯度盐酸西那卡塞的制备方法 |
| CN107311844A (zh) * | 2017-08-04 | 2017-11-03 | 六安佳诺生化科技有限公司 | 间三氟甲基苯丙醇的合成 |
| CN120004740B (zh) * | 2025-01-22 | 2025-11-18 | 天津大学 | 一种盐酸西那卡塞的合成方法 |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4966988A (en) * | 1989-02-17 | 1990-10-30 | Chevron Research Company | Process for preparing acetonitrile 3-trifluoromethyl benzene |
| US6031003A (en) * | 1991-08-23 | 2000-02-29 | Nps Pharmaceuticals, Inc. | Calcium receptor-active molecules |
| US6011068A (en) * | 1991-08-23 | 2000-01-04 | Nps Pharmaceuticals, Inc. | Calcium receptor-active molecules |
| US6313146B1 (en) * | 1991-08-23 | 2001-11-06 | Nps Pharmaceuticals, Inc. | Calcium receptor-active molecules |
| EP1203761B1 (de) * | 1994-10-21 | 2005-01-19 | Nps Pharmaceuticals, Inc. | Kalzium-Rezeptor aktive Verbindungen |
| US5648541A (en) * | 1995-09-28 | 1997-07-15 | Nps Pharmaceuticals, Inc. | Chiral reductions of imines leading to the syntheses of optically active amines |
| IT1276165B1 (it) * | 1995-11-24 | 1997-10-27 | Caffaro Spa Ind Chim | Procedimento per la sintesi enantioselettiva di derivati chirali di s-3-(4'-tert-butil)-fenil-2-metil propilammina, fungicidi sistemici |
| ES2401769T5 (es) * | 2003-09-12 | 2020-07-01 | Amgen Inc | Formulación de disolución rápida de cinacalcet HCl |
| US20050234261A1 (en) | 2004-04-14 | 2005-10-20 | Honeywell International Inc. | Process for preparing cinnamic acids and alkyl esters thereof |
-
2006
- 2006-05-16 US US11/435,430 patent/US7250533B2/en not_active Expired - Fee Related
- 2006-05-16 KR KR1020077025656A patent/KR20070116286A/ko not_active Ceased
- 2006-05-16 EP EP06760041A patent/EP1881954B1/de not_active Expired - Lifetime
- 2006-05-16 WO PCT/US2006/019131 patent/WO2006125026A2/en not_active Ceased
- 2006-05-16 AT AT06760041T patent/ATE443038T1/de not_active IP Right Cessation
- 2006-05-16 CA CA002603145A patent/CA2603145A1/en not_active Abandoned
- 2006-05-16 JP JP2007521726A patent/JP4773436B2/ja not_active Expired - Fee Related
- 2006-05-16 ES ES06760041T patent/ES2332016T3/es not_active Expired - Lifetime
-
2007
- 2007-08-07 IL IL185107A patent/IL185107A0/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CA2603145A1 (en) | 2006-11-23 |
| IL185107A0 (en) | 2007-12-03 |
| KR20070116286A (ko) | 2007-12-07 |
| WO2006125026A2 (en) | 2006-11-23 |
| ES2332016T3 (es) | 2010-01-22 |
| US7250533B2 (en) | 2007-07-31 |
| JP2008505981A (ja) | 2008-02-28 |
| US20070043243A1 (en) | 2007-02-22 |
| EP1881954B1 (de) | 2009-09-16 |
| WO2006125026A3 (en) | 2007-03-08 |
| JP4773436B2 (ja) | 2011-09-14 |
| EP1881954A2 (de) | 2008-01-30 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |