ATE443136T1 - Methode für dna synthese - Google Patents
Methode für dna syntheseInfo
- Publication number
- ATE443136T1 ATE443136T1 AT07104945T AT07104945T ATE443136T1 AT E443136 T1 ATE443136 T1 AT E443136T1 AT 07104945 T AT07104945 T AT 07104945T AT 07104945 T AT07104945 T AT 07104945T AT E443136 T1 ATE443136 T1 AT E443136T1
- Authority
- AT
- Austria
- Prior art keywords
- dna synthesis
- dna
- synthesis reaction
- enhancer
- reaction
- Prior art date
Links
- 230000006820 DNA synthesis Effects 0.000 title abstract 13
- 238000000034 method Methods 0.000 title 1
- 102000016928 DNA-directed DNA polymerase Human genes 0.000 abstract 5
- 108010014303 DNA-directed DNA polymerase Proteins 0.000 abstract 5
- 238000003786 synthesis reaction Methods 0.000 abstract 5
- 239000003623 enhancer Substances 0.000 abstract 4
- 108010010677 Phosphodiesterase I Proteins 0.000 abstract 3
- 230000000694 effects Effects 0.000 abstract 3
- 238000000338 in vitro Methods 0.000 abstract 2
- 238000001308 synthesis method Methods 0.000 abstract 2
- 230000002378 acidificating effect Effects 0.000 abstract 1
- 125000002091 cationic group Chemical group 0.000 abstract 1
- 238000006243 chemical reaction Methods 0.000 abstract 1
- 239000000126 substance Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P19/00—Preparation of compounds containing saccharide radicals
- C12P19/26—Preparation of nitrogen-containing carbohydrates
- C12P19/28—N-glycosides
- C12P19/30—Nucleotides
- C12P19/34—Polynucleotides, e.g. nucleic acids, oligoribonucleotides
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/10—Transferases (2.)
- C12N9/12—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
- C12N9/1241—Nucleotidyltransferases (2.7.7)
- C12N9/1252—DNA-directed DNA polymerase (2.7.7.7), i.e. DNA replicase
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/96—Stabilising an enzyme by forming an adduct or a composition; Forming enzyme conjugates
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6806—Preparing nucleic acids for analysis, e.g. for polymerase chain reaction [PCR] assay
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S435/00—Chemistry: molecular biology and microbiology
- Y10S435/975—Kit
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Genetics & Genomics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Molecular Biology (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- Biomedical Technology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Medicinal Chemistry (AREA)
- Analytical Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Physics & Mathematics (AREA)
- Biophysics (AREA)
- General Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Crystallography & Structural Chemistry (AREA)
- Plant Pathology (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Enzymes And Modification Thereof (AREA)
- Saccharide Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP11400598 | 1998-04-23 | ||
| JP31524398 | 1998-11-06 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE443136T1 true ATE443136T1 (de) | 2009-10-15 |
Family
ID=26452869
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT07104945T ATE443136T1 (de) | 1998-04-23 | 1999-04-21 | Methode für dna synthese |
Country Status (10)
| Country | Link |
|---|---|
| US (2) | US7521178B1 (de) |
| EP (3) | EP1816197B1 (de) |
| JP (2) | JP3748378B2 (de) |
| KR (1) | KR100519895B1 (de) |
| CN (2) | CN1637146A (de) |
| AT (1) | ATE443136T1 (de) |
| AU (1) | AU3534199A (de) |
| CA (1) | CA2326725A1 (de) |
| DE (1) | DE69941441D1 (de) |
| WO (1) | WO1999054455A1 (de) |
Families Citing this family (45)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP3724321B2 (ja) * | 2000-03-21 | 2005-12-07 | 株式会社島津製作所 | 核酸合成法 |
| JP3897805B2 (ja) | 2003-12-25 | 2007-03-28 | 独立行政法人理化学研究所 | 核酸の増幅法およびこれを利用した変異核酸の検出法 |
| US7462475B2 (en) * | 2004-05-20 | 2008-12-09 | Dna Poleymerase Technology, Inc. | Use of whole blood in PCR reactions |
| JP2008151771A (ja) | 2006-11-22 | 2008-07-03 | Fujifilm Corp | マイクロ流体チップ |
| CA2622649C (en) | 2007-03-09 | 2018-04-24 | Riken | Nucleic acid amplification method using primer exhibiting exciton effect |
| US20100221787A1 (en) | 2007-10-25 | 2010-09-02 | Riken | Isothermal amplification method and dna polymerase used in the same |
| WO2009107816A1 (ja) * | 2008-02-29 | 2009-09-03 | 独立行政法人理化学研究所 | 酵素の反応性を改善する方法 |
| US20110236900A1 (en) | 2008-11-27 | 2011-09-29 | Riken | Novel muts protein and method for determing mutation using the same |
| JP5818688B2 (ja) * | 2009-01-08 | 2015-11-18 | バイオ−ラッド ラボラトリーズ インコーポレーティッド | 核酸増幅反応の効率を改善するための方法および組成物 |
| US9410194B2 (en) | 2010-06-21 | 2016-08-09 | Life Technologies Corporation | Compositions, kits and methods for synthesis and/or detection of nucleic acids |
| CA2807552A1 (en) | 2010-08-06 | 2012-02-09 | Moderna Therapeutics, Inc. | Engineered nucleic acids and methods of use thereof |
| EP2857499A1 (de) | 2010-10-01 | 2015-04-08 | Moderna Therapeutics, Inc. | Manipulierte Nukleinsäuren und Verfahren zur Verwendung davon |
| EP2669385B1 (de) * | 2011-01-24 | 2017-03-08 | Takara Bio Inc. | Verfahren für nukleinsäuremodifikation |
| CA2831613A1 (en) | 2011-03-31 | 2012-10-04 | Moderna Therapeutics, Inc. | Delivery and formulation of engineered nucleic acids |
| EP2746395B1 (de) | 2011-09-08 | 2017-11-29 | Kabushiki Kaisha DNAFORM | Primer-set, verfahren zur amplifizierung einer nukleinsäuresequenz damit und verfahren zur erkennung von mutierter nukleinsäure damit |
| US9464124B2 (en) | 2011-09-12 | 2016-10-11 | Moderna Therapeutics, Inc. | Engineered nucleic acids and methods of use thereof |
| PT3682905T (pt) | 2011-10-03 | 2022-04-07 | Modernatx Inc | Nucleósidos, nucleótidos e ácidos nucleicos modificados e respetivas utilizações |
| ES2923757T3 (es) | 2011-12-16 | 2022-09-30 | Modernatx Inc | Composiciones de ARNm modificado |
| WO2013151664A1 (en) | 2012-04-02 | 2013-10-10 | modeRNA Therapeutics | Modified polynucleotides for the production of proteins |
| US10501512B2 (en) | 2012-04-02 | 2019-12-10 | Modernatx, Inc. | Modified polynucleotides |
| US9572897B2 (en) | 2012-04-02 | 2017-02-21 | Modernatx, Inc. | Modified polynucleotides for the production of cytoplasmic and cytoskeletal proteins |
| US9283287B2 (en) | 2012-04-02 | 2016-03-15 | Moderna Therapeutics, Inc. | Modified polynucleotides for the production of nuclear proteins |
| US9816102B2 (en) | 2012-09-13 | 2017-11-14 | Indiana University Research And Technology Corporation | Compositions and systems for conferring disease resistance in plants and methods of use thereof |
| PT2922554T (pt) | 2012-11-26 | 2022-06-28 | Modernatx Inc | Arn modificado nas porções terminais |
| US8980864B2 (en) | 2013-03-15 | 2015-03-17 | Moderna Therapeutics, Inc. | Compositions and methods of altering cholesterol levels |
| CA2923029A1 (en) | 2013-09-03 | 2015-03-12 | Moderna Therapeutics, Inc. | Chimeric polynucleotides |
| KR20160067219A (ko) | 2013-10-03 | 2016-06-13 | 모더나 세라퓨틱스, 인코포레이티드 | 저밀도 지단백질 수용체를 암호화하는 폴리뉴클레오타이드 |
| EP3090061A2 (de) | 2013-12-31 | 2016-11-09 | F. Hoffmann-La Roche AG | Verfahren zur beurteilung der epigenetischen regulierung einer genomfunktion über den dna-methylierungsstatus sowie systeme und kits dafür |
| CA2936157C (en) | 2014-01-15 | 2021-08-24 | Tokyo Institute Of Technology | Covered sequence conversion dna and detection methods |
| WO2016011226A1 (en) | 2014-07-16 | 2016-01-21 | Moderna Therapeutics, Inc. | Chimeric polynucleotides |
| ES2791280T3 (es) | 2014-12-24 | 2020-11-03 | Abbott Lab | Método de detección, composición y kit basados en reacciones en cascada de ADN amplificador de señal con extensión de la diana |
| KR101785074B1 (ko) | 2015-01-28 | 2017-10-12 | 고려대학교 산학협력단 | Dna 합성용 마이크로 칩 및 이를 이용한 dna 합성방법 |
| SMT202200310T1 (it) | 2015-12-23 | 2022-09-14 | Modernatx Inc | Metodi di utilizzo dei polinucleotidi codificanti il ligando di ox40 |
| US20190241658A1 (en) | 2016-01-10 | 2019-08-08 | Modernatx, Inc. | Therapeutic mRNAs encoding anti CTLA-4 antibodies |
| PL3458083T3 (pl) | 2016-05-18 | 2023-03-13 | Modernatx, Inc. | Polinukleotydy kodujące interleukinę-12 (il12) i ich zastosowania |
| RS63625B1 (sr) | 2016-05-18 | 2022-10-31 | Modernatx Inc | Kombinacije irnk koje kodiraju imunomodulirajuće polipeptide i njihova upotreba |
| CN106916909B (zh) * | 2017-05-09 | 2018-09-11 | 广州海力特生物科技有限公司 | 一种HBV pgRNA的实时荧光定量RT-PCR检测引物组、探针组、试剂盒及方法 |
| US20200131498A1 (en) | 2017-06-14 | 2020-04-30 | Modernatx, Inc. | Polynucleotides encoding methylmalonyl-coa mutase |
| BR112020016306A2 (pt) | 2018-02-12 | 2020-12-15 | Curators Of The University Of Missouri | Gene (saur) suprarregulado pequeno de auxina para o melhoramento da arquitetura do sistema radicular da planta, tolerância ao encharcamento, resistência à seca, e rendimento |
| CN113454238B (zh) | 2019-01-25 | 2025-02-11 | 哈佛大学校长及研究员协会 | 用于合成核酸的组合物和方法 |
| CN115176027A (zh) | 2019-12-12 | 2022-10-11 | 哈佛大学校长及研究员协会 | 用于光指导的生物分子条形码化的组合物和方法 |
| CA3176545A1 (en) | 2020-04-22 | 2021-10-28 | President And Fellows Of Harvard College | Isothermal methods, compositions, kits, and systems for detecting nucleic acids |
| JP2023545038A (ja) | 2020-10-06 | 2023-10-26 | プレジデント・アンド・フェロウズ・オブ・ハーバード・カレッジ | 中和標的のシグナルオン検出のための方法、組成物、キット、およびシステム |
| IL328051A (en) | 2023-11-14 | 2026-06-01 | Lilly Co Eli | Fc RECEPTOR BASED ASSAYS FOR ANALYZING IgG ANTIBODIES |
| EP4729632A1 (de) | 2024-10-18 | 2026-04-22 | AskBio Inc. | Verfahren zur synthese von dna |
Family Cites Families (34)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4072574A (en) * | 1976-07-30 | 1978-02-07 | The Institute For Cancer Research | System for in vitro assay for mutagenicity and/or carcinogenicity of chemicals or other exogenous agents |
| US5225556A (en) * | 1985-01-18 | 1993-07-06 | The Trustees Of Columbia University In The City Of New York | Chemical probes for left-handed DNA and for A-DNA; chiral metal complexes as Z-specific antitumor agents and as double strand cleavers |
| DE3601136A1 (de) * | 1986-01-16 | 1987-07-23 | Max Planck Gesellschaft | Hemmstoffe der reversen transkriptase fuer prophylaxe und therapie von retrovirus-infektionen in saeugetieren |
| CA2065719A1 (en) | 1991-04-30 | 1992-10-31 | John B. Findlay | Nucleic acid amplification and detection methods using rapid polymerase chain reaction cycle |
| DE69231178T2 (de) * | 1991-08-30 | 2000-11-23 | Syngenix Ltd., Cambridge | Nukleinsäure-amplifikation durch polymerase-reaktion |
| US5418162A (en) * | 1991-10-22 | 1995-05-23 | Duke University | Serotonin transporter CDNA |
| WO1993023574A1 (en) * | 1992-05-14 | 1993-11-25 | Kozal Michael J | Polymerase chain reaction assays for monitoring antiviral therapy |
| EP0590327B1 (de) * | 1992-09-11 | 2003-04-09 | F. Hoffmann-La Roche Ag | Nachweis von Nukleinsäuren im Blut |
| RU2048522C1 (ru) * | 1992-10-14 | 1995-11-20 | Институт белка РАН | Способ размножения нуклеиновых кислот, способ их экспрессии и среда для их осуществления |
| US5436149A (en) * | 1993-02-19 | 1995-07-25 | Barnes; Wayne M. | Thermostable DNA polymerase with enhanced thermostability and enhanced length and efficiency of primer extension |
| US6410277B1 (en) * | 1993-02-19 | 2002-06-25 | Takara Shuzo Co., Ltd. | DNA polymersases with enhanced length of primer extension |
| US5556772A (en) * | 1993-12-08 | 1996-09-17 | Stratagene | Polymerase compositions and uses thereof |
| US6087097A (en) * | 1994-05-12 | 2000-07-11 | Mayo Foundation For Medical Education And Research | PCR detection of Borrelia burgdorferi |
| EP0745687A1 (de) | 1995-04-08 | 1996-12-04 | Roche Diagnostics GmbH | Verfahren zur spezifischen Vervielfältigung und zum Nachweis von DNA bzw. RNA |
| US5789206A (en) * | 1995-07-07 | 1998-08-04 | Myriad Genetics, Inc. | Method for ligating adaptors to nucleic acids which methods are useful for obtaining the ends of genes |
| US5795722A (en) * | 1997-03-18 | 1998-08-18 | Visible Genetics Inc. | Method and kit for quantitation and nucleic acid sequencing of nucleic acid analytes in a sample |
| CN1552869A (zh) | 1995-12-27 | 2004-12-08 | 宝酒造株式会社 | 新型dna聚合酶 |
| AU720004B2 (en) | 1996-01-26 | 2000-05-18 | Research Institute For Glycotechnology | Apoptosis inducers |
| EP0929694A4 (de) * | 1996-03-15 | 2002-05-02 | Penn State Res Found | Nachweis von extrazellulärer tumor-assoziierter nukleinsäuren im blutplasma oder -serum mittels eines nukleinsäure-amplifizierungsverfahren |
| US5917031A (en) | 1996-04-19 | 1999-06-29 | Taiko Pharmaceutical Co., Ltd. | Method of synthesizing polydeoxyribonucleotides |
| US5928906A (en) * | 1996-05-09 | 1999-07-27 | Sequenom, Inc. | Process for direct sequencing during template amplification |
| DE69736110T2 (de) | 1996-06-12 | 2007-01-18 | Takara Bio Inc., Otsu | Verwendung von Fucoidin |
| DE69725076T2 (de) | 1996-07-29 | 2004-04-15 | Toyo Boseki K.K. | Modifizierte thermostabile DNA Polymerase und eine DNA Polymerasezusammensetzung zur Amplifikation von Nukleinsäuren |
| JP3463780B2 (ja) | 1996-07-30 | 2003-11-05 | 東洋紡績株式会社 | 核酸増幅用ｄｎａポリメラーゼ組成物 |
| EP1705253B1 (de) * | 1997-04-03 | 2010-11-03 | Life Technologies Corporation | Verfahren und Produkte zur reversen Transkription gekoppelt mit Polymerasekettenreaktion (RT-PCR) |
| US5939259A (en) * | 1997-04-09 | 1999-08-17 | Schleicher & Schuell, Inc. | Methods and devices for collecting and storing clinical samples for genetic analysis |
| US6348336B1 (en) * | 1997-07-01 | 2002-02-19 | Alpha Therapeutic Corporation | Process for purification of PCR test samples |
| EP1111044A4 (de) * | 1998-09-08 | 2003-06-04 | Takara Shuzo Co | Methode zur dna-synthese |
| EP0989192A3 (de) | 1998-09-21 | 2004-02-25 | Shimadzu Corporation | Verfahren zur Nucleinsäuresynthese |
| JP2001029078A (ja) | 1999-07-16 | 2001-02-06 | Shimadzu Corp | Ｒｎａ増幅法 |
| GB0001450D0 (en) * | 2000-01-21 | 2000-03-08 | Genpoint As | Cell isolation method |
| DE10006662A1 (de) * | 2000-02-15 | 2001-08-23 | Antigen Produktions Gmbh | Gefäß zur Nukleinsäureanalytik |
| US6350580B1 (en) * | 2000-10-11 | 2002-02-26 | Stratagene | Methods for detection of a target nucleic acid using a probe comprising secondary structure |
| US6667165B2 (en) * | 2001-11-13 | 2003-12-23 | Eppendorf Ag | Method and compositions for reversible inhibition of thermostable polymerases |
-
1999
- 1999-04-21 WO PCT/JP1999/002121 patent/WO1999054455A1/ja not_active Ceased
- 1999-04-21 CN CNA2004100825674A patent/CN1637146A/zh active Pending
- 1999-04-21 EP EP07104945A patent/EP1816197B1/de not_active Expired - Lifetime
- 1999-04-21 CN CNB998077097A patent/CN1177931C/zh not_active Expired - Lifetime
- 1999-04-21 US US09/673,884 patent/US7521178B1/en not_active Expired - Fee Related
- 1999-04-21 AU AU35341/99A patent/AU3534199A/en not_active Abandoned
- 1999-04-21 JP JP2000544787A patent/JP3748378B2/ja not_active Expired - Lifetime
- 1999-04-21 DE DE69941441T patent/DE69941441D1/de not_active Expired - Lifetime
- 1999-04-21 AT AT07104945T patent/ATE443136T1/de not_active IP Right Cessation
- 1999-04-21 EP EP99917081A patent/EP1072678A4/de not_active Withdrawn
- 1999-04-21 EP EP09167571.0A patent/EP2116600B1/de not_active Expired - Lifetime
- 1999-04-21 CA CA002326725A patent/CA2326725A1/en not_active Abandoned
- 1999-04-21 KR KR10-2000-7011784A patent/KR100519895B1/ko not_active Expired - Fee Related
-
2005
- 2005-10-14 JP JP2005300626A patent/JP4214142B2/ja not_active Expired - Fee Related
-
2008
- 2008-10-15 US US12/285,866 patent/US8367328B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| US20090098613A1 (en) | 2009-04-16 |
| EP1072678A1 (de) | 2001-01-31 |
| US7521178B1 (en) | 2009-04-21 |
| DE69941441D1 (de) | 2009-10-29 |
| CN1306570A (zh) | 2001-08-01 |
| WO1999054455A1 (fr) | 1999-10-28 |
| KR100519895B1 (ko) | 2005-10-13 |
| JP3748378B2 (ja) | 2006-02-22 |
| EP1816197A3 (de) | 2007-11-28 |
| EP1816197A2 (de) | 2007-08-08 |
| EP1816197B1 (de) | 2009-09-16 |
| JP4214142B2 (ja) | 2009-01-28 |
| CN1177931C (zh) | 2004-12-01 |
| AU3534199A (en) | 1999-11-08 |
| JP2006061164A (ja) | 2006-03-09 |
| CA2326725A1 (en) | 1999-10-28 |
| KR20010042958A (ko) | 2001-05-25 |
| EP2116600A3 (de) | 2010-01-13 |
| CN1637146A (zh) | 2005-07-13 |
| EP2116600A2 (de) | 2009-11-11 |
| EP1072678A4 (de) | 2006-09-27 |
| US8367328B2 (en) | 2013-02-05 |
| EP2116600B1 (de) | 2013-09-18 |
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