DK0625194T3 - Forøgelse af ribozym-katalytisk aktivitet med et tilstødende facilitator oligonukleotid - Google Patents

Forøgelse af ribozym-katalytisk aktivitet med et tilstødende facilitator oligonukleotid

Info

Publication number
DK0625194T3
DK0625194T3 DK93904711.4T DK93904711T DK0625194T3 DK 0625194 T3 DK0625194 T3 DK 0625194T3 DK 93904711 T DK93904711 T DK 93904711T DK 0625194 T3 DK0625194 T3 DK 0625194T3
Authority
DK
Denmark
Prior art keywords
ribozyme
catalytic activity
facilitator oligonucleotide
adjacent
increase
Prior art date
Application number
DK93904711.4T
Other languages
English (en)
Inventor
John Goodchild
Original Assignee
Worcester Found Ex Biology
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Worcester Found Ex Biology filed Critical Worcester Found Ex Biology
Application granted granted Critical
Publication of DK0625194T3 publication Critical patent/DK0625194T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1131—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against viruses
    • C12N15/1132—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against viruses against retroviridae, e.g. HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/11—Antisense
    • C12N2310/111—Antisense spanning the whole gene, or a large part of it
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/12—Type of nucleic acid catalytic nucleic acids, e.g. ribozymes
    • C12N2310/121—Hammerhead
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2740/00—Reverse transcribing RNA viruses
    • C12N2740/00011—Details
    • C12N2740/10011—Retroviridae
    • C12N2740/16011—Human Immunodeficiency Virus, HIV
    • C12N2740/16022—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Virology (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Biotechnology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • AIDS & HIV (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Microbiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Plant Pathology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Physics & Mathematics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Catalysts (AREA)
  • Enzymes And Modification Thereof (AREA)
DK93904711.4T 1992-02-04 1993-02-04 Forøgelse af ribozym-katalytisk aktivitet med et tilstødende facilitator oligonukleotid DK0625194T3 (da)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US83071392A 1992-02-04 1992-02-04
PCT/US1993/000783 WO1993015194A1 (en) 1992-02-04 1993-02-04 Enhancement of ribozyme catalytic activity by a neighboring facilitator oligonucleotide
CA002106015A CA2106015A1 (en) 1992-02-04 1993-09-13 Ribozymes having 2'-0 substituted nucleotides in the flanking sequences

Publications (1)

Publication Number Publication Date
DK0625194T3 true DK0625194T3 (da) 1996-05-28

Family

ID=25676634

Family Applications (1)

Application Number Title Priority Date Filing Date
DK93904711.4T DK0625194T3 (da) 1992-02-04 1993-02-04 Forøgelse af ribozym-katalytisk aktivitet med et tilstødende facilitator oligonukleotid

Country Status (10)

Country Link
EP (1) EP0625194B1 (da)
JP (1) JPH07508638A (da)
AT (1) ATE137263T1 (da)
AU (1) AU661124B2 (da)
CA (2) CA2117428A1 (da)
DE (1) DE69302369T2 (da)
DK (1) DK0625194T3 (da)
ES (1) ES2085767T3 (da)
GR (1) GR3019911T3 (da)
WO (1) WO1993015194A1 (da)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3933384A1 (de) * 1989-10-06 1991-04-18 Hoechst Ag Multifunktionelle rna mit selbstprozessierungsaktivitaet, ihre herstellung und ihre verwendung
US5739309A (en) * 1993-07-19 1998-04-14 Gen-Probe Incorporated Enhancement of oligonucleotide inhibition of protein production, cell proliferation and / or multiplication of infectious disease pathogens
AU689129B2 (en) * 1993-07-19 1998-03-26 Gen-Probe Incorporated Enhancement of oligonucleotide inhibition of protein production, cell proliferation, and/or multiplication of infectious disease pathogens
US5998193A (en) * 1994-06-24 1999-12-07 Gene Shears Pty., Ltd. Ribozymes with optimized hybridizing arms, stems, and loops, tRNA embedded ribozymes and compositions thereof
US5700923A (en) * 1994-09-29 1997-12-23 Hybridon, Inc. Finderons and methods of their preparation and use
US5650502A (en) * 1994-11-09 1997-07-22 Hybridon, Inc. Ribozyme analogs having rigid non-nucleotidic linkers
US5545729A (en) * 1994-12-22 1996-08-13 Hybridon, Inc. Stabilized ribozyme analogs
US20060182949A1 (en) * 2005-02-17 2006-08-17 3M Innovative Properties Company Surfacing and/or joining method

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3933384A1 (de) * 1989-10-06 1991-04-18 Hoechst Ag Multifunktionelle rna mit selbstprozessierungsaktivitaet, ihre herstellung und ihre verwendung

Also Published As

Publication number Publication date
GR3019911T3 (en) 1996-08-31
DE69302369D1 (de) 1996-05-30
ES2085767T3 (es) 1996-06-01
AU661124B2 (en) 1995-07-13
CA2106015A1 (en) 1995-03-14
JPH07508638A (ja) 1995-09-28
WO1993015194A1 (en) 1993-08-05
DE69302369T2 (de) 1996-09-05
EP0625194B1 (en) 1996-04-24
AU3597793A (en) 1993-09-01
ATE137263T1 (de) 1996-05-15
CA2117428A1 (en) 1993-08-05
EP0625194A1 (en) 1994-11-23

Similar Documents

Publication Publication Date Title
DE69403642D1 (de) 7-deazapurin modifizierte oligonukleotide
CY1110633T1 (el) Τροποποιηση αντιθετης φορας της εκφρασης σουρβιβινης
ES2065919T3 (es) Ribozimas.
EP1325019A4 (en) ANTISENSE MODULATION OF CLUSTERINEXPRESSION
DE69637256D1 (de) Synthese von Methoxynukleoside und enzymatische Nukleisäure Moleküle
DE69628864D1 (de) Invertierte chimäre und hybrid-oligonukleotide
ATE443136T1 (de) Methode für dna synthese
ATE312202T1 (de) Menschliche rnase h und entsprechende oligonukleotidverbindungen
DE69432934D1 (de) Oligonukleotidmodulation der expression von multiwirkstoff-resistenz -assoziiertem protein
DE60030970D1 (de) Verfahren und zusammensetzungen für nichtvirale gentherapie zur behandlung von hyperproliferativen krankheiten
AU5121399A (en) Rna targeted 2'-modified oligonucleotides that are conformationally preorganized
PT1053313E (pt) Oligonucleotidos ''antisense'' optimizados complementares de sequencias de dna metiltransferase
EP1123414A4 (en) ANTISENSE MODULATION OF THE EXPRESSION OF INTEGRIN ALPHA 4
EP1250157A4 (en) ANTISENS MODULATION OF THE EXPRESSION OF THE INDUCIBLE NITROGEN MONOXIDE SYNTHASE
EA199900632A1 (ru) 2-амино-6-(2-замещенные-4-фенокси)-замещенные-пиридины
DE69634698D1 (de) Gewebespezifische und ziel-rna-spezifische ribozyme
DK1175489T3 (da) Oligonukleotider indeholdende en antisense-sekvens stabiliseret af en sekundær struktur og farmaceutiske præparater indeholdende disse oligonukleotider
EP1131107A4 (en) ANTISENSE MODULATION OF THE EXPRESSION OF INHIBITOR-KAPPA-B-KINASE-ALPHA
EP1131332A4 (en) ANTISENSE MODULATION OF THE INHIBITOR KAPPA B KINASE-BETA EXPRESSION
GR3019911T3 (en) Enhancement of ribozyme catalytic activity by a neighboring facilitator oligonucleotide.
EP1250347A4 (en) ANTISENSE MODULATION OF THE AKT-3 EXPRESSION
EP1163373A4 (en) ANTISENSE MODULATION OF THE CELLULAR INHIBITANT OF THE APOPTOSIS EXPRESSION
EP1066312A4 (en) HAMMER HEAD RIBOZYMES AND THEIR DERIVATIVES AS CIRCULAR, HAIRPIN, CIRCULAR / HAIRPIN, LASSO, HAIRPIN / LASSO
Ueno et al. Nucleosides and Nucleotides. 208. Alternate-Strand Triple-Helix Formation by the 3 ‘-3 ‘-Linked Oligodeoxynucleotides with the Anthraquinonyl Group at the Junction Point
EP1173458A4 (en) ANTINSENS MODULATION OF THE SRA EXPRESSION