ATE443161T1 - Mittel und verfahren für den nachweis von methylierter dna - Google Patents
Mittel und verfahren für den nachweis von methylierter dnaInfo
- Publication number
- ATE443161T1 ATE443161T1 AT05810547T AT05810547T ATE443161T1 AT E443161 T1 ATE443161 T1 AT E443161T1 AT 05810547 T AT05810547 T AT 05810547T AT 05810547 T AT05810547 T AT 05810547T AT E443161 T1 ATE443161 T1 AT E443161T1
- Authority
- AT
- Austria
- Prior art keywords
- nucleic acid
- polypeptide
- acid molecule
- present application
- methods
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 3
- 229920001184 polypeptide Polymers 0.000 abstract 6
- 102000004196 processed proteins & peptides Human genes 0.000 abstract 6
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 6
- 108020004707 nucleic acids Proteins 0.000 abstract 4
- 102000039446 nucleic acids Human genes 0.000 abstract 4
- 150000007523 nucleic acids Chemical class 0.000 abstract 4
- 210000004027 cell Anatomy 0.000 abstract 2
- 102000031635 methyl-CpG binding proteins Human genes 0.000 abstract 2
- 108091009877 methyl-CpG binding proteins Proteins 0.000 abstract 2
- 239000000203 mixture Substances 0.000 abstract 2
- 239000013598 vector Substances 0.000 abstract 2
- 230000004568 DNA-binding Effects 0.000 abstract 1
- 230000001588 bifunctional effect Effects 0.000 abstract 1
- 230000027455 binding Effects 0.000 abstract 1
- 239000002773 nucleotide Substances 0.000 abstract 1
- 125000003729 nucleotide group Chemical group 0.000 abstract 1
- 102000004169 proteins and genes Human genes 0.000 abstract 1
- 108090000623 proteins and genes Proteins 0.000 abstract 1
- 210000004881 tumor cell Anatomy 0.000 abstract 1
Classifications
-
- H—ELECTRICITY
- H04—ELECTRIC COMMUNICATION TECHNIQUE
- H04N—PICTORIAL COMMUNICATION, e.g. TELEVISION
- H04N21/00—Selective content distribution, e.g. interactive television or video on demand [VOD]
- H04N21/20—Servers specifically adapted for the distribution of content, e.g. VOD servers; Operations thereof
- H04N21/23—Processing of content or additional data; Elementary server operations; Server middleware
- H04N21/24—Monitoring of processes or resources, e.g. monitoring of server load, available bandwidth, upstream requests
- H04N21/2402—Monitoring of the downstream path of the transmission network, e.g. bandwidth available
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
- C07K14/4702—Regulators; Modulating activity
- C07K14/4703—Inhibitors; Suppressors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
- C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
-
- H—ELECTRICITY
- H04—ELECTRIC COMMUNICATION TECHNIQUE
- H04N—PICTORIAL COMMUNICATION, e.g. TELEVISION
- H04N21/00—Selective content distribution, e.g. interactive television or video on demand [VOD]
- H04N21/20—Servers specifically adapted for the distribution of content, e.g. VOD servers; Operations thereof
- H04N21/23—Processing of content or additional data; Elementary server operations; Server middleware
- H04N21/24—Monitoring of processes or resources, e.g. monitoring of server load, available bandwidth, upstream requests
- H04N21/2401—Monitoring of the client buffer
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/52—Constant or Fc region; Isotype
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/20—Fusion polypeptide containing a tag with affinity for a non-protein ligand
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/80—Fusion polypeptide containing a DNA binding domain, e.g. Lacl or Tet-repressor
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2537/00—Reactions characterised by the reaction format or use of a specific feature
- C12Q2537/10—Reactions characterised by the reaction format or use of a specific feature the purpose or use of
- C12Q2537/164—Methylation detection other then bisulfite or methylation sensitive restriction endonucleases
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Zoology (AREA)
- Medicinal Chemistry (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Wood Science & Technology (AREA)
- Analytical Chemistry (AREA)
- Pathology (AREA)
- Immunology (AREA)
- Multimedia (AREA)
- Signal Processing (AREA)
- Gastroenterology & Hepatology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Toxicology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Microbiology (AREA)
- Physics & Mathematics (AREA)
- Biotechnology (AREA)
- Oncology (AREA)
- Hospice & Palliative Care (AREA)
- General Engineering & Computer Science (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP04028267 | 2004-11-29 | ||
| PCT/EP2005/012707 WO2006056480A2 (en) | 2004-11-29 | 2005-11-28 | Means and methods for detecting methylated dna |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE443161T1 true ATE443161T1 (de) | 2009-10-15 |
Family
ID=34927572
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT05810547T ATE443161T1 (de) | 2004-11-29 | 2005-11-28 | Mittel und verfahren für den nachweis von methylierter dna |
Country Status (9)
| Country | Link |
|---|---|
| US (4) | US9074013B2 (de) |
| EP (1) | EP1817430B1 (de) |
| JP (2) | JP5149013B2 (de) |
| CN (1) | CN101243191B (de) |
| AT (1) | ATE443161T1 (de) |
| AU (1) | AU2005308918B2 (de) |
| CA (1) | CA2589487C (de) |
| DE (1) | DE602005016712D1 (de) |
| WO (1) | WO2006056480A2 (de) |
Families Citing this family (101)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20210371901A1 (en) * | 2004-11-29 | 2021-12-02 | Sequenom, Inc. | Kits and Methods for Detecting Methylated DNA |
| JP5149013B2 (ja) | 2004-11-29 | 2013-02-20 | セクエノム,インコーポレイティド | メチル化dnaを検出する手段、及び方法 |
| US9249464B2 (en) | 2004-11-29 | 2016-02-02 | Sequenom, Inc. | Kits and methods for detecting methylated DNA |
| EP3617321B1 (de) | 2006-05-31 | 2024-10-23 | Sequenom, Inc. | Kit zur nukleinsäureextraktion und -verstärkung aus einer probe |
| US7902345B2 (en) | 2006-12-05 | 2011-03-08 | Sequenom, Inc. | Detection and quantification of biomolecules using mass spectrometry |
| US8652780B2 (en) | 2007-03-26 | 2014-02-18 | Sequenom, Inc. | Restriction endonuclease enhanced polymorphic sequence detection |
| JP5211790B2 (ja) * | 2007-03-26 | 2013-06-12 | 住友化学株式会社 | Dnaメチル化測定方法 |
| WO2009032781A2 (en) | 2007-08-29 | 2009-03-12 | Sequenom, Inc. | Methods and compositions for universal size-specific polymerase chain reaction |
| US7888127B2 (en) | 2008-01-15 | 2011-02-15 | Sequenom, Inc. | Methods for reducing adduct formation for mass spectrometry analysis |
| WO2009120808A2 (en) | 2008-03-26 | 2009-10-01 | Sequenom, Inc. | Restriction endonuclease enhanced polymorphic sequence detection |
| CN102089444A (zh) | 2008-05-14 | 2011-06-08 | 德玛泰克国际公司 | 利用核酸分析方法来诊断黑素瘤和太阳能雀斑 |
| EP3103871B1 (de) | 2008-09-16 | 2020-07-29 | Sequenom, Inc. | Verfahren zur methylierungsbasierten anreicherung fetaler nukleinsäure aus einer mütterlichen probe für fetale nukleinsäure quantifizierung |
| US8476013B2 (en) * | 2008-09-16 | 2013-07-02 | Sequenom, Inc. | Processes and compositions for methylation-based acid enrichment of fetal nucleic acid from a maternal sample useful for non-invasive prenatal diagnoses |
| US8962247B2 (en) | 2008-09-16 | 2015-02-24 | Sequenom, Inc. | Processes and compositions for methylation-based enrichment of fetal nucleic acid from a maternal sample useful for non invasive prenatal diagnoses |
| EP3514244B1 (de) | 2009-04-03 | 2021-07-07 | Sequenom, Inc. | Verfahren für die herstellung von nukleinsäuren |
| CN101906414B (zh) * | 2009-06-03 | 2012-12-26 | 博尔诚(北京)科技有限公司 | 甲基化dna的浓缩方法和检测方法以及试剂盒 |
| EP2484698A4 (de) * | 2009-09-28 | 2014-07-02 | Sysmex Corp | Hybridome zur produktion von antikörpern gegen methylierte dna und verwendung davon |
| JP5854464B2 (ja) * | 2009-10-16 | 2016-02-09 | 国立研究開発法人理化学研究所 | メチル化dna結合ペプチド |
| ES2577017T3 (es) | 2009-12-22 | 2016-07-12 | Sequenom, Inc. | Procedimientos y kits para identificar la aneuploidia |
| WO2011092592A2 (en) | 2010-01-26 | 2011-08-04 | Nipd Genetics Ltd | Methods and compositions for noninvasive prenatal diagnosis of fetal aneuploidies |
| JP5492696B2 (ja) * | 2010-07-26 | 2014-05-14 | 大屋敷 一馬 | 一分子蛍光分析法によるdnaのメチル化度の決定方法 |
| JP5832760B2 (ja) * | 2011-02-28 | 2015-12-16 | シスメックス株式会社 | 試料中のメチル化dnaを検出する方法 |
| US9145580B2 (en) * | 2011-04-02 | 2015-09-29 | New England Biolabs, Inc. | Methods and compositions for enriching either target polynucleotides or non-target polynucleotides from a mixture of target and non-target polynucleotides |
| US8980553B2 (en) | 2011-04-02 | 2015-03-17 | New England Biolabs, Inc. | Methods and compositions for enriching either target polynucleotides or non-target polynucleotides from a mixture of target and non-target polynucleotides |
| KR101274765B1 (ko) * | 2011-04-27 | 2013-06-14 | 피씨엘 (주) | 바이오칩 제조용 졸-겔 키트 및 이를 이용한 바이오 칩의 제조방법 |
| US8951736B2 (en) | 2011-04-29 | 2015-02-10 | Sequenom, Inc. | Multimer glycosylated nucleic acid binding protein conjugates and uses thereof |
| US20140235474A1 (en) | 2011-06-24 | 2014-08-21 | Sequenom, Inc. | Methods and processes for non invasive assessment of a genetic variation |
| JP6073902B2 (ja) | 2011-10-06 | 2017-02-01 | セクエノム, インコーポレイテッド | 遺伝的変異の非侵襲的評価のための方法およびプロセス |
| WO2013052907A2 (en) | 2011-10-06 | 2013-04-11 | Sequenom, Inc. | Methods and processes for non-invasive assessment of genetic variations |
| US9367663B2 (en) | 2011-10-06 | 2016-06-14 | Sequenom, Inc. | Methods and processes for non-invasive assessment of genetic variations |
| US9984198B2 (en) | 2011-10-06 | 2018-05-29 | Sequenom, Inc. | Reducing sequence read count error in assessment of complex genetic variations |
| US10424394B2 (en) | 2011-10-06 | 2019-09-24 | Sequenom, Inc. | Methods and processes for non-invasive assessment of genetic variations |
| US10196681B2 (en) | 2011-10-06 | 2019-02-05 | Sequenom, Inc. | Methods and processes for non-invasive assessment of genetic variations |
| ES2624686T3 (es) | 2011-10-11 | 2017-07-17 | Sequenom, Inc. | Métodos y procesos para la evaluación no invasiva de variaciones genéticas |
| US8688388B2 (en) | 2011-10-11 | 2014-04-01 | Sequenom, Inc. | Methods and processes for non-invasive assessment of genetic variations |
| CA2861856C (en) | 2012-01-20 | 2020-06-02 | Sequenom, Inc. | Diagnostic processes that factor experimental conditions |
| EP2820129A1 (de) | 2012-03-02 | 2015-01-07 | Sequenom, Inc. | Verfahren und prozesse zur nichtinvasiven beurteilung genetischer variationen |
| WO2013131083A1 (en) | 2012-03-02 | 2013-09-06 | Winthrop-University Hospital | METHOD FOR USING PROBE BASED PCR DETECTION TO MEASURE THE LEVELS OF CIRCULATING DEMETHYLATED β CELL DERIVED DNA AS A MEASURE OF β CELL LOSS IN DIABETES |
| US10504613B2 (en) | 2012-12-20 | 2019-12-10 | Sequenom, Inc. | Methods and processes for non-invasive assessment of genetic variations |
| US9920361B2 (en) | 2012-05-21 | 2018-03-20 | Sequenom, Inc. | Methods and compositions for analyzing nucleic acid |
| EP3978621B1 (de) | 2012-05-21 | 2023-08-30 | Sequenom, Inc. | Verfahren und prozesse zur nichtinvasiven beurteilung genetischer variationen |
| AU2012380717B2 (en) | 2012-05-24 | 2018-08-16 | Fundacio Institucio Catalana De Recerca I Estudis Avancats | Method for the identification of the origin of a cancer of unknown primary origin by methylation analysis |
| US10497461B2 (en) | 2012-06-22 | 2019-12-03 | Sequenom, Inc. | Methods and processes for non-invasive assessment of genetic variations |
| US20140093873A1 (en) | 2012-07-13 | 2014-04-03 | Sequenom, Inc. | Processes and compositions for methylation-based enrichment of fetal nucleic acid from a maternal sample useful for non-invasive prenatal diagnoses |
| US10482994B2 (en) | 2012-10-04 | 2019-11-19 | Sequenom, Inc. | Methods and processes for non-invasive assessment of genetic variations |
| CA3120521A1 (en) | 2012-10-04 | 2014-04-10 | Sequenom, Inc. | Methods and processes for non-invasive assessment of genetic variations |
| EP2746403A1 (de) * | 2012-12-21 | 2014-06-25 | Life Science Inkubator GmbH & Co. KG | Verfahren zur Bestimmung des DNA-Methylierungsgrades |
| US20130309666A1 (en) | 2013-01-25 | 2013-11-21 | Sequenom, Inc. | Methods and processes for non-invasive assessment of genetic variations |
| US20140235484A1 (en) * | 2013-02-19 | 2014-08-21 | The Johns Hopkins University | Methods for detection and differentiation of origin of viral dna |
| US20130189684A1 (en) | 2013-03-12 | 2013-07-25 | Sequenom, Inc. | Quantification of cell-specific nucleic acid markers |
| US9305756B2 (en) | 2013-03-13 | 2016-04-05 | Agena Bioscience, Inc. | Preparation enhancements and methods of use for MALDI mass spectrometry |
| US11060145B2 (en) | 2013-03-13 | 2021-07-13 | Sequenom, Inc. | Methods and compositions for identifying presence or absence of hypermethylation or hypomethylation locus |
| US10930368B2 (en) | 2013-04-03 | 2021-02-23 | Sequenom, Inc. | Methods and processes for non-invasive assessment of genetic variations |
| KR102665592B1 (ko) | 2013-05-24 | 2024-05-21 | 시쿼넘, 인코포레이티드 | 유전적 변이의 비침습 평가를 위한 방법 및 프로세스 |
| ES3037160T3 (en) | 2013-06-21 | 2025-09-29 | Sequenom Inc | Methods and processes for non-invasive assessment of genetic variations |
| EP3936222A1 (de) * | 2013-08-30 | 2022-01-12 | University of Washington through its Center for Commercialization | Selektive modifizierung von polymeruntereinheiten zur verbesserung von nanoporenbasierter analyse |
| KR102384620B1 (ko) | 2013-10-04 | 2022-04-11 | 시쿼넘, 인코포레이티드 | 유전적 변이의 비침습 평가를 위한 방법 및 프로세스 |
| CN105874082B (zh) | 2013-10-07 | 2020-06-02 | 塞昆纳姆股份有限公司 | 用于非侵入性评估染色体改变的方法和过程 |
| EP3736344A1 (de) | 2014-03-13 | 2020-11-11 | Sequenom, Inc. | Verfahren und prozesse zur nichtinvasiven beurteilung genetischer variationen |
| EP3149640B1 (de) | 2014-05-30 | 2019-09-04 | Sequenom, Inc. | Chromosomendarstellungsbestimmungen |
| US11783911B2 (en) | 2014-07-30 | 2023-10-10 | Sequenom, Inc | Methods and processes for non-invasive assessment of genetic variations |
| EP3730629A1 (de) | 2014-10-10 | 2020-10-28 | Sequenom, Inc. | Verfahren und prozesse zur nichtinvasiven beurteilung genetischer variationen |
| US9984201B2 (en) | 2015-01-18 | 2018-05-29 | Youhealth Biotech, Limited | Method and system for determining cancer status |
| EP3666902B1 (de) | 2015-05-22 | 2024-07-03 | Medicover Public Co Ltd | Multiplexierte parallelanalyse von gezielten genomregionen für nicht-invasive pränatale tests |
| EP4043581A1 (de) | 2016-05-27 | 2022-08-17 | Sequenom, Inc. | Verfahren zur erzeugung eines paralog assay systems |
| US10202650B2 (en) | 2016-05-31 | 2019-02-12 | Youhealth Biotech, Limited | Methods for monitoring ELOVL2, KLF14 and PENK gene expression following treatment with vitamin C |
| EP3481941A4 (de) | 2016-07-06 | 2020-04-15 | Youhealth Biotech, Limited | Methylierungsmarker für brust- und ovarialkrebs und deren verwendung |
| US10093986B2 (en) | 2016-07-06 | 2018-10-09 | Youhealth Biotech, Limited | Leukemia methylation markers and uses thereof |
| WO2018009696A1 (en) | 2016-07-06 | 2018-01-11 | Youhealth Biotech, Limited | Colon cancer methylation markers and uses thereof |
| CN113151458A (zh) | 2016-07-06 | 2021-07-23 | 优美佳肿瘤技术有限公司 | 实体瘤甲基化标志物及其用途 |
| WO2018009705A1 (en) | 2016-07-06 | 2018-01-11 | Youhealth Biotech, Limited | Liver cancer methylation markers and uses thereof |
| JP7048105B2 (ja) | 2016-07-15 | 2022-04-05 | ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア | 核酸ライブラリを生成する方法 |
| CA3030894A1 (en) | 2016-07-27 | 2018-02-01 | Sequenom, Inc. | Methods for non-invasive assessment of genomic instability |
| CA3030890A1 (en) | 2016-07-27 | 2018-02-01 | Sequenom, Inc. | Genetic copy number alteration classifications |
| CA3049457C (en) | 2017-01-20 | 2023-05-16 | Sequenom, Inc. | Methods for non-invasive assessment of copy number alterations |
| CA3049455C (en) | 2017-01-20 | 2023-06-13 | Sequenom, Inc. | Sequencing adapter manufacture and use |
| CA3049682C (en) | 2017-01-20 | 2023-06-27 | Sequenom, Inc. | Methods for non-invasive assessment of genetic alterations |
| CA3207879A1 (en) | 2017-01-24 | 2018-08-02 | Sequenom, Inc. | Methods and processes for assessment of genetic variations |
| US10465187B2 (en) | 2017-02-06 | 2019-11-05 | Trustees Of Boston University | Integrated system for programmable DNA methylation |
| BR112019018272A2 (pt) | 2017-03-02 | 2020-07-28 | Youhealth Oncotech, Limited | marcadores metilação para diagnosticar hepatocelular carcinoma e câncer |
| JP7370862B2 (ja) | 2017-03-17 | 2023-10-30 | セクエノム, インコーポレイテッド | 遺伝子モザイク症のための方法およびプロセス |
| CN106951729A (zh) * | 2017-03-19 | 2017-07-14 | 中国海洋大学 | 一种利用细胞器基因组的同源模块进行系统发生分析的方法 |
| US11433074B2 (en) | 2017-06-22 | 2022-09-06 | Triact Therapeutics, Inc. | Methods of treating glioblastoma |
| EP3687501A4 (de) | 2017-09-29 | 2021-06-23 | Triact Therapeutics, Inc. | Iniparib-formulierungen und verwendungen davon |
| AU2019207900B2 (en) | 2018-01-12 | 2025-07-10 | Claret Bioscience, Llc | Methods and compositions for analyzing nucleic acid |
| CA3090785A1 (en) | 2018-02-14 | 2019-08-22 | John Daniel Dobak Iii | Novel gene classifiers and uses thereof in non-melanoma skin cancers |
| WO2019236726A1 (en) | 2018-06-06 | 2019-12-12 | The Regents Of The University Of California | Methods of producing nucleic acid libraries and compositions and kits for practicing same |
| JP2022524641A (ja) | 2019-03-26 | 2022-05-09 | ダームテック,インク. | 皮膚癌における新規な遺伝子分類子とその使用 |
| WO2020206143A1 (en) | 2019-04-05 | 2020-10-08 | Claret Bioscience, Llc | Methods and compositions for analyzing nucleic acid |
| US11891653B2 (en) | 2019-09-30 | 2024-02-06 | Guardant Health, Inc. | Compositions and methods for analyzing cell-free DNA in methylation partitioning assays |
| AU2020363787A1 (en) | 2019-10-09 | 2022-04-21 | Claret Bioscience, Llc | Methods and compositions for analyzing nucleic acid |
| CA3159786A1 (en) | 2019-10-31 | 2021-05-06 | Sequenom, Inc. | Application of mosaicism ratio in multifetal gestations and personalized risk assessment |
| EP4617375A3 (de) * | 2019-11-26 | 2025-10-29 | Guardant Health, Inc. | Verfahren, zusammensetzungen und systeme zur verbesserung der bindung methylierter polynukleotide |
| EP4428244B1 (de) | 2020-06-24 | 2025-10-15 | Claret Bioscience, LLC | Verfahren und zusammensetzungen zur analyse von nukleinsäuren |
| WO2022076574A1 (en) | 2020-10-08 | 2022-04-14 | Claret Bioscience, Llc | Methods and compositions for analyzing nucleic acid |
| JP2023547620A (ja) | 2020-10-23 | 2023-11-13 | ガーダント ヘルス, インコーポレイテッド | 分配および塩基変換を使用してdnaを解析するための組成物および方法 |
| IL293201B2 (en) * | 2022-05-22 | 2023-04-01 | Nucleix Ltd | Preparations contain a reaction buffer for DNA amplification and sequencing |
| WO2024186778A1 (en) | 2023-03-03 | 2024-09-12 | Laboratory Corporation Of America Holdings | Methods and systems for positive cfdna screening on genetic variations using mosaicism ratio |
| EP4713926A1 (de) | 2023-05-15 | 2026-03-25 | Laboratory Corporation of America Holdings | Maschinenlernansätze zum pan-krebs-screening in der gesamtgenomsequenzierung |
| CN117003850B (zh) * | 2023-09-19 | 2024-04-12 | 汲迈生命科技(苏州)有限公司 | 一种甲基化富集蛋白及其编码基因、制备方法和应用 |
| CN117965739A (zh) * | 2024-02-21 | 2024-05-03 | 中山大学附属第一医院 | 用于宫颈癌相关基因甲基化检测的标志物、引物组合及其应用 |
Family Cites Families (29)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4116638A (en) * | 1977-03-03 | 1978-09-26 | Warner-Lambert Company | Immunoassay device |
| US5175086A (en) * | 1983-01-24 | 1992-12-29 | Olympus Optical Co., Ltd. | Method for effecting heterogeneous immunological analysis |
| JPH0614048B2 (ja) | 1983-02-14 | 1994-02-23 | オリンパス光学工業株式会社 | 酵素免疫学的自動分析装置 |
| US4608231A (en) * | 1984-12-12 | 1986-08-26 | Becton, Dickinson And Company | Self-contained reagent package device for an assay |
| JPS61292556A (ja) | 1985-06-20 | 1986-12-23 | Green Cross Corp:The | 酵素免疫測定方法およびキツト |
| EP0322102A3 (de) | 1987-11-30 | 1990-06-13 | McCue, John P. | Verfahren und Fangtests für Antigene und dafür geeignete Verbindungen |
| JPH04136762A (ja) | 1990-09-28 | 1992-05-11 | Hitachi Ltd | イムノアッセイ用反応容器 |
| DE4037837A1 (de) * | 1990-11-28 | 1992-06-04 | Behringwerke Ag | Zellfreie rezeptorbindungsteste, ihre herstellung und verwendung |
| US5399500A (en) * | 1992-06-26 | 1995-03-21 | Becton Dickinson And Company | Two step process for coating of antibodies to a solid phase |
| US5441895A (en) * | 1993-12-07 | 1995-08-15 | Jakubowicz; Raymond F. | Reagent cup shape allowing stacking without dislodging reagent |
| FR2733165B1 (fr) * | 1995-04-20 | 1997-06-13 | Inst Francais Du Petrole | Carbonates alcalins ou alcalino-terreux colloidaux contenant un compose de calcium,de phospore et de soufre sous forme miscellisee |
| CA2315251A1 (en) | 1997-12-17 | 1999-06-24 | Immunex Corporation | Cell surface glycoproteins associated with human b cell lymphomas - ulbp, dna and polypeptides |
| ES2312205T3 (es) | 1998-03-10 | 2009-02-16 | Genentech, Inc. | Nuevo polipeptido y acidos nucleicos que lo codifican. |
| US6927024B2 (en) * | 1998-11-30 | 2005-08-09 | Genentech, Inc. | PCR assay |
| DE19941756B4 (de) | 1999-09-02 | 2013-05-16 | Christof Niemeyer | Verfahren zur Verwendung von oligomeren Nucleinsäure-Protein-Konjugaten als Reagenzien für immunologische Nachweisverfahren insbesondere die Immuno-PCR |
| JP2005500806A (ja) * | 2000-09-15 | 2005-01-13 | コーリー ファーマシューティカル ゲーエムベーハー | CpGに基づく免疫アゴニスト/免疫アンタゴニストの高スループットスクリーニングのためのプロセス |
| CA2477043A1 (en) | 2001-02-27 | 2002-09-06 | Eos Biotechnology, Inc. | Novel methods of diagnosis of metastatic colorectal cancer, compositions and methods of screening for modulators of metastatic colorectal cancer |
| DE10112515B4 (de) | 2001-03-09 | 2004-02-12 | Epigenomics Ag | Verfahren zum Nachweis von Cytosin-Methylierungsmustern mit hoher Sensitivität |
| US20020197639A1 (en) | 2001-06-08 | 2002-12-26 | Shia Michael A. | Methods and products for analyzing nucleic acids based on methylation status |
| JP2003125766A (ja) | 2001-10-24 | 2003-05-07 | Toray Res Center:Kk | 抗5−メチル−2’−デオキシシチジン抗体および5−メチル−2’−デオキシシチジンの測定法 |
| US6783759B2 (en) * | 2002-03-27 | 2004-08-31 | Trustees Of The University Of Pennsylvania | Compositions and methods for modulating variola virus |
| EP1541668A4 (de) | 2002-06-17 | 2008-08-06 | Prec System Science Co Ltd | REAKTIONSGEFûSS UND REAKTIONSPRODUKT-EXTRAKTIONSVORRICHTUNG |
| GB0230203D0 (en) * | 2002-12-27 | 2003-02-05 | Domantis Ltd | Fc fusion |
| AU2003900368A0 (en) | 2003-01-24 | 2003-02-13 | Human Genetic Signatures Pty Ltd | Assay for nucleic acid molecules |
| GB0423991D0 (en) | 2004-10-29 | 2004-12-01 | Univ Edinburgh | Applications of nucleic acid fragments |
| US9249464B2 (en) | 2004-11-29 | 2016-02-02 | Sequenom, Inc. | Kits and methods for detecting methylated DNA |
| JP5149013B2 (ja) * | 2004-11-29 | 2013-02-20 | セクエノム,インコーポレイティド | メチル化dnaを検出する手段、及び方法 |
| DE102005034628B4 (de) | 2005-07-19 | 2007-08-23 | Epigenomics Ag | Verfahren zur Untersuchung von Cytosin-Methylierungen in DNA |
| US7906288B2 (en) * | 2006-01-04 | 2011-03-15 | The Johns Hopkins University | Compare-MS: method rapid, sensitive and accurate detection of DNA methylation |
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2005
- 2005-11-28 JP JP2007541869A patent/JP5149013B2/ja not_active Expired - Lifetime
- 2005-11-28 EP EP05810547A patent/EP1817430B1/de not_active Expired - Lifetime
- 2005-11-28 AU AU2005308918A patent/AU2005308918B2/en not_active Expired
- 2005-11-28 WO PCT/EP2005/012707 patent/WO2006056480A2/en not_active Ceased
- 2005-11-28 US US11/569,051 patent/US9074013B2/en active Active
- 2005-11-28 AT AT05810547T patent/ATE443161T1/de not_active IP Right Cessation
- 2005-11-28 CA CA2589487A patent/CA2589487C/en not_active Expired - Lifetime
- 2005-11-28 DE DE602005016712T patent/DE602005016712D1/de not_active Expired - Lifetime
- 2005-11-28 CN CN200580047175.7A patent/CN101243191B/zh not_active Expired - Lifetime
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- 2012-09-24 JP JP2012209790A patent/JP2013027399A/ja active Pending
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- 2018-01-22 US US15/876,844 patent/US20180220176A1/en not_active Abandoned
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| Publication number | Publication date |
|---|---|
| CN101243191A (zh) | 2008-08-13 |
| US20180220176A1 (en) | 2018-08-02 |
| EP1817430A2 (de) | 2007-08-15 |
| JP5149013B2 (ja) | 2013-02-20 |
| JP2008521389A (ja) | 2008-06-26 |
| DE602005016712D1 (de) | 2009-10-29 |
| AU2005308918A1 (en) | 2006-06-01 |
| WO2006056480A3 (en) | 2008-03-27 |
| WO2006056480A2 (en) | 2006-06-01 |
| US9074013B2 (en) | 2015-07-07 |
| JP2013027399A (ja) | 2013-02-07 |
| AU2005308918B2 (en) | 2012-09-27 |
| CN101243191B (zh) | 2014-04-16 |
| US9873919B2 (en) | 2018-01-23 |
| US20150267263A1 (en) | 2015-09-24 |
| EP1817430B1 (de) | 2009-09-16 |
| CA2589487C (en) | 2014-07-29 |
| US20210337252A1 (en) | 2021-10-28 |
| CA2589487A1 (en) | 2006-06-01 |
| US20080260743A1 (en) | 2008-10-23 |
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