ATE443161T1 - Mittel und verfahren für den nachweis von methylierter dna - Google Patents

Mittel und verfahren für den nachweis von methylierter dna

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Publication number
ATE443161T1
ATE443161T1 AT05810547T AT05810547T ATE443161T1 AT E443161 T1 ATE443161 T1 AT E443161T1 AT 05810547 T AT05810547 T AT 05810547T AT 05810547 T AT05810547 T AT 05810547T AT E443161 T1 ATE443161 T1 AT E443161T1
Authority
AT
Austria
Prior art keywords
nucleic acid
polypeptide
acid molecule
present application
methods
Prior art date
Application number
AT05810547T
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English (en)
Inventor
Michael Rehli
Original Assignee
Univ Regensburg Klinikum
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Application granted granted Critical
Publication of ATE443161T1 publication Critical patent/ATE443161T1/de

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    • HELECTRICITY
    • H04ELECTRIC COMMUNICATION TECHNIQUE
    • H04NPICTORIAL COMMUNICATION, e.g. TELEVISION
    • H04N21/00Selective content distribution, e.g. interactive television or video on demand [VOD]
    • H04N21/20Servers specifically adapted for the distribution of content, e.g. VOD servers; Operations thereof
    • H04N21/23Processing of content or additional data; Elementary server operations; Server middleware
    • H04N21/24Monitoring of processes or resources, e.g. monitoring of server load, available bandwidth, upstream requests
    • H04N21/2402Monitoring of the downstream path of the transmission network, e.g. bandwidth available
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4702Regulators; Modulating activity
    • C07K14/4703Inhibitors; Suppressors
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C12Q1/6886Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
    • HELECTRICITY
    • H04ELECTRIC COMMUNICATION TECHNIQUE
    • H04NPICTORIAL COMMUNICATION, e.g. TELEVISION
    • H04N21/00Selective content distribution, e.g. interactive television or video on demand [VOD]
    • H04N21/20Servers specifically adapted for the distribution of content, e.g. VOD servers; Operations thereof
    • H04N21/23Processing of content or additional data; Elementary server operations; Server middleware
    • H04N21/24Monitoring of processes or resources, e.g. monitoring of server load, available bandwidth, upstream requests
    • H04N21/2401Monitoring of the client buffer
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/50Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52Constant or Fc region; Isotype
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2319/00Fusion polypeptide
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2319/00Fusion polypeptide
    • C07K2319/20Fusion polypeptide containing a tag with affinity for a non-protein ligand
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2319/00Fusion polypeptide
    • C07K2319/30Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2319/00Fusion polypeptide
    • C07K2319/80Fusion polypeptide containing a DNA binding domain, e.g. Lacl or Tet-repressor
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2537/00Reactions characterised by the reaction format or use of a specific feature
    • C12Q2537/10Reactions characterised by the reaction format or use of a specific feature the purpose or use of
    • C12Q2537/164Methylation detection other then bisulfite or methylation sensitive restriction endonucleases

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Medicinal Chemistry (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Wood Science & Technology (AREA)
  • Analytical Chemistry (AREA)
  • Pathology (AREA)
  • Immunology (AREA)
  • Multimedia (AREA)
  • Signal Processing (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Toxicology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Biotechnology (AREA)
  • Oncology (AREA)
  • Hospice & Palliative Care (AREA)
  • General Engineering & Computer Science (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
AT05810547T 2004-11-29 2005-11-28 Mittel und verfahren für den nachweis von methylierter dna ATE443161T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP04028267 2004-11-29
PCT/EP2005/012707 WO2006056480A2 (en) 2004-11-29 2005-11-28 Means and methods for detecting methylated dna

Publications (1)

Publication Number Publication Date
ATE443161T1 true ATE443161T1 (de) 2009-10-15

Family

ID=34927572

Family Applications (1)

Application Number Title Priority Date Filing Date
AT05810547T ATE443161T1 (de) 2004-11-29 2005-11-28 Mittel und verfahren für den nachweis von methylierter dna

Country Status (9)

Country Link
US (4) US9074013B2 (de)
EP (1) EP1817430B1 (de)
JP (2) JP5149013B2 (de)
CN (1) CN101243191B (de)
AT (1) ATE443161T1 (de)
AU (1) AU2005308918B2 (de)
CA (1) CA2589487C (de)
DE (1) DE602005016712D1 (de)
WO (1) WO2006056480A2 (de)

Families Citing this family (101)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20210371901A1 (en) * 2004-11-29 2021-12-02 Sequenom, Inc. Kits and Methods for Detecting Methylated DNA
JP5149013B2 (ja) 2004-11-29 2013-02-20 セクエノム,インコーポレイティド メチル化dnaを検出する手段、及び方法
US9249464B2 (en) 2004-11-29 2016-02-02 Sequenom, Inc. Kits and methods for detecting methylated DNA
EP3617321B1 (de) 2006-05-31 2024-10-23 Sequenom, Inc. Kit zur nukleinsäureextraktion und -verstärkung aus einer probe
US7902345B2 (en) 2006-12-05 2011-03-08 Sequenom, Inc. Detection and quantification of biomolecules using mass spectrometry
US8652780B2 (en) 2007-03-26 2014-02-18 Sequenom, Inc. Restriction endonuclease enhanced polymorphic sequence detection
JP5211790B2 (ja) * 2007-03-26 2013-06-12 住友化学株式会社 Dnaメチル化測定方法
WO2009032781A2 (en) 2007-08-29 2009-03-12 Sequenom, Inc. Methods and compositions for universal size-specific polymerase chain reaction
US7888127B2 (en) 2008-01-15 2011-02-15 Sequenom, Inc. Methods for reducing adduct formation for mass spectrometry analysis
WO2009120808A2 (en) 2008-03-26 2009-10-01 Sequenom, Inc. Restriction endonuclease enhanced polymorphic sequence detection
CN102089444A (zh) 2008-05-14 2011-06-08 德玛泰克国际公司 利用核酸分析方法来诊断黑素瘤和太阳能雀斑
EP3103871B1 (de) 2008-09-16 2020-07-29 Sequenom, Inc. Verfahren zur methylierungsbasierten anreicherung fetaler nukleinsäure aus einer mütterlichen probe für fetale nukleinsäure quantifizierung
US8476013B2 (en) * 2008-09-16 2013-07-02 Sequenom, Inc. Processes and compositions for methylation-based acid enrichment of fetal nucleic acid from a maternal sample useful for non-invasive prenatal diagnoses
US8962247B2 (en) 2008-09-16 2015-02-24 Sequenom, Inc. Processes and compositions for methylation-based enrichment of fetal nucleic acid from a maternal sample useful for non invasive prenatal diagnoses
EP3514244B1 (de) 2009-04-03 2021-07-07 Sequenom, Inc. Verfahren für die herstellung von nukleinsäuren
CN101906414B (zh) * 2009-06-03 2012-12-26 博尔诚(北京)科技有限公司 甲基化dna的浓缩方法和检测方法以及试剂盒
EP2484698A4 (de) * 2009-09-28 2014-07-02 Sysmex Corp Hybridome zur produktion von antikörpern gegen methylierte dna und verwendung davon
JP5854464B2 (ja) * 2009-10-16 2016-02-09 国立研究開発法人理化学研究所 メチル化dna結合ペプチド
ES2577017T3 (es) 2009-12-22 2016-07-12 Sequenom, Inc. Procedimientos y kits para identificar la aneuploidia
WO2011092592A2 (en) 2010-01-26 2011-08-04 Nipd Genetics Ltd Methods and compositions for noninvasive prenatal diagnosis of fetal aneuploidies
JP5492696B2 (ja) * 2010-07-26 2014-05-14 大屋敷 一馬 一分子蛍光分析法によるdnaのメチル化度の決定方法
JP5832760B2 (ja) * 2011-02-28 2015-12-16 シスメックス株式会社 試料中のメチル化dnaを検出する方法
US9145580B2 (en) * 2011-04-02 2015-09-29 New England Biolabs, Inc. Methods and compositions for enriching either target polynucleotides or non-target polynucleotides from a mixture of target and non-target polynucleotides
US8980553B2 (en) 2011-04-02 2015-03-17 New England Biolabs, Inc. Methods and compositions for enriching either target polynucleotides or non-target polynucleotides from a mixture of target and non-target polynucleotides
KR101274765B1 (ko) * 2011-04-27 2013-06-14 피씨엘 (주) 바이오칩 제조용 졸-겔 키트 및 이를 이용한 바이오 칩의 제조방법
US8951736B2 (en) 2011-04-29 2015-02-10 Sequenom, Inc. Multimer glycosylated nucleic acid binding protein conjugates and uses thereof
US20140235474A1 (en) 2011-06-24 2014-08-21 Sequenom, Inc. Methods and processes for non invasive assessment of a genetic variation
JP6073902B2 (ja) 2011-10-06 2017-02-01 セクエノム, インコーポレイテッド 遺伝的変異の非侵襲的評価のための方法およびプロセス
WO2013052907A2 (en) 2011-10-06 2013-04-11 Sequenom, Inc. Methods and processes for non-invasive assessment of genetic variations
US9367663B2 (en) 2011-10-06 2016-06-14 Sequenom, Inc. Methods and processes for non-invasive assessment of genetic variations
US9984198B2 (en) 2011-10-06 2018-05-29 Sequenom, Inc. Reducing sequence read count error in assessment of complex genetic variations
US10424394B2 (en) 2011-10-06 2019-09-24 Sequenom, Inc. Methods and processes for non-invasive assessment of genetic variations
US10196681B2 (en) 2011-10-06 2019-02-05 Sequenom, Inc. Methods and processes for non-invasive assessment of genetic variations
ES2624686T3 (es) 2011-10-11 2017-07-17 Sequenom, Inc. Métodos y procesos para la evaluación no invasiva de variaciones genéticas
US8688388B2 (en) 2011-10-11 2014-04-01 Sequenom, Inc. Methods and processes for non-invasive assessment of genetic variations
CA2861856C (en) 2012-01-20 2020-06-02 Sequenom, Inc. Diagnostic processes that factor experimental conditions
EP2820129A1 (de) 2012-03-02 2015-01-07 Sequenom, Inc. Verfahren und prozesse zur nichtinvasiven beurteilung genetischer variationen
WO2013131083A1 (en) 2012-03-02 2013-09-06 Winthrop-University Hospital METHOD FOR USING PROBE BASED PCR DETECTION TO MEASURE THE LEVELS OF CIRCULATING DEMETHYLATED β CELL DERIVED DNA AS A MEASURE OF β CELL LOSS IN DIABETES
US10504613B2 (en) 2012-12-20 2019-12-10 Sequenom, Inc. Methods and processes for non-invasive assessment of genetic variations
US9920361B2 (en) 2012-05-21 2018-03-20 Sequenom, Inc. Methods and compositions for analyzing nucleic acid
EP3978621B1 (de) 2012-05-21 2023-08-30 Sequenom, Inc. Verfahren und prozesse zur nichtinvasiven beurteilung genetischer variationen
AU2012380717B2 (en) 2012-05-24 2018-08-16 Fundacio Institucio Catalana De Recerca I Estudis Avancats Method for the identification of the origin of a cancer of unknown primary origin by methylation analysis
US10497461B2 (en) 2012-06-22 2019-12-03 Sequenom, Inc. Methods and processes for non-invasive assessment of genetic variations
US20140093873A1 (en) 2012-07-13 2014-04-03 Sequenom, Inc. Processes and compositions for methylation-based enrichment of fetal nucleic acid from a maternal sample useful for non-invasive prenatal diagnoses
US10482994B2 (en) 2012-10-04 2019-11-19 Sequenom, Inc. Methods and processes for non-invasive assessment of genetic variations
CA3120521A1 (en) 2012-10-04 2014-04-10 Sequenom, Inc. Methods and processes for non-invasive assessment of genetic variations
EP2746403A1 (de) * 2012-12-21 2014-06-25 Life Science Inkubator GmbH & Co. KG Verfahren zur Bestimmung des DNA-Methylierungsgrades
US20130309666A1 (en) 2013-01-25 2013-11-21 Sequenom, Inc. Methods and processes for non-invasive assessment of genetic variations
US20140235484A1 (en) * 2013-02-19 2014-08-21 The Johns Hopkins University Methods for detection and differentiation of origin of viral dna
US20130189684A1 (en) 2013-03-12 2013-07-25 Sequenom, Inc. Quantification of cell-specific nucleic acid markers
US9305756B2 (en) 2013-03-13 2016-04-05 Agena Bioscience, Inc. Preparation enhancements and methods of use for MALDI mass spectrometry
US11060145B2 (en) 2013-03-13 2021-07-13 Sequenom, Inc. Methods and compositions for identifying presence or absence of hypermethylation or hypomethylation locus
US10930368B2 (en) 2013-04-03 2021-02-23 Sequenom, Inc. Methods and processes for non-invasive assessment of genetic variations
KR102665592B1 (ko) 2013-05-24 2024-05-21 시쿼넘, 인코포레이티드 유전적 변이의 비침습 평가를 위한 방법 및 프로세스
ES3037160T3 (en) 2013-06-21 2025-09-29 Sequenom Inc Methods and processes for non-invasive assessment of genetic variations
EP3936222A1 (de) * 2013-08-30 2022-01-12 University of Washington through its Center for Commercialization Selektive modifizierung von polymeruntereinheiten zur verbesserung von nanoporenbasierter analyse
KR102384620B1 (ko) 2013-10-04 2022-04-11 시쿼넘, 인코포레이티드 유전적 변이의 비침습 평가를 위한 방법 및 프로세스
CN105874082B (zh) 2013-10-07 2020-06-02 塞昆纳姆股份有限公司 用于非侵入性评估染色体改变的方法和过程
EP3736344A1 (de) 2014-03-13 2020-11-11 Sequenom, Inc. Verfahren und prozesse zur nichtinvasiven beurteilung genetischer variationen
EP3149640B1 (de) 2014-05-30 2019-09-04 Sequenom, Inc. Chromosomendarstellungsbestimmungen
US11783911B2 (en) 2014-07-30 2023-10-10 Sequenom, Inc Methods and processes for non-invasive assessment of genetic variations
EP3730629A1 (de) 2014-10-10 2020-10-28 Sequenom, Inc. Verfahren und prozesse zur nichtinvasiven beurteilung genetischer variationen
US9984201B2 (en) 2015-01-18 2018-05-29 Youhealth Biotech, Limited Method and system for determining cancer status
EP3666902B1 (de) 2015-05-22 2024-07-03 Medicover Public Co Ltd Multiplexierte parallelanalyse von gezielten genomregionen für nicht-invasive pränatale tests
EP4043581A1 (de) 2016-05-27 2022-08-17 Sequenom, Inc. Verfahren zur erzeugung eines paralog assay systems
US10202650B2 (en) 2016-05-31 2019-02-12 Youhealth Biotech, Limited Methods for monitoring ELOVL2, KLF14 and PENK gene expression following treatment with vitamin C
EP3481941A4 (de) 2016-07-06 2020-04-15 Youhealth Biotech, Limited Methylierungsmarker für brust- und ovarialkrebs und deren verwendung
US10093986B2 (en) 2016-07-06 2018-10-09 Youhealth Biotech, Limited Leukemia methylation markers and uses thereof
WO2018009696A1 (en) 2016-07-06 2018-01-11 Youhealth Biotech, Limited Colon cancer methylation markers and uses thereof
CN113151458A (zh) 2016-07-06 2021-07-23 优美佳肿瘤技术有限公司 实体瘤甲基化标志物及其用途
WO2018009705A1 (en) 2016-07-06 2018-01-11 Youhealth Biotech, Limited Liver cancer methylation markers and uses thereof
JP7048105B2 (ja) 2016-07-15 2022-04-05 ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア 核酸ライブラリを生成する方法
CA3030894A1 (en) 2016-07-27 2018-02-01 Sequenom, Inc. Methods for non-invasive assessment of genomic instability
CA3030890A1 (en) 2016-07-27 2018-02-01 Sequenom, Inc. Genetic copy number alteration classifications
CA3049457C (en) 2017-01-20 2023-05-16 Sequenom, Inc. Methods for non-invasive assessment of copy number alterations
CA3049455C (en) 2017-01-20 2023-06-13 Sequenom, Inc. Sequencing adapter manufacture and use
CA3049682C (en) 2017-01-20 2023-06-27 Sequenom, Inc. Methods for non-invasive assessment of genetic alterations
CA3207879A1 (en) 2017-01-24 2018-08-02 Sequenom, Inc. Methods and processes for assessment of genetic variations
US10465187B2 (en) 2017-02-06 2019-11-05 Trustees Of Boston University Integrated system for programmable DNA methylation
BR112019018272A2 (pt) 2017-03-02 2020-07-28 Youhealth Oncotech, Limited marcadores metilação para diagnosticar hepatocelular carcinoma e câncer
JP7370862B2 (ja) 2017-03-17 2023-10-30 セクエノム, インコーポレイテッド 遺伝子モザイク症のための方法およびプロセス
CN106951729A (zh) * 2017-03-19 2017-07-14 中国海洋大学 一种利用细胞器基因组的同源模块进行系统发生分析的方法
US11433074B2 (en) 2017-06-22 2022-09-06 Triact Therapeutics, Inc. Methods of treating glioblastoma
EP3687501A4 (de) 2017-09-29 2021-06-23 Triact Therapeutics, Inc. Iniparib-formulierungen und verwendungen davon
AU2019207900B2 (en) 2018-01-12 2025-07-10 Claret Bioscience, Llc Methods and compositions for analyzing nucleic acid
CA3090785A1 (en) 2018-02-14 2019-08-22 John Daniel Dobak Iii Novel gene classifiers and uses thereof in non-melanoma skin cancers
WO2019236726A1 (en) 2018-06-06 2019-12-12 The Regents Of The University Of California Methods of producing nucleic acid libraries and compositions and kits for practicing same
JP2022524641A (ja) 2019-03-26 2022-05-09 ダームテック,インク. 皮膚癌における新規な遺伝子分類子とその使用
WO2020206143A1 (en) 2019-04-05 2020-10-08 Claret Bioscience, Llc Methods and compositions for analyzing nucleic acid
US11891653B2 (en) 2019-09-30 2024-02-06 Guardant Health, Inc. Compositions and methods for analyzing cell-free DNA in methylation partitioning assays
AU2020363787A1 (en) 2019-10-09 2022-04-21 Claret Bioscience, Llc Methods and compositions for analyzing nucleic acid
CA3159786A1 (en) 2019-10-31 2021-05-06 Sequenom, Inc. Application of mosaicism ratio in multifetal gestations and personalized risk assessment
EP4617375A3 (de) * 2019-11-26 2025-10-29 Guardant Health, Inc. Verfahren, zusammensetzungen und systeme zur verbesserung der bindung methylierter polynukleotide
EP4428244B1 (de) 2020-06-24 2025-10-15 Claret Bioscience, LLC Verfahren und zusammensetzungen zur analyse von nukleinsäuren
WO2022076574A1 (en) 2020-10-08 2022-04-14 Claret Bioscience, Llc Methods and compositions for analyzing nucleic acid
JP2023547620A (ja) 2020-10-23 2023-11-13 ガーダント ヘルス, インコーポレイテッド 分配および塩基変換を使用してdnaを解析するための組成物および方法
IL293201B2 (en) * 2022-05-22 2023-04-01 Nucleix Ltd Preparations contain a reaction buffer for DNA amplification and sequencing
WO2024186778A1 (en) 2023-03-03 2024-09-12 Laboratory Corporation Of America Holdings Methods and systems for positive cfdna screening on genetic variations using mosaicism ratio
EP4713926A1 (de) 2023-05-15 2026-03-25 Laboratory Corporation of America Holdings Maschinenlernansätze zum pan-krebs-screening in der gesamtgenomsequenzierung
CN117003850B (zh) * 2023-09-19 2024-04-12 汲迈生命科技(苏州)有限公司 一种甲基化富集蛋白及其编码基因、制备方法和应用
CN117965739A (zh) * 2024-02-21 2024-05-03 中山大学附属第一医院 用于宫颈癌相关基因甲基化检测的标志物、引物组合及其应用

Family Cites Families (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4116638A (en) * 1977-03-03 1978-09-26 Warner-Lambert Company Immunoassay device
US5175086A (en) * 1983-01-24 1992-12-29 Olympus Optical Co., Ltd. Method for effecting heterogeneous immunological analysis
JPH0614048B2 (ja) 1983-02-14 1994-02-23 オリンパス光学工業株式会社 酵素免疫学的自動分析装置
US4608231A (en) * 1984-12-12 1986-08-26 Becton, Dickinson And Company Self-contained reagent package device for an assay
JPS61292556A (ja) 1985-06-20 1986-12-23 Green Cross Corp:The 酵素免疫測定方法およびキツト
EP0322102A3 (de) 1987-11-30 1990-06-13 McCue, John P. Verfahren und Fangtests für Antigene und dafür geeignete Verbindungen
JPH04136762A (ja) 1990-09-28 1992-05-11 Hitachi Ltd イムノアッセイ用反応容器
DE4037837A1 (de) * 1990-11-28 1992-06-04 Behringwerke Ag Zellfreie rezeptorbindungsteste, ihre herstellung und verwendung
US5399500A (en) * 1992-06-26 1995-03-21 Becton Dickinson And Company Two step process for coating of antibodies to a solid phase
US5441895A (en) * 1993-12-07 1995-08-15 Jakubowicz; Raymond F. Reagent cup shape allowing stacking without dislodging reagent
FR2733165B1 (fr) * 1995-04-20 1997-06-13 Inst Francais Du Petrole Carbonates alcalins ou alcalino-terreux colloidaux contenant un compose de calcium,de phospore et de soufre sous forme miscellisee
CA2315251A1 (en) 1997-12-17 1999-06-24 Immunex Corporation Cell surface glycoproteins associated with human b cell lymphomas - ulbp, dna and polypeptides
ES2312205T3 (es) 1998-03-10 2009-02-16 Genentech, Inc. Nuevo polipeptido y acidos nucleicos que lo codifican.
US6927024B2 (en) * 1998-11-30 2005-08-09 Genentech, Inc. PCR assay
DE19941756B4 (de) 1999-09-02 2013-05-16 Christof Niemeyer Verfahren zur Verwendung von oligomeren Nucleinsäure-Protein-Konjugaten als Reagenzien für immunologische Nachweisverfahren insbesondere die Immuno-PCR
JP2005500806A (ja) * 2000-09-15 2005-01-13 コーリー ファーマシューティカル ゲーエムベーハー CpGに基づく免疫アゴニスト/免疫アンタゴニストの高スループットスクリーニングのためのプロセス
CA2477043A1 (en) 2001-02-27 2002-09-06 Eos Biotechnology, Inc. Novel methods of diagnosis of metastatic colorectal cancer, compositions and methods of screening for modulators of metastatic colorectal cancer
DE10112515B4 (de) 2001-03-09 2004-02-12 Epigenomics Ag Verfahren zum Nachweis von Cytosin-Methylierungsmustern mit hoher Sensitivität
US20020197639A1 (en) 2001-06-08 2002-12-26 Shia Michael A. Methods and products for analyzing nucleic acids based on methylation status
JP2003125766A (ja) 2001-10-24 2003-05-07 Toray Res Center:Kk 抗5−メチル−2’−デオキシシチジン抗体および5−メチル−2’−デオキシシチジンの測定法
US6783759B2 (en) * 2002-03-27 2004-08-31 Trustees Of The University Of Pennsylvania Compositions and methods for modulating variola virus
EP1541668A4 (de) 2002-06-17 2008-08-06 Prec System Science Co Ltd REAKTIONSGEFûSS UND REAKTIONSPRODUKT-EXTRAKTIONSVORRICHTUNG
GB0230203D0 (en) * 2002-12-27 2003-02-05 Domantis Ltd Fc fusion
AU2003900368A0 (en) 2003-01-24 2003-02-13 Human Genetic Signatures Pty Ltd Assay for nucleic acid molecules
GB0423991D0 (en) 2004-10-29 2004-12-01 Univ Edinburgh Applications of nucleic acid fragments
US9249464B2 (en) 2004-11-29 2016-02-02 Sequenom, Inc. Kits and methods for detecting methylated DNA
JP5149013B2 (ja) * 2004-11-29 2013-02-20 セクエノム,インコーポレイティド メチル化dnaを検出する手段、及び方法
DE102005034628B4 (de) 2005-07-19 2007-08-23 Epigenomics Ag Verfahren zur Untersuchung von Cytosin-Methylierungen in DNA
US7906288B2 (en) * 2006-01-04 2011-03-15 The Johns Hopkins University Compare-MS: method rapid, sensitive and accurate detection of DNA methylation

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CN101243191A (zh) 2008-08-13
US20180220176A1 (en) 2018-08-02
EP1817430A2 (de) 2007-08-15
JP5149013B2 (ja) 2013-02-20
JP2008521389A (ja) 2008-06-26
DE602005016712D1 (de) 2009-10-29
AU2005308918A1 (en) 2006-06-01
WO2006056480A3 (en) 2008-03-27
WO2006056480A2 (en) 2006-06-01
US9074013B2 (en) 2015-07-07
JP2013027399A (ja) 2013-02-07
AU2005308918B2 (en) 2012-09-27
CN101243191B (zh) 2014-04-16
US9873919B2 (en) 2018-01-23
US20150267263A1 (en) 2015-09-24
EP1817430B1 (de) 2009-09-16
CA2589487C (en) 2014-07-29
US20210337252A1 (en) 2021-10-28
CA2589487A1 (en) 2006-06-01
US20080260743A1 (en) 2008-10-23

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