ATE443707T1 - Isoxazolin-indol-derivate mit verbesserter antipsychotischer und anxiolytischer aktivität - Google Patents

Isoxazolin-indol-derivate mit verbesserter antipsychotischer und anxiolytischer aktivität

Info

Publication number
ATE443707T1
ATE443707T1 AT05816247T AT05816247T ATE443707T1 AT E443707 T1 ATE443707 T1 AT E443707T1 AT 05816247 T AT05816247 T AT 05816247T AT 05816247 T AT05816247 T AT 05816247T AT E443707 T1 ATE443707 T1 AT E443707T1
Authority
AT
Austria
Prior art keywords
indole derivatives
isoxazoline
receptors
anxiolytic activity
towards dopamine
Prior art date
Application number
AT05816247T
Other languages
English (en)
Inventor
Jose I Andres-Gil
Jose M Bartolome-Nebreda
Manuel J Alcazar-Vaca
M Garcia-Martin
Antonius Megens
Original Assignee
Janssen Pharmaceutica Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv
Application granted granted Critical
Publication of ATE443707T1 publication Critical patent/ATE443707T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
AT05816247T 2004-11-26 2005-11-25 Isoxazolin-indol-derivate mit verbesserter antipsychotischer und anxiolytischer aktivität ATE443707T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP04106123 2004-11-26
PCT/EP2005/056229 WO2006056600A1 (en) 2004-11-26 2005-11-25 Isoxazoline-indole derivatives with an improved antipsychotic and anxiolytic a ivity

Publications (1)

Publication Number Publication Date
ATE443707T1 true ATE443707T1 (de) 2009-10-15

Family

ID=34929957

Family Applications (1)

Application Number Title Priority Date Filing Date
AT05816247T ATE443707T1 (de) 2004-11-26 2005-11-25 Isoxazolin-indol-derivate mit verbesserter antipsychotischer und anxiolytischer aktivität

Country Status (10)

Country Link
US (1) US7635696B2 (de)
EP (1) EP1819713B1 (de)
JP (1) JP2008521771A (de)
CN (1) CN101084225B (de)
AT (1) ATE443707T1 (de)
AU (1) AU2005308778B2 (de)
CA (1) CA2585857A1 (de)
DE (1) DE602005016836D1 (de)
ES (1) ES2331144T3 (de)
WO (1) WO2006056600A1 (de)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2010012121A1 (zh) * 2008-07-28 2010-02-04 江苏国华投资有限公司 芳烷基哌啶（嗪）衍生物及其在治疗精神分裂症中的应用
JP5701213B2 (ja) * 2008-10-10 2015-04-15 インスティチュート オブ ファーマコロジー アンド トキシコロジー アカデミー オブ ミリタリー メディカル サイエンシズ ピー．エル．エー．チャイナ 新規なドーパミンｄ３受容体リガンド、その調製及び使用
US9227944B2 (en) 2008-10-10 2016-01-05 Institute Of Pharmacology And Toxicology Academy Of Military Science P.L.A. China Dopamine D3 receptor ligands and preparation and medical uses of the same
EP2263672A1 (de) * 2009-05-19 2010-12-22 Bioprojet Neuartige pharmazeutisch unbedenkliche Salze von 4-(1H-Imidazol-4-ylmethyl)pyridin und ihre therapeutischen Verwendungen
US9090593B2 (en) 2010-12-09 2015-07-28 Amgen Inc. Bicyclic compounds as Pim inhibitors
CA2830780A1 (en) 2011-03-22 2012-09-27 Amgen Inc. Azole compounds as pim inhibitors
US20250101001A1 (en) * 2021-12-15 2025-03-27 Delix Therapeutics, Inc. Constrained amine psychoplastogens and uses thereof

Family Cites Families (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5965595A (en) * 1993-07-01 1999-10-12 The Procter & Gamble Company 2-Imidazolinylamino heterocyclic compounds useful as alpha-2 adrenoceptor agonists
US5698571A (en) 1994-10-05 1997-12-16 Eli Lilly And Company 5-HT1F mediated inhibition of neurogenic meningeal extravasation: a method for the treatment of migraine
WO1998022455A1 (en) 1996-11-19 1998-05-28 Kyowa Hakko Kogyo Co., Ltd. Oxygenic heterocyclic compounds
ZA9711376B (en) * 1996-12-20 1998-07-21 Lundbeck & Co As H Indole or dihydroindole derivatives
AR015036A1 (es) 1998-04-29 2001-04-11 American Home Prod Derivados de indolilo antisicoticos, composicion farmaceutica que los contiene y su uso para la manufactura de un medicamento
AU2494300A (en) 1999-01-07 2000-07-24 American Home Products Corporation 3,4-dihydro-2h-benzo(1,4)oxazine derivatives
US6313126B1 (en) * 1999-01-07 2001-11-06 American Home Products Corp Arylpiperazinyl-cyclohexyl indole derivatives for the treatment of depression
TW546299B (en) 1999-01-07 2003-08-11 Wyeth Corp 3,4-dihydro-2H-benzo[1,4]oxazinyl-methyl-[3-(1H-indol-3-yl)-alkyl]-amines
AR028475A1 (es) 1999-04-22 2003-05-14 Wyeth Corp Derivados de azaindol y uso de los mismos para la manufactura de un medicamento para el tratamiento de la depresion.
CA2373855A1 (en) * 1999-05-12 2000-11-23 Solvay Pharmaceuticals B.V. Method of treating psychotic disorders
FR2797874B1 (fr) 1999-08-27 2002-03-29 Adir Nouveaux derives de la pyridine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
WO2002048105A2 (en) 2000-11-16 2002-06-20 Wyeth Aryloxy piperidinyl derivatives for the treatment of depression
EP1349848A2 (de) 2000-11-17 2003-10-08 Wyeth Aryloxy-piperidinylindole für die behandlung von depressionen
ATE337322T1 (de) * 2001-02-21 2006-09-15 Janssen Pharmaceutica Nv Isoxazolin-derivate als antidepressiva
US6656950B2 (en) 2001-04-25 2003-12-02 Wyeth Antidepressant azaheterocyclylmethyl derivatives of 1,4-dioxino[2,3-b]pyridine
US6800648B2 (en) * 2001-04-26 2004-10-05 Wyeth Antipsychotic aminomethyl derivatives of 7,8-dihydro-3H-1,6,9-trioxa-3-AZA-cyclopenta[a]naphthalen-2-one
US6800641B2 (en) * 2001-04-26 2004-10-05 Wyeth Antipsychotic aminomethyl derivatives of 7,8-dihydro-3H-6,9-dioxa-2,3-diaza-cyclopenta[a]naphthalene
CA2451228A1 (en) 2001-06-29 2003-01-09 H. Lundbeck A/S Novel heteroaryl derivatives, their preparation and use
CN100338058C (zh) 2001-06-29 2007-09-19 H·隆德贝克有限公司 新的吲哚衍生物
US6903110B2 (en) 2001-07-25 2005-06-07 Wyeth Antidepressant azaheterocyclylmethyl derivatives of 7,8-dihydro-6H-5-oxa-1-aza-phenanthrene
DE60316134T2 (de) 2002-04-02 2008-05-29 Janssen Pharmaceutica N.V. Substituierte aminoisoxazolinderivate und ihre verwendung als antidepressiva
AR040967A1 (es) 2002-08-12 2005-04-27 Janssen Pharmaceutica Nv Derivados de isoxazolina triciclicos c- sustituidos y su uso como anti- depresivos
CN100522972C (zh) 2002-08-15 2009-08-05 詹森药业有限公司 稠合杂环异噁唑啉衍生物和它们作为抗抑郁剂的用途
US7462717B2 (en) 2002-08-21 2008-12-09 Janssen Pharmaceutica N.V. C6-and C9-substituted chromeno[4,3-c]isoxazoline derivatives and their use as anti-depressants
US7227023B2 (en) * 2003-04-30 2007-06-05 Wyeth Quinoline 3-amino chroman derivatives

Also Published As

Publication number Publication date
WO2006056600A1 (en) 2006-06-01
US7635696B2 (en) 2009-12-22
CN101084225B (zh) 2011-03-02
US20080113988A1 (en) 2008-05-15
ES2331144T3 (es) 2009-12-22
EP1819713B1 (de) 2009-09-23
EP1819713A1 (de) 2007-08-22
JP2008521771A (ja) 2008-06-26
CN101084225A (zh) 2007-12-05
DE602005016836D1 (de) 2009-11-05
AU2005308778A1 (en) 2006-06-01
CA2585857A1 (en) 2006-06-01
AU2005308778B2 (en) 2011-03-24

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