ATE443707T1 - Isoxazolin-indol-derivate mit verbesserter antipsychotischer und anxiolytischer aktivität - Google Patents

Isoxazolin-indol-derivate mit verbesserter antipsychotischer und anxiolytischer aktivität

Info

Publication number
ATE443707T1
ATE443707T1 AT05816247T AT05816247T ATE443707T1 AT E443707 T1 ATE443707 T1 AT E443707T1 AT 05816247 T AT05816247 T AT 05816247T AT 05816247 T AT05816247 T AT 05816247T AT E443707 T1 ATE443707 T1 AT E443707T1
Authority
AT
Austria
Prior art keywords
indole derivatives
isoxazoline
receptors
anxiolytic activity
towards dopamine
Prior art date
Application number
AT05816247T
Other languages
English (en)
Inventor
Jose I Andres-Gil
Jose M Bartolome-Nebreda
Manuel J Alcazar-Vaca
M Garcia-Martin
Antonius Megens
Original Assignee
Janssen Pharmaceutica Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv
Application granted granted Critical
Publication of ATE443707T1 publication Critical patent/ATE443707T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
AT05816247T 2004-11-26 2005-11-25 Isoxazolin-indol-derivate mit verbesserter antipsychotischer und anxiolytischer aktivität ATE443707T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP04106123 2004-11-26
PCT/EP2005/056229 WO2006056600A1 (en) 2004-11-26 2005-11-25 Isoxazoline-indole derivatives with an improved antipsychotic and anxiolytic a ivity

Publications (1)

Publication Number Publication Date
ATE443707T1 true ATE443707T1 (de) 2009-10-15

Family

ID=34929957

Family Applications (1)

Application Number Title Priority Date Filing Date
AT05816247T ATE443707T1 (de) 2004-11-26 2005-11-25 Isoxazolin-indol-derivate mit verbesserter antipsychotischer und anxiolytischer aktivität

Country Status (10)

Country Link
US (1) US7635696B2 (de)
EP (1) EP1819713B1 (de)
JP (1) JP2008521771A (de)
CN (1) CN101084225B (de)
AT (1) ATE443707T1 (de)
AU (1) AU2005308778B2 (de)
CA (1) CA2585857A1 (de)
DE (1) DE602005016836D1 (de)
ES (1) ES2331144T3 (de)
WO (1) WO2006056600A1 (de)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8653069B2 (en) * 2008-07-28 2014-02-18 Jiangsu Hengyi Pharmaceutical Co., Ltd. Aralkyl substituted piperidine or piperazine derivatives and their use for treating schizophrenia
CN102264733B (zh) * 2008-10-10 2014-07-30 中国人民解放军军事医学科学院毒物药物研究所 新型多巴胺d3受体配体，其制备方法及其医药用途
US9227944B2 (en) 2008-10-10 2016-01-05 Institute Of Pharmacology And Toxicology Academy Of Military Science P.L.A. China Dopamine D3 receptor ligands and preparation and medical uses of the same
EP2263672A1 (de) * 2009-05-19 2010-12-22 Bioprojet Neuartige pharmazeutisch unbedenkliche Salze von 4-(1H-Imidazol-4-ylmethyl)pyridin und ihre therapeutischen Verwendungen
CA2819373A1 (en) * 2010-12-09 2012-06-14 Amgen Inc. Bicyclic compounds as pim inhibitors
JP2014510105A (ja) 2011-03-22 2014-04-24 アムジエン・インコーポレーテツド Ｐｉｍ阻害剤としてのアゾール化合物
US20250101001A1 (en) * 2021-12-15 2025-03-27 Delix Therapeutics, Inc. Constrained amine psychoplastogens and uses thereof

Family Cites Families (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5965595A (en) 1993-07-01 1999-10-12 The Procter & Gamble Company 2-Imidazolinylamino heterocyclic compounds useful as alpha-2 adrenoceptor agonists
US5698571A (en) 1994-10-05 1997-12-16 Eli Lilly And Company 5-HT1F mediated inhibition of neurogenic meningeal extravasation: a method for the treatment of migraine
EP0943613A4 (de) 1996-11-19 2002-07-10 Kyowa Hakko Kogyo Kk Sauerstoff enthaltende heterocyclische verbindungen
ZA9711376B (en) * 1996-12-20 1998-07-21 Lundbeck & Co As H Indole or dihydroindole derivatives
EP1076647A2 (de) 1998-04-29 2001-02-21 American Home Products Corporation Antipsychotisch wirkende indolyl-derivate
AU2494300A (en) 1999-01-07 2000-07-24 American Home Products Corporation 3,4-dihydro-2h-benzo(1,4)oxazine derivatives
TW546299B (en) 1999-01-07 2003-08-11 Wyeth Corp 3,4-dihydro-2H-benzo[1,4]oxazinyl-methyl-[3-(1H-indol-3-yl)-alkyl]-amines
US6313126B1 (en) 1999-01-07 2001-11-06 American Home Products Corp Arylpiperazinyl-cyclohexyl indole derivatives for the treatment of depression
AR028475A1 (es) 1999-04-22 2003-05-14 Wyeth Corp Derivados de azaindol y uso de los mismos para la manufactura de un medicamento para el tratamiento de la depresion.
JP2002544223A (ja) * 1999-05-12 2002-12-24 ソルベイ・フアーマシユーチカルズ・ベー・ブイ 精神病性障害の治療方法
FR2797874B1 (fr) 1999-08-27 2002-03-29 Adir Nouveaux derives de la pyridine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
AU2002243394A1 (en) 2000-11-16 2002-06-24 Wyeth Aryloxy piperidinyl derivatives for the treatment of depression
EP1349848A2 (de) 2000-11-17 2003-10-08 Wyeth Aryloxy-piperidinylindole für die behandlung von depressionen
MXPA03007432A (es) 2001-02-21 2003-11-18 Janssen Pharmaceutica Nv Derivados de isoxazolinas y su uso como antidepresivos.
US6656950B2 (en) 2001-04-25 2003-12-02 Wyeth Antidepressant azaheterocyclylmethyl derivatives of 1,4-dioxino[2,3-b]pyridine
US6800641B2 (en) * 2001-04-26 2004-10-05 Wyeth Antipsychotic aminomethyl derivatives of 7,8-dihydro-3H-6,9-dioxa-2,3-diaza-cyclopenta[a]naphthalene
US6800648B2 (en) * 2001-04-26 2004-10-05 Wyeth Antipsychotic aminomethyl derivatives of 7,8-dihydro-3H-1,6,9-trioxa-3-AZA-cyclopenta[a]naphthalen-2-one
MXPA03011769A (es) 2001-06-29 2004-04-02 Lundbeck & Co As H Derivados de heteroarilo novedosos, su preparacion y uso.
KR20040019027A (ko) 2001-06-29 2004-03-04 하. 룬트벡 아크티에 셀스카브 신규한 인돌 유도체
US6903110B2 (en) 2001-07-25 2005-06-07 Wyeth Antidepressant azaheterocyclylmethyl derivatives of 7,8-dihydro-6H-5-oxa-1-aza-phenanthrene
NZ536109A (en) 2002-04-02 2006-06-30 Janssen Pharmaceutica Nv Substituted amino isoxazoline derivatives and their use as anti-depressants
AR040967A1 (es) 2002-08-12 2005-04-27 Janssen Pharmaceutica Nv Derivados de isoxazolina triciclicos c- sustituidos y su uso como anti- depresivos
ATE456568T1 (de) 2002-08-15 2010-02-15 Janssen Pharmaceutica Nv Kondensierte heterocyclische isoxazolinderivate und deren verwendung als antidepressiva
ATE387455T1 (de) * 2002-08-21 2008-03-15 Janssen Pharmaceutica Nv C6- und c9-substituierte chromeno(4,3- c)isoxazoline und ihre verwendung als anti- depressiva
US7227023B2 (en) * 2003-04-30 2007-06-05 Wyeth Quinoline 3-amino chroman derivatives

Also Published As

Publication number Publication date
AU2005308778A1 (en) 2006-06-01
CN101084225B (zh) 2011-03-02
US20080113988A1 (en) 2008-05-15
JP2008521771A (ja) 2008-06-26
EP1819713B1 (de) 2009-09-23
AU2005308778B2 (en) 2011-03-24
WO2006056600A1 (en) 2006-06-01
CN101084225A (zh) 2007-12-05
EP1819713A1 (de) 2007-08-22
DE602005016836D1 (de) 2009-11-05
US7635696B2 (en) 2009-12-22
ES2331144T3 (es) 2009-12-22
CA2585857A1 (en) 2006-06-01

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