ATE444081T1 - Proteine-abgabe durch polare epithelzellen schichte - Google Patents
Proteine-abgabe durch polare epithelzellen schichteInfo
- Publication number
- ATE444081T1 ATE444081T1 AT00975326T AT00975326T ATE444081T1 AT E444081 T1 ATE444081 T1 AT E444081T1 AT 00975326 T AT00975326 T AT 00975326T AT 00975326 T AT00975326 T AT 00975326T AT E444081 T1 ATE444081 T1 AT E444081T1
- Authority
- AT
- Austria
- Prior art keywords
- bioactive
- epithelial cell
- cell layer
- moiety
- polar epithelial
- Prior art date
Links
- 102000004169 proteins and genes Human genes 0.000 title abstract 2
- 108090000623 proteins and genes Proteins 0.000 title abstract 2
- 210000002919 epithelial cell Anatomy 0.000 title 1
- 230000000975 bioactive effect Effects 0.000 abstract 5
- 238000000034 method Methods 0.000 abstract 2
- 102000001851 Low Density Lipoprotein Receptor-Related Protein-1 Human genes 0.000 abstract 1
- 230000004071 biological effect Effects 0.000 abstract 1
- 230000005859 cell recognition Effects 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 210000004955 epithelial membrane Anatomy 0.000 abstract 1
- 230000028993 immune response Effects 0.000 abstract 1
- 230000002163 immunogen Effects 0.000 abstract 1
- 238000002347 injection Methods 0.000 abstract 1
- 239000007924 injection Substances 0.000 abstract 1
- 101150084157 lrp-1 gene Proteins 0.000 abstract 1
- 238000007911 parenteral administration Methods 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
- A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
- A61K47/6425—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent the peptide or protein in the drug conjugate being a receptor, e.g. CD4, a cell surface antigen, i.e. not a peptide ligand targeting the antigen, or a cell surface determinant, i.e. a part of the surface of a cell
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Immunology (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Diabetes (AREA)
- Cell Biology (AREA)
- Epidemiology (AREA)
- Molecular Biology (AREA)
- Emergency Medicine (AREA)
- Endocrinology (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Medicinal Preparation (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US16092399P | 1999-10-22 | 1999-10-22 | |
| PCT/US2000/029080 WO2001030392A2 (en) | 1999-10-22 | 2000-10-18 | Delivery of proteins across polar epithelial cell layers |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE444081T1 true ATE444081T1 (de) | 2009-10-15 |
Family
ID=22579051
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT00975326T ATE444081T1 (de) | 1999-10-22 | 2000-10-18 | Proteine-abgabe durch polare epithelzellen schichte |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US7824695B1 (de) |
| EP (1) | EP1242122B1 (de) |
| JP (2) | JP2003512441A (de) |
| AT (1) | ATE444081T1 (de) |
| AU (1) | AU784657B2 (de) |
| CA (1) | CA2389302C (de) |
| DE (1) | DE60043070D1 (de) |
| WO (1) | WO2001030392A2 (de) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1000163B1 (de) * | 1997-07-11 | 2005-10-19 | THE GOVERNMENT OF THE UNITED STATES OF AMERICA as represented by the Secretary of the Department of Health and Human Services | Pseudomonas exotoxin-a-ähnliche chimerische immunogene |
| CA2389302C (en) * | 1999-10-22 | 2011-03-15 | David J. Fitzgerald | Delivery of proteins across polar epithelial cell layers |
| EP1804832A4 (de) * | 2004-10-04 | 2008-12-24 | Trinity Biosystems Inc | Verfahren und zusammensetzungen zur nadellosen abgabe von makromolekülen |
| US20070148131A1 (en) * | 2005-12-05 | 2007-06-28 | Trinity Biosystems, Inc. | Methods and compositions for needleless delivery of binding partners |
| US7666991B2 (en) | 2005-12-05 | 2010-02-23 | Trinity Biosystems, Inc. | Compositions for needleless delivery of antibodies |
| EP2010205A2 (de) * | 2006-03-16 | 2009-01-07 | Trinity Biosystems, Inc. | Verfahren zur erhöhung der grösse von tieren mit nadellos abgegebenen konstrukten |
| US11246915B2 (en) | 2010-09-15 | 2022-02-15 | Applied Molecular Transport Inc. | Cholix toxin-derived fusion molecules for oral delivery of biologically active cargo |
| KR20250174998A (ko) | 2018-03-08 | 2025-12-15 | 어플라이드 몰레큘라 트랜스포트 인크. | 경구 전달용 독소-유래 전달 구조체 |
| JP7487193B2 (ja) | 2018-11-07 | 2024-05-20 | アプライド モレキュラー トランスポート インコーポレイテッド | 異種ペイロードの経口送達のためのコリックス由来担体 |
| CN114599665A (zh) | 2019-08-16 | 2022-06-07 | 应用分子转运公司 | 组合物、制剂及白细胞介素产生和纯化 |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL78775A (en) * | 1985-05-15 | 1992-06-21 | Biotech Australia Pty Ltd | Oral vaccines |
| WO1994000481A1 (en) * | 1992-06-23 | 1994-01-06 | Associated Synapse Biologics | Pharmaceutical composition containing botulinum b complex |
| DE69415026D1 (de) * | 1993-09-06 | 1999-01-14 | Menarini Richerche Sud S P A | Ribosom-inaktievirende proteine, die aus saponaria ocymoides und vaccaria pyramidata samen extrahiert sind sowie deren herstellung und immunotoxine, die sie enthalten |
| CA2190101A1 (en) | 1994-05-13 | 1995-11-23 | Donald Leonard Nicholas Cardy | Improvements in or relating to peptide delivery |
| JP2001504334A (ja) * | 1996-11-06 | 2001-04-03 | アメリカ合衆国 | プロテアーゼ活性化可能なＰｓｅｕｄｏｍｏｎａｓ体外毒素Ａ様プロタンパク質 |
| WO1998042876A1 (en) * | 1997-03-26 | 1998-10-01 | Board Of Regents, The University Of Texas System | Methods and compositions for using membrane-penetrating proteins to carry materials across cell membranes |
| EP1000163B1 (de) * | 1997-07-11 | 2005-10-19 | THE GOVERNMENT OF THE UNITED STATES OF AMERICA as represented by the Secretary of the Department of Health and Human Services | Pseudomonas exotoxin-a-ähnliche chimerische immunogene |
| US20030054012A1 (en) | 2000-05-12 | 2003-03-20 | Fitzgerald David J. | Pseudomonas exotoxin a-like chimeric immunogens for eliciting a secretory iga-mediated immune response |
| US6472140B1 (en) * | 1997-09-05 | 2002-10-29 | The General Hospital Corporation | α-2- macroglobulin therapies and drug screening methods for Alzheimer's disease. |
| AU779473B2 (en) * | 1999-10-22 | 2005-01-27 | Government Of The United States Of America, As Represented By The Secretary Of The Department Of Health And Human Services, The | Disulfide conjugated cell toxins and methods of making and using them |
| CA2389302C (en) * | 1999-10-22 | 2011-03-15 | David J. Fitzgerald | Delivery of proteins across polar epithelial cell layers |
| US7314625B2 (en) | 2000-12-21 | 2008-01-01 | The United States As Represented By The Secretary Of The Department Of Health And Human Services | Chimeric protein comprising non-toxic Pseudomonas exotoxin A and Type IV pilin sequences |
-
2000
- 2000-10-18 CA CA2389302A patent/CA2389302C/en not_active Expired - Fee Related
- 2000-10-18 AT AT00975326T patent/ATE444081T1/de not_active IP Right Cessation
- 2000-10-18 WO PCT/US2000/029080 patent/WO2001030392A2/en not_active Ceased
- 2000-10-18 JP JP2001532809A patent/JP2003512441A/ja not_active Withdrawn
- 2000-10-18 AU AU13392/01A patent/AU784657B2/en not_active Ceased
- 2000-10-18 US US10/110,880 patent/US7824695B1/en not_active Expired - Fee Related
- 2000-10-18 EP EP00975326A patent/EP1242122B1/de not_active Expired - Lifetime
- 2000-10-18 DE DE60043070T patent/DE60043070D1/de not_active Expired - Lifetime
-
2011
- 2011-11-21 JP JP2011254351A patent/JP2012051939A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| AU1339201A (en) | 2001-05-08 |
| EP1242122A2 (de) | 2002-09-25 |
| EP1242122B1 (de) | 2009-09-30 |
| WO2001030392A2 (en) | 2001-05-03 |
| JP2003512441A (ja) | 2003-04-02 |
| CA2389302A1 (en) | 2001-05-03 |
| WO2001030392A3 (en) | 2002-07-11 |
| JP2012051939A (ja) | 2012-03-15 |
| DE60043070D1 (de) | 2009-11-12 |
| AU784657B2 (en) | 2006-05-18 |
| US7824695B1 (en) | 2010-11-02 |
| CA2389302C (en) | 2011-03-15 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |