DK0969873T3 - Multiple carbonhydratholdige glycopeptid-antigener, vaccine indeholdende dem og anvendelse deraf - Google Patents

Multiple carbonhydratholdige glycopeptid-antigener, vaccine indeholdende dem og anvendelse deraf

Info

Publication number: DK0969873T3
Authority: DK; Denmark
Prior art keywords: carbohydrate; multiple carbohydrate; vaccine; glycopeptide antigens; subject
Prior art date: 1997-03-27

Application number

DK98913748T

Other languages

English (en)

Inventor

Claude Leclerc

Sylvie Bay

Daniele Cantacuzene

Richard Lo-Man

Original Assignee

Pasteur Institut

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1997-03-27

Filing date

1998-03-27

Publication date

2006-10-09

1998-03-27 Application filed by Pasteur Institut filed Critical Pasteur Institut

2006-10-09 Application granted granted Critical

2006-10-09 Publication of DK0969873T3 publication Critical patent/DK0969873T3/da

Links

150000001720 carbohydrates Chemical class 0.000 title abstract 5
DQJCDTNMLBYVAY-ZXXIYAEKSA-N (2S,5R,10R,13R)-16-{[(2R,3S,4R,5R)-3-{[(2S,3R,4R,5S,6R)-3-acetamido-4,5-dihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy}-5-(ethylamino)-6-hydroxy-2-(hydroxymethyl)oxan-4-yl]oxy}-5-(4-aminobutyl)-10-carbamoyl-2,13-dimethyl-4,7,12,15-tetraoxo-3,6,11,14-tetraazaheptadecan-1-oic acid Chemical compound NCCCC[C@H](C(=O)N[C@@H](C)C(O)=O)NC(=O)CC[C@H](C(N)=O)NC(=O)[C@@H](C)NC(=O)C(C)O[C@@H]1[C@@H](NCC)C(O)O[C@H](CO)[C@H]1O[C@H]1[C@H](NC(C)=O)[C@@H](O)[C@H](O)[C@@H](CO)O1 DQJCDTNMLBYVAY-ZXXIYAEKSA-N 0.000 title 1
102000002068 Glycopeptides Human genes 0.000 title 1
108010015899 Glycopeptides Proteins 0.000 title 1
239000000427 antigen Substances 0.000 title 1
102000036639 antigens Human genes 0.000 title 1
108091007433 antigens Proteins 0.000 title 1
229960005486 vaccine Drugs 0.000 title 1
239000000863 peptide conjugate Substances 0.000 abstract 2
210000002966 serum Anatomy 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/0005—Vertebrate antigens
- A61K39/0011—Cancer antigens
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
- A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
- A61K47/645—Polycationic or polyanionic oligopeptides, polypeptides or polyamino acids, e.g. polylysine, polyarginine, polyglutamic acid or peptide TAT
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/001—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof by chemical synthesis
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
- C07K14/22—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Neisseriaceae (F)
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
- C07K14/285—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Pasteurellaceae (F), e.g. Haemophilus influenza
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
- C07K14/305—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Micrococcaceae (F)
- C07K14/31—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Micrococcaceae (F) from Staphylococcus (G)
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
- C07K14/315—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Streptococcus (G), e.g. Enterococci
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K9/00—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof
- C07K9/001—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof the peptide sequence having less than 12 amino acids and not being part of a ring structure
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55505—Inorganic adjuvants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/64—Medicinal preparations containing antigens or antibodies characterised by the architecture of the carrier-antigen complex, e.g. repetition of carrier-antigen units
- A61K2039/645—Dendrimers; Multiple antigen peptides
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Medicinal Chemistry (AREA)
General Health & Medical Sciences (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Molecular Biology (AREA)
Genetics & Genomics (AREA)
Biophysics (AREA)
Biochemistry (AREA)
Gastroenterology & Hepatology (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Immunology (AREA)
Bioinformatics & Cheminformatics (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Engineering & Computer Science (AREA)
Epidemiology (AREA)
Oncology (AREA)
Communicable Diseases (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Microbiology (AREA)
Mycology (AREA)
Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Peptides Or Proteins (AREA)
Carbon And Carbon Compounds (AREA)

DK98913748T 1997-03-27 1998-03-27 Multiple carbonhydratholdige glycopeptid-antigener, vaccine indeholdende dem og anvendelse deraf DK0969873T3 (da)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US4172697P	1997-03-27	1997-03-27

Publications (1)

Publication Number	Publication Date
DK0969873T3 true DK0969873T3 (da)	2006-10-09

Family

ID=21918009

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK98913748T DK0969873T3 (da)	1997-03-27	1998-03-27	Multiple carbonhydratholdige glycopeptid-antigener, vaccine indeholdende dem og anvendelse deraf

Country Status (10)

Country	Link
US (1)	US7696326B2 (da)
EP (1)	EP0969873B1 (da)
AT (1)	ATE328611T1 (da)
AU (1)	AU6832398A (da)
CA (1)	CA2285018C (da)
DE (1)	DE69834808T2 (da)
DK (1)	DK0969873T3 (da)
ES (1)	ES2265162T3 (da)
PT (1)	PT969873E (da)
WO (1)	WO1998043677A1 (da)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US6660842B1 (en)	1994-04-28	2003-12-09	Tripep Ab	Ligand/receptor specificity exchangers that redirect antibodies to receptors on a pathogen
US6933366B2 (en)	1996-12-27	2005-08-23	Tripep Ab	Specificity exchangers that redirect antibodies to bacterial adhesion receptors
US7018637B2 (en) *	1998-02-23	2006-03-28	Aventis Pasteur, Inc	Multi-oligosaccharide glycoconjugate bacterial meningitis vaccines
GB9808932D0 (en) *	1998-04-27	1998-06-24	Chiron Spa	Polyepitope carrier protein
WO2000047229A2 (en) *	1999-02-11	2000-08-17	Genzyme Corporation	Polynucleotide encoding multimers of antigenic peptides in order to enhance presentation of the antigenic peptide by mhc molecules
EP1417965A1 (en) *	2002-11-07	2004-05-12	Vereniging Voor Christelijk Wetenschappelijk Onderwijs	C-type lectin binding molecules, identification and uses thereof
US8133881B2 (en)	2003-01-13	2012-03-13	Shire Llc	Carbohydrate conjugates to prevent abuse of controlled substances
US7335359B2 (en)	2003-02-06	2008-02-26	Tripep Ab	Glycosylated specificity exchangers
KR20050099536A (ko)	2003-02-06	2005-10-13	트리펩 아베	글리코실화된 특이성 교환체
EP1670509A4 (en) *	2003-09-03	2007-10-31	Dendritherapeutics Inc	MULTIPLEX VACCINES
WO2006037979A2 (en) *	2004-10-01	2006-04-13	Midatech Limited	Nanoparticles comprising antigens and adjuvants and immunogenic structure
GB0428394D0 (en) *	2004-12-24	2005-02-02	Chiron Srl	Saccharide conjugate vaccines
WO2007079448A2 (en)	2006-01-03	2007-07-12	University Of Georgia Research Foundation, Inc.	Three component carbohydrate vaccine
EP1808442B1 (en)	2006-01-13	2011-05-11	Institut Pasteur	Enzymatic large-scale synthesis of mucin glyconjugates, and immunogenic applications thereof
WO2008017122A1 (en)	2006-08-11	2008-02-14	Starpharma Pty Ltd	Polylysine dendrimer contrast agent
PL2052011T3 (pl) *	2006-08-11	2021-03-08	Starpharma Pty Limited	Nakierowany środek terapeutyczny będący dendrymerem polilizynowym
US20120039984A1 (en)	2008-07-03	2012-02-16	University Of Georgia Research Foundation, Inc.	Glycopeptide and uses thereof
RU2016137258A (ru) *	2009-04-01	2018-12-13	Юниверсити Оф Майами	Композиции вакцин и способы их применения
EP2500033A1 (en)	2011-03-17	2012-09-19	Institut Pasteur	Method for preparing muliple antigen glycopeptide carbohydrate conjugates
CA2885625A1 (en) *	2012-10-02	2014-04-10	Glaxosmithkline Biologicals S.A.	Nonlinear saccharide conjugates
US9815886B2 (en)	2014-10-28	2017-11-14	Adma Biologics, Inc.	Compositions and methods for the treatment of immunodeficiency
US20180371018A1 (en) *	2015-12-14	2018-12-27	Su HAN	Polypeptide compound, preparation method therefor and use thereof
US10259865B2 (en)	2017-03-15	2019-04-16	Adma Biologics, Inc.	Anti-pneumococcal hyperimmune globulin for the treatment and prevention of pneumococcal infection

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4386026A (en) *	1981-04-20	1983-05-31	Merck & Co., Inc.	Cell-specific glycopeptide ligands
US5229490A (en) *	1987-05-06	1993-07-20	The Rockefeller University	Multiple antigen peptide system
ATE126442T1 (de) *	1990-05-18	1995-09-15	Boehringer Ingelheim Int	Neue protein-polykation-konjugate.
GB9202219D0 (en) *	1992-02-03	1992-03-18	Connaught Lab	A synthetic heamophilus influenzae conjugate vaccine
IL105503A (en) *	1992-04-28	1999-05-09	Astra Ab	Carbon peptide couplets capable of eliciting an immune response of T cells
WO1993022343A1 (en) *	1992-05-01	1993-11-11	The Rockfeller University	Multiple antigen peptide system having adjuvant properties and vaccines prepared therefrom

1998
- 1998-03-27 PT PT98913748T patent/PT969873E/pt unknown
- 1998-03-27 WO PCT/EP1998/001922 patent/WO1998043677A1/en not_active Ceased
- 1998-03-27 AT AT98913748T patent/ATE328611T1/de active
- 1998-03-27 DK DK98913748T patent/DK0969873T3/da active
- 1998-03-27 AU AU68323/98A patent/AU6832398A/en not_active Abandoned
- 1998-03-27 CA CA2285018A patent/CA2285018C/en not_active Expired - Lifetime
- 1998-03-27 DE DE69834808T patent/DE69834808T2/de not_active Expired - Lifetime
- 1998-03-27 EP EP98913748A patent/EP0969873B1/en not_active Expired - Lifetime
- 1998-03-27 ES ES98913748T patent/ES2265162T3/es not_active Expired - Lifetime
2007
- 2007-01-03 US US11/619,457 patent/US7696326B2/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
AU6832398A (en)	1998-10-22
DE69834808D1 (de)	2006-07-20
WO1998043677A1 (en)	1998-10-08
CA2285018A1 (en)	1998-10-08
EP0969873B1 (en)	2006-06-07
ES2265162T3 (es)	2007-02-01
EP0969873A1 (en)	2000-01-12
CA2285018C (en)	2011-01-04
PT969873E (pt)	2006-09-29
DE69834808T2 (de)	2007-06-06
US20070098730A1 (en)	2007-05-03
US7696326B2 (en)	2010-04-13
ATE328611T1 (de)	2006-06-15

Publication	Publication Date	Title
DE69834808D1 (de)	2006-07-20	Multiple,kohlenhydrathaltige glycopeptid-antigene, daraus entwickelte impfstoffe sowie deren verwendung
YU49370B (sh)	2005-09-19	Postupak za pripremanje vakcine protiv lajmske bolesti
BR9809656A (pt)	2000-07-11	Composição imunopotencializante
FI972945L (fi)	1997-07-11	Antigeenien antamiseen soveltuvia koostumuksia
EP1378525A3 (en)	2004-01-14	Humanized antibodies that bind to the antigen bound by antibody NR-LU-13 and their use in pretargeting methods
IL143797A0 (en)	2002-04-21	Human monoclonal antibodies to cytotoxic t lymphocyte antigen 4
WO1998057994A3 (en)	1999-03-25	Opsonic and protective monoclonal and chimeric antibodies specific for lipoteichoic acid of gram positive bacteria
NZ332625A (en)	2000-04-28	Concentrated antibody preparation containing greater than 100 mg/ml of the antibody
DE69129302D1 (de)	1998-05-28	Inhibitoren des tumorwachstums aus geweben, methoden ihrer herstellung und verwendungen
WO1996029605A3 (en)	1996-11-21	Compounds and methods for the dectection of t. cruzi infection
NZ503763A (en)	2003-01-31	Antigenic compositions and vaccines comprising a high molecular weight (HMW) protein of Clamydia for therapeutic and prophylactic use
ES2093778T3 (es)	1997-01-01	Nuevos anticuerpos y metodos para su uso.
BG102714A (en)	1999-06-30	Pharmaceutical composition for immunomodulation based on peptides and adjuvants
EP0866133A3 (en)	2001-09-26	A group b streptococcus vaccine
AU2002223462A1 (en)	2002-04-22	Use of cd28-specific monoclonal antibodies for stimulating blood cells that lackcd28
FI962844A7 (fi)	1996-08-29	T-soluantigeenireseptorin V-alueen proteiineja ja menetelmiä niiden va lmistamiseksi
IS4922A (is)	1998-12-11	Fjölpeptíð sem geta myndað formgerðir mótefnisvakabindinga með sérvirkni fyrir resus D mótefnisvaka, DNA-ið sem táknar þau og aðferðin til að búa þautil og notkun
DK0859957T3 (da)	2002-07-29	Patientspecifikke immunadsorbenser til ekstraporal apherese og fremgangsmåde til deres fremstilling
EP1003494A4 (en)	2002-10-16	(d) -METHADONE, NON-OPIOID ANALGESIC
SE9401460D0 (sv)	1994-04-28	Antigen/antibody specificity exhanger
DE69638024D1 (de)	2009-10-22	Melanoma antigene p15 und deren anwendung in diagnostischen und therapeutischen verfahren
ES2118939T3 (es)	1998-10-01	Peptido para el diagnostico e inmunizacion contra la infeccion con t.cruzi.
DE60027905D1 (de)	2006-06-14	Glycokonjugate, glycoaminosäure, deren zwischenprodukte, und ihre verwendung
BG103872A (en)	2000-07-31	Glycoconjugates of 20(s)-camptotecin
BR0109164A (pt)	2002-11-26	Anticorpos monoclonais para o receptor humano para ldl, produção e uso dos mesmos