ATE444369T1 - Penicillin v amidohydrolase gen aus fusarium oxysporum - Google Patents

Penicillin v amidohydrolase gen aus fusarium oxysporum

Info

Publication number
ATE444369T1
ATE444369T1 AT95120437T AT95120437T ATE444369T1 AT E444369 T1 ATE444369 T1 AT E444369T1 AT 95120437 T AT95120437 T AT 95120437T AT 95120437 T AT95120437 T AT 95120437T AT E444369 T1 ATE444369 T1 AT E444369T1
Authority
AT
Austria
Prior art keywords
pva
given
fragments
construction
promoter
Prior art date
Application number
AT95120437T
Other languages
English (en)
Inventor
Shu-Jen Chiang
William V Burnett Jr
Sean M Tonzi
Original Assignee
Bristol Myers Squibb Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Squibb Co filed Critical Bristol Myers Squibb Co
Application granted granted Critical
Publication of ATE444369T1 publication Critical patent/ATE444369T1/de

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0012—Oxidoreductases (1.) acting on nitrogen containing compounds as donors (1.4, 1.5, 1.6, 1.7)
    • C12N9/0014—Oxidoreductases (1.) acting on nitrogen containing compounds as donors (1.4, 1.5, 1.6, 1.7) acting on the CH-NH2 group of donors (1.4)
    • C12N9/0022—Oxidoreductases (1.) acting on nitrogen containing compounds as donors (1.4, 1.5, 1.6, 1.7) acting on the CH-NH2 group of donors (1.4) with oxygen as acceptor (1.4.3)
    • C12N9/0024—D-Amino acid oxidase (1.4.3.3)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y104/00—Oxidoreductases acting on the CH-NH2 group of donors (1.4)
    • C12Y104/03—Oxidoreductases acting on the CH-NH2 group of donors (1.4) with oxygen as acceptor (1.4.3)
    • C12Y104/03003—D-Amino-acid oxidase (1.4.3.3)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/80—Vectors or expression systems specially adapted for eukaryotic hosts for fungi
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/78—Hydrolases (3) acting on carbon to nitrogen bonds other than peptide bonds (3.5)
    • C12N9/80—Hydrolases (3) acting on carbon to nitrogen bonds other than peptide bonds (3.5) acting on amide bonds in linear amides (3.5.1)
    • C12N9/84—Penicillin amidase (3.5.1.11)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00—Preparation of peptides or proteins
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y305/00—Hydrolases acting on carbon-nitrogen bonds, other than peptide bonds (3.5)
    • C12Y305/01—Hydrolases acting on carbon-nitrogen bonds, other than peptide bonds (3.5) in linear amides (3.5.1)
    • C12Y305/01011—Penicillin amidase (3.5.1.11), i.e. penicillin-amidohydrolase

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Physics & Mathematics (AREA)
  • Medicinal Chemistry (AREA)
  • Biophysics (AREA)
  • Plant Pathology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Saccharide Compounds (AREA)
AT95120437T 1994-12-23 1995-12-22 Penicillin v amidohydrolase gen aus fusarium oxysporum ATE444369T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US08/363,475 US5516679A (en) 1994-12-23 1994-12-23 Penicillin V amidohydrolase gene from Fusarium oxysporum

Publications (1)

Publication Number Publication Date
ATE444369T1 true ATE444369T1 (de) 2009-10-15

Family

ID=23430378

Family Applications (1)

Application Number Title Priority Date Filing Date
AT95120437T ATE444369T1 (de) 1994-12-23 1995-12-22 Penicillin v amidohydrolase gen aus fusarium oxysporum

Country Status (14)

Country Link
US (1) US5516679A (de)
EP (1) EP0718402B1 (de)
JP (1) JPH08266290A (de)
KR (2) KR100454831B1 (de)
CN (1) CN1100877C (de)
AT (1) ATE444369T1 (de)
AU (1) AU699051B2 (de)
CA (1) CA2163159A1 (de)
DE (1) DE69536009D1 (de)
FI (1) FI956234A7 (de)
HU (1) HU218265B (de)
IL (1) IL116019A (de)
SG (1) SG34344A1 (de)
TW (1) TW461919B (de)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2144139T3 (es) * 1994-08-12 2000-06-01 Dsm Nv Genes de la penicilina g-acilasa mutados.
ATE402997T1 (de) 1996-11-05 2008-08-15 Bristol Myers Squibb Co Mutierte penicillin g acylasen
JP2002517181A (ja) * 1998-02-06 2002-06-18 キュラサイト・アクチェンゲゼルシャフト 細胞の活性化を調節するために提供される核酸
US7091023B2 (en) 2000-08-07 2006-08-15 Novozymes A/S Stereoselective esterase from Aspergillus oryzae
US20050020685A1 (en) * 2003-06-12 2005-01-27 Skonezny Paul M. Process for recovery of 6-aminopenicillanic acid from an aqueous discharge stream
WO2006053929A1 (es) * 2004-03-16 2006-05-26 Antibióticos, S.A.U. Procedimiento para producir la enzima penicilina v acilasa de streptomyces lavendulae en microorganismos recombinantes.
DE102007027825A1 (de) * 2007-06-13 2008-12-18 C-Lecta Gmbh Amidohydrolasen zur Aufbereitung von Nahrungs- oder Genussmitteln
CN104114711B (zh) * 2012-02-24 2017-05-03 百时美施贵宝公司 用于拆分环丙基二酯的方法
JP2025523626A (ja) * 2022-07-08 2025-07-23 メルク・シャープ・アンド・ドーム・エルエルシー ベルズチファンの合成に有用なヒドロキシル化インダノン中間体を調製するための操作された酵素
CN116240198B (zh) * 2023-03-22 2023-08-22 云南师范大学 一种新型单宁酶及其应用

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AT233739B (de) * 1962-02-14 1964-05-25 Biochemie Gmbh Verfahren zur Heranführung von Fusarien oder Hefen für die enzymatische Spaltung von Phenoxymethylpenicillin
SE8403929L (sv) * 1984-07-31 1986-02-21 Sten Gatenbeck Rekombinant-dna-molekyl, transformerade mikroorganismer och forfarande for framstellning av penicillin v-amidas
FR2569723B1 (fr) * 1984-08-31 1986-09-19 Centre Nat Rech Scient Application des antibiotiques de la famille des phleomycines a titre d'agent de selection dans le domaine du genie genetique
DE3439843A1 (de) * 1984-10-31 1986-04-30 Boehringer Mannheim Gmbh, 6800 Mannheim Plasmide zur erhoehten produktion von penicillin g-amidase
FR2594846B1 (fr) * 1986-02-21 1989-10-20 Genetica Procede de preparation de la serum albumine humaine mature
NZ225599A (en) * 1987-08-04 1991-09-25 Bristol Myers Co Antibody-enzyme conjugates and combinations with prodrugs for the treatment of tumour cells
KR0152667B1 (ko) * 1990-04-18 1998-10-01 한스 월터 라벤 페니실린 g 아실라아제, 이 효소를 코드화한 유전자 및 이 효소의 제조방법
JPH0880196A (ja) * 1994-07-12 1996-03-26 Kikkoman Corp タンナーゼ遺伝子を含有するｄｎａ断片、新規な組み換え体プラスミド、タンナーゼの製造方法およびプロモーター

Also Published As

Publication number Publication date
HU218265B (hu) 2000-06-28
JPH08266290A (ja) 1996-10-15
AU4062295A (en) 1996-07-04
FI956234L (fi) 1996-06-24
CA2163159A1 (en) 1996-06-24
AU699051B2 (en) 1998-11-19
HU9503656D0 (en) 1996-02-28
FI956234A7 (fi) 1996-06-24
US5516679A (en) 1996-05-14
IL116019A (en) 2005-07-25
TW461919B (en) 2001-11-01
DE69536009D1 (de) 2009-11-12
KR100469873B1 (ko) 2005-02-03
CN1100877C (zh) 2003-02-05
KR100454831B1 (ko) 2005-01-13
KR960023056A (ko) 1996-07-18
CN1132251A (zh) 1996-10-02
EP0718402A3 (de) 1997-12-17
FI956234A0 (fi) 1995-12-22
SG34344A1 (en) 1996-12-06
HUT74834A (en) 1997-02-28
IL116019A0 (en) 1996-01-31
EP0718402A2 (de) 1996-06-26
EP0718402B1 (de) 2009-09-30

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