ATE445158T1 - Toxizitätstypisierung unter verwendung von leberstammzellen - Google Patents
Toxizitätstypisierung unter verwendung von leberstammzellenInfo
- Publication number
- ATE445158T1 ATE445158T1 AT01946391T AT01946391T ATE445158T1 AT E445158 T1 ATE445158 T1 AT E445158T1 AT 01946391 T AT01946391 T AT 01946391T AT 01946391 T AT01946391 T AT 01946391T AT E445158 T1 ATE445158 T1 AT E445158T1
- Authority
- AT
- Austria
- Prior art keywords
- toxicity
- stem cells
- chemical compositions
- typing
- liver stem
- Prior art date
Links
- 230000001988 toxicity Effects 0.000 title abstract 5
- 231100000419 toxicity Toxicity 0.000 title abstract 5
- 210000004185 liver Anatomy 0.000 title 1
- 210000000130 stem cell Anatomy 0.000 title 1
- 239000000203 mixture Substances 0.000 abstract 4
- 239000000126 substance Substances 0.000 abstract 3
- 108090000623 proteins and genes Proteins 0.000 abstract 2
- 101150000157 ARHGEF1 gene Proteins 0.000 abstract 1
- 230000004075 alteration Effects 0.000 abstract 1
- 238000000506 liquid--solid chromatography Methods 0.000 abstract 1
- 101150055452 lsc gene Proteins 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 102000004169 proteins and genes Human genes 0.000 abstract 1
- 238000012216 screening Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6809—Methods for determination or identification of nucleic acids involving differential detection
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
- G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
- G01N33/5014—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing toxicity
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Immunology (AREA)
- Analytical Chemistry (AREA)
- Molecular Biology (AREA)
- Biomedical Technology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- General Health & Medical Sciences (AREA)
- Physics & Mathematics (AREA)
- Biotechnology (AREA)
- Biochemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Microbiology (AREA)
- Urology & Nephrology (AREA)
- Hematology (AREA)
- Toxicology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- General Engineering & Computer Science (AREA)
- General Physics & Mathematics (AREA)
- Cell Biology (AREA)
- Food Science & Technology (AREA)
- Medicinal Chemistry (AREA)
- Tropical Medicine & Parasitology (AREA)
- Pathology (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
- Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US21160600P | 2000-06-14 | 2000-06-14 | |
| PCT/US2001/019187 WO2001096866A1 (en) | 2000-06-14 | 2001-06-14 | Toxicity typing using liver stem cells |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE445158T1 true ATE445158T1 (de) | 2009-10-15 |
Family
ID=22787620
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT01946391T ATE445158T1 (de) | 2000-06-14 | 2001-06-14 | Toxizitätstypisierung unter verwendung von leberstammzellen |
Country Status (12)
| Country | Link |
|---|---|
| US (3) | US20020012905A1 (de) |
| EP (1) | EP1290444B1 (de) |
| JP (1) | JP2004503256A (de) |
| KR (1) | KR100865664B1 (de) |
| AT (1) | ATE445158T1 (de) |
| AU (1) | AU2001268449A1 (de) |
| CA (1) | CA2412361C (de) |
| DE (1) | DE60140120D1 (de) |
| DK (1) | DK1290444T3 (de) |
| ES (1) | ES2334639T3 (de) |
| HK (1) | HK1054980A1 (de) |
| WO (1) | WO2001096866A1 (de) |
Families Citing this family (30)
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| US7555492B2 (en) * | 1999-11-05 | 2009-06-30 | The Board Of Trustees At The Leland Stanford Junior University | System and method for internet-accessible tools and knowledge base for protocol design, metadata capture and laboratory experiment management |
| DK1290444T3 (da) | 2000-06-14 | 2010-01-18 | Vistagen Inc | Toxicitetstypisering under anvendelse af lever-stamceller |
| US20050060102A1 (en) * | 2000-10-12 | 2005-03-17 | O'reilly David J. | Interactive correlation of compound information and genomic information |
| AU2003214981A1 (en) * | 2002-01-31 | 2003-09-02 | Gene Logic, Inc. | Molecular hepatotoxicology modeling |
| CA2471631A1 (en) * | 2002-02-04 | 2003-08-14 | Gene Logic, Inc. | Primary rat hepatocyte toxicity modeling |
| US20040067507A1 (en) * | 2002-05-10 | 2004-04-08 | Nolan Timothy D. | Liver inflammation predictive genes |
| WO2004097585A2 (en) * | 2003-04-24 | 2004-11-11 | Stanford University | System and method for internet-accessible tools and knowledge base for protocol design, metadata capture and laboratory experiment management |
| EP1654536A4 (de) * | 2003-08-07 | 2008-07-30 | Ocimum Biosolutions Inc | Primäre ratten-hepatozyten-toxizitätsmodellierung |
| JP2007535305A (ja) * | 2003-11-24 | 2007-12-06 | ジーン ロジック インコーポレイテッド | 分子毒性モデリングのための方法 |
| US20080085554A1 (en) * | 2004-02-13 | 2008-04-10 | Norio Nakatsuji | Culture Medium for Culturing Feeder Cells for Embryonic Stem Cells Culture and the Prepared Feeder Cells |
| WO2005124650A2 (en) * | 2004-06-10 | 2005-12-29 | Iconix Pharmaceuticals, Inc. | Sufficient and necessary reagent sets for chemogenomic analysis |
| US7588892B2 (en) * | 2004-07-19 | 2009-09-15 | Entelos, Inc. | Reagent sets and gene signatures for renal tubule injury |
| US20060040338A1 (en) * | 2004-08-18 | 2006-02-23 | Odyssey Thera, Inc. | Pharmacological profiling of drugs with cell-based assays |
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| WO2006077981A1 (ja) * | 2005-01-21 | 2006-07-27 | Miyazaki Prefecture | 高スループット機能性評価方法、プログラム、及び装置 |
| JP4721752B2 (ja) * | 2005-04-06 | 2011-07-13 | 独立行政法人科学技術振興機構 | 妊娠状態における薬物代謝予測法 |
| US7795390B2 (en) | 2005-06-24 | 2010-09-14 | Teijin Pharma Limited | Biological substance nesfatin and its related substances and uses thereof |
| KR101206377B1 (ko) | 2005-09-20 | 2012-11-29 | 마이크로 모우션, 인코포레이티드 | 진동 유량계에 대한 구동 신호를 생성하기 위한 방법 및 계측 전자장치 |
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| US20070198653A1 (en) * | 2005-12-30 | 2007-08-23 | Kurt Jarnagin | Systems and methods for remote computer-based analysis of user-provided chemogenomic data |
| US20100021885A1 (en) * | 2006-09-18 | 2010-01-28 | Mark Fielden | Reagent sets and gene signatures for non-genotoxic hepatocarcinogenicity |
| CA2665183A1 (en) * | 2006-10-02 | 2008-04-10 | Cellartis Ab | Novel toxicity assay based on human blastocyst-derived stem cells and progenitor cells |
| EP2342359B1 (de) * | 2008-08-01 | 2015-03-04 | Brown University | System und verfahren zur bestimmung von molekülen anhand von massenspektrometrie sowie entsprechende verfahren |
| GB201103828D0 (en) * | 2011-03-07 | 2011-04-20 | Dundee Cell Products Ltd | Evaluation of therapeutic agent |
| JP5820320B2 (ja) * | 2012-03-27 | 2015-11-24 | 株式会社東芝 | 情報処理端末及び方法、並びに、情報管理装置及び方法 |
| WO2016029211A1 (en) * | 2014-08-22 | 2016-02-25 | The General Hospital Corporation | Systems and methods for discovery and characterization of neuroactive drugs |
| US10179896B2 (en) | 2015-05-12 | 2019-01-15 | Baker Group, LLP | Method and system for a bioartificial organ |
| US10303757B2 (en) | 2016-08-19 | 2019-05-28 | Cognex Corporation | Apparatuses, systems, and methods for providing a visual program for machine vision systems |
| KR102083408B1 (ko) * | 2017-04-28 | 2020-03-02 | 가천대학교 산학협력단 | 줄기세포 기반의 독성 물질 스크리닝 방법 |
| CN111549112A (zh) * | 2020-04-02 | 2020-08-18 | 中国农业大学 | 一种丙烯酰胺暴露检测的标志物及其应用 |
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-
2001
- 2001-06-14 DK DK01946391.8T patent/DK1290444T3/da active
- 2001-06-14 CA CA2412361A patent/CA2412361C/en not_active Expired - Fee Related
- 2001-06-14 WO PCT/US2001/019187 patent/WO2001096866A1/en not_active Ceased
- 2001-06-14 ES ES01946391T patent/ES2334639T3/es not_active Expired - Lifetime
- 2001-06-14 AU AU2001268449A patent/AU2001268449A1/en not_active Abandoned
- 2001-06-14 JP JP2002510944A patent/JP2004503256A/ja active Pending
- 2001-06-14 EP EP01946391A patent/EP1290444B1/de not_active Expired - Lifetime
- 2001-06-14 AT AT01946391T patent/ATE445158T1/de not_active IP Right Cessation
- 2001-06-14 KR KR1020027017109A patent/KR100865664B1/ko not_active Expired - Fee Related
- 2001-06-14 US US09/881,526 patent/US20020012905A1/en not_active Abandoned
- 2001-06-14 HK HK03106524.9A patent/HK1054980A1/zh unknown
- 2001-06-14 DE DE60140120T patent/DE60140120D1/de not_active Expired - Lifetime
-
2006
- 2006-06-01 US US11/445,733 patent/US8143009B2/en not_active Expired - Fee Related
-
2012
- 2012-02-21 US US13/401,623 patent/US8512957B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| US8143009B2 (en) | 2012-03-27 |
| CA2412361C (en) | 2011-08-23 |
| US8512957B2 (en) | 2013-08-20 |
| US20020012905A1 (en) | 2002-01-31 |
| WO2001096866A1 (en) | 2001-12-20 |
| EP1290444A1 (de) | 2003-03-12 |
| JP2004503256A (ja) | 2004-02-05 |
| AU2001268449A1 (en) | 2001-12-24 |
| US20120220469A1 (en) | 2012-08-30 |
| KR20030009532A (ko) | 2003-01-29 |
| DE60140120D1 (de) | 2009-11-19 |
| HK1054980A1 (zh) | 2003-12-19 |
| KR100865664B1 (ko) | 2008-10-29 |
| DK1290444T3 (da) | 2010-01-18 |
| CA2412361A1 (en) | 2001-12-20 |
| ES2334639T3 (es) | 2010-03-15 |
| EP1290444B1 (de) | 2009-10-07 |
| US20070111195A1 (en) | 2007-05-17 |
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