ATE44649T1 - Glykosylierte insulinabkoemmlinge. - Google Patents

Glykosylierte insulinabkoemmlinge.

Info

Publication number
ATE44649T1
ATE44649T1 AT83903886T AT83903886T ATE44649T1 AT E44649 T1 ATE44649 T1 AT E44649T1 AT 83903886 T AT83903886 T AT 83903886T AT 83903886 T AT83903886 T AT 83903886T AT E44649 T1 ATE44649 T1 AT E44649T1
Authority
AT
Austria
Prior art keywords
combat
mannopyranosides
gluco
alpha
phenyl
Prior art date
Application number
AT83903886T
Other languages
English (en)
Inventor
James C Mcrea
Original Assignee
Univ Utah
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Utah filed Critical Univ Utah
Application granted granted Critical
Publication of ATE44649T1 publication Critical patent/ATE44649T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/203—Monocyclic carbocyclic rings other than cyclohexane rings; Bicyclic carbocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/62—Insulins
    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01B—CABLES; CONDUCTORS; INSULATORS; SELECTION OF MATERIALS FOR THEIR CONDUCTIVE, INSULATING OR DIELECTRIC PROPERTIES
    • H01B11/00—Communication cables or conductors
    • H01B11/02—Cables with twisted pairs or quads
    • H01B11/04—Cables with twisted pairs or quads with pairs or quads mutually positioned to reduce cross-talk
    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01B—CABLES; CONDUCTORS; INSULATORS; SELECTION OF MATERIALS FOR THEIR CONDUCTIVE, INSULATING OR DIELECTRIC PROPERTIES
    • H01B13/00—Apparatus or processes specially adapted for manufacturing conductors or cables
    • H01B13/02—Stranding-up
    • H01B13/04—Mutually positioning pairs or quads to reduce cross-talk
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Diabetes (AREA)
  • Medicinal Chemistry (AREA)
  • Biophysics (AREA)
  • Endocrinology (AREA)
  • Toxicology (AREA)
  • Manufacturing & Machinery (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biotechnology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Saccharide Compounds (AREA)
AT83903886T 1982-11-17 1983-11-15 Glykosylierte insulinabkoemmlinge. ATE44649T1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US06/442,362 US4444683A (en) 1982-11-17 1982-11-17 Glycosylated insulin derivatives
PCT/US1983/001780 WO1984001896A1 (en) 1982-11-17 1983-11-15 Glycosylated insulin derivatives
EP83903886A EP0125299B1 (de) 1982-11-17 1983-11-15 Glykosylierte insulinabkömmlinge

Publications (1)

Publication Number Publication Date
ATE44649T1 true ATE44649T1 (de) 1989-08-15

Family

ID=23756525

Family Applications (2)

Application Number Title Priority Date Filing Date
AT83903886T ATE44649T1 (de) 1982-11-17 1983-11-15 Glykosylierte insulinabkoemmlinge.
AT8888120072T ATE105296T1 (de) 1982-11-17 1983-11-15 Glycosylierte insulin-derivate.

Family Applications After (1)

Application Number Title Priority Date Filing Date
AT8888120072T ATE105296T1 (de) 1982-11-17 1983-11-15 Glycosylierte insulin-derivate.

Country Status (8)

Country Link
US (2) US4444683A (de)
EP (2) EP0125299B1 (de)
JP (1) JPH0613556B2 (de)
AT (2) ATE44649T1 (de)
CA (1) CA1216578A (de)
DE (2) DE3382749T2 (de)
IT (1) IT1207992B (de)
WO (1) WO1984001896A1 (de)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE8102194L (sv) * 1981-04-06 1982-10-07 Pharmacia Ab Terapeutiskt aktiv organisk forening och farmaceutisk beredning innehallande denna
DE3790635B4 (de) * 1986-10-13 2007-11-22 Novartis Ag Verfahren zur Herstellung eines Peptidalkohols und Ausgangsverbindungen dafür
NL194729C (nl) * 1986-10-13 2003-01-07 Novartis Ag Werkwijze voor de bereiding van peptidealcoholen via vaste fase.
US4885163A (en) * 1987-02-24 1989-12-05 Eli Lilly And Company Topical use of IGF-II for wound healing
DE3829798A1 (de) * 1988-09-02 1990-03-08 Bosch Gmbh Robert Kraftstoffeinspritzpumpe fuer brennkraftmaschinen
US5218092A (en) * 1988-09-29 1993-06-08 Kyowa Hakko Kogyo Co., Ltd. Modified granulocyte-colony stimulating factor polypeptide with added carbohydrate chains
DK111489D0 (da) * 1989-03-08 1989-03-08 Novo Nordisk As Peptider
JP2648584B2 (ja) * 1990-02-16 1997-09-03 株式会社ディ・ディ・エス研究所 グリコシル−蛋白誘導体
JP3318602B2 (ja) 1997-11-10 2002-08-26 独立行政法人産業技術総合研究所 糖鎖付加型ヘパリン結合性タンパク質、その製造方法およびそれを含有する医薬組成物
US6323311B1 (en) 1999-09-22 2001-11-27 University Of Utah Research Foundation Synthesis of insulin derivatives
US7316999B2 (en) * 2000-06-02 2008-01-08 Novo Nordisk A/S Glucose dependent release of insulin from glucose sensing insulin derivatives
US7176278B2 (en) 2001-08-30 2007-02-13 Biorexis Technology, Inc. Modified transferrin fusion proteins
US7317000B2 (en) * 2001-12-02 2008-01-08 Novo Nordisk A/S Glucose-dependent insulins
JP5063359B2 (ja) * 2004-12-06 2012-10-31 ヴェトロックス・アーゲー 硬質の表面、特にガラス表面を研磨するための装置
US7687608B2 (en) * 2005-10-19 2010-03-30 Smartcells, Inc. Methods for reducing the mitogenicity of lectin compositions
KR100829257B1 (ko) * 2006-06-22 2008-05-14 부경대학교 산학협력단 인간 섬유육종세포에서 메트릭스 메탈로프로테이나제-9의발현 및 활성을 억제하는 카복시화 글루코사민 화합물 및이를 함유한 메트릭스 메탈로프로테이나제-9 억제제
JP2008214256A (ja) * 2007-03-02 2008-09-18 Yaizu Suisankagaku Industry Co Ltd 双頭型配糖化合物の製造方法及び双頭型配糖化合物並びに該双頭型配糖化合物を含有する糖鎖認識タンパク質結合剤
WO2010088300A1 (en) 2009-01-28 2010-08-05 Smartcells, Inc. Crystalline insulin-conjugates
BRPI1007457A2 (pt) 2009-01-28 2015-08-25 Smartcells Inc Conjungado, formulação de liberação prolongada, e, sistema de distribuição de bomba.
WO2010088268A1 (en) 2009-01-28 2010-08-05 Smartcells, Inc. Exogenously triggered controlled release materials and uses thereof
WO2010088286A1 (en) 2009-01-28 2010-08-05 Smartcells, Inc. Synthetic conjugates and uses thereof
US8623345B2 (en) 2009-03-20 2014-01-07 Smartcells Terminally-functionalized conjugates and uses thereof
WO2010107520A1 (en) 2009-03-20 2010-09-23 Smartcells, Inc. Soluble non-depot insulin conjugates and uses thereof
JP2013535467A (ja) 2010-07-28 2013-09-12 スマートセルズ・インコーポレイテツド 組換えにより発現されたインスリンポリペプチドおよびその使用
EP2598522A4 (de) 2010-07-28 2014-11-12 Smartcells Inc Rekombinante lektine, bindungsstellenmodifizierte lektine und anwendungen davon
AU2011282977A1 (en) 2010-07-28 2013-02-21 Smartcells, Inc. Drug-ligand conjugates, synthesis thereof, and intermediates thereto
US9707276B2 (en) 2012-12-03 2017-07-18 Merck Sharp & Dohme Corp. O-glycosylated carboxy terminal portion (CTP) peptide-based insulin and insulin analogues
KR20160065930A (ko) 2013-10-04 2016-06-09 머크 샤프 앤드 돔 코포레이션 글루코스-반응성 인슐린 접합체

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3591574A (en) * 1968-05-29 1971-07-06 American Home Prod Tri-n-phenylglycyl derivatives of insulin
US3723617A (en) * 1968-12-31 1973-03-27 Smith Kline French Lab Anti-inflammatory compositions containing acylated-{62 -d-glucopyranosides and methods of using them
US3847890A (en) * 1971-11-01 1974-11-12 A Green Acidic monosaccharide-substituted proteins
US3755569A (en) * 1972-07-25 1973-08-28 American Home Prod Acyl substituted insulins
US4152513A (en) * 1977-06-01 1979-05-01 University Of Delaware Preparation of alkyl glycosides of amino sugars
DE3220427A1 (de) * 1982-05-29 1983-12-01 Behringwerke Ag, 3550 Marburg Ss-d-galactosederivate, verfahren zu ihrer herstellung und ihre verwendung

Also Published As

Publication number Publication date
JPH0613556B2 (ja) 1994-02-23
EP0312127B1 (de) 1994-05-04
ATE105296T1 (de) 1994-05-15
US4444683A (en) 1984-04-24
DE3382749T2 (de) 1994-09-29
DE3380199D1 (en) 1989-08-24
IT1207992B (it) 1989-06-01
EP0125299B1 (de) 1989-07-19
DE3382749D1 (de) 1994-06-09
IT8323762A0 (it) 1983-11-17
JPS59502065A (ja) 1984-12-13
EP0125299A1 (de) 1984-11-21
WO1984001896A1 (en) 1984-05-24
EP0312127A3 (de) 1991-09-25
CA1216578A (en) 1987-01-13
EP0125299A4 (de) 1986-02-13
US4478746A (en) 1984-10-23
EP0312127A2 (de) 1989-04-19

Similar Documents

Publication Publication Date Title
ATE44649T1 (de) Glykosylierte insulinabkoemmlinge.
FI871592A0 (fi) Bilddisplay.
FI882890A7 (fi) Faktori VIII:C:n kaltainen koagulaatioaktiivisuutta omaava molekyyli.
ZA862961B (en) New 2,5-diaryl tetrahydrofurans and analogs thereof as paf-antagonists
EP0304782A3 (en) 6-acyl-(6h)-dibenz ûc,e¨ û1,2¨ oxaphosphorin-6-oxides, their preparation and use as photoinitiators
DE3887338D1 (de) Superaktive menschliche insulin-analoge.
IL102346A0 (en) Cysteine depleted il-6 muteins
NZ230155A (en) N-2,3-butadienyl-n"-substituted-triamindalkanes and alkenes, and pharmaceutical compositions
ATE45163T1 (de) 5'-methylthio-5'-deoxyadenosin mit langkettigen alkylsulphonsaeuren.
TW221379B (de)
EP0344333A4 (de) Kryogene adsorptionspumpe.
ATE44286T1 (de) Aetherhaltige mischungen in flexiblem pvc.
GR3006357T3 (de)
DK423886A (da) Forbindelsen (+)-6-chlor-5,10-dihydro-5-((1-methyl-4-piperidinyl)acetyl)-11h-dibenzo(b,e)(1,4)diazepin-11-on, dens isolering og anvendelsesom laegemiddel
ATE12539T1 (de) Hydrostatisches lager.
IT8467291A1 (it) Composizione farmaceutica per rinforzare i vasi sangugni.
BG45853A3 (bg) Метод за получаване на бензамидни съединения
KR910009280A (ko) 원발성 흉막암 치료용 제약 조성물의 제조에 있어서 감마 인터페론 활성을 갖는 폴리펩티드의 용도
Kmet Calculation of augmentation terminals
IT8420381A0 (it) Struttura di contenitore portatile, particolarmente studiata per consentire l'effettuazione di bisogni fisiologici.
IT8620124A0 (it) Composizione liquida e plimerizzabile adatta per laproduzione di vetri organici dotati di elevata resistenza all'abrasione.
JPS57106659A (en) 1-carboxy-azaalkanoylindoline-2-carboxylic acid, manufacture, pharmaceutic medicine containing same and therapeutical use
IT1197892B (it) Composizioni farmaceutiche ad attivita' cicatrizzante
KR860000969A (ko) 직선 각도기의 자
TH3925S (th) ภาชนะที่ยืดหยุ่นได้

Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification
REN Ceased due to non-payment of the annual fee