IT1207992B - Derivati glicosilati dell'insulina. - Google Patents

Derivati glicosilati dell'insulina.

Info

Publication number
IT1207992B
IT1207992B IT8323762A IT2376283A IT1207992B IT 1207992 B IT1207992 B IT 1207992B IT 8323762 A IT8323762 A IT 8323762A IT 2376283 A IT2376283 A IT 2376283A IT 1207992 B IT1207992 B IT 1207992B
Authority
IT
Italy
Prior art keywords
insulin
mannopyranosides
gluco
alpha
phenyl
Prior art date
Application number
IT8323762A
Other languages
English (en)
Other versions
IT8323762A0 (it
Inventor
James C Mcrea
Sung Wan Kim
Seo Young Jeong
Original Assignee
Salt Lake City Utah U S A A
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Salt Lake City Utah U S A A filed Critical Salt Lake City Utah U S A A
Publication of IT8323762A0 publication Critical patent/IT8323762A0/it
Application granted granted Critical
Publication of IT1207992B publication Critical patent/IT1207992B/it

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/203—Monocyclic carbocyclic rings other than cyclohexane rings; Bicyclic carbocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/62—Insulins
    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01B—CABLES; CONDUCTORS; INSULATORS; SELECTION OF MATERIALS FOR THEIR CONDUCTIVE, INSULATING OR DIELECTRIC PROPERTIES
    • H01B11/00—Communication cables or conductors
    • H01B11/02—Cables with twisted pairs or quads
    • H01B11/04—Cables with twisted pairs or quads with pairs or quads mutually positioned to reduce cross-talk
    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01B—CABLES; CONDUCTORS; INSULATORS; SELECTION OF MATERIALS FOR THEIR CONDUCTIVE, INSULATING OR DIELECTRIC PROPERTIES
    • H01B13/00—Apparatus or processes specially adapted for manufacturing conductors or cables
    • H01B13/02—Stranding-up
    • H01B13/04—Mutually positioning pairs or quads to reduce cross-talk
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Diabetes (AREA)
  • Medicinal Chemistry (AREA)
  • Biophysics (AREA)
  • Endocrinology (AREA)
  • Toxicology (AREA)
  • Manufacturing & Machinery (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biotechnology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Saccharide Compounds (AREA)
IT8323762A 1982-11-17 1983-11-17 Derivati glicosilati dell'insulina. IT1207992B (it)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/442,362 US4444683A (en) 1982-11-17 1982-11-17 Glycosylated insulin derivatives

Publications (2)

Publication Number Publication Date
IT8323762A0 IT8323762A0 (it) 1983-11-17
IT1207992B true IT1207992B (it) 1989-06-01

Family

ID=23756525

Family Applications (1)

Application Number Title Priority Date Filing Date
IT8323762A IT1207992B (it) 1982-11-17 1983-11-17 Derivati glicosilati dell'insulina.

Country Status (8)

Country Link
US (2) US4444683A (it)
EP (2) EP0125299B1 (it)
JP (1) JPH0613556B2 (it)
AT (2) ATE44649T1 (it)
CA (1) CA1216578A (it)
DE (2) DE3382749T2 (it)
IT (1) IT1207992B (it)
WO (1) WO1984001896A1 (it)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE8102194L (sv) * 1981-04-06 1982-10-07 Pharmacia Ab Terapeutiskt aktiv organisk forening och farmaceutisk beredning innehallande denna
DE3790635B4 (de) * 1986-10-13 2007-11-22 Novartis Ag Verfahren zur Herstellung eines Peptidalkohols und Ausgangsverbindungen dafür
NL194729C (nl) * 1986-10-13 2003-01-07 Novartis Ag Werkwijze voor de bereiding van peptidealcoholen via vaste fase.
US4885163A (en) * 1987-02-24 1989-12-05 Eli Lilly And Company Topical use of IGF-II for wound healing
DE3829798A1 (de) * 1988-09-02 1990-03-08 Bosch Gmbh Robert Kraftstoffeinspritzpumpe fuer brennkraftmaschinen
US5218092A (en) * 1988-09-29 1993-06-08 Kyowa Hakko Kogyo Co., Ltd. Modified granulocyte-colony stimulating factor polypeptide with added carbohydrate chains
DK111489D0 (da) * 1989-03-08 1989-03-08 Novo Nordisk As Peptider
JP2648584B2 (ja) * 1990-02-16 1997-09-03 株式会社ディ・ディ・エス研究所 グリコシル−蛋白誘導体
JP3318602B2 (ja) 1997-11-10 2002-08-26 独立行政法人産業技術総合研究所 糖鎖付加型ヘパリン結合性タンパク質、その製造方法およびそれを含有する医薬組成物
US6323311B1 (en) 1999-09-22 2001-11-27 University Of Utah Research Foundation Synthesis of insulin derivatives
US7316999B2 (en) * 2000-06-02 2008-01-08 Novo Nordisk A/S Glucose dependent release of insulin from glucose sensing insulin derivatives
US7176278B2 (en) 2001-08-30 2007-02-13 Biorexis Technology, Inc. Modified transferrin fusion proteins
US7317000B2 (en) * 2001-12-02 2008-01-08 Novo Nordisk A/S Glucose-dependent insulins
JP5063359B2 (ja) * 2004-12-06 2012-10-31 ヴェトロックス・アーゲー 硬質の表面、特にガラス表面を研磨するための装置
US7687608B2 (en) * 2005-10-19 2010-03-30 Smartcells, Inc. Methods for reducing the mitogenicity of lectin compositions
KR100829257B1 (ko) * 2006-06-22 2008-05-14 부경대학교 산학협력단 인간 섬유육종세포에서 메트릭스 메탈로프로테이나제-9의발현 및 활성을 억제하는 카복시화 글루코사민 화합물 및이를 함유한 메트릭스 메탈로프로테이나제-9 억제제
JP2008214256A (ja) * 2007-03-02 2008-09-18 Yaizu Suisankagaku Industry Co Ltd 双頭型配糖化合物の製造方法及び双頭型配糖化合物並びに該双頭型配糖化合物を含有する糖鎖認識タンパク質結合剤
WO2010088300A1 (en) 2009-01-28 2010-08-05 Smartcells, Inc. Crystalline insulin-conjugates
BRPI1007457A2 (pt) 2009-01-28 2015-08-25 Smartcells Inc Conjungado, formulação de liberação prolongada, e, sistema de distribuição de bomba.
WO2010088268A1 (en) 2009-01-28 2010-08-05 Smartcells, Inc. Exogenously triggered controlled release materials and uses thereof
WO2010088286A1 (en) 2009-01-28 2010-08-05 Smartcells, Inc. Synthetic conjugates and uses thereof
US8623345B2 (en) 2009-03-20 2014-01-07 Smartcells Terminally-functionalized conjugates and uses thereof
WO2010107520A1 (en) 2009-03-20 2010-09-23 Smartcells, Inc. Soluble non-depot insulin conjugates and uses thereof
JP2013535467A (ja) 2010-07-28 2013-09-12 スマートセルズ・インコーポレイテツド 組換えにより発現されたインスリンポリペプチドおよびその使用
EP2598522A4 (en) 2010-07-28 2014-11-12 Smartcells Inc RECOMBINANT LKTINE, BINDING POINT MODIFIED LECTIN AND APPLICATIONS THEREOF
AU2011282977A1 (en) 2010-07-28 2013-02-21 Smartcells, Inc. Drug-ligand conjugates, synthesis thereof, and intermediates thereto
US9707276B2 (en) 2012-12-03 2017-07-18 Merck Sharp & Dohme Corp. O-glycosylated carboxy terminal portion (CTP) peptide-based insulin and insulin analogues
KR20160065930A (ko) 2013-10-04 2016-06-09 머크 샤프 앤드 돔 코포레이션 글루코스-반응성 인슐린 접합체

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3591574A (en) * 1968-05-29 1971-07-06 American Home Prod Tri-n-phenylglycyl derivatives of insulin
US3723617A (en) * 1968-12-31 1973-03-27 Smith Kline French Lab Anti-inflammatory compositions containing acylated-{62 -d-glucopyranosides and methods of using them
US3847890A (en) * 1971-11-01 1974-11-12 A Green Acidic monosaccharide-substituted proteins
US3755569A (en) * 1972-07-25 1973-08-28 American Home Prod Acyl substituted insulins
US4152513A (en) * 1977-06-01 1979-05-01 University Of Delaware Preparation of alkyl glycosides of amino sugars
DE3220427A1 (de) * 1982-05-29 1983-12-01 Behringwerke Ag, 3550 Marburg Ss-d-galactosederivate, verfahren zu ihrer herstellung und ihre verwendung

Also Published As

Publication number Publication date
JPH0613556B2 (ja) 1994-02-23
EP0312127B1 (en) 1994-05-04
ATE105296T1 (de) 1994-05-15
US4444683A (en) 1984-04-24
DE3382749T2 (de) 1994-09-29
DE3380199D1 (en) 1989-08-24
EP0125299B1 (en) 1989-07-19
ATE44649T1 (de) 1989-08-15
DE3382749D1 (de) 1994-06-09
IT8323762A0 (it) 1983-11-17
JPS59502065A (ja) 1984-12-13
EP0125299A1 (en) 1984-11-21
WO1984001896A1 (en) 1984-05-24
EP0312127A3 (en) 1991-09-25
CA1216578A (en) 1987-01-13
EP0125299A4 (en) 1986-02-13
US4478746A (en) 1984-10-23
EP0312127A2 (en) 1989-04-19

Similar Documents

Publication Publication Date Title
IT1207992B (it) Derivati glicosilati dell'insulina.
MA20402A1 (fr) Polypeptide physiologiquement actif humain,acide desoxybromidrique comprenant une sequence de base cordant ce polypeptide,procede de production de ce polypeptide et composition les contenant
IT1179635B (it) Composizione e preparato per la somministrazione di medicamenti per via cutanea
DE3669315D1 (de) Phenoxyalkylaminopyrimidinderivate, deren herstellung und diese enthaltende insektizide und akarizide zusammensetzungen.
EP0564739A3 (it)
FI882890A7 (fi) Faktori VIII:C:n kaltainen koagulaatioaktiivisuutta omaava molekyyli.
DE3679908D1 (de) Hexadecylphosphocolin enthaltende arzneimittel mit antitumorwirkung.
FR2392971A1 (fr) Derives de l'acide prostanoique, leur preparation et medicament contenant ces substances
FI854227A0 (fi) Menetelmä analgeettisena aineena käyttökelpoisten polypeptidien valmistamiseksi
BE858605A (fr) Nouveaux acides 5-alkoxymidazo (1,2-a)quinoleine-2-carboxyliques et leurs derives et composition pharmaceutique les contenant
IT1150608B (it) Complessi platino-diamminici e procedimento per la loro preparazione nonche' formulazioni farmaceutiche antitumorali contenenti tali complessi
ATE82857T1 (de) Interleukin-2-zusammensetzungen.
MY101175A (en) External medication
DK0416678T3 (da) Topiske præparater indeholdende Defibrotid
SE8400723L (sv) Farmaceutisk komposition
IT8719048A0 (it) Composizione farmaceutica contenente sulglicotide per la terapia dell'ulcera gastrica
ATE77048T1 (de) Bioemulgatoren enthaltende kosmetische und pharmazeutische zusammensetzungen.
SE8405588D0 (sv) New compounds
FI925745A0 (fi) Interleukin-6-kompositioner och foerfarande foer deras framstaellning
DE3578597D1 (de) 4-phenylphthalazin-derivate, deren herstellung und diese enthaltende pharmazeutische zusammenstellungen.
ATE55123T1 (de) Alkylcarbonsaeureamide von pyridinalkylaminen, ihre herstellung und ihre verwendung als arzneimittel.
BG45853A3 (bg) Метод за получаване на бензамидни съединения
PT84011A (fr) Procede de preparation de nouveaux analogues de composes polypeptidiques hypocalcemiants epargnant de calcium de l:organisme
FR2500823B1 (fr) 1-aminoalkyl-1, 2, 3, 4-tetrahydroanphtalenes mono- ou disubstitues utiles notamment comme adrenergiques et medicaments les contenant
IL52644A0 (en) Novel 2,3-alkylene bis(oxy)benzamide derivatives,their preparation and pharmaceutical compositions containing them