ATE446675T1 - Humane chronische lymphozytische leukämie im mausmodell durch gezielte expression von tcl1 - Google Patents

Humane chronische lymphozytische leukämie im mausmodell durch gezielte expression von tcl1

Info

Publication number
ATE446675T1
ATE446675T1 AT03731057T AT03731057T ATE446675T1 AT E446675 T1 ATE446675 T1 AT E446675T1 AT 03731057 T AT03731057 T AT 03731057T AT 03731057 T AT03731057 T AT 03731057T AT E446675 T1 ATE446675 T1 AT E446675T1
Authority
AT
Austria
Prior art keywords
lymphocytic leukemia
tcl1
chronic lymphocytic
mouse model
human chronic
Prior art date
Application number
AT03731057T
Other languages
English (en)
Inventor
Carlo Croce
Original Assignee
Univ Jefferson
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Jefferson filed Critical Univ Jefferson
Application granted granted Critical
Publication of ATE446675T1 publication Critical patent/ATE446675T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
    • A01K67/027—New or modified breeds of vertebrates
    • A01K67/0275—Genetically modified vertebrates, e.g. transgenic
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/8509—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells for producing genetically modified animals, e.g. transgenic
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2227/00—Animals characterised by species
    • A01K2227/10—Mammal
    • A01K2227/105—Murine
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2267/00—Animals characterised by purpose
    • A01K2267/03—Animal model, e.g. for test or diseases
    • A01K2267/0331—Animal model for proliferative diseases

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Chemical & Material Sciences (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Wood Science & Technology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Environmental Sciences (AREA)
  • Plant Pathology (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Physics & Mathematics (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biodiversity & Conservation Biology (AREA)
  • Microbiology (AREA)
  • Animal Husbandry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
AT03731057T 2002-04-29 2003-04-29 Humane chronische lymphozytische leukämie im mausmodell durch gezielte expression von tcl1 ATE446675T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US37646402P 2002-04-29 2002-04-29
PCT/US2003/013306 WO2003092370A1 (en) 2002-04-29 2003-04-29 Human chronic lymphocytic leukemia modeled in mouse by targeted tcl1 expression

Publications (1)

Publication Number Publication Date
ATE446675T1 true ATE446675T1 (de) 2009-11-15

Family

ID=29401350

Family Applications (1)

Application Number Title Priority Date Filing Date
AT03731057T ATE446675T1 (de) 2002-04-29 2003-04-29 Humane chronische lymphozytische leukämie im mausmodell durch gezielte expression von tcl1

Country Status (8)

Country Link
US (3) US20040078834A1 (de)
EP (1) EP1499182B1 (de)
JP (1) JP2005523712A (de)
AT (1) ATE446675T1 (de)
AU (1) AU2003241325A1 (de)
CA (1) CA2484920A1 (de)
DE (1) DE60329836D1 (de)
WO (1) WO2003092370A1 (de)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN111616106A (zh) * 2020-06-23 2020-09-04 成都欧林生物科技股份有限公司 一种骨折相关的金黄色葡萄球菌感染动物模型建立方法

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CN103820562B (zh) * 2005-08-01 2015-05-13 俄亥俄州立大学研究基金会 用于乳腺癌的诊断、预后和治疗的基于MicroRNA的方法和组合物
JP2009507918A (ja) * 2005-09-12 2009-02-26 ジ・オハイオ・ステイト・ユニバーシティ・リサーチ・ファウンデイション Ｂｃｌ２関連癌の診断及び療法のための組成物及び方法
US20090270484A1 (en) * 2005-10-05 2009-10-29 The Ohio State University Research Foundation WWOX Vectors and Uses in Treatment of Cancer
ES2553442T3 (es) 2006-01-05 2015-12-09 The Ohio State University Research Foundation Procedimientos basados en los microARN para el diagnóstico, pronóstico y tratamiento del cáncer de pulmón
US7670840B2 (en) 2006-01-05 2010-03-02 The Ohio State University Research Foundation Micro-RNA expression abnormalities of pancreatic, endocrine and acinar tumors
EP1969147B1 (de) 2006-01-05 2014-07-30 The Ohio State University Research Foundation mikro-RNA-basierte verfahren zur Diagnose von Magenkrebs
EP2369011A1 (de) 2006-03-20 2011-09-28 The Ohio State University Research Foundation Miko-RNA-Fingerabdrücke während humaner Megakaryozytopoiese
EP2041317A4 (de) 2006-07-13 2009-10-14 Univ Ohio State Res Found Mikro-rna-basierte verfahren und zusammensetzungen zur diagnose und behandlung von erkrankungen in zusammenhang mit darmkrebs
EP2061907B1 (de) * 2006-09-19 2011-11-23 The Ohio State University Research Foundation Tcl1-expression in durch mir-29 und mir-181 regulierter chronischer lymphozyten-leukämie (cll)
US8252538B2 (en) 2006-11-01 2012-08-28 The Ohio State University MicroRNA expression signature for predicting survival and metastases in hepatocellular carcinoma
WO2008094545A2 (en) * 2007-01-31 2008-08-07 The Ohio State University Research Foundation Mic orna-based methods and compositions for the treatment of acute myeloid leukemia
AU2008248319B2 (en) * 2007-04-30 2013-09-05 The Ohio State University Research Foundation Methods for differentiating pancreatic cancer from normal pancreatic function and/or chronic pancreatitis
ES2537349T3 (es) * 2007-06-08 2015-06-05 The Government Of The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Métodos para determinar un subtipo de carcinoma hepatocelular
CN101918424A (zh) 2007-06-15 2010-12-15 俄亥俄州立大学研究基金会 用于靶向由Drosha介导的微小RNA加工的致癌ALL-1融合蛋白
CN101809169B (zh) * 2007-07-31 2013-07-17 俄亥俄州立大学研究基金会 通过靶向dnmt3a和dnmt3b恢复甲基化的方法
EP2653561B1 (de) * 2007-08-03 2016-03-02 The Ohio State University Research Foundation Ultrakonservierte Bereiche zur Codierung von ncRNA
EP3028708A1 (de) * 2007-08-22 2016-06-08 The Ohio State University Research Foundation Verfahren und zusammensetzungen zur induzierung von epha7-deregulierung und erk-phosphorlylierung bei humaner akuter leukämie
EP2775001B1 (de) * 2007-09-06 2016-03-09 The Ohio State University Research Foundation MikroRNA-Signaturen in menschlichem Ovarialkarzinom
EP2212440A4 (de) * 2007-10-11 2011-04-06 Univ Ohio State Res Found Verfahren und zusammensetzungen zur diagnose und behandlung von adenokarzinomen der speiseröhre
CA2703707A1 (en) 2007-10-26 2009-04-30 The Ohio State University Research Foundation Methods for identifying fragile histidine triad (fhit) interaction and uses thereof
CN101918594A (zh) * 2007-11-30 2010-12-15 俄亥俄州立大学研究基金会 肺癌中外周血中的微rna表达特征谱和靶向
CN102027129B (zh) * 2008-02-28 2014-03-12 俄亥俄州立大学研究基金会 用于前列腺相关病症的诊断、预后和治疗的基于微rna的方法和组合物
CA2717026A1 (en) * 2008-02-28 2009-09-03 The Ohio State University Research Foundation Microrna signatures associated with human chronic lymphocytic leukemia (ccl) and uses thereof
EP2307028B1 (de) 2008-06-11 2013-10-02 The Government of the United States of America as represented by The Secretary of the Department of Health and Human Services Verwendung der mir-26-familie als prädiktiver marker für hepatozelluläres karzinom und des ansprechens auf die therapie
AU2010321555B2 (en) 2009-11-23 2015-10-15 The Ohio State University Materials and methods useful for affecting tumor cell growth, migration and invasion
JP2013534824A (ja) * 2010-06-24 2013-09-09 ジ・オハイオ・ステート・ユニバーシティ 標的化されたｍｉＲ−２９発現によりマウスにおいてモデル化された慢性リンパ性白血病
ES2606146T3 (es) 2010-11-12 2017-03-22 The Ohio State University Research Foundation Métodos relacionados con microARN-21 y reparación de desapareamiento en cáncer colorrectal
CN103313706A (zh) 2010-11-15 2013-09-18 俄亥俄州立大学研究基金会 控制释放粘膜粘合系统
US8664192B2 (en) 2011-03-07 2014-03-04 The Ohio State University Mutator activity induced by microRNA-155 (miR-155) links inflammation and cancer
EP2766500A4 (de) 2011-10-14 2015-10-14 Univ Ohio State Verfahren und materialien in verbindung mit eierstockkrebs
AU2012352265B2 (en) 2011-12-13 2017-02-16 Ohio State Innovation Foundation Methods and compositions related to miR-21 and miR-29a, exosome inhibition, and cancer metastasis
US8859202B2 (en) 2012-01-20 2014-10-14 The Ohio State University Breast cancer biomarker signatures for invasiveness and prognosis
CN108165580A (zh) * 2017-10-16 2018-06-15 中国医学科学院基础医学研究所 Nok基因及其表达产物在构建慢性b淋巴细胞白血病动物模型中的用途

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US4873191A (en) 1981-06-12 1989-10-10 Ohio University Genetic transformation of zygotes
US4870009A (en) 1982-11-22 1989-09-26 The Salk Institute For Biological Studies Method of obtaining gene product through the generation of transgenic animals
US4736866B1 (en) 1984-06-22 1988-04-12 Transgenic non-human mammals
GB8615942D0 (en) 1986-06-30 1986-08-06 Animal & Food Research Council Peptide production
GB8826446D0 (en) 1988-11-11 1988-12-14 Agricultural & Food Res Peptide production
US5550316A (en) * 1991-01-02 1996-08-27 Fox Chase Cancer Center Transgenic animal model system for human cutaneous melanoma
EP0591219B1 (de) 1991-01-11 2001-12-19 American Red Cross Expression von aktivem menschlichem Protein C im Milchdrüsengewebe transgener Tiere

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN111616106A (zh) * 2020-06-23 2020-09-04 成都欧林生物科技股份有限公司 一种骨折相关的金黄色葡萄球菌感染动物模型建立方法

Also Published As

Publication number Publication date
US20100192235A1 (en) 2010-07-29
WO2003092370A1 (en) 2003-11-13
US8168854B2 (en) 2012-05-01
DE60329836D1 (de) 2009-12-10
CA2484920A1 (en) 2003-11-13
US20040078834A1 (en) 2004-04-22
EP1499182A1 (de) 2005-01-26
JP2005523712A (ja) 2005-08-11
EP1499182A4 (de) 2007-10-10
US20080256650A1 (en) 2008-10-16
AU2003241325A1 (en) 2003-11-17
EP1499182B1 (de) 2009-10-28
US7728189B2 (en) 2010-06-01

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