ATE447573T1 - Chinoxalinyl-makrocyclische hepatitis c serin protease-hemmer - Google Patents

Chinoxalinyl-makrocyclische hepatitis c serin protease-hemmer

Info

Publication number
ATE447573T1
ATE447573T1 AT04750236T AT04750236T ATE447573T1 AT E447573 T1 ATE447573 T1 AT E447573T1 AT 04750236 T AT04750236 T AT 04750236T AT 04750236 T AT04750236 T AT 04750236T AT E447573 T1 ATE447573 T1 AT E447573T1
Authority
AT
Austria
Prior art keywords
present
compounds
serine protease
hepatitis
formula
Prior art date
Application number
AT04750236T
Other languages
English (en)
Inventor
Suanne Nakajima
Ying Sun
Datong Tang
Gouyou Xu
Brian Porter
Yat OR
Zhe Wang
Zhenwei Miao
Original Assignee
Enanta Pharm Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Enanta Pharm Inc filed Critical Enanta Pharm Inc
Application granted granted Critical
Publication of ATE447573T1 publication Critical patent/ATE447573T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0802—Tripeptides with the first amino acid being neutral
    • C07K5/0804—Tripeptides with the first amino acid being neutral and aliphatic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Communicable Diseases (AREA)
  • Virology (AREA)
  • Oncology (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
AT04750236T 2003-04-18 2004-04-16 Chinoxalinyl-makrocyclische hepatitis c serin protease-hemmer ATE447573T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US41875903A 2003-04-18 2003-04-18
PCT/US2004/011841 WO2004093798A2 (en) 2003-04-18 2004-04-16 Quinoxalinyl macrocyclic hepatitis c serine protease inhibitors

Publications (1)

Publication Number Publication Date
ATE447573T1 true ATE447573T1 (de) 2009-11-15

Family

ID=33309537

Family Applications (1)

Application Number Title Priority Date Filing Date
AT04750236T ATE447573T1 (de) 2003-04-18 2004-04-16 Chinoxalinyl-makrocyclische hepatitis c serin protease-hemmer

Country Status (15)

Country Link
EP (2) EP1615613B1 (de)
JP (2) JP4778893B2 (de)
KR (1) KR101031825B1 (de)
CN (1) CN1788006A (de)
AT (1) ATE447573T1 (de)
AU (2) AU2004231987C1 (de)
CA (1) CA2522561C (de)
CY (1) CY1109748T1 (de)
DE (1) DE602004023924D1 (de)
DK (1) DK1615613T3 (de)
ES (2) ES2535147T3 (de)
PL (1) PL1615613T3 (de)
PT (1) PT1615613E (de)
SI (1) SI1615613T1 (de)
WO (1) WO2004093798A2 (de)

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US7323447B2 (en) 2005-02-08 2008-01-29 Bristol-Myers Squibb Company Hepatitis C virus inhibitors
US7592336B2 (en) 2005-05-10 2009-09-22 Bristol-Myers Squibb Company Hepatitis C virus inhibitors
US7608592B2 (en) 2005-06-30 2009-10-27 Virobay, Inc. HCV inhibitors
US7601686B2 (en) 2005-07-11 2009-10-13 Bristol-Myers Squibb Company Hepatitis C virus inhibitors
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US7816348B2 (en) 2006-02-03 2010-10-19 Boehringer Ingelheim International Gmbh Viral polymerase inhibitors
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US7935670B2 (en) 2006-07-11 2011-05-03 Bristol-Myers Squibb Company Hepatitis C virus inhibitors
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Also Published As

Publication number Publication date
DE602004023924D1 (en) 2009-12-17
AU2004231987C1 (en) 2010-09-30
JP2007525455A (ja) 2007-09-06
JP2011178781A (ja) 2011-09-15
WO2004093798A3 (en) 2005-12-08
EP1615613A2 (de) 2006-01-18
CY1109748T1 (el) 2014-09-10
PT1615613E (pt) 2010-02-09
AU2004231987A1 (en) 2004-11-04
WO2004093798A2 (en) 2004-11-04
AU2010200619B2 (en) 2013-11-07
CA2522561C (en) 2012-07-17
HK1140214A1 (en) 2010-10-08
EP1615613A4 (de) 2007-02-14
HK1083337A1 (en) 2006-06-30
AU2010200619A1 (en) 2010-03-11
CN1788006A (zh) 2006-06-14
EP1615613B1 (de) 2009-11-04
PL1615613T3 (pl) 2010-04-30
SI1615613T1 (sl) 2010-03-31
CA2522561A1 (en) 2004-11-04
EP2143727A1 (de) 2010-01-13
ES2535147T3 (es) 2015-05-06
JP4778893B2 (ja) 2011-09-21
EP2143727B1 (de) 2015-01-21
KR101031825B1 (ko) 2011-04-29
DK1615613T3 (da) 2010-03-22
KR20050123170A (ko) 2005-12-29
ES2335887T3 (es) 2010-04-06
AU2004231987B2 (en) 2009-11-19

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