ATE349463T1 - Verbrückte bizyklische serinproteaseinhibitoren - Google Patents

Verbrückte bizyklische serinproteaseinhibitoren

Info

Publication number
ATE349463T1
ATE349463T1 AT02749965T AT02749965T ATE349463T1 AT E349463 T1 ATE349463 T1 AT E349463T1 AT 02749965 T AT02749965 T AT 02749965T AT 02749965 T AT02749965 T AT 02749965T AT E349463 T1 ATE349463 T1 AT E349463T1
Authority
AT
Austria
Prior art keywords
serine protease
bridged
bizyclic
compounds
protease inhibitors
Prior art date
Application number
AT02749965T
Other languages
English (en)
Inventor
Luc Farmer
Janos Pitlik
Robert Perni
Lawrence Courtney
Drie John Van
Original Assignee
Vertex Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Vertex Pharma filed Critical Vertex Pharma
Application granted granted Critical
Publication of ATE349463T1 publication Critical patent/ATE349463T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/08—Bridged systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/02—Linear peptides containing at least one abnormal peptide link
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/10—Tetrapeptides
    • C07K5/1002—Tetrapeptides with the first amino acid being neutral
    • C07K5/1005—Tetrapeptides with the first amino acid being neutral and aliphatic
    • C07K5/1008—Tetrapeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atoms, i.e. Gly, Ala
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/10—Tetrapeptides
    • C07K5/1002—Tetrapeptides with the first amino acid being neutral
    • C07K5/1016—Tetrapeptides with the first amino acid being neutral and aromatic or cycloaliphatic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/10—Tetrapeptides
    • C07K5/1019—Tetrapeptides with the first amino acid being basic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/10—Tetrapeptides
    • C07K5/1024—Tetrapeptides with the first amino acid being heterocyclic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Chemical & Material Sciences (AREA)
  • Virology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
AT02749965T 2001-07-11 2002-07-11 Verbrückte bizyklische serinproteaseinhibitoren ATE349463T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US30461501P 2001-07-11 2001-07-11
US32271401P 2001-09-17 2001-09-17

Publications (1)

Publication Number Publication Date
ATE349463T1 true ATE349463T1 (de) 2007-01-15

Family

ID=26974129

Family Applications (1)

Application Number Title Priority Date Filing Date
AT02749965T ATE349463T1 (de) 2001-07-11 2002-07-11 Verbrückte bizyklische serinproteaseinhibitoren

Country Status (14)

Country Link
US (1) US6909000B2 (de)
EP (1) EP1404704B9 (de)
JP (1) JP4455056B2 (de)
KR (1) KR100926244B1 (de)
CN (1) CN100402549C (de)
AT (1) ATE349463T1 (de)
CA (1) CA2449504A1 (de)
DE (1) DE60217114T2 (de)
ES (1) ES2279879T3 (de)
IL (2) IL159087A0 (de)
MX (1) MXPA04000293A (de)
NO (1) NO20040127L (de)
NZ (1) NZ530000A (de)
WO (1) WO2003006490A1 (de)

Families Citing this family (85)

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EP1497282A2 (de) * 2002-04-11 2005-01-19 Vertex Pharmaceuticals Incorporated Hemmer der serin-protease, besonders der ns3-ns4-protease des hepatitis-c-virus
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MY148123A (en) * 2003-09-05 2013-02-28 Vertex Pharma Inhibitors of serine proteases, particularly hcv ns3-ns4a protease
EP1664091A1 (de) * 2003-09-18 2006-06-07 Vertex Pharmaceuticals Incorporated Inhibitoren von serinproteasen, insbesondere hcv-ns3-ns4a-protease
US7365092B2 (en) 2003-10-10 2008-04-29 Vertex Pharmaceuticals Incorporated Inhibitors of serine proteases, particularly HCV NS3-NS4A protease
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EP1944042A1 (de) 2003-10-27 2008-07-16 Vertex Pharmceuticals Incorporated Kombinationen für die HCV-Behandlung
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EP1711515A2 (de) * 2004-02-04 2006-10-18 Vertex Pharmaceuticals Incorporated Inhibitoren von serinproteasen, insbesondere hcv-ns3-ns4a-protease
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FR2575753B1 (fr) 1985-01-07 1987-02-20 Adir Nouveaux derives peptidiques a structure polycyclique azotee, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
AU2933797A (en) 1996-05-10 1997-12-05 Schering Corporation Synthetic inhibitors of hepatitis c virus ns3 protease
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Also Published As

Publication number Publication date
NZ530000A (en) 2007-03-30
EP1404704A1 (de) 2004-04-07
KR100926244B1 (ko) 2009-11-12
DE60217114D1 (de) 2007-02-08
WO2003006490A1 (en) 2003-01-23
MXPA04000293A (es) 2004-05-04
JP4455056B2 (ja) 2010-04-21
IL159087A (en) 2009-08-03
CN100402549C (zh) 2008-07-16
EP1404704B1 (de) 2006-12-27
EP1404704B9 (de) 2008-02-20
NO20040127L (no) 2004-03-11
JP2005522409A (ja) 2005-07-28
HK1065322A1 (en) 2005-02-18
US6909000B2 (en) 2005-06-21
ES2279879T3 (es) 2007-09-01
US20030119752A1 (en) 2003-06-26
CN1525979A (zh) 2004-09-01
KR20040018445A (ko) 2004-03-03
CA2449504A1 (en) 2003-01-23
IL159087A0 (en) 2004-05-12
DE60217114T2 (de) 2007-10-25

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