ATE447583T1 - Polypeptide und dafür kodierende nukleinsäure - Google Patents

Polypeptide und dafür kodierende nukleinsäure

Info

Publication number
ATE447583T1
ATE447583T1 AT05024504T AT05024504T ATE447583T1 AT E447583 T1 ATE447583 T1 AT E447583T1 AT 05024504 T AT05024504 T AT 05024504T AT 05024504 T AT05024504 T AT 05024504T AT E447583 T1 ATE447583 T1 AT E447583T1
Authority
AT
Austria
Prior art keywords
polypeptides
present
nucleic acids
acids coding
coding therefor
Prior art date
Application number
AT05024504T
Other languages
English (en)
Inventor
William I Wood
Austin L Gurney
Audrey Goddard
Diane Pennica
Jian Chen
Jean Yuan
Original Assignee
Genentech Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Genentech Inc filed Critical Genentech Inc
Application granted granted Critical
Publication of ATE447583T1 publication Critical patent/ATE447583T1/de

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/11DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00Drugs for disorders of the urinary system
    • A61P13/12Drugs for disorders of the urinary system of the kidneys
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • A61P17/06Antipsoriatics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/14Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16Anti-Parkinson drugs
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/575Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/5758Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumours, cancers or neoplasias, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides or metabolites
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/20Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2319/00Fusion polypeptide
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2319/00Fusion polypeptide
    • C07K2319/30Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Immunology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Cell Biology (AREA)
  • Food Science & Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Analytical Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Zoology (AREA)
  • Biophysics (AREA)
  • Toxicology (AREA)
  • General Engineering & Computer Science (AREA)
  • Dermatology (AREA)
  • Wood Science & Technology (AREA)
  • Gastroenterology & Hepatology (AREA)
AT05024504T 1997-09-17 1998-09-16 Polypeptide und dafür kodierende nukleinsäure ATE447583T1 (de)

Applications Claiming Priority (50)

Application Number Priority Date Filing Date Title
US5911797P 1997-09-17 1997-09-17
US5918497P 1997-09-17 1997-09-17
US5912197P 1997-09-17 1997-09-17
US5911997P 1997-09-17 1997-09-17
US5912297P 1997-09-17 1997-09-17
US5911597P 1997-09-17 1997-09-17
US5911397P 1997-09-17 1997-09-17
US5926697P 1997-09-18 1997-09-18
US5926397P 1997-09-18 1997-09-18
US6212597P 1997-10-15 1997-10-15
US6228797P 1997-10-17 1997-10-17
US6228597P 1997-10-17 1997-10-17
US6348697P 1997-10-21 1997-10-21
US6312097P 1997-10-24 1997-10-24
US6304597P 1997-10-24 1997-10-24
US6312897P 1997-10-24 1997-10-24
US6312797P 1997-10-24 1997-10-24
US6281497P 1997-10-24 1997-10-24
US6312197P 1997-10-24 1997-10-24
US6281697P 1997-10-24 1997-10-24
US6332797P 1997-10-27 1997-10-27
US6332997P 1997-10-27 1997-10-27
US6354497P 1997-10-28 1997-10-28
US6356497P 1997-10-28 1997-10-28
US6354197P 1997-10-28 1997-10-28
US6355097P 1997-10-28 1997-10-28
US6354997P 1997-10-28 1997-10-28
US6354297P 1997-10-28 1997-10-28
US6373497P 1997-10-29 1997-10-29
US6370497P 1997-10-29 1997-10-29
US6373897P 1997-10-29 1997-10-29
US6343597P 1997-10-29 1997-10-29
US6373597P 1997-10-29 1997-10-29
US6373297P 1997-10-29 1997-10-29
US6421597P 1997-10-29 1997-10-29
US6387097P 1997-10-31 1997-10-31
US6410397P 1997-10-31 1997-10-31
US6424897P 1997-11-03 1997-11-03
US6480997P 1997-11-07 1997-11-07
US6518697P 1997-11-12 1997-11-12
US6584697P 1997-11-17 1997-11-17
US6569397P 1997-11-18 1997-11-18
US6636497P 1997-11-21 1997-11-21
US6612097P 1997-11-21 1997-11-21
US6646697P 1997-11-24 1997-11-24
US6645397P 1997-11-24 1997-11-24
US6677297P 1997-11-24 1997-11-24
US6651197P 1997-11-24 1997-11-24
US6677097P 1997-11-24 1997-11-24
US6684097P 1997-11-25 1997-11-25

Publications (1)

Publication Number Publication Date
ATE447583T1 true ATE447583T1 (de) 2009-11-15

Family

ID=27586996

Family Applications (1)

Application Number Title Priority Date Filing Date
AT05024504T ATE447583T1 (de) 1997-09-17 1998-09-16 Polypeptide und dafür kodierende nukleinsäure

Country Status (9)

Country Link
US (1) US7208312B1 (de)
JP (6) JP2001516580A (de)
KR (1) KR100502596B1 (de)
AT (1) ATE447583T1 (de)
AU (1) AU741060C (de)
CA (1) CA2303834A1 (de)
IL (2) IL134968A0 (de)
NZ (1) NZ503343A (de)
WO (1) WO1999014328A2 (de)

Families Citing this family (121)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001004311A1 (en) * 1999-07-07 2001-01-18 Genentech, Inc. Secreted and transmembrane polypeptides and nucleic acids encoding the same
WO2001019991A1 (en) * 1999-09-15 2001-03-22 Genentech, Inc. Compositions and methods for the treatment of immune related diseases
WO2000015797A2 (en) * 1998-09-17 2000-03-23 Genentech, Inc. Compositions and methods for the treatment of immune related diseases
US5728546A (en) 1995-06-05 1998-03-17 Human Genome Sciences, Inc. Fibroblast growth factor 13
US6403557B1 (en) 1996-11-27 2002-06-11 Human Genome Sciences, Inc. Fibroblast growth factor-13
US7026447B2 (en) 1997-10-09 2006-04-11 Human Genome Sciences, Inc. 53 human secreted proteins
EP0970209A1 (de) * 1997-03-28 2000-01-12 Genetics Institute, Inc. Sekretierte proteine und polynukleotide die für diese kodieren
US20020137890A1 (en) 1997-03-31 2002-09-26 Genentech, Inc. Secreted and transmembrane polypeptides and nucleic acids encoding the same
US7057017B2 (en) 1997-04-16 2006-06-06 Millennium Pharmaceuticals, Inc. Human dickkopf-related protein and nucleic acid molecules and uses therefor
US20030092002A1 (en) 1997-09-17 2003-05-15 Genentech, Inc. Secreted and transmembrane polypeptides and nucleic acids encoding the same
US7169906B2 (en) 1997-09-17 2007-01-30 Genentech, Inc. PRO211 polypeptides
US20020192659A1 (en) * 1997-09-17 2002-12-19 Genentech, Inc. Secreted and transmembrane polypeptides and nucleic acids encoding the same
US20030022293A1 (en) 1997-09-18 2003-01-30 Genentech, Inc. Secreted and transmembrane polypeptides and nucleic acids encoding the same
US6974689B1 (en) 1997-09-18 2005-12-13 Genentech, Inc. Nucleic acid encoding PRO211 polypeptides
US7307152B2 (en) 1997-10-17 2007-12-11 Genentech, Inc. Secreted and transmembrane polypeptides and nucleic acids encoding the same
KR20050009764A (ko) * 1997-11-25 2005-01-25 제넨테크, 인크. 섬유아세포 성장 인자-19
US7446181B2 (en) 1998-01-15 2008-11-04 Millennium Pharmaceuticals, Inc. Antibodies that bind human Dickkopf-1 proteins
US7045333B1 (en) 1998-01-16 2006-05-16 Incyte Corporation Human protease molecules
US6203979B1 (en) 1998-01-16 2001-03-20 Incyte Pharmaceuticals, Inc. Human protease molecules
EP0939124A3 (de) * 1998-02-24 2001-03-21 Smithkline Beecham Plc MBGP1-Sequenzen
WO1999043831A1 (en) * 1998-02-25 1999-09-02 Smithkline Beecham Plc Cprot03, a human cysteine protease
US20020076753A1 (en) * 2000-03-31 2002-06-20 Glucksmann Maria Alexandra 31939, a novel human leucine-rich repeat family member and uses thereof
EP1108042B1 (de) 1998-08-07 2008-11-26 Immunex Corporation B7l-1 moleküle
US6168920B1 (en) * 1998-08-10 2001-01-02 Incyte Genomics, Inc. Extracellular adhesive proteins
KR20010103576A (ko) * 1998-09-10 2001-11-23 제넨테크, 인크. 종양 치료용 조성물 및 치료 방법
MXPA01002546A (es) * 1998-09-14 2004-06-11 Genentech Inc Promocion o inibhicion de angiogenesis y cardiovascularizacion.
AU5922999A (en) * 1998-09-16 2000-04-03 Genentech Inc. Secreted and transmembrane polypeptides and nucleic acids encoding the same
US6344541B1 (en) * 1998-09-25 2002-02-05 Amgen Inc. DKR polypeptides
US7030235B1 (en) * 1998-09-29 2006-04-18 The Brigham & Women's Hospital, Inc. Compositions to detect lesions associated with hearing loss in the cochlear gene, COCH5B2
WO2000018923A2 (en) * 1998-09-30 2000-04-06 Millennium Pharmaceuticals, Inc. Slgp protein and nucleic acid molecule and uses therefor
US6808895B1 (en) 1999-10-06 2004-10-26 Incyte Corporation DNA encoding oxidoreductase and polypeptide encoded thereby
WO2000020604A2 (en) * 1998-10-06 2000-04-13 Incyte Pharmaceuticals, Inc. Oxidoreductase molecules
AU758462B2 (en) * 1998-10-13 2003-03-20 Genentech Inc. Methods and compositions for inhibiting neoplastic cell growth
US6902892B1 (en) 1998-10-19 2005-06-07 Diadexus, Inc. Method of diagnosing, monitoring, staging, imaging and treating prostate cancer
DE69933647T2 (de) * 1998-11-19 2007-08-23 Azwell Inc. Rekombinante lysophosphatidsäure - phosphatase.
US20050053983A1 (en) 1998-11-20 2005-03-10 Fuso Pharmaceutical Industries, Ltd. Novel serine protease BSSP4
AU761575B2 (en) * 1998-11-20 2003-06-05 Fuso Pharmaceutical Industries, Ltd. Novel serine proteases BSSP4
WO2000032633A1 (en) * 1998-12-02 2000-06-08 Icos Corporation Novel adhesion molecule and methods of use
EP2075335A3 (de) * 1998-12-22 2009-09-30 Genentech, Inc. Verfahren und Zusammensetzungen zur Hemmung des neoplastischen Zellenwachstums
WO2000039296A1 (en) * 1998-12-23 2000-07-06 Immunex Corporation Lectin s3939 dna and polypeptides
CA2357677A1 (en) * 1999-01-07 2000-07-13 Incyte Pharmaceuticals, Inc. Insulin-synthesis genes
US6174682B1 (en) * 1999-03-08 2001-01-16 Millenium Pharmaceuticals, Inc. Thioredoxin family active site molecules and uses therefor
AU1749800A (en) * 1999-03-12 2000-10-04 Genentech Inc. Methods and compositions for inhibiting neoplastic cell growth
US6436642B1 (en) 1999-04-20 2002-08-20 Curagen Corporation Method of classifying a thyroid carcinoma using differential gene expression
US6485957B1 (en) 1999-04-30 2002-11-26 Ortho-Mcneil Pharmaceutical, Inc. DNA encoding the human serine protease EOS
US7034132B2 (en) 2001-06-04 2006-04-25 Anderson David W Therapeutic polypeptides, nucleic acids encoding same, and methods of use
DE60043367D1 (de) * 1999-06-15 2009-12-31 Genentech Inc Sekretierte und Transmembran-Polypeptide sowie Nukleinsäuren zu deren Kodierung
EP1208195A2 (de) * 1999-06-15 2002-05-29 Genentech Inc. Ausgeschiedene und transmembran-polypeptide und dafür kodierende nukleinsäure
US6960651B2 (en) 1999-06-29 2005-11-01 Millennium Pharmaceuticals, Inc. TANGO 332 polypeptides
US7001766B2 (en) 1999-07-20 2006-02-21 Curagen Corporation Nucleic acid sequences encoding human angiopoietin-like polypeptides
AU2390700A (en) * 1999-07-20 2001-02-05 Genentech Inc. Polypeptidic compositions and methods for the treatment of tumors
US6458564B1 (en) 1999-08-31 2002-10-01 Ortho-Mcneil Pharmaceutical, Inc. DNA encoding the human serine protease T
US6426199B1 (en) 1999-08-31 2002-07-30 Ortho-Mcneil Pharmaceutical, Inc. Dna
EP1214409B1 (de) * 1999-09-08 2006-05-17 Genentech, Inc. Fibroblasten-wachstumsfaktor-19 (fgf-19) nukleinsäure und polypeptide und verfahren zu deren verwendung für behandlung von fettleibigkeit
AU7452300A (en) * 1999-10-01 2001-05-10 Kyowa Hakko Kogyo Co. Ltd. Shear stress-response dna
US6824780B1 (en) 1999-10-29 2004-11-30 Genentech, Inc. Anti-tumor antibody compositions and methods of use
US7115665B1 (en) 2000-11-16 2006-10-03 Onocozyme Pharma, Inc. Inhibitors of endo-exonuclease activity for treating cancer
CN1402784A (zh) 1999-11-19 2003-03-12 久光制药株式会社 细胞增殖抑制蛋白质、多核苷酸、与多核苷酸对应的反义核苷酸,以及细胞增殖抑制剂、癌症诊断试剂、癌症治疗剂和用于基因治疗的组合物
CA2491433A1 (en) * 1999-12-01 2001-06-07 Genentech, Inc. Secreted and transmembrane polypeptides and nucleic acids encoding the same
WO2001051636A2 (en) * 2000-01-14 2001-07-19 Incyte Genomics, Inc. Secreted proteins
US7122631B2 (en) 2000-02-22 2006-10-17 Genentech, Inc. Secreted and transmembrane polypeptides and nucleic acids encoding the same
EP1259607A2 (de) * 2000-02-24 2002-11-27 Oxford GlycoSciences (UK) Limited Protein und gen und deren verwendung zur diagnose und behandlung von schizophrenie
WO2001063295A2 (en) * 2000-02-24 2001-08-30 Oxford Glycosciences (Uk) Ltd. Dpi-6, a therapeutic biomarker in neurological disorders
EP1918366A1 (de) 2000-02-26 2008-05-07 Artecel, Inc. Pluripotente Stammzellen aus Bindegewebszellen aus dem Fettgewebe und Verwendungen dafür
WO2001064882A2 (en) * 2000-02-29 2001-09-07 Millennium Pharmaceuticals, Inc. 1983, 52881, 2398, 45449, 50289, and 52872, g protein-coupled receptors and uses therefor
US6627423B2 (en) 2000-03-24 2003-09-30 Millennium Pharmaceuticals, Inc. 21481, a novel dehydrogenase molecule and uses therefor
US6511834B1 (en) 2000-03-24 2003-01-28 Millennium Pharmaceuticals, Inc. 32142,21481,25964,21686, novel human dehydrogenase molecules and uses therefor
WO2001075099A1 (en) * 2000-04-04 2001-10-11 National Cancer Centre Of Singapore Pte Ltd Nucleic acid molecule encoding a uterine estrogen agonist-inducible protein
AU2001273077A1 (en) * 2000-06-30 2002-01-14 Millennium Pharmaceuticals, Inc. Slgp protein and nucleic acid molecules and uses therefor
DE10106835A1 (de) * 2001-02-14 2002-09-05 Basf Lynx Bioscience Ag Signaltransduktionsproteine 15B3, 15B3-1 und 15B3-2 und zugrundeliegende DNA-Sequenzen
EP1402070B1 (de) 2001-06-27 2012-01-11 Cancer Research Technology Limited Verfahren zur krebsdiagnose, die auf dem obcam- und ntm-gen basieren
WO2003025162A2 (en) * 2001-09-20 2003-03-27 Bayer Healthcare Ag Regulation of human prolyl 4-hydroxylase alpha subunit precursor
WO2003034984A2 (en) * 2001-10-19 2003-05-01 Genentech, Inc. Compositions and methods for the diagnosis and treatment of inflammatory bowel disorders
WO2003072773A1 (fr) * 2002-02-08 2003-09-04 Seikagaku Corporation Proteine fusionnee ayant une activite de glucuronyltransferase
CA2480386A1 (en) * 2002-03-29 2003-10-09 National Institute Of Advanced Industrial Science And Technology Novel galactose transferases, peptides thereof and nucleic acid encoding the same
EP1553912A4 (de) 2002-06-07 2007-08-08 Genentech Inc Zusammensetzungen und verfahren f r die tumordiagnose und behandlung
WO2004002515A1 (ja) * 2002-06-28 2004-01-08 Takeda Chemical Industries, Ltd. 呼吸器疾患の診断・予防・治療剤
AU2003280992A1 (en) 2002-07-10 2004-02-02 Takeda Pharmaceutical Company Limited Novel proteins and use thereof
CA2511556A1 (en) * 2002-12-27 2004-07-29 Applied Research Systems Ars Holding N.V. Novel fibrillin-like polypeptides
CA2519227C (en) 2003-03-19 2013-12-03 Biogen Idec Ma Inc. Nogo receptor binding protein
US7595379B2 (en) 2003-05-30 2009-09-29 Agensys, Inc. Antibodies and related molecules that bind to PSCA proteins
US7541442B2 (en) 2003-05-30 2009-06-02 Agensys, Inc. Antibodies and related molecules that bind to PSCA proteins
CA2526274C (en) 2003-05-30 2015-12-01 Agensys, Inc. Prostate stem cell antigen (psca) variants and subsequences thereof
WO2005058028A2 (en) * 2003-12-16 2005-06-30 Genentech, Inc. Novel gene disruptions, compositions and methods relating thereto
HUE027902T2 (en) 2004-02-09 2016-11-28 Human Genome Sciences Inc Corp Service Company Albumin fusion proteins
WO2005079566A2 (en) * 2004-02-12 2005-09-01 Lexicon Genetics Incorporated Gene disruptions, compositions and methods relating thereto
US20100031378A1 (en) 2008-08-04 2010-02-04 Edwards Joel A Novel gene disruptions, compositions and methods relating thereto
GB0406215D0 (en) 2004-03-19 2004-04-21 Procure Therapeutics Ltd Prostate stem cell
JP4566603B2 (ja) * 2004-03-31 2010-10-20 財団法人かずさディー・エヌ・エー研究所 細胞付着ポリペプチド
AU2005244742A1 (en) * 2004-05-12 2005-12-01 Genentech, Inc. Novel gene disruptions, compositions and methods relating thereto
US8486893B2 (en) 2004-06-24 2013-07-16 Biogen Idec Ma Inc. Treatment of conditions involving demyelination
WO2006015373A2 (en) 2004-08-04 2006-02-09 Amgen Inc Antibodies to dkk-1
US7544659B2 (en) 2004-08-13 2009-06-09 Genentech, Inc. Promotion of axonal regeneration
EP1831370A4 (de) 2004-12-13 2009-08-12 Alethia Biotherapeutics Inc An der knochenneuformung beteiligte polynukleotide und polypeptidsequenzen
HRP20131066T1 (hr) 2005-07-08 2013-12-06 Biogen Idec Ma Inc. Sp35 antitijela i njihova upotreba
US8128926B2 (en) 2007-01-09 2012-03-06 Biogen Idec Ma Inc. Sp35 antibodies and uses thereof
EP2285961A4 (de) * 2008-05-15 2012-10-17 Topigen Pharmaceuticals Inc Oligonukleotide zur behandlung von entzündungen und neoplastischer zellvermehrung
CA2729961C (en) 2008-07-09 2018-05-01 Biogen Idec Ma Inc. Li113, li62 variant co2, anti-lingo antibodies
WO2010054096A1 (en) * 2008-11-07 2010-05-14 The Cleveland Clinic Foundation Method for detecting and purifying pancreatic beta cells
AU2009319864A1 (en) 2008-11-25 2011-07-14 Biogen Idec Ma Inc. Use of DR6 and P75 antagonists to promote survival of cells of the nervous system
CN105601748B (zh) 2011-07-01 2021-08-27 恩格姆生物制药公司 用于代谢病症和疾病治疗的组合物、应用和方法
KR102142161B1 (ko) 2012-05-14 2020-08-06 바이오젠 엠에이 인코포레이티드 운동 뉴런 관련 병태 치료용 lingo-2 길항제
US9290557B2 (en) 2012-11-28 2016-03-22 Ngm Biopharmaceuticals, Inc. Compositions comprising variants and fusions of FGF19 polypeptides
HK1214832A1 (zh) 2012-11-28 2016-08-05 恩格姆生物制药公司 用於代謝病症和疾病治療的組合物和方法
US9273107B2 (en) 2012-12-27 2016-03-01 Ngm Biopharmaceuticals, Inc. Uses and methods for modulating bile acid homeostasis and treatment of bile acid disorders and diseases
ES2915851T3 (es) 2012-12-27 2022-06-27 Ngm Biopharmaceuticals Inc Péptidos quiméricos de FGF19 para usar en el tratamiento de trastornos de ácidos biliares
CA2927592C (en) 2013-10-28 2020-08-18 Ngm Biopharmaceuticals, Inc. Fgf-19 variants for treating a fgf-19 dependent cancer or tumor
PE20170256A1 (es) 2014-01-24 2017-04-22 Ngm Biopharmaceuticals Inc Proteinas de union y sus metodos de uso
WO2015183890A2 (en) 2014-05-28 2015-12-03 Ngm Biopharmaceuticals, Inc. Methods and compositions for the treatment of metabolic disorders and diseases
AU2015277438B2 (en) 2014-06-16 2020-02-27 Ngm Biopharmaceuticals, Inc. Methods and uses for modulating bile acid homeostasis and treatment of bile acid disorders and diseases
US9616114B1 (en) 2014-09-18 2017-04-11 David Gordon Bermudes Modified bacteria having improved pharmacokinetics and tumor colonization enhancing antitumor activity
RU2729161C2 (ru) 2014-10-23 2020-08-04 ЭнДжиЭм БАЙОФАРМАСЬЮТИКАЛЗ, ИНК. Фармацевтические композиции, содержащие варианты пептидов, и способы их применения
US10434144B2 (en) 2014-11-07 2019-10-08 Ngm Biopharmaceuticals, Inc. Methods for treatment of bile acid-related disorders and prediction of clinical sensitivity to treatment of bile acid-related disorders
JP2018504400A (ja) 2015-01-08 2018-02-15 バイオジェン・エムエイ・インコーポレイテッドBiogen MA Inc. Lingo‐1拮抗薬及び脱髄障害の治療のための使用
US10676723B2 (en) 2015-05-11 2020-06-09 David Gordon Bermudes Chimeric protein toxins for expression by therapeutic bacteria
US10800843B2 (en) 2015-07-29 2020-10-13 Ngm Biopharmaceuticals, Inc. Beta klotho-binding proteins
JP6728352B2 (ja) 2015-11-09 2020-07-22 エヌジーエム バイオファーマシューティカルス,インコーポレーテッド 胆汁酸に関係した障害の治療方法
CA3034399A1 (en) 2016-08-26 2018-03-01 Ngm Biopharmaceuticals, Inc. Methods of treating fibroblast growth factor 19-mediated cancers and tumors
US11129906B1 (en) 2016-12-07 2021-09-28 David Gordon Bermudes Chimeric protein toxins for expression by therapeutic bacteria
US11180535B1 (en) 2016-12-07 2021-11-23 David Gordon Bermudes Saccharide binding, tumor penetration, and cytotoxic antitumor chimeric peptides from therapeutic bacteria
CN107271337B (zh) * 2017-04-24 2023-09-15 中国人民解放军军事医学科学院卫生装备研究所 一种人体肺泡气溶胶沉积测量实验系统

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030092002A1 (en) * 1997-09-17 2003-05-15 Genentech, Inc. Secreted and transmembrane polypeptides and nucleic acids encoding the same

Also Published As

Publication number Publication date
US20070105191A1 (en) 2007-05-10
IL134968A (en) 2007-05-15
AU741060B2 (en) 2001-11-22
US7208312B1 (en) 2007-04-24
NZ503343A (en) 2002-09-27
JP2002238587A (ja) 2002-08-27
KR20010024085A (ko) 2001-03-26
JP2001516580A (ja) 2001-10-02
AU741060C (en) 2002-09-19
JP2002238588A (ja) 2002-08-27
JP2002253280A (ja) 2002-09-10
KR100502596B1 (ko) 2005-07-22
AU9317898A (en) 1999-04-05
IL134968A0 (en) 2001-05-20
JP2002238586A (ja) 2002-08-27
WO1999014328A3 (en) 2000-06-15
JP2002223786A (ja) 2002-08-13
CA2303834A1 (en) 1999-03-25
WO1999014328A2 (en) 1999-03-25

Similar Documents

Publication Publication Date Title
ATE447583T1 (de) Polypeptide und dafür kodierende nukleinsäure
ATE478145T1 (de) Sekretierte und transmembran polypeptide und dafür kodierende nukleinsäuren
MXPA01002592A (es) Polipeptidos de transmembrana y secretados y acidos nucleicos que codifican los mismos.
KR100468977B1 (ko) 분비 및 막횡단 폴리펩티드, 및 이를 코딩하는 핵산
ATE417063T1 (de) Sekretierte transmembranproteine und dafür kodierende nukleinsäuren
ATE310810T1 (de) Polypeptid und dafür kodierendes nukeinsäure
KR100515858B1 (en) PRO617 Polypeptides
ATE282047T1 (de) Polypeptide und dafür kodierende nukleinsäure
ATE300553T1 (de) Sekretiertes polypeptide und dafür kodierende nukleinsäuren
KR100515855B1 (en) PRO351 Polypeptides
KR100515856B1 (en) PRO618 Polypeptides
DK1241180T3 (da) Humant A33 antigen-lignende protein og nucleinsyrer, der koder for dette
DE69824455D1 (de) PRO241 Polypeptide und dafür kodierende Nukleinsäuren
KR100515857B1 (en) PRO792 Polypeptides
ATE291085T1 (de) Polypeptide und dafür kodierende nukleinsäure
ATE321136T1 (de) Sekretierte und transmembrane polypeptide und dafür kodierende nukleinsäuren
PT1241184E (pt) Proteína semelhante a sinaptogirina e ácidos nucleicos que a codificam
DE69829230D1 (de) Polypeptid und dafür kodieredes Nukleinsäure
DK1241183T3 (da) Humant HCAR-agtig protein og nucleinsyrer kodende derfor
ATE363537T1 (de) Ausgeschiedene und transmembranpolypeptide und dafür kodierende nukleinsäure
ATE396201T1 (de) Ausgeschiedene und transmembranpolypeptide und dafür kodierende nukleinsäure
ATE447026T1 (de) Ausgeschiedene und transmembrane polypeptide und dafür kodierende nukleinsäure

Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties