ATE448221T1 - Verfahren zur herstellung von 1,3,4,5-tetrahydro- 2h-3-benzazepin-2-on-derivaten und dessen anwendung in der herstellung von ivabradin sowie dessen pharmazeutisch verträglichen salze - Google Patents

Verfahren zur herstellung von 1,3,4,5-tetrahydro- 2h-3-benzazepin-2-on-derivaten und dessen anwendung in der herstellung von ivabradin sowie dessen pharmazeutisch verträglichen salze

Info

Publication number: ATE448221T1
Authority: AT; Austria
Prior art keywords: ivabradine; benzazepine; tetrahydro; derivatives; producing
Prior art date: 2004-04-13

Application number

AT05290383T

Other languages

English (en)

Inventor

Jean-Michel Lerestif

Jean-Pierre Lecouve

Jean-Claude Souvie

Daniel Brigot

Original Assignee

Servier Lab

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2004-04-13

Filing date

2005-02-21

Publication date

2009-11-15

2005-02-21 Application filed by Servier Lab filed Critical Servier Lab

2009-11-15 Application granted granted Critical

2009-11-15 Publication of ATE448221T1 publication Critical patent/ATE448221T1/de

Links

238000004519 manufacturing process Methods 0.000 title 2
GYIYVTGAOWHWRI-UHFFFAOYSA-N 1,2,3,5-tetrahydro-3-benzazepin-4-one Chemical class C1CNC(=O)CC2=CC=CC=C21 GYIYVTGAOWHWRI-UHFFFAOYSA-N 0.000 title 1
ACRHBAYQBXXRTO-OAQYLSRUSA-N ivabradine Chemical compound C1CC2=CC(OC)=C(OC)C=C2CC(=O)N1CCCN(C)C[C@H]1CC2=C1C=C(OC)C(OC)=C2 ACRHBAYQBXXRTO-OAQYLSRUSA-N 0.000 title 1
229960003825 ivabradine Drugs 0.000 title 1
150000003839 salts Chemical class 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
- C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D223/16—Benzazepines; Hydrogenated benzazepines
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings

Landscapes

Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Animal Behavior & Ethology (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Veterinary Medicine (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Vascular Medicine (AREA)
Urology & Nephrology (AREA)
Hospice & Palliative Care (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Other In-Based Heterocyclic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)

AT05290383T 2004-04-13 2005-02-21 Verfahren zur herstellung von 1,3,4,5-tetrahydro- 2h-3-benzazepin-2-on-derivaten und dessen anwendung in der herstellung von ivabradin sowie dessen pharmazeutisch verträglichen salze ATE448221T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
FR0403828A FR2868775B1 (fr)	2004-04-13	2004-04-13	Nouveau procede de synthese de derives de la 1,3,4,5- tetrahydro-2h-3-benzazepin-2-one, et application a la synthese de l'ivabradine et de ses sels d'addition a un acide pharmaceutiquement acceptable

Publications (1)

Publication Number	Publication Date
ATE448221T1 true ATE448221T1 (de)	2009-11-15

Family

ID=34941961

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT05290383T ATE448221T1 (de)	2004-04-13	2005-02-21	Verfahren zur herstellung von 1,3,4,5-tetrahydro- 2h-3-benzazepin-2-on-derivaten und dessen anwendung in der herstellung von ivabradin sowie dessen pharmazeutisch verträglichen salze

Country Status (32)

Country	Link
US (1)	US7064200B2 (de)
EP (1)	EP1614687B1 (de)
JP (2)	JP4515933B2 (de)
KR (1)	KR100636499B1 (de)
CN (1)	CN100348585C (de)
AR (1)	AR047707A1 (de)
AT (1)	ATE448221T1 (de)
AU (1)	AU2005200884B2 (de)
BR (1)	BRPI0500590B8 (de)
CA (1)	CA2496712C (de)
CY (1)	CY1109740T1 (de)
DE (1)	DE602005017541D1 (de)
DK (1)	DK1614687T3 (de)
EA (1)	EA007743B1 (de)
EG (1)	EG25619A (de)
ES (1)	ES2336461T3 (de)
FR (1)	FR2868775B1 (de)
GE (1)	GEP20074136B (de)
HR (1)	HRP20100024T1 (de)
MA (1)	MA27598A1 (de)
MX (1)	MXPA05003696A (de)
MY (1)	MY140904A (de)
NO (1)	NO329861B1 (de)
NZ (1)	NZ538328A (de)
PL (1)	PL1614687T3 (de)
PT (1)	PT1614687E (de)
RS (1)	RS51232B (de)
SG (1)	SG116574A1 (de)
SI (1)	SI1614687T1 (de)
UA (1)	UA81773C2 (de)
WO (1)	WO2005111027A1 (de)
ZA (1)	ZA200501468B (de)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
FR2868775B1 (fr) *	2004-04-13	2008-04-11	Servier Lab	Nouveau procede de synthese de derives de la 1,3,4,5- tetrahydro-2h-3-benzazepin-2-one, et application a la synthese de l'ivabradine et de ses sels d'addition a un acide pharmaceutiquement acceptable
FR2868777B1 (fr) *	2004-04-13	2006-05-26	Servier Lab	Nouveau procede de synthese de l'ivabradine et de ses sels d'addition a un acide pharmaceutiquement acceptable
GT200500185A (es) *	2004-08-09	2006-04-10		Moduladores del receptor de progesterona que comprenden derivados de pirrol-oxindol y sus usos
KR101478855B1 (ko)	2007-05-30	2015-01-02	인드-스위프트 래버러토리즈 리미티드	이바브라딘 히드로클로라이드 및 그의 다형태의 제조방법
EP2367782B1 (de)	2008-12-22	2013-02-13	KRKA, D.D., Novo Mesto	Verfahren zur herstellung von ivabradin
FR2940287B1 (fr) *	2008-12-24	2010-12-24	Servier Lab	Nouveau procede de synthese de l'ivabradine et de ses sels d'addition a un acide pharmaceutiquement acceptable.
SI23290A (sl)	2010-02-12	2011-08-31	Krka D.D., Novo Mesto	Nove oblike ivabradin hidroklorida
FR2956401B1 (fr) *	2010-02-17	2012-02-03	Servier Lab	Nouveau procede de synthese de l'ivabradine et de ses sels d'addition a un acide pharmaceutiquement acceptable
FR2971507B1 (fr) *	2011-02-14	2013-01-18	Servier Lab	Nouveau procede de synthese de l'ivabradine et de ses sels d'addition a un acide pharmaceutiquement acceptable
FR2984320B1 (fr) *	2011-12-20	2013-11-29	Servier Lab	Nouveau procede de synthese de l'ivabradine et de ses sels d'addition a un acide pharmaceutiquement acceptable
FR2993561B1 (fr) *	2012-07-17	2014-10-31	Servier Lab	Procede de synthese enzymatique de la (7s)-1-(3,4-dimethoxy bicyclo[4.2.0]octa-1,3,5-triene 7-yl) n-methyl methanamine, et application a la synthese de l'ivabradine et de ses sels
FR3003859B1 (fr) *	2013-03-26	2015-03-13	Servier Lab	"procede de synthese de derives de la 7,8-dimethoxy-1,3-dihydro-2h-3-benzazepin-2-one et application a la synthese de l'ivabradine"

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE3119874A1 (de) *	1981-05-19	1982-12-09	Dr. Karl Thomae Gmbh, 7950 Biberach	"benzazepinderivate, ihre herstellung und ihre verwendung als arzneimittel"
DE3418270A1 (de) *	1984-05-17	1985-11-21	Dr. Karl Thomae Gmbh, 7950 Biberach	Neue aminotetralinderivate, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung
EP0204349A3 (de)	1985-06-01	1990-01-03	Dr. Karl Thomae GmbH	Neue heteroaromatische Aminderivate, diese Verbindungen enthaltende Arzneimittel und Verfahren zu ihrer Herstellung
DE3519735A1 (de) *	1985-06-01	1986-12-04	Dr. Karl Thomae Gmbh, 7950 Biberach	Neue heteroaromatische aminderivate, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung
FR2681862B1 (fr) *	1991-09-27	1993-11-12	Adir Cie	Nouvelles (benzocycloalkyl)alkylamines, leur procede de preparation, et les compositions pharmaceutiques qui les contiennent.
FR2868775B1 (fr) *	2004-04-13	2008-04-11	Servier Lab	Nouveau procede de synthese de derives de la 1,3,4,5- tetrahydro-2h-3-benzazepin-2-one, et application a la synthese de l'ivabradine et de ses sels d'addition a un acide pharmaceutiquement acceptable
FR2868777B1 (fr) *	2004-04-13	2006-05-26	Servier Lab	Nouveau procede de synthese de l'ivabradine et de ses sels d'addition a un acide pharmaceutiquement acceptable

2004
- 2004-04-13 FR FR0403828A patent/FR2868775B1/fr not_active Expired - Fee Related
2005
- 2005-02-07 CA CA2496712A patent/CA2496712C/fr not_active Expired - Lifetime
- 2005-02-15 SG SG200500770A patent/SG116574A1/en unknown
- 2005-02-17 US US11/060,043 patent/US7064200B2/en not_active Expired - Lifetime
- 2005-02-18 NO NO20050888A patent/NO329861B1/no unknown
- 2005-02-18 BR BRPI0500590A patent/BRPI0500590B8/pt not_active IP Right Cessation
- 2005-02-18 NZ NZ538328A patent/NZ538328A/en not_active IP Right Cessation
- 2005-02-18 AU AU2005200884A patent/AU2005200884B2/en not_active Expired
- 2005-02-18 MY MYPI20050621A patent/MY140904A/en unknown
- 2005-02-18 AR ARP050100586A patent/AR047707A1/es active IP Right Grant
- 2005-02-18 CN CNB2005100542167A patent/CN100348585C/zh not_active Expired - Lifetime
- 2005-02-18 ZA ZA2005/01468A patent/ZA200501468B/en unknown
- 2005-02-18 MA MA28112A patent/MA27598A1/fr unknown
- 2005-02-18 GE GEAP8647A patent/GEP20074136B/en unknown
- 2005-02-18 UA UAA200501524A patent/UA81773C2/uk unknown
- 2005-02-18 JP JP2005041810A patent/JP4515933B2/ja not_active Expired - Lifetime
- 2005-02-19 KR KR1020050013860A patent/KR100636499B1/ko not_active Expired - Lifetime
- 2005-02-19 EG EG2005020086A patent/EG25619A/xx active
- 2005-02-21 EA EA200500240A patent/EA007743B1/ru unknown
- 2005-02-21 EP EP05290383A patent/EP1614687B1/de not_active Expired - Lifetime
- 2005-02-21 PT PT05290383T patent/PT1614687E/pt unknown
- 2005-02-21 DE DE602005017541T patent/DE602005017541D1/de not_active Expired - Lifetime
- 2005-02-21 DK DK05290383.8T patent/DK1614687T3/da active
- 2005-02-21 RS RSP-2010/0006A patent/RS51232B/sr unknown
- 2005-02-21 AT AT05290383T patent/ATE448221T1/de active
- 2005-02-21 PL PL05290383T patent/PL1614687T3/pl unknown
- 2005-02-21 SI SI200530864T patent/SI1614687T1/sl unknown
- 2005-02-21 ES ES05290383T patent/ES2336461T3/es not_active Expired - Lifetime
- 2005-02-21 WO PCT/FR2005/000396 patent/WO2005111027A1/fr not_active Ceased
- 2005-04-07 MX MXPA05003696A patent/MXPA05003696A/es active IP Right Grant
2009
- 2009-09-25 JP JP2009220529A patent/JP5277130B2/ja not_active Expired - Lifetime
2010
- 2010-01-13 HR HR20100024T patent/HRP20100024T1/hr unknown
- 2010-01-19 CY CY20101100053T patent/CY1109740T1/el unknown

Also Published As

Publication number	Publication date
MA27598A1 (fr)	2005-11-01
AR047707A1 (es)	2006-02-08
JP2005298478A (ja)	2005-10-27
RS51232B (sr)	2010-12-31
EP1614687A1 (de)	2006-01-11
WO2005111027A1 (fr)	2005-11-24
UA81773C2 (uk)	2008-02-11
EA200500240A1 (ru)	2005-10-27
JP5277130B2 (ja)	2013-08-28
US7064200B2 (en)	2006-06-20
CY1109740T1 (el)	2014-09-10
JP4515933B2 (ja)	2010-08-04
CA2496712C (fr)	2010-04-06
ES2336461T3 (es)	2010-04-13
PL1614687T3 (pl)	2010-04-30
SI1614687T1 (sl)	2010-01-29
GEP20074136B (en)	2007-06-25
PT1614687E (pt)	2009-12-02
US20050228178A1 (en)	2005-10-13
ZA200501468B (en)	2005-11-30
DE602005017541D1 (de)	2009-12-24
NZ538328A (en)	2005-10-28
EA007743B1 (ru)	2006-12-29
NO20050888L (no)	2005-10-14
BRPI0500590B1 (pt)	2018-10-09
BRPI0500590A (pt)	2005-11-16
MY140904A (en)	2010-01-29
MXPA05003696A (es)	2006-01-24
HK1079777A1 (zh)	2006-04-13
KR20060042117A (ko)	2006-05-12
NO20050888D0 (no)	2005-02-18
EP1614687B1 (de)	2009-11-11
JP2010047577A (ja)	2010-03-04
DK1614687T3 (da)	2010-03-29
CN100348585C (zh)	2007-11-14
BRPI0500590B8 (pt)	2021-05-25
KR100636499B1 (ko)	2006-10-18
AU2005200884B2 (en)	2010-07-15
SG116574A1 (en)	2005-11-28
CA2496712A1 (fr)	2005-10-13
NO329861B1 (no)	2011-01-17
FR2868775A1 (fr)	2005-10-14
HRP20100024T1 (hr)	2010-02-28
EG25619A (en)	2012-03-26
CN1683343A (zh)	2005-10-19
AU2005200884A1 (en)	2005-10-27
FR2868775B1 (fr)	2008-04-11

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2010-05-15

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