ATE449187T1 - Molekulare eigenschaften von nichtkleinzelligem lungenkrebs - Google Patents

Molekulare eigenschaften von nichtkleinzelligem lungenkrebs

Info

Publication number
ATE449187T1
ATE449187T1 AT02794901T AT02794901T ATE449187T1 AT E449187 T1 ATE449187 T1 AT E449187T1 AT 02794901 T AT02794901 T AT 02794901T AT 02794901 T AT02794901 T AT 02794901T AT E449187 T1 ATE449187 T1 AT E449187T1
Authority
AT
Austria
Prior art keywords
sage
small cell
gene expression
lung cancer
normal
Prior art date
Application number
AT02794901T
Other languages
German (de)
English (en)
Inventor
Mariana Nacht
Tatiana Dracheva
David Sidransky
Stephen L Madden
Jin Jen
Original Assignee
Us Health
Genzyme Corp
Univ Johns Hopkins
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Us Health, Genzyme Corp, Univ Johns Hopkins filed Critical Us Health
Application granted granted Critical
Publication of ATE449187T1 publication Critical patent/ATE449187T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/112—Disease subtyping, staging or classification
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/158—Expression markers

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Immunology (AREA)
  • Wood Science & Technology (AREA)
  • Engineering & Computer Science (AREA)
  • Analytical Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Pathology (AREA)
  • General Health & Medical Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Oncology (AREA)
  • General Engineering & Computer Science (AREA)
  • Hospice & Palliative Care (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Microbiology (AREA)
  • Biophysics (AREA)
  • Biotechnology (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
AT02794901T 2001-08-16 2002-08-16 Molekulare eigenschaften von nichtkleinzelligem lungenkrebs ATE449187T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US31240001P 2001-08-16 2001-08-16
PCT/US2002/026027 WO2003015613A2 (fr) 2001-08-16 2002-08-16 Caracteristiques moleculaires du cancer du poumon non a petites cellules

Publications (1)

Publication Number Publication Date
ATE449187T1 true ATE449187T1 (de) 2009-12-15

Family

ID=23211260

Family Applications (1)

Application Number Title Priority Date Filing Date
AT02794901T ATE449187T1 (de) 2001-08-16 2002-08-16 Molekulare eigenschaften von nichtkleinzelligem lungenkrebs

Country Status (8)

Country Link
US (2) US7332590B2 (fr)
EP (1) EP1453977B1 (fr)
JP (1) JP2005503145A (fr)
AT (1) ATE449187T1 (fr)
AU (1) AU2002355963A1 (fr)
CA (1) CA2456334A1 (fr)
DE (1) DE60234467D1 (fr)
WO (1) WO2003015613A2 (fr)

Families Citing this family (67)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2002355963A1 (en) * 2001-08-16 2003-03-03 Genzyme Corporation Molecular characteristics of non-small cell lung cancer
ATE331044T1 (de) * 2003-03-04 2006-07-15 Pamgene Bv Verfahren zur integrierten integritätsbewertung und analyse von nukleinsäuren
GB0307403D0 (en) 2003-03-31 2003-05-07 Medical Res Council Selection by compartmentalised screening
US20060078893A1 (en) 2004-10-12 2006-04-13 Medical Research Council Compartmentalised combinatorial chemistry by microfluidic control
GB0307428D0 (en) 2003-03-31 2003-05-07 Medical Res Council Compartmentalised combinatorial chemistry
CA2527680A1 (fr) * 2003-05-30 2005-06-02 Astrazeneca Uk Limited Marqueurs de reactivite d'un inhibiteur de la tyrosine kinase du recepteur erbb
EP2327795B1 (fr) * 2003-06-10 2017-08-09 The Trustees Of Boston University Méthodes de détection de troubles poulmonaires
US20060003391A1 (en) * 2003-08-11 2006-01-05 Ring Brian Z Reagents and methods for use in cancer diagnosis, classification and therapy
WO2005032495A2 (fr) * 2003-10-03 2005-04-14 Bayer Pharmaceuticals Corporation Profils d'expression genique et leurs methodes d'utilisation
US7700573B2 (en) * 2004-03-23 2010-04-20 Oncotherapy Science, Inc. Method for diagnosing non-small lung cancer
US20050221339A1 (en) 2004-03-31 2005-10-06 Medical Research Council Harvard University Compartmentalised screening by microfluidic control
US7968287B2 (en) 2004-10-08 2011-06-28 Medical Research Council Harvard University In vitro evolution in microfluidic systems
WO2006056080A1 (fr) * 2004-11-29 2006-06-01 Diagnocure Inc. Gene gpx2, cible specifique et sensible pour le diagnostic, le pronostic et/ou la theranose concernant le cancer du poumon
EP3211093A1 (fr) 2005-04-14 2017-08-30 The Trustees of Boston University Diagnostic des troubles pulmonaires à l'aide d'une prédiction de classe
US7504225B2 (en) 2005-05-12 2009-03-17 Applied Genomics, Inc. Reagents and methods for use in cancer diagnosis, classification and therapy
KR100710462B1 (ko) 2005-08-24 2007-04-24 광주과학기술원 폐암 진단용 퍼옥시레독신-ｉ자가항체 마커 및 이를 이용한진단키트
WO2007081385A2 (fr) 2006-01-11 2007-07-19 Raindance Technologies, Inc. Dispositifs microfluidiques et leurs procédés d'utilisation dans la formation et le contrôle de nanoréacteurs
WO2007103541A2 (fr) 2006-03-09 2007-09-13 The Trustees Of Boston University Méthodes de diagnostic et de pronostic pour troubles des poumons utilisant des profils d'expression de gènes de cellules épithéliales nasales
US9562837B2 (en) 2006-05-11 2017-02-07 Raindance Technologies, Inc. Systems for handling microfludic droplets
EP2530167A1 (fr) 2006-05-11 2012-12-05 Raindance Technologies, Inc. Dispositifs microfluidiques
EP2077912B1 (fr) 2006-08-07 2019-03-27 The President and Fellows of Harvard College Tensioactifs fluorocarbonés stabilisateurs d'émulsions
EA010352B1 (ru) * 2006-10-09 2008-08-29 Институт Молекулярной Генетики Российской Академии Наук (Имг Ран) Способ дифференциального анализа протеомов
WO2008097559A2 (fr) 2007-02-06 2008-08-14 Brandeis University Manipulation de fluides et de réactions dans des systèmes microfluidiques
US8592221B2 (en) 2007-04-19 2013-11-26 Brandeis University Manipulation of fluids, fluid components and reactions in microfluidic systems
CN101990577A (zh) 2007-09-19 2011-03-23 波士顿大学理事会 鉴定肺病药物开发的新途径
EP2288741B1 (fr) * 2008-05-14 2015-01-28 University Health Network Signature génique prédictive et pronostique pour le cancer du poumon non à petites cellules et chimiothérapie adjuvante
EP2145964A1 (fr) * 2008-07-17 2010-01-20 Universität Zu Köln Procédé de détection précoce du cancer des poumons et pronostic
US12038438B2 (en) 2008-07-18 2024-07-16 Bio-Rad Laboratories, Inc. Enzyme quantification
EP4047367A1 (fr) 2008-07-18 2022-08-24 Bio-Rad Laboratories, Inc. Procedé de détection d'analytes cibles au moyens des bibliothèques de gouttelettes
US10236078B2 (en) 2008-11-17 2019-03-19 Veracyte, Inc. Methods for processing or analyzing a sample of thyroid tissue
US9495515B1 (en) 2009-12-09 2016-11-15 Veracyte, Inc. Algorithms for disease diagnostics
WO2010099923A1 (fr) * 2009-03-04 2010-09-10 Roche Diagnostics Gmbh Serpine b 13 en tant que marqueur du carcinome épidermoïde du poumon
WO2010111231A1 (fr) 2009-03-23 2010-09-30 Raindance Technologies, Inc. Manipulation de gouttelettes microfluidiques
EP3360978A3 (fr) 2009-05-07 2018-09-26 Veracyte, Inc. Procédés pour le diagnostic d'affections thyroïdiennes
US10520500B2 (en) 2009-10-09 2019-12-31 Abdeslam El Harrak Labelled silica-based nanomaterial with enhanced properties and uses thereof
WO2011051278A1 (fr) * 2009-10-26 2011-05-05 Externautics S.P.A. Marqueurs de tumeurs du poumon et leurs méthodes d'utilisation
WO2011060215A1 (fr) 2009-11-13 2011-05-19 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Composés diazéniumdiolatés, compositions pharmaceutiques et procédé de traitement du cancer
US10837883B2 (en) 2009-12-23 2020-11-17 Bio-Rad Laboratories, Inc. Microfluidic systems and methods for reducing the exchange of molecules between droplets
US9366632B2 (en) 2010-02-12 2016-06-14 Raindance Technologies, Inc. Digital analyte analysis
EP4484577A3 (fr) 2010-02-12 2025-03-26 Bio-Rad Laboratories, Inc. Analyse numérique d'analyte
US9399797B2 (en) 2010-02-12 2016-07-26 Raindance Technologies, Inc. Digital analyte analysis
US10351905B2 (en) 2010-02-12 2019-07-16 Bio-Rad Laboratories, Inc. Digital analyte analysis
US9562897B2 (en) 2010-09-30 2017-02-07 Raindance Technologies, Inc. Sandwich assays in droplets
EP3412778A1 (fr) 2011-02-11 2018-12-12 Raindance Technologies, Inc. Procédés permettant de former des gouttelettes mélangées
WO2012112804A1 (fr) 2011-02-18 2012-08-23 Raindance Technoligies, Inc. Compositions et méthodes de marquage moléculaire
EP3216872B1 (fr) 2011-06-02 2020-04-01 Bio-Rad Laboratories, Inc. Quantification d'enzyme
US8841071B2 (en) 2011-06-02 2014-09-23 Raindance Technologies, Inc. Sample multiplexing
US8658430B2 (en) 2011-07-20 2014-02-25 Raindance Technologies, Inc. Manipulating droplet size
WO2013120089A1 (fr) 2012-02-10 2013-08-15 Raindance Technologies, Inc. Dosage de type criblage diagnostique moléculaire
EP2844768B1 (fr) 2012-04-30 2019-03-13 Raindance Technologies, Inc. Analyse d'analyte numérique
EP2968988A4 (fr) 2013-03-14 2016-11-16 Allegro Diagnostics Corp Procédés d'évaluation de l'état d'une maladie pulmonaire obstructive chronique (copd)
US11976329B2 (en) 2013-03-15 2024-05-07 Veracyte, Inc. Methods and systems for detecting usual interstitial pneumonia
WO2014172288A2 (fr) 2013-04-19 2014-10-23 Raindance Technologies, Inc. Analyse d'analyte numérique
US20150087728A1 (en) * 2013-09-20 2015-03-26 Integrated Diagnostics, Inc. Compositions, methods and kits for diagnosis of lung cancer
US11901041B2 (en) 2013-10-04 2024-02-13 Bio-Rad Laboratories, Inc. Digital analysis of nucleic acid modification
US9944977B2 (en) 2013-12-12 2018-04-17 Raindance Technologies, Inc. Distinguishing rare variations in a nucleic acid sequence from a sample
WO2015103367A1 (fr) 2013-12-31 2015-07-09 Raindance Technologies, Inc. Système et procédé de détection d'une espèce d'arn
WO2015117133A1 (fr) 2014-02-03 2015-08-06 Integrated Diagnostics, Inc. Procédé de quantification intégré pour la mesure de protéines en protéomique clinique
US12297505B2 (en) 2014-07-14 2025-05-13 Veracyte, Inc. Algorithms for disease diagnostics
US20170335396A1 (en) 2014-11-05 2017-11-23 Veracyte, Inc. Systems and methods of diagnosing idiopathic pulmonary fibrosis on transbronchial biopsies using machine learning and high dimensional transcriptional data
CN105154542B (zh) * 2015-09-01 2018-04-17 杭州源清生物科技有限公司 一组用于肺癌分子分型的基因及其应用
US10647981B1 (en) 2015-09-08 2020-05-12 Bio-Rad Laboratories, Inc. Nucleic acid library generation methods and compositions
WO2017197335A1 (fr) 2016-05-12 2017-11-16 Trustees Of Boston University Signature et classificateur d'expression génique de l'épithélium nasal pour la prédiction du cancer du poumon
US10927417B2 (en) 2016-07-08 2021-02-23 Trustees Of Boston University Gene expression-based biomarker for the detection and monitoring of bronchial premalignant lesions
US10998178B2 (en) 2017-08-28 2021-05-04 Purdue Research Foundation Systems and methods for sample analysis using swabs
EP3947737A2 (fr) * 2019-04-02 2022-02-09 INSERM (Institut National de la Santé et de la Recherche Médicale) Méthodes de prédiction et de prévention du cancer chez des patients ayant des lésions prémalignes
CN116144778A (zh) * 2023-02-16 2023-05-23 广东省人民医院 利用肠道菌区分晚期突变型和野生型非小细胞肺癌的方法

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4445990A (en) * 1981-11-12 1984-05-01 General Electric Company Electrolytic reactor for cleaning wastewater
US5763165A (en) 1994-03-10 1998-06-09 Ludwig Institute For Cancer Research Method for determining lung adenocarcinomas by assaying for one or more of MAGE-1, MAGE-2 and MAGE-3
US6087102A (en) 1998-01-07 2000-07-11 Clontech Laboratories, Inc. Polymeric arrays and methods for their use in binding assays
JP2002509707A (ja) 1998-03-31 2002-04-02 ジェンザイム・コーポレーション 肺腫瘍細胞を同定するための組成物および方法
CA2328138A1 (fr) 1998-05-21 1999-11-25 Diadexus Llc Technique de diagnostic, de suivi et de stadification du cancer du poumon
US20030065157A1 (en) * 2001-04-04 2003-04-03 Lasek Amy W. Genes expressed in lung cancer
AU2002355963A1 (en) * 2001-08-16 2003-03-03 Genzyme Corporation Molecular characteristics of non-small cell lung cancer
US20060151337A1 (en) * 2005-01-07 2006-07-13 Gilmore F W Electrocoagulation Reaction Chamber

Also Published As

Publication number Publication date
WO2003015613A3 (fr) 2004-06-24
EP1453977B1 (fr) 2009-11-18
CA2456334A1 (fr) 2003-02-27
AU2002355963A1 (en) 2003-03-03
DE60234467D1 (de) 2009-12-31
US7332590B2 (en) 2008-02-19
EP1453977A4 (fr) 2005-04-20
EP1453977A2 (fr) 2004-09-08
US7709202B2 (en) 2010-05-04
JP2005503145A (ja) 2005-02-03
WO2003015613A2 (fr) 2003-02-27
US20090270265A1 (en) 2009-10-29
US20050136403A1 (en) 2005-06-23

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