ATE450535T1 - Neues verfahren zur herstellung von pleuromutilinderivaten - Google Patents

Neues verfahren zur herstellung von pleuromutilinderivaten

Info

Publication number
ATE450535T1
ATE450535T1 AT04782599T AT04782599T ATE450535T1 AT E450535 T1 ATE450535 T1 AT E450535T1 AT 04782599 T AT04782599 T AT 04782599T AT 04782599 T AT04782599 T AT 04782599T AT E450535 T1 ATE450535 T1 AT E450535T1
Authority
AT
Austria
Prior art keywords
new process
pleuromutilin derivatives
mutilin
ylsulfanyl
azabicyclo
Prior art date
Application number
AT04782599T
Other languages
English (en)
Inventor
Gary Breen
Michael Forth
Susan Kopelman
Francis Muller
Francis Sanderson
Original Assignee
Glaxo Group Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Glaxo Group Ltd filed Critical Glaxo Group Ltd
Application granted granted Critical
Publication of ATE450535T1 publication Critical patent/ATE450535T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
    • C07D451/04—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/439—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom the ring forming part of a bridged ring system, e.g. quinuclidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0014—Skin, i.e. galenical aspects of topical compositions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/10—Anti-acne agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Dermatology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicinal Preparation (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
AT04782599T 2003-09-03 2004-08-30 Neues verfahren zur herstellung von pleuromutilinderivaten ATE450535T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US49978103P 2003-09-03 2003-09-03
PCT/US2004/028159 WO2005023257A1 (en) 2003-09-03 2004-08-30 Novel process, salts, compositions and use

Publications (1)

Publication Number Publication Date
ATE450535T1 true ATE450535T1 (de) 2009-12-15

Family

ID=34272868

Family Applications (1)

Application Number Title Priority Date Filing Date
AT04782599T ATE450535T1 (de) 2003-09-03 2004-08-30 Neues verfahren zur herstellung von pleuromutilinderivaten

Country Status (7)

Country Link
US (2) US7875630B2 (de)
EP (2) EP1663220B1 (de)
JP (4) JP5460947B2 (de)
AT (1) ATE450535T1 (de)
DE (1) DE602004024417D1 (de)
ES (1) ES2335284T3 (de)
WO (1) WO2005023257A1 (de)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
UY25225A1 (es) 1997-10-29 2000-12-29 Smithkline Beecham Plc Derivados de pleuromutilina utiles como agentes antimicrobianos
ATE450535T1 (de) * 2003-09-03 2009-12-15 Glaxo Group Ltd Neues verfahren zur herstellung von pleuromutilinderivaten
GB0504314D0 (en) * 2005-03-02 2005-04-06 Glaxo Group Ltd Novel polymorph
EP1860943A4 (de) * 2005-03-10 2008-06-18 Smithkline Beecham Corp Neuartiges verfahren
GB0513058D0 (en) * 2005-06-27 2005-08-03 Sandoz Ag Organic compounds
UA97382C2 (ru) * 2006-12-14 2012-02-10 Тева Фармасьютікл Індастріз, Лтд. Таннат разагилина
AU2007334428B2 (en) * 2006-12-14 2014-05-29 Teva Pharmaceutical Industries, Ltd. Crystalline solid rasagiline base
JP5322927B2 (ja) 2007-05-24 2013-10-23 杏林製薬株式会社 １４位置換基に複素芳香環カルボン酸構造を有するムチリン誘導体
US20090234125A1 (en) * 2007-11-26 2009-09-17 Eli Lancry Amorphous retapamulin and processes for preparation thereof
US20090149655A1 (en) * 2007-12-05 2009-06-11 Lilach Hedvati Process for the preparation of Retapamulin and its intermediates
WO2009095634A1 (en) * 2008-02-01 2009-08-06 Pliva Hrvatska D.O.O. Amorphous forms of retapamulin
US20100184987A1 (en) * 2008-11-13 2010-07-22 Teva Pharmaceutical Industries Ltd. Preparation of Retapamulin via its Pleuromutilin-thiol precursor
EP2399904A1 (de) * 2010-05-26 2011-12-28 Nabriva Therapeutics AG Verfahren zur Herstellung von Pleuromutilinen
EP2624817A1 (de) * 2010-10-08 2013-08-14 Helperby Therapeutics Limited Neuartige zusammensetzung
CN102267992B (zh) * 2011-06-17 2012-10-31 华南农业大学 一种截短侧耳素类抗生素的制备方法
CN105198873B (zh) * 2014-06-11 2017-08-04 上海医药工业研究院 一种制备瑞他莫林的方法
RU2766579C2 (ru) 2015-07-02 2022-03-15 ХОРАЙЗОН ОРФАН ЭлЭлСи Цистеаминдиоксигеназа-резистентные аналоги цистеамина и их применение
TWI762573B (zh) * 2017-02-10 2022-05-01 奧地利商納畢瓦治療有限責任公司 截短側耳素之純化
CN107324998B (zh) * 2017-07-31 2020-07-14 重庆华邦胜凯制药有限公司 一种制备外用抗生素类药物瑞他莫林的方法
EP4007559B1 (de) * 2019-08-01 2024-10-23 Unilever IP Holdings B.V. Antischuppenzusammensetzung
CN119930552B (zh) * 2024-04-28 2026-02-27 瑞普生物股份有限公司 具有呋喃侧链的截短侧耳素衍生物及其制备方法与应用

Family Cites Families (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE789629A (fr) * 1971-10-05 1973-04-03 Sandoz Sa Nouveaux derives de la pleuromutiline, leur preparation et leurapplication en therapeutique
US4130709A (en) 1977-12-08 1978-12-19 Eli Lilly And Company Pleuromutilin glycoside derivatives
JPS54160358A (en) * 1978-06-06 1979-12-19 Sandoz Ag Improvement for organic compound
EP0013768B1 (de) * 1979-01-12 1984-02-01 Sandoz Ag Pleuromutilin-Derivate, ihre Herstellung und sie enthaltende pharmazeutische Zusammensetzungen
JPH0613528B2 (ja) * 1985-08-20 1994-02-23 塩野義製薬株式会社 セフエム化合物のメトキシ化法
KR0166088B1 (ko) 1990-01-23 1999-01-15 . 수용해도가 증가된 시클로덱스트린 유도체 및 이의 용도
US5376645A (en) 1990-01-23 1994-12-27 University Of Kansas Derivatives of cyclodextrins exhibiting enhanced aqueous solubility and the use thereof
AT397654B (de) * 1992-05-04 1994-06-27 Biochemie Gmbh Neue pleuromutilinderivate, ihre verwendung und verfahren zu ihrer herstellung
GB9711643D0 (en) 1997-06-05 1997-07-30 Janssen Pharmaceutica Nv Glass thermoplastic systems
GB9713730D0 (en) * 1997-06-30 1997-09-03 Ciba Geigy Ag Organic compounds
UY25225A1 (es) 1997-10-29 2000-12-29 Smithkline Beecham Plc Derivados de pleuromutilina utiles como agentes antimicrobianos
CZ20012294A3 (cs) * 1998-12-22 2001-12-12 F. Hoffmann-La Roche Ag Sulfonamidové hydroxamáty
GB9918037D0 (en) * 1999-07-30 1999-09-29 Biochemie Gmbh Organic compounds
TWI260220B (en) * 1999-11-22 2006-08-21 Novartis Ag A pharmaceutical composition for the transdermal treatment of bacterial infections in animals
EP1294358B1 (de) 2000-06-28 2004-08-18 Smithkline Beecham Plc Nassvermahlung
KR20030076650A (ko) * 2001-02-02 2003-09-26 미쯔비시 웰 파마 가부시키가이샤 디하이드로피라졸로피리딘 화합물 및 그의 약학적 용도
GB0207495D0 (en) * 2002-03-28 2002-05-08 Biochemie Gmbh Organic compounds
DE60317208T2 (de) * 2002-07-24 2008-08-07 Nabriva Therapeutics Forschungs Gmbh Pleuromutilinderivate als antimikrobielle mittel
ATE450535T1 (de) 2003-09-03 2009-12-15 Glaxo Group Ltd Neues verfahren zur herstellung von pleuromutilinderivaten
GB0504314D0 (en) 2005-03-02 2005-04-06 Glaxo Group Ltd Novel polymorph
EP1860943A4 (de) 2005-03-10 2008-06-18 Smithkline Beecham Corp Neuartiges verfahren

Also Published As

Publication number Publication date
EP1663220B1 (de) 2009-12-02
JP2015013882A (ja) 2015-01-22
EP1663220A1 (de) 2006-06-07
EP2181995A3 (de) 2010-06-16
US20060276503A1 (en) 2006-12-07
EP1663220A4 (de) 2007-04-18
JP2012020998A (ja) 2012-02-02
US20110144151A1 (en) 2011-06-16
US7875630B2 (en) 2011-01-25
JP5460947B2 (ja) 2014-04-02
JP2007504231A (ja) 2007-03-01
JP5685156B2 (ja) 2015-03-18
US8207191B2 (en) 2012-06-26
JP5719331B2 (ja) 2015-05-20
ES2335284T3 (es) 2010-03-24
JP2012236850A (ja) 2012-12-06
DE602004024417D1 (de) 2010-01-14
WO2005023257A1 (en) 2005-03-17
EP2181995A2 (de) 2010-05-05

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