ATE451102T1 - Thiazol-derivate zur verwendung als entzündungshemmende mittel - Google Patents

Thiazol-derivate zur verwendung als entzündungshemmende mittel

Info

Publication number
ATE451102T1
ATE451102T1 AT01943850T AT01943850T ATE451102T1 AT E451102 T1 ATE451102 T1 AT E451102T1 AT 01943850 T AT01943850 T AT 01943850T AT 01943850 T AT01943850 T AT 01943850T AT E451102 T1 ATE451102 T1 AT E451102T1
Authority
AT
Austria
Prior art keywords
substituted
unsubstituted
hydrogen
inflammatory agents
thiazole derivatives
Prior art date
Application number
AT01943850T
Other languages
English (en)
Inventor
Norio Fujiwara
Hitoshi Fujita
Fujio Antoku
Toshinari Sugasawa
Hajime Kawakami
Original Assignee
Dainippon Sumitomo Pharma Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dainippon Sumitomo Pharma Co filed Critical Dainippon Sumitomo Pharma Co
Application granted granted Critical
Publication of ATE451102T1 publication Critical patent/ATE451102T1/de

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D417/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D231/00Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • A61P37/06Immunosuppressants, e.g. drugs for graft rejection
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/08Antiallergic agents
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D233/00Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D249/00Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/081,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D277/00Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/38Nitrogen atoms
    • C07D277/42Amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D417/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D417/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/06Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D417/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Transplantation (AREA)
  • Pulmonology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
AT01943850T 2000-06-30 2001-06-28 Thiazol-derivate zur verwendung als entzündungshemmende mittel ATE451102T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2000198074 2000-06-30
PCT/JP2001/005540 WO2002002542A1 (fr) 2000-06-30 2001-06-28 Compose annulaire a cinq chainons

Publications (1)

Publication Number Publication Date
ATE451102T1 true ATE451102T1 (de) 2009-12-15

Family

ID=18696291

Family Applications (1)

Application Number Title Priority Date Filing Date
AT01943850T ATE451102T1 (de) 2000-06-30 2001-06-28 Thiazol-derivate zur verwendung als entzündungshemmende mittel

Country Status (15)

Country Link
US (2) US6919361B2 (de)
EP (2) EP1300401B1 (de)
JP (1) JP3785397B2 (de)
KR (2) KR100758775B1 (de)
CN (2) CN1944417A (de)
AT (1) ATE451102T1 (de)
AU (2) AU6634501A (de)
CA (1) CA2413000C (de)
CY (1) CY1109863T1 (de)
DE (1) DE60140748D1 (de)
DK (1) DK1300401T3 (de)
ES (1) ES2336425T3 (de)
PT (1) PT1300401E (de)
TW (1) TWI313266B (de)
WO (1) WO2002002542A1 (de)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2002361117A1 (en) * 2001-12-28 2003-07-24 Sumitomo Pharmaceuticals Co., Ltd. 5-membered cyclic compounds
EP1348433A1 (de) * 2002-03-28 2003-10-01 Warner-Lambert Company LLC Thiazol-5-yl-imine als PDE7-Inhibitoren
DE10254336A1 (de) * 2002-11-21 2004-06-03 Merck Patent Gmbh Carbonsäureamide
WO2005000825A1 (ja) * 2003-06-27 2005-01-06 Dainippon Sumitomo Pharma Co., Ltd. チアゾールイミン類およびオキサゾールイミン類
EP2187396B1 (de) * 2003-10-10 2019-03-27 Sharp Kabushiki Kaisha Wiedergabevorrichtung, Wiedergabeverfahren, System, Software und computerlesbares Aufzeichnungsmedium, das Software speichert für die Priorisierung der Wiedergabesteuerinformation
MY162179A (en) * 2004-04-01 2017-05-31 Elan Pharm Inc Steroid sparing agents and methods of using same
EP1820504A1 (de) * 2004-11-15 2007-08-22 Taisho Pharmaceutical Co., Ltd Iminverbindung
EP1875915A4 (de) * 2005-04-28 2010-11-17 Dainippon Sumitomo Pharma Co Therapeutikum für chronische obstruktive lungenerkrankung
JP2007015999A (ja) * 2005-07-11 2007-01-25 Sumitomo Chemical Co Ltd イミノチアゾール化合物の製造方法
AU2006343735A1 (en) * 2006-05-11 2007-11-22 Dainippon Sumitomo Pharma Co., Ltd. A medicament containing a thiazole derivative as an active ingredient
CA2647598A1 (en) 2006-05-31 2007-12-06 Abbott Laboratories Compounds as cannabinoid receptor ligands and uses thereof
US8841334B2 (en) 2006-05-31 2014-09-23 Abbvie Inc. Compounds as cannabinoid receptor ligands and uses thereof
CN101765594A (zh) 2007-03-28 2010-06-30 雅培制药有限公司 作为大麻素受体配体的1,3-噻唑-2(3h)-亚基化合物
US7872033B2 (en) 2007-04-17 2011-01-18 Abbott Laboratories Compounds as cannabinoid receptor ligands
JP2010527929A (ja) 2007-05-18 2010-08-19 アボット・ラボラトリーズ カンナビノイド受容体リガンドとしての新規な化合物
KR100863239B1 (ko) 2007-05-23 2008-10-15 한국과학기술연구원 신규한 2-이미노-1,3-티아졸린계 화합물 및 이를 함유하는t-형 칼슘 채널 저해제
US9193713B2 (en) 2007-10-12 2015-11-24 Abbvie Inc. Compounds as cannabinoid receptor ligands
WO2009131171A1 (ja) 2008-04-25 2009-10-29 大日本住友製薬株式会社 新規5員環化合物
EP2272844A4 (de) * 2008-04-25 2012-02-22 Dainippon Sumitomo Pharma Co Fünfgliedrige ringverbindung
US8846730B2 (en) 2008-09-08 2014-09-30 Abbvie Inc. Compounds as cannabinoid receptor ligands
AU2009293319A1 (en) 2008-09-16 2010-03-25 Abbott Laboratories Substituted benzamides as cannabinoid receptor ligands
PA8854001A1 (es) 2008-12-16 2010-07-27 Abbott Lab Compuestos novedosos como ligandos de receptores de canabinoides
US8492371B2 (en) 2009-03-27 2013-07-23 Abbvie Inc. Compounds as cannabinoid receptor ligands
WO2014052831A1 (en) * 2012-09-28 2014-04-03 Xavier University Of Louisiana Anti-migration and anti-invasion thiazole analogs for treatment of cellular proliferative disease

Family Cites Families (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE941288C (de) 1950-10-31 1956-04-05 Goodrich Co B F Verfahren zur Herstellung substituierter 2-Imino-4-thiazoline oder von Salzen derselben bzw. von substituierten 2-Aminothiazolen
EP0848059A1 (de) 1996-12-12 1998-06-17 Vetigen ICYP (Iodocyanopindolol) Rezeptor von Säugetieren und dessen Anwendungen
US7076307B2 (en) * 2002-05-09 2006-07-11 Boveja Birinder R Method and system for modulating the vagus nerve (10th cranial nerve) with electrical pulses using implanted and external components, to provide therapy neurological and neuropsychiatric disorders
FR2796643B1 (fr) * 1999-07-22 2005-04-29 Sod Conseils Rech Applic Derives de 2-arylimino-2, 3-dihydrothiazoles, leurs procedes de preparation et leur utilisation therapeutique
EP1237849A1 (de) * 1999-11-05 2002-09-11 University College London Aktivatoren der löslichen guanylatcyclase
US20030208212A1 (en) * 1999-12-07 2003-11-06 Valerio Cigaina Removable gastric band
DE19959825C1 (de) * 1999-12-10 2001-07-26 Dorma Gmbh & Co Kg Schiebewand mit mehreren seitlich verschiebbaren Wandelementen
US6885888B2 (en) * 2000-01-20 2005-04-26 The Cleveland Clinic Foundation Electrical stimulation of the sympathetic nerve chain
US6708064B2 (en) * 2000-02-24 2004-03-16 Ali R. Rezai Modulation of the brain to affect psychiatric disorders
US6639077B2 (en) * 2000-03-23 2003-10-28 Merck Frosst Canada & Co. Tri-aryl-substituted-ethane PDE4 inhibitors
US6684105B2 (en) * 2001-08-31 2004-01-27 Biocontrol Medical, Ltd. Treatment of disorders by unidirectional nerve stimulation
US7054686B2 (en) * 2001-08-30 2006-05-30 Biophan Technologies, Inc. Pulsewidth electrical stimulation
EP1476221A4 (de) * 2002-02-01 2008-04-23 Cleveland Clinic Foundation Verstellbare simulierungsvorrichtung und verwendungsverfahren dafür
US7831308B2 (en) * 2002-02-01 2010-11-09 The Cleveland Clinic Foundation Neural stimulation delivery device with independently moveable delivery structures
AU2003210752A1 (en) * 2002-02-01 2003-09-02 The Cleveland Clinic Foundation Modulation of the pain circuitry to affect chronic pain
US7689276B2 (en) * 2002-09-13 2010-03-30 Leptos Biomedical, Inc. Dynamic nerve stimulation for treatment of disorders
US20040015205A1 (en) * 2002-06-20 2004-01-22 Whitehurst Todd K. Implantable microstimulators with programmable multielectrode configuration and uses thereof
US7292890B2 (en) * 2002-06-20 2007-11-06 Advanced Bionics Corporation Vagus nerve stimulation via unidirectional propagation of action potentials
US20040210270A1 (en) * 2002-07-26 2004-10-21 John Erickson High frequency pulse generator for an implantable neurostimulator
US7209790B2 (en) * 2002-09-30 2007-04-24 Medtronic, Inc. Multi-mode programmer for medical device communication
US7844338B2 (en) * 2003-02-03 2010-11-30 Enteromedics Inc. High frequency obesity treatment
US7613515B2 (en) * 2003-02-03 2009-11-03 Enteromedics Inc. High frequency vagal blockage therapy
US7444183B2 (en) * 2003-02-03 2008-10-28 Enteromedics, Inc. Intraluminal electrode apparatus and method
US20040172084A1 (en) * 2003-02-03 2004-09-02 Knudson Mark B. Method and apparatus for treatment of gastro-esophageal reflux disease (GERD)
US7444184B2 (en) * 2003-05-11 2008-10-28 Neuro And Cardial Technologies, Llc Method and system for providing therapy for bulimia/eating disorders by providing electrical pulses to vagus nerve(s)
US7149574B2 (en) * 2003-06-09 2006-12-12 Palo Alto Investors Treatment of conditions through electrical modulation of the autonomic nervous system
US7263405B2 (en) * 2003-08-27 2007-08-28 Neuro And Cardiac Technologies Llc System and method for providing electrical pulses to the vagus nerve(s) to provide therapy for obesity, eating disorders, neurological and neuropsychiatric disorders with a stimulator, comprising bi-directional communication and network capabilities
US7252090B2 (en) * 2003-09-15 2007-08-07 Medtronic, Inc. Selection of neurostimulator parameter configurations using neural network
US7184837B2 (en) * 2003-09-15 2007-02-27 Medtronic, Inc. Selection of neurostimulator parameter configurations using bayesian networks
US7239926B2 (en) * 2003-09-15 2007-07-03 Medtronic, Inc. Selection of neurostimulator parameter configurations using genetic algorithms
US7617002B2 (en) * 2003-09-15 2009-11-10 Medtronic, Inc. Selection of neurostimulator parameter configurations using decision trees
US7418292B2 (en) * 2003-10-01 2008-08-26 Medtronic, Inc. Device and method for attenuating an immune response
CA2573785A1 (en) * 2004-07-20 2006-02-02 Medtronic, Inc. Therapy programming guidance based on stored programming history

Also Published As

Publication number Publication date
JP3785397B2 (ja) 2006-06-14
KR20070086998A (ko) 2007-08-27
KR20030011377A (ko) 2003-02-07
CN1944417A (zh) 2007-04-11
AU6634501A (en) 2002-01-14
US7396842B2 (en) 2008-07-08
EP1300401A1 (de) 2003-04-09
DE60140748D1 (de) 2010-01-21
PT1300401E (pt) 2010-01-25
US20040072827A1 (en) 2004-04-15
KR100758775B1 (ko) 2007-09-14
US20050222226A1 (en) 2005-10-06
AU2001266345B2 (en) 2006-03-02
CN1620442A (zh) 2005-05-25
EP1669070A2 (de) 2006-06-14
CY1109863T1 (el) 2014-09-10
WO2002002542A1 (fr) 2002-01-10
EP1300401B1 (de) 2009-12-09
CA2413000C (en) 2010-01-19
DK1300401T3 (da) 2010-02-01
CA2413000A1 (en) 2002-01-10
ES2336425T3 (es) 2010-04-13
EP1669070A3 (de) 2007-05-23
CN100369903C (zh) 2008-02-20
US6919361B2 (en) 2005-07-19
EP1300401A4 (de) 2004-07-21
KR100824156B1 (ko) 2008-04-21
TWI313266B (en) 2009-08-11

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