ATE451124T1 - Polysaccharid-peptid-konjugate - Google Patents
Polysaccharid-peptid-konjugateInfo
- Publication number
- ATE451124T1 ATE451124T1 AT98906928T AT98906928T ATE451124T1 AT E451124 T1 ATE451124 T1 AT E451124T1 AT 98906928 T AT98906928 T AT 98906928T AT 98906928 T AT98906928 T AT 98906928T AT E451124 T1 ATE451124 T1 AT E451124T1
- Authority
- AT
- Austria
- Prior art keywords
- polysaccharide
- linker
- spacer
- immunogenic
- conjugate
- Prior art date
Links
- 229920001231 Polysaccharide peptide Polymers 0.000 title abstract 2
- 239000000863 peptide conjugate Substances 0.000 title abstract 2
- 108010022457 polysaccharide peptide Proteins 0.000 title abstract 2
- 150000004676 glycans Chemical class 0.000 abstract 5
- 229920001282 polysaccharide Polymers 0.000 abstract 3
- 239000005017 polysaccharide Substances 0.000 abstract 3
- -1 amino, hydroxyl Chemical group 0.000 abstract 2
- 239000000562 conjugate Substances 0.000 abstract 2
- 230000002163 immunogen Effects 0.000 abstract 2
- 125000005647 linker group Chemical group 0.000 abstract 2
- 150000004804 polysaccharides Polymers 0.000 abstract 2
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 1
- 230000021615 conjugation Effects 0.000 abstract 1
- 125000000151 cysteine group Chemical group N[C@@H](CS)C(=O)* 0.000 abstract 1
- KZNICNPSHKQLFF-UHFFFAOYSA-N dihydromaleimide Natural products O=C1CCC(=O)N1 KZNICNPSHKQLFF-UHFFFAOYSA-N 0.000 abstract 1
- 230000028993 immune response Effects 0.000 abstract 1
- 230000007774 longterm Effects 0.000 abstract 1
- 244000000010 microbial pathogen Species 0.000 abstract 1
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 1
- 230000001681 protective effect Effects 0.000 abstract 1
- 125000006850 spacer group Chemical group 0.000 abstract 1
- 229960002317 succinimide Drugs 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
- A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
- A61K47/646—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent the entire peptide or protein drug conjugate elicits an immune response, e.g. conjugate vaccines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Immunology (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical & Material Sciences (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Epidemiology (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Virology (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP97100884 | 1997-01-21 | ||
| PCT/EP1998/000654 WO1998031393A2 (en) | 1997-01-21 | 1998-01-21 | Polysaccharide-peptide-conjugates |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE451124T1 true ATE451124T1 (de) | 2009-12-15 |
Family
ID=8226387
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT98906928T ATE451124T1 (de) | 1997-01-21 | 1998-01-21 | Polysaccharid-peptid-konjugate |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US6472506B1 (de) |
| EP (1) | EP0959905B1 (de) |
| JP (1) | JP4290766B2 (de) |
| KR (1) | KR100593466B1 (de) |
| AT (1) | ATE451124T1 (de) |
| AU (1) | AU722315B2 (de) |
| CA (1) | CA2246760C (de) |
| DE (1) | DE69841362D1 (de) |
| DK (1) | DK0959905T3 (de) |
| ES (1) | ES2335557T3 (de) |
| NO (1) | NO323870B1 (de) |
| NZ (1) | NZ331578A (de) |
| PT (1) | PT959905E (de) |
| WO (1) | WO1998031393A2 (de) |
Families Citing this family (36)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20040001842A1 (en) * | 1997-05-12 | 2004-01-01 | Dov Michaeli | Immunogenic compositions to the CCK-B/gastrin receptor and methods for the treatment of tumors |
| DE19821859A1 (de) * | 1998-05-15 | 1999-12-09 | M Alexander Schmidt | Darstellung immunogener (Kapsel-)Polysaccharid-Konjugate durch orientierte Kupplung synthetischer T-Zell-Epitope zur Erzeugung von Vakzinen gegen N.meningitidis |
| MXPA00012586A (es) * | 1998-06-16 | 2004-05-21 | Univ Oklahoma | Glicosulfopeptidos y metodos de sintesis y uso de los mismos. |
| US7223845B2 (en) | 1998-06-16 | 2007-05-29 | The Board Of Regents Of The University Of Oklahoma | Synthetic glycosulfopeptides and methods of synthesis thereof |
| US6858211B1 (en) * | 1998-07-20 | 2005-02-22 | The United States Of America As Represented By The Department Of Health And Human Services | Vaccines against Escherichia coli O157 infection |
| US7723296B2 (en) | 2001-01-18 | 2010-05-25 | Genzyme Corporation | Methods for introducing mannose-6-phosphate and other oligosaccharides onto glycoproteins and its application thereof |
| EP2957300B1 (de) | 2001-01-23 | 2021-07-14 | Sanofi Pasteur Inc. | Mehrwertiger meningokokkus-polysaccharid-proteinkonjugat-impfstoff |
| CA2441228A1 (en) | 2001-03-23 | 2002-10-03 | Aphton Corporation | Combination treatment of pancreatic cancer |
| US20090191232A1 (en) | 2001-05-04 | 2009-07-30 | Gevas Philip C | Combination therapy for the treatment of tumors |
| AU2002309706A1 (en) * | 2001-05-11 | 2002-11-25 | Aventis Pasteur, Inc. | Novel meningitis conjugate vaccine |
| GB0115176D0 (en) | 2001-06-20 | 2001-08-15 | Chiron Spa | Capular polysaccharide solubilisation and combination vaccines |
| GB0220198D0 (en) * | 2002-08-30 | 2002-10-09 | Chiron Spa | Modified saccharides,conjugates thereof and their manufacture |
| US6695447B1 (en) | 2002-09-30 | 2004-02-24 | Eastman Kodak Company | Ink jet recording element |
| US20050118199A1 (en) * | 2003-10-07 | 2005-06-02 | Esser Mark T. | Process for covalently conjugating polysaccharides to microspheres or biomolecules |
| JP2008513536A (ja) | 2004-09-22 | 2008-05-01 | レセプター バイオロジックス インコーポレイテッド | プロガストリンに対するモノクローナル抗体 |
| TWI264608B (en) * | 2005-04-08 | 2006-10-21 | Delta Electronics Inc | Light tunnel module |
| AU2006298960B2 (en) * | 2005-10-06 | 2011-05-12 | Nestec S.A. | Probiotic enterococci for improved immunity |
| TW200745163A (en) | 2006-02-17 | 2007-12-16 | Syntonix Pharmaceuticals Inc | Peptides that block the binding of IgG to FcRn |
| FR2899110A1 (fr) * | 2006-03-31 | 2007-10-05 | Sanofi Pasteur Sa | Polysaccharides capsulaires de type 5 et de type 8 des souches surproductrices de staphylococcus aureus |
| CA2675968C (en) | 2007-01-18 | 2019-05-21 | Genzyme Corporation | Oligosaccharides comprising an aminooxy group and conjugates thereof |
| EP2203471A2 (de) * | 2007-08-09 | 2010-07-07 | Syntonix Pharmaceuticals, Inc. | Immunmodulatorische peptide |
| JP2009242372A (ja) * | 2008-03-11 | 2009-10-22 | Yokohama City Univ | 均一な糖鎖構造を有するエリスロポエチン誘導体 |
| US20100048488A1 (en) * | 2008-08-01 | 2010-02-25 | Syntonix Pharmaceuticals, Inc. | Immunomodulatory peptides |
| SI2889043T1 (sl) | 2008-12-16 | 2019-08-30 | Genzyme Corporation | Sintetične vmesne spojine za pripravo konjugatov oligosaharid-protein |
| WO2010130896A2 (fr) | 2009-05-14 | 2010-11-18 | Sanofi Pasteur | Procédé pour adjuver le lipopolysaccharide (lps) des bactéries à gram-négatif |
| CA2761924C (fr) | 2009-05-14 | 2017-10-31 | Sanofi Pasteur | Vaccin meningocoque a base de lipooligosaccharide (los) provenant de souches modifiees de neisseria meningitidis d'immunotype l6 |
| GB201003922D0 (en) | 2010-03-09 | 2010-04-21 | Glaxosmithkline Biolog Sa | Conjugation process |
| US10226536B2 (en) | 2011-11-28 | 2019-03-12 | Case Western Reserve University | Polysaccharide therapeutic conjugates |
| WO2015184453A1 (en) | 2014-05-30 | 2015-12-03 | Case Western Reserve University | Retinylamine derivitives for treatment of ocular disorders |
| US11129845B2 (en) | 2014-06-18 | 2021-09-28 | Case Western Reserve University | Compositions and methods for the delivery of nucleic acids |
| US10925980B2 (en) | 2014-08-04 | 2021-02-23 | Case Western Reserve University | Molecular probes and methods of use |
| US11407786B2 (en) | 2015-06-18 | 2022-08-09 | Case Western Reserve University | Compositions and methods for the delivery of nucleic acids |
| US12060318B2 (en) | 2015-10-09 | 2024-08-13 | Case Western Reserve University | Compositions and methods for the delivery of nucleic acids |
| EP3471778A4 (de) | 2016-06-20 | 2020-02-19 | The Regents of The University of Michigan | Zusammensetzungen und verfahren zur abgabe von biomakromolekülwirkstoffen |
| JP7469225B2 (ja) | 2017-06-15 | 2024-04-16 | キャンサー アドヴァンシーズ インク． | 腫瘍及び癌に対する体液性及び細胞性免疫を誘発するための組成物及び方法 |
| US12150978B2 (en) | 2017-06-15 | 2024-11-26 | Cancer Advances Inc. | Compositions and methods for preventing tumors and cancer |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4695624A (en) * | 1984-05-10 | 1987-09-22 | Merck & Co., Inc. | Covalently-modified polyanionic bacterial polysaccharides, stable covalent conjugates of such polysaccharides and immunogenic proteins with bigeneric spacers, and methods of preparing such polysaccharides and conjugates and of confirming covalency |
| NZ214503A (en) * | 1984-12-20 | 1990-02-26 | Merck & Co Inc | Covalently-modified neutral bacterial polysaccharides, stable covalent conjugates of such polysaccharides and immunogenic proteins, and methods of preparing such polysaccharides and conjugates |
| EP0326111A3 (de) * | 1988-01-29 | 1989-12-27 | New York Blood Center, Inc. | Peptid-Derivate, immunogenisch gemacht bei Verabreichung zusammen mit Alaun als Zusatzmittel |
| CA2047033A1 (en) * | 1990-07-19 | 1992-01-20 | Elizabeth E. Sugg | Cyclic hiv principal neutralizing determinant peptides |
-
1998
- 1998-01-21 AT AT98906928T patent/ATE451124T1/de active
- 1998-01-21 PT PT98906928T patent/PT959905E/pt unknown
- 1998-01-21 US US09/155,077 patent/US6472506B1/en not_active Expired - Fee Related
- 1998-01-21 WO PCT/EP1998/000654 patent/WO1998031393A2/en not_active Ceased
- 1998-01-21 DE DE69841362T patent/DE69841362D1/de not_active Expired - Lifetime
- 1998-01-21 CA CA2246760A patent/CA2246760C/en not_active Expired - Fee Related
- 1998-01-21 NZ NZ331578A patent/NZ331578A/xx not_active IP Right Cessation
- 1998-01-21 DK DK98906928.1T patent/DK0959905T3/da active
- 1998-01-21 JP JP53376898A patent/JP4290766B2/ja not_active Expired - Fee Related
- 1998-01-21 ES ES98906928T patent/ES2335557T3/es not_active Expired - Lifetime
- 1998-01-21 AU AU62957/98A patent/AU722315B2/en not_active Ceased
- 1998-01-21 KR KR1019980707414A patent/KR100593466B1/ko not_active Expired - Fee Related
- 1998-01-21 EP EP98906928A patent/EP0959905B1/de not_active Expired - Lifetime
- 1998-09-18 NO NO19984341A patent/NO323870B1/no not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| AU6295798A (en) | 1998-08-07 |
| NO323870B1 (no) | 2007-07-16 |
| KR20000064696A (ko) | 2000-11-06 |
| CA2246760C (en) | 2012-01-10 |
| NZ331578A (en) | 2000-05-26 |
| ES2335557T3 (es) | 2010-03-29 |
| US6472506B1 (en) | 2002-10-29 |
| JP2000507974A (ja) | 2000-06-27 |
| PT959905E (pt) | 2010-02-05 |
| WO1998031393A3 (en) | 1998-09-11 |
| EP0959905B1 (de) | 2009-12-09 |
| WO1998031393A2 (en) | 1998-07-23 |
| JP4290766B2 (ja) | 2009-07-08 |
| AU722315B2 (en) | 2000-07-27 |
| CA2246760A1 (en) | 1998-07-23 |
| NO984341D0 (no) | 1998-09-18 |
| KR100593466B1 (ko) | 2007-04-25 |
| NO984341L (no) | 1998-11-11 |
| EP0959905A2 (de) | 1999-12-01 |
| DK0959905T3 (da) | 2010-04-06 |
| DE69841362D1 (de) | 2010-01-21 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification |
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