ATE451124T1 - Polysaccharid-peptid-konjugate - Google Patents
Polysaccharid-peptid-konjugateInfo
- Publication number
- ATE451124T1 ATE451124T1 AT98906928T AT98906928T ATE451124T1 AT E451124 T1 ATE451124 T1 AT E451124T1 AT 98906928 T AT98906928 T AT 98906928T AT 98906928 T AT98906928 T AT 98906928T AT E451124 T1 ATE451124 T1 AT E451124T1
- Authority
- AT
- Austria
- Prior art keywords
- polysaccharide
- linker
- spacer
- immunogenic
- conjugate
- Prior art date
Links
- 229920001231 Polysaccharide peptide Polymers 0.000 title abstract 2
- 239000000863 peptide conjugate Substances 0.000 title abstract 2
- 108010022457 polysaccharide peptide Proteins 0.000 title abstract 2
- 150000004676 glycans Chemical class 0.000 abstract 5
- 229920001282 polysaccharide Polymers 0.000 abstract 3
- 239000005017 polysaccharide Substances 0.000 abstract 3
- -1 amino, hydroxyl Chemical group 0.000 abstract 2
- 239000000562 conjugate Substances 0.000 abstract 2
- 230000002163 immunogen Effects 0.000 abstract 2
- 125000005647 linker group Chemical group 0.000 abstract 2
- 150000004804 polysaccharides Polymers 0.000 abstract 2
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 1
- 230000021615 conjugation Effects 0.000 abstract 1
- 125000000151 cysteine group Chemical group N[C@@H](CS)C(=O)* 0.000 abstract 1
- KZNICNPSHKQLFF-UHFFFAOYSA-N dihydromaleimide Natural products O=C1CCC(=O)N1 KZNICNPSHKQLFF-UHFFFAOYSA-N 0.000 abstract 1
- 230000028993 immune response Effects 0.000 abstract 1
- 230000007774 longterm Effects 0.000 abstract 1
- 244000000010 microbial pathogen Species 0.000 abstract 1
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 1
- 230000001681 protective effect Effects 0.000 abstract 1
- 125000006850 spacer group Chemical group 0.000 abstract 1
- 229960002317 succinimide Drugs 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
- A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
- A61K47/646—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent the entire peptide or protein drug conjugate elicits an immune response, e.g. conjugate vaccines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Immunology (AREA)
- Public Health (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Epidemiology (AREA)
- Virology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP97100884 | 1997-01-21 | ||
| PCT/EP1998/000654 WO1998031393A2 (en) | 1997-01-21 | 1998-01-21 | Polysaccharide-peptide-conjugates |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE451124T1 true ATE451124T1 (de) | 2009-12-15 |
Family
ID=8226387
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT98906928T ATE451124T1 (de) | 1997-01-21 | 1998-01-21 | Polysaccharid-peptid-konjugate |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US6472506B1 (de) |
| EP (1) | EP0959905B1 (de) |
| JP (1) | JP4290766B2 (de) |
| KR (1) | KR100593466B1 (de) |
| AT (1) | ATE451124T1 (de) |
| AU (1) | AU722315B2 (de) |
| CA (1) | CA2246760C (de) |
| DE (1) | DE69841362D1 (de) |
| DK (1) | DK0959905T3 (de) |
| ES (1) | ES2335557T3 (de) |
| NO (1) | NO323870B1 (de) |
| NZ (1) | NZ331578A (de) |
| PT (1) | PT959905E (de) |
| WO (1) | WO1998031393A2 (de) |
Families Citing this family (36)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20040001842A1 (en) * | 1997-05-12 | 2004-01-01 | Dov Michaeli | Immunogenic compositions to the CCK-B/gastrin receptor and methods for the treatment of tumors |
| DE19821859A1 (de) * | 1998-05-15 | 1999-12-09 | M Alexander Schmidt | Darstellung immunogener (Kapsel-)Polysaccharid-Konjugate durch orientierte Kupplung synthetischer T-Zell-Epitope zur Erzeugung von Vakzinen gegen N.meningitidis |
| JP2002518354A (ja) * | 1998-06-16 | 2002-06-25 | ザ ボード オブ リージェンツ オブ ザ ユニヴァーシティー オブ オクラホマ | 糖硫酸ペプチド、その合成方法および使用方法 |
| US7223845B2 (en) | 1998-06-16 | 2007-05-29 | The Board Of Regents Of The University Of Oklahoma | Synthetic glycosulfopeptides and methods of synthesis thereof |
| US6858211B1 (en) * | 1998-07-20 | 2005-02-22 | The United States Of America As Represented By The Department Of Health And Human Services | Vaccines against Escherichia coli O157 infection |
| US7723296B2 (en) | 2001-01-18 | 2010-05-25 | Genzyme Corporation | Methods for introducing mannose-6-phosphate and other oligosaccharides onto glycoproteins and its application thereof |
| SI21352A (sl) * | 2001-01-23 | 2004-06-30 | Aventis Pasteur | Multivalentno meningokokno cepivo iz konjugata polisaharida-proteina |
| CA2441228A1 (en) | 2001-03-23 | 2002-10-03 | Aphton Corporation | Combination treatment of pancreatic cancer |
| US20090191232A1 (en) | 2001-05-04 | 2009-07-30 | Gevas Philip C | Combination therapy for the treatment of tumors |
| WO2002091998A2 (en) * | 2001-05-11 | 2002-11-21 | Aventis Pasteur, Inc. | Novel meningitis conjugate vaccine |
| GB0115176D0 (en) | 2001-06-20 | 2001-08-15 | Chiron Spa | Capular polysaccharide solubilisation and combination vaccines |
| GB0220198D0 (en) * | 2002-08-30 | 2002-10-09 | Chiron Spa | Modified saccharides,conjugates thereof and their manufacture |
| US6695447B1 (en) | 2002-09-30 | 2004-02-24 | Eastman Kodak Company | Ink jet recording element |
| US20050118199A1 (en) * | 2003-10-07 | 2005-06-02 | Esser Mark T. | Process for covalently conjugating polysaccharides to microspheres or biomolecules |
| DK1794586T3 (da) | 2004-09-22 | 2013-05-13 | Cancer Advances Inc | Monoklonale antistoffer til progastrin |
| TWI264608B (en) * | 2005-04-08 | 2006-10-21 | Delta Electronics Inc | Light tunnel module |
| BRPI0616866A8 (pt) * | 2005-10-06 | 2018-07-31 | Nestec Sa | Enterococos probióticos para melhorar a imunidade |
| TW200745163A (en) | 2006-02-17 | 2007-12-16 | Syntonix Pharmaceuticals Inc | Peptides that block the binding of IgG to FcRn |
| FR2899110A1 (fr) * | 2006-03-31 | 2007-10-05 | Sanofi Pasteur Sa | Polysaccharides capsulaires de type 5 et de type 8 des souches surproductrices de staphylococcus aureus |
| WO2008089403A2 (en) | 2007-01-18 | 2008-07-24 | Genzyme Corporation | Oligosaccharides comprising an aminooxy group and conjugates thereof |
| TW200911289A (en) * | 2007-08-09 | 2009-03-16 | Syntonix Pharmaceuticals Inc | Immunomodulatory peptides |
| JP2009242372A (ja) * | 2008-03-11 | 2009-10-22 | Yokohama City Univ | 均一な糖鎖構造を有するエリスロポエチン誘導体 |
| WO2010014909A1 (en) * | 2008-08-01 | 2010-02-04 | Syntonix Pharmaceuticals, Inc. | Immunomodulatory peptides |
| CN102369023A (zh) | 2008-12-16 | 2012-03-07 | 建新公司 | 寡糖-蛋白缀合物 |
| CA2761924C (fr) | 2009-05-14 | 2017-10-31 | Sanofi Pasteur | Vaccin meningocoque a base de lipooligosaccharide (los) provenant de souches modifiees de neisseria meningitidis d'immunotype l6 |
| WO2010130896A2 (fr) | 2009-05-14 | 2010-11-18 | Sanofi Pasteur | Procédé pour adjuver le lipopolysaccharide (lps) des bactéries à gram-négatif |
| GB201003922D0 (en) | 2010-03-09 | 2010-04-21 | Glaxosmithkline Biolog Sa | Conjugation process |
| US10226536B2 (en) | 2011-11-28 | 2019-03-12 | Case Western Reserve University | Polysaccharide therapeutic conjugates |
| US10471118B2 (en) | 2014-05-30 | 2019-11-12 | Case Western Reserve University | Retinylamine derivitives for treatment of ocular disorders |
| US11129845B2 (en) | 2014-06-18 | 2021-09-28 | Case Western Reserve University | Compositions and methods for the delivery of nucleic acids |
| US10925980B2 (en) | 2014-08-04 | 2021-02-23 | Case Western Reserve University | Molecular probes and methods of use |
| US11407786B2 (en) | 2015-06-18 | 2022-08-09 | Case Western Reserve University | Compositions and methods for the delivery of nucleic acids |
| US12060318B2 (en) | 2015-10-09 | 2024-08-13 | Case Western Reserve University | Compositions and methods for the delivery of nucleic acids |
| US12257352B2 (en) | 2016-06-20 | 2025-03-25 | The Regents Of The University Of Michigan | Compositions and methods for delivery of biomacromolecule agents |
| US12150978B2 (en) | 2017-06-15 | 2024-11-26 | Cancer Advances Inc. | Compositions and methods for preventing tumors and cancer |
| EP3624841A4 (de) | 2017-06-15 | 2021-01-27 | Cancer Advances, Inc., | Zusammensetzungen und verfahren zur induzierung humoraler und zellulärer immunitäten gegen tumore und krebs |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4695624A (en) * | 1984-05-10 | 1987-09-22 | Merck & Co., Inc. | Covalently-modified polyanionic bacterial polysaccharides, stable covalent conjugates of such polysaccharides and immunogenic proteins with bigeneric spacers, and methods of preparing such polysaccharides and conjugates and of confirming covalency |
| NZ214503A (en) | 1984-12-20 | 1990-02-26 | Merck & Co Inc | Covalently-modified neutral bacterial polysaccharides, stable covalent conjugates of such polysaccharides and immunogenic proteins, and methods of preparing such polysaccharides and conjugates |
| EP0326111A3 (de) | 1988-01-29 | 1989-12-27 | New York Blood Center, Inc. | Peptid-Derivate, immunogenisch gemacht bei Verabreichung zusammen mit Alaun als Zusatzmittel |
| CA2047033A1 (en) * | 1990-07-19 | 1992-01-20 | Elizabeth E. Sugg | Cyclic hiv principal neutralizing determinant peptides |
-
1998
- 1998-01-21 US US09/155,077 patent/US6472506B1/en not_active Expired - Fee Related
- 1998-01-21 CA CA2246760A patent/CA2246760C/en not_active Expired - Fee Related
- 1998-01-21 AT AT98906928T patent/ATE451124T1/de active
- 1998-01-21 PT PT98906928T patent/PT959905E/pt unknown
- 1998-01-21 WO PCT/EP1998/000654 patent/WO1998031393A2/en not_active Ceased
- 1998-01-21 JP JP53376898A patent/JP4290766B2/ja not_active Expired - Fee Related
- 1998-01-21 NZ NZ331578A patent/NZ331578A/xx not_active IP Right Cessation
- 1998-01-21 DK DK98906928.1T patent/DK0959905T3/da active
- 1998-01-21 ES ES98906928T patent/ES2335557T3/es not_active Expired - Lifetime
- 1998-01-21 AU AU62957/98A patent/AU722315B2/en not_active Ceased
- 1998-01-21 DE DE69841362T patent/DE69841362D1/de not_active Expired - Lifetime
- 1998-01-21 EP EP98906928A patent/EP0959905B1/de not_active Expired - Lifetime
- 1998-01-21 KR KR1019980707414A patent/KR100593466B1/ko not_active Expired - Fee Related
- 1998-09-18 NO NO19984341A patent/NO323870B1/no not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| WO1998031393A3 (en) | 1998-09-11 |
| KR100593466B1 (ko) | 2007-04-25 |
| PT959905E (pt) | 2010-02-05 |
| WO1998031393A2 (en) | 1998-07-23 |
| DK0959905T3 (da) | 2010-04-06 |
| ES2335557T3 (es) | 2010-03-29 |
| KR20000064696A (ko) | 2000-11-06 |
| AU6295798A (en) | 1998-08-07 |
| NO984341L (no) | 1998-11-11 |
| EP0959905A2 (de) | 1999-12-01 |
| JP2000507974A (ja) | 2000-06-27 |
| EP0959905B1 (de) | 2009-12-09 |
| US6472506B1 (en) | 2002-10-29 |
| JP4290766B2 (ja) | 2009-07-08 |
| CA2246760A1 (en) | 1998-07-23 |
| DE69841362D1 (de) | 2010-01-21 |
| CA2246760C (en) | 2012-01-10 |
| NO323870B1 (no) | 2007-07-16 |
| NZ331578A (en) | 2000-05-26 |
| NO984341D0 (no) | 1998-09-18 |
| AU722315B2 (en) | 2000-07-27 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| DE69841362D1 (de) | Polysaccharid-peptid-konjugate | |
| IL135148A0 (en) | A polysaccharide conjugate and pharmaceutical compositions containing the same | |
| ATE238064T1 (de) | Verbesserte meningokokken polysaccharid-konjugat vakzine | |
| BR9711045A (pt) | Drogas de atua-Æo prolongada e composi-{es farmac-uticas compreendendo as mesmas | |
| WO2006116475A3 (en) | Immunostimulatory compositions | |
| YU6297A (sh) | Farmaceutski preparati za imunomodulaciju | |
| IS2608B (is) | Bóluefnissamsetning sem samanstendur af mótefnisvaka og peptíði sem hefur ónæmisglæðandi eiginleika. | |
| WO2001051510A3 (en) | G-csf conjugates | |
| CA2283868A1 (en) | Photosensitizer conjugates for pathogen targeting | |
| DK1346731T3 (da) | Konjugater til behandling af inflammatoriske forstyrrelser og tilsvarende vævsskade | |
| BG104484A (bg) | Сайт - специфично получаване на конюгати от полиетилен- гликол - grf | |
| DK0969873T3 (da) | Multiple carbonhydratholdige glycopeptid-antigener, vaccine indeholdende dem og anvendelse deraf | |
| EP0830456A4 (de) | ISOLIERTES FrpB NUKLEINSÄUREMOLEKÜL UND ENTSPRECHENDE IMPFSTOFF | |
| WO1998019697A3 (en) | Novel pharmaceutical compositions | |
| CA2324467A1 (en) | Formulations for protection of peg-interferon alpha conjugates | |
| DE69317435D1 (de) | Entzündungshemmende tolerogene und inmonoinhibitorische eigenschaften von karbohyhydrate bindenden peptiden | |
| DE69921486D1 (de) | Dextran-leptin konjugate, pharmazeutische zusammentsetzungen und verbundene verfahren | |
| DE60116146D1 (de) | Konjugate definierter stöchiometrie | |
| RU93057952A (ru) | Биологический активный макромолекулярный конъюгат, гидразинсодержащие конъюгаты полипептидов и гликополипептидов с полимерами |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification |
Ref document number: 0959905 Country of ref document: EP |