ATE451361T1 - Materialien und methoden zur behandlung von koagulationsstörungen - Google Patents

Materialien und methoden zur behandlung von koagulationsstörungen

Info

Publication number
ATE451361T1
ATE451361T1 AT05733799T AT05733799T ATE451361T1 AT E451361 T1 ATE451361 T1 AT E451361T1 AT 05733799 T AT05733799 T AT 05733799T AT 05733799 T AT05733799 T AT 05733799T AT E451361 T1 ATE451361 T1 AT E451361T1
Authority
AT
Austria
Prior art keywords
sub
compounds
methods
materials
salts
Prior art date
Application number
AT05733799T
Other languages
English (en)
Inventor
Pascal Druzgala
Cyrus Becker
Original Assignee
Aryx Therapeutics
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US10/822,129 external-priority patent/US7145020B2/en
Application filed by Aryx Therapeutics filed Critical Aryx Therapeutics
Application granted granted Critical
Publication of ATE451361T1 publication Critical patent/ATE451361T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/42—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms in positions 2 and 4
    • C07D311/56—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms in positions 2 and 4 without hydrogen atoms in position 3
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/365—Lactones
    • A61K31/366—Lactones having six-membered rings, e.g. delta-lactones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Compounds Of Unknown Constitution (AREA)
  • Saccharide Compounds (AREA)
  • Steroid Compounds (AREA)
  • Pyrane Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyridine Compounds (AREA)
AT05733799T 2004-04-08 2005-04-08 Materialien und methoden zur behandlung von koagulationsstörungen ATE451361T1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US56112104P 2004-04-08 2004-04-08
US10/822,129 US7145020B2 (en) 2001-04-24 2004-04-08 Materials and methods for treating coagulation disorders
PCT/US2005/012091 WO2005100336A1 (en) 2004-04-08 2005-04-08 Materials and methods for treating coagulation disorders

Publications (1)

Publication Number Publication Date
ATE451361T1 true ATE451361T1 (de) 2009-12-15

Family

ID=34965219

Family Applications (1)

Application Number Title Priority Date Filing Date
AT05733799T ATE451361T1 (de) 2004-04-08 2005-04-08 Materialien und methoden zur behandlung von koagulationsstörungen

Country Status (17)

Country Link
US (1) US7285671B2 (de)
EP (1) EP1735296B1 (de)
JP (1) JP5036532B2 (de)
KR (1) KR101203124B1 (de)
AT (1) ATE451361T1 (de)
AU (1) AU2005233614C1 (de)
BR (1) BRPI0508392A (de)
CA (1) CA2559568C (de)
CY (1) CY1109763T1 (de)
DE (1) DE602005018181D1 (de)
DK (1) DK1735296T3 (de)
ES (2) ES2340690T3 (de)
IL (1) IL178122A (de)
NO (1) NO338837B1 (de)
PT (1) PT1735296E (de)
RU (1) RU2495034C2 (de)
WO (1) WO2005100336A1 (de)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK1383756T3 (da) * 2001-04-24 2008-06-23 Aryx Therapeutics Cumarinderivater til anvendelse som antikoagulanter
DK2161261T3 (da) * 2004-04-08 2013-11-04 Armetheon Inc Materialer og fremgangsmåder til behandling af koagulationslidelser
EP2998288B1 (de) * 2005-12-01 2022-08-24 ACADIA Pharmaceuticals Inc. Substituierte phenethylamine mit serotoninergischer und/oder norepinephrinergischer aktivität
CN101188435B (zh) * 2007-01-08 2011-03-16 中兴通讯股份有限公司 一种比特交织装置与方法
KR20100125316A (ko) 2008-03-26 2010-11-30 다이이찌 산쿄 가부시키가이샤 하이드록시퀴녹살린카르복사마이드 유도체
US20110136779A1 (en) * 2009-11-23 2011-06-09 Milner Peter G Methods for stroke reduction in atrial fibrillation patients
US9549912B2 (en) 2009-11-23 2017-01-24 Armetheon, Inc. Methods for treating atrial fibrillation
JP5848712B2 (ja) * 2009-12-11 2016-01-27 ノノ インコーポレイテッド 虚血性疾患および他の疾患を治療するための薬剤および方法
WO2011099978A1 (en) 2010-02-12 2011-08-18 N30 Pharmaceuticals, Llc Chromone inhibitors of s-nitrosoglutathione reductase
SI2533638T1 (sl) 2010-02-12 2016-05-31 Nivalis Therapeutics, Inc. Novi inhibitorji S-nitrozoglutation reduktaze
US10292982B2 (en) 2014-01-15 2019-05-21 Southern Methodist University Inhibitors of multidrug resistance transporter P-glycoprotein
US9561227B2 (en) 2014-01-15 2017-02-07 Southern Methodist University Inhibitors of multidrug resistance transporter P-glycoprotein
US11013739B2 (en) 2014-01-15 2021-05-25 Southern Methodist University Inhibitors of multidrug resistance transporter p-glycoprotein
US11234978B2 (en) 2014-01-15 2022-02-01 Southern Methodist University Inhibitors of multidrug resistance transporter P-glycoprotein
CN114524791B (zh) * 2022-01-26 2024-01-26 江苏慧聚药业股份有限公司 替卡法林的制备方法

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL108459A0 (en) * 1993-02-05 1994-04-12 Opjohn Company 4-Hydroxy-benzopyran-2-ones and 4-hydroxy-cycloalkyl [B] pyran-2-ones useful for treating infections due to hiv and other retroviruses
US5510375A (en) * 1993-11-19 1996-04-23 Warner-Lambert Company Coumarin derivatives as protease inhibitors and antiviral agents
GB9324517D0 (en) * 1993-11-30 1994-01-19 Octel Chem Ltd Process for the preparation of substituted 4-hydroxycoumarins
FR2749585B1 (fr) * 1996-06-11 1998-08-14 Hoechst Marion Roussel Inc Nouveaux derives aromatiques substitues par un ribose, leur procede de preparation et leur application comme medicaments
FR2807032B1 (fr) * 2000-03-29 2003-04-18 Warner Lambert Co Modification de la chimioselectivite lors de l'oxydation de composes organiques azotes
US7145020B2 (en) * 2001-04-24 2006-12-05 Aryx Therapeutics Materials and methods for treating coagulation disorders
DK1383756T3 (da) * 2001-04-24 2008-06-23 Aryx Therapeutics Cumarinderivater til anvendelse som antikoagulanter
WO2003031415A1 (en) * 2001-10-10 2003-04-17 Aryx Therapeutics Mibefradil-based compounds as calcium channel blockers useful in the treatment of hypertension and angina
US7179838B2 (en) * 2002-07-30 2007-02-20 New Century Pharmaceuticals, Inc. Coumarin analog compounds for safer anticoagulant treatment

Also Published As

Publication number Publication date
EP1735296B1 (de) 2009-12-09
US20060287388A1 (en) 2006-12-21
CY1109763T1 (el) 2014-09-10
JP2007532575A (ja) 2007-11-15
JP5036532B2 (ja) 2012-09-26
US7285671B2 (en) 2007-10-23
RU2008120295A (ru) 2009-11-27
ES2436298T3 (es) 2013-12-30
KR20060133081A (ko) 2006-12-22
KR101203124B1 (ko) 2012-11-20
AU2005233614B2 (en) 2011-11-24
PT1735296E (pt) 2010-02-09
AU2005233614A1 (en) 2005-10-27
BRPI0508392A (pt) 2007-08-07
NO20065079L (no) 2006-11-03
WO2005100336A1 (en) 2005-10-27
NO338837B1 (no) 2016-10-24
DK1735296T3 (da) 2010-02-01
IL178122A0 (en) 2006-12-31
HK1105200A1 (en) 2008-02-06
AU2005233614C1 (en) 2012-07-19
CA2559568A1 (en) 2005-10-27
CA2559568C (en) 2013-05-28
HK1138265A1 (en) 2010-08-20
DE602005018181D1 (de) 2010-01-21
ES2340690T3 (es) 2010-06-08
IL178122A (en) 2013-01-31
RU2495034C2 (ru) 2013-10-10
EP1735296A1 (de) 2006-12-27

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