EA200601802A1 - Производные морфолина - Google Patents
Производные морфолинаInfo
- Publication number
- EA200601802A1 EA200601802A1 EA200601802A EA200601802A EA200601802A1 EA 200601802 A1 EA200601802 A1 EA 200601802A1 EA 200601802 A EA200601802 A EA 200601802A EA 200601802 A EA200601802 A EA 200601802A EA 200601802 A1 EA200601802 A1 EA 200601802A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- compounds
- formula
- morpholine
- derivatives
- relates
- Prior art date
Links
- YNAVUWVOSKDBBP-UHFFFAOYSA-N Morpholine Chemical class C1COCCN1 YNAVUWVOSKDBBP-UHFFFAOYSA-N 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 2
- 208000006096 Attention Deficit Disorder with Hyperactivity Diseases 0.000 abstract 1
- 208000036864 Attention deficit/hyperactivity disease Diseases 0.000 abstract 1
- 208000001640 Fibromyalgia Diseases 0.000 abstract 1
- 208000002193 Pain Diseases 0.000 abstract 1
- 208000026723 Urinary tract disease Diseases 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 206010036596 premature ejaculation Diseases 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 208000014001 urinary system disease Diseases 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
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- C07D265/28—1,4-Oxazines; Hydrogenated 1,4-oxazines
- C07D265/30—1,4-Oxazines; Hydrogenated 1,4-oxazines not condensed with other rings
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- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Public Health (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Psychiatry (AREA)
- Addiction (AREA)
- Diabetes (AREA)
- Reproductive Health (AREA)
- Pain & Pain Management (AREA)
- Endocrinology (AREA)
- Cardiology (AREA)
- Urology & Nephrology (AREA)
- Hematology (AREA)
- Heart & Thoracic Surgery (AREA)
- Epidemiology (AREA)
- Gynecology & Obstetrics (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Hospice & Palliative Care (AREA)
- Immunology (AREA)
- Psychology (AREA)
- Pulmonology (AREA)
- Ophthalmology & Optometry (AREA)
- Obesity (AREA)
- Dermatology (AREA)
- Physical Education & Sports Medicine (AREA)
- Anesthesiology (AREA)
Abstract
Настоящее изобретение относится к соединениям формулы (I), где R, R, Rи n имеют значения, определенные в описании, и к их фармацевтически приемлемым солям, которые используются в качестве агентов в лечении состояний включающих расстройства мочевых путей, боль, преждевременную эякуляцию, ADHD и фибромиалгию. Изобретение также относится к фармацевтическим композициям, включающим одно или несколько соединений формулы I.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB0409744.0A GB0409744D0 (en) | 2004-04-30 | 2004-04-30 | Novel compounds |
| PCT/IB2005/001154 WO2005105100A1 (en) | 2004-04-30 | 2005-04-20 | Morpholine compounds |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| EA200601802A1 true EA200601802A1 (ru) | 2007-02-27 |
Family
ID=32482498
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| EA200601802A EA200601802A1 (ru) | 2004-04-30 | 2005-04-20 | Производные морфолина |
Country Status (33)
| Country | Link |
|---|---|
| US (3) | US20050250775A1 (ru) |
| EP (1) | EP1744754A1 (ru) |
| JP (2) | JP4181622B2 (ru) |
| KR (4) | KR20090006889A (ru) |
| CN (1) | CN1950089A (ru) |
| AP (1) | AP2006003767A0 (ru) |
| AR (1) | AR048934A1 (ru) |
| AU (1) | AU2005237301A1 (ru) |
| BR (1) | BRPI0510515A (ru) |
| CA (1) | CA2564990C (ru) |
| CR (1) | CR8717A (ru) |
| DO (1) | DOP2005000064A (ru) |
| EA (1) | EA200601802A1 (ru) |
| EC (1) | ECSP066958A (ru) |
| GB (1) | GB0409744D0 (ru) |
| GE (1) | GEP20084549B (ru) |
| GT (1) | GT200500098A (ru) |
| IL (1) | IL178313A0 (ru) |
| MA (1) | MA28554B1 (ru) |
| MX (1) | MXPA06012640A (ru) |
| NI (1) | NI200600257A (ru) |
| NL (1) | NL1028927C2 (ru) |
| NO (1) | NO20064282L (ru) |
| NZ (1) | NZ550054A (ru) |
| PA (1) | PA8631601A1 (ru) |
| PE (1) | PE20060305A1 (ru) |
| SV (1) | SV2005002099A (ru) |
| TN (1) | TNSN06347A1 (ru) |
| TW (2) | TWI309165B (ru) |
| UA (1) | UA86970C2 (ru) |
| UY (1) | UY28873A1 (ru) |
| WO (1) | WO2005105100A1 (ru) |
| ZA (1) | ZA200608661B (ru) |
Families Citing this family (29)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7704527B2 (en) * | 2002-10-25 | 2010-04-27 | Collegium Pharmaceutical, Inc. | Modified release compositions of milnacipran |
| JP4185154B2 (ja) * | 2004-04-30 | 2008-11-26 | ワーナー−ランバート カンパニー リミテッド ライアビリティー カンパニー | 中枢神経系障害治療用の置換モルホリン化合物 |
| GB0409744D0 (en) * | 2004-04-30 | 2004-06-09 | Pfizer Ltd | Novel compounds |
| JP2009516705A (ja) * | 2005-11-18 | 2009-04-23 | アストラゼネカ・アクチエボラーグ | 塩の形態 |
| WO2007062339A2 (en) * | 2005-11-18 | 2007-05-31 | Astrazeneca Ab | Liquid formulations |
| US8389510B2 (en) * | 2005-11-18 | 2013-03-05 | Astrazeneca Ab | Crystalline forms |
| WO2007062337A2 (en) * | 2005-11-18 | 2007-05-31 | Astrazeneca Ab | Crystalline forms |
| WO2007062338A2 (en) * | 2005-11-18 | 2007-05-31 | Astrazeneca Ab | Solid formulations |
| AU2007209903B2 (en) * | 2006-02-01 | 2012-09-13 | Merck Sharp & Dohme Corp. | Potassium channel inhibitors |
| EP1892530A1 (en) * | 2006-08-25 | 2008-02-27 | Boehringer Ingelheim Pharma GmbH & Co. KG | Method for determining transport activity of a transport protein |
| KR101103118B1 (ko) * | 2007-11-02 | 2012-01-04 | 동아제약주식회사 | 신규한 1,3-디히드로-5-이소벤조퓨란카르보니트릴 유도체 화합물 및 이를 함유하는 조루증 치료용 약학조성물 |
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