ATE451365T1 - Als atm-inhibitoren geeignete pyranone - Google Patents

Als atm-inhibitoren geeignete pyranone

Info

Publication number: ATE451365T1
Authority: AT; Austria
Prior art keywords: pyranones; atm inhibitors; sulfonamino; acylamido; prodrugs
Prior art date: 2002-02-25

Application number

AT03742608T

Other languages

English (en)

Inventor

Graeme Smith

Niall Martin

Stephen Jackson

Mark O'connor

Alan Lau

Xiao-Ling Fan Cockcroft

Ian Matthews

Keith Menear

Laurent Rigoreau

Marc Hummersone

Roger Griffin

Original Assignee

Kudos Pharm Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2002-02-25

Filing date

2003-02-24

Publication date

2009-12-15

2002-02-25 Priority claimed from GBGB0204350.3A external-priority patent/GB0204350D0/en

2003-02-24 Application filed by Kudos Pharm Ltd filed Critical Kudos Pharm Ltd

2009-12-15 Application granted granted Critical

2009-12-15 Publication of ATE451365T1 publication Critical patent/ATE451365T1/de

Links

239000012827 ATM inhibitor Substances 0.000 title 1
RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 abstract 2
125000002252 acyl group Chemical group 0.000 abstract 1
125000003368 amide group Chemical group 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
150000002148 esters Chemical class 0.000 abstract 1
125000000623 heterocyclic group Chemical group 0.000 abstract 1
229910052757 nitrogen Inorganic materials 0.000 abstract 1
125000004433 nitrogen atom Chemical group N* 0.000 abstract 1
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
229940002612 prodrug Drugs 0.000 abstract 1
239000000651 prodrug Substances 0.000 abstract 1
125000006413 ring segment Chemical group 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
239000012453 solvate Substances 0.000 abstract 1
125000001424 substituent group Chemical group 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Veterinary Medicine (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Virology (AREA)
Oncology (AREA)
Communicable Diseases (AREA)
Molecular Biology (AREA)
Immunology (AREA)
Neurology (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
AIDS & HIV (AREA)
Tropical Medicine & Parasitology (AREA)
Biomedical Technology (AREA)
Vascular Medicine (AREA)
Neurosurgery (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Pyrane Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Polysaccharides And Polysaccharide Derivatives (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

AT03742608T 2002-02-25 2003-02-24 Als atm-inhibitoren geeignete pyranone ATE451365T1 (de)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
GBGB0204350.3A GB0204350D0 (en)	2002-02-25	2002-02-25	ATM inhibitors
US39588402P	2002-07-15	2002-07-15
PCT/GB2003/000770 WO2003070726A1 (en)	2002-02-25	2003-02-24	Pyranones useful as atm inhibitors

Publications (1)

Publication Number	Publication Date
ATE451365T1 true ATE451365T1 (de)	2009-12-15

Family

ID=27758841

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT03742608T ATE451365T1 (de)	2002-02-25	2003-02-24	Als atm-inhibitoren geeignete pyranone

Country Status (19)

Country	Link
EP (2)	EP1485377B9 (de)
JP (1)	JP2005521689A (de)
CN (1)	CN100358891C (de)
AT (1)	ATE451365T1 (de)
AU (1)	AU2003209990B8 (de)
BR (1)	BR0307944A (de)
CA (1)	CA2473100A1 (de)
CY (1)	CY1109835T1 (de)
DE (1)	DE60330442D1 (de)
DK (1)	DK1485377T5 (de)
ES (1)	ES2336206T3 (de)
GB (1)	GB2401606B (de)
MX (1)	MXPA04007809A (de)
NO (1)	NO329806B1 (de)
NZ (1)	NZ534821A (de)
PL (1)	PL370074A1 (de)
PT (1)	PT1485377E (de)
SI (1)	SI1485377T1 (de)
WO (1)	WO2003070726A1 (de)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US7151102B2 (en)	2000-10-30	2006-12-19	Kudos Pharmaceuticals Limited	Phthalazinone derivatives
GB0119865D0 (en)	2001-08-14	2001-10-10	Cancer Res Campaign Tech	DNA-PK inhibitors
GB0119863D0 (en)	2001-08-14	2001-10-10	Cancer Res Campaign Tech	DNA-PK inhibitors
US7196085B2 (en)	2002-04-30	2007-03-27	Kudos Pharmaceuticals Limited	Phthalazinone derivatives
US7413738B2 (en)	2002-08-13	2008-08-19	Enzon Pharmaceuticals, Inc.	Releasable polymeric conjugates based on biodegradable linkers
US7122189B2 (en)	2002-08-13	2006-10-17	Enzon, Inc.	Releasable polymeric conjugates based on aliphatic biodegradable linkers
US7449464B2 (en)	2003-03-12	2008-11-11	Kudos Pharmaceuticals Limited	Phthalazinone derivatives
GB0305681D0 (en)	2003-03-12	2003-04-16	Kudos Pharm Ltd	Phthalazinone derivatives
US20070099186A1 (en) *	2003-05-01	2007-05-03	D Adda Di Fagagna Fabrizio	Methods and means for the treatment of disorders associated with cellular senescence
BRPI0413467A (pt) *	2003-08-13	2006-10-17	Kudos Pharm Ltd	aminopironas e seu uso como inibidoras da atm
TWI338000B (en)	2003-12-01	2011-03-01	Kudos Pharm Ltd	Dna damage repair inhibitors for treatment of cancer
WO2005118543A1 (ja) *	2004-06-03	2005-12-15	Ono Pharmaceutical Co., Ltd.	キナーゼ阻害薬およびその用途
GB0419072D0 (en)	2004-08-26	2004-09-29	Kudos Pharm Ltd	Phthalazinone derivatives
US7402607B2 (en)	2004-09-20	2008-07-22	Kudos Pharmaceuticals Limited	DNA-PK inhibitors
JP2008529995A (ja) *	2005-02-09	2008-08-07	クドスファーマシューティカルズリミテッド	Ａｔｍ阻害剤
AR053358A1 (es)	2005-04-15	2007-05-02	Cancer Rec Tech Ltd	Inhibidores de adn - pk
UY29774A1 (es) *	2005-08-31	2007-03-30	Kudos Pharm Ltd	Inhibidor de atm
GB0521373D0 (en)	2005-10-20	2005-11-30	Kudos Pharm Ltd	Pthalazinone derivatives
AU2008299721A1 (en)	2007-09-14	2009-03-19	Astrazeneca Ab	Phthalazinone derivatives
BR122021018683B1 (pt)	2008-10-07	2022-11-16	Kudos Pharmaceuticals Limited	Formulação farmacêutica de 4-[3-(4-ciclopropanocarbonil- piperazina-1-carbonil)-4-flúor- benzil]-2h-ftalazin-1-ona, uso de um polímero de matriz, forma de dosagem e método para produzir uma dispersão amorfa sólida
EP2486923B1 (de) *	2011-02-11	2015-09-09	Dr. Felix Jäger und Dr. Stefan Drinkuth Laborgemeinschaft OHG	Histon-Deacetylase (HDAC) hemmende Verbindungen und Verfahren zu deren Herstellung
CN103765212A (zh)	2011-06-27	2014-04-30	杰克逊实验室	治疗癌症和自体免疫性疾病的方法和组合物
JP6074043B2 (ja) *	2013-08-29	2017-02-01	富士フイルム株式会社	新規なモルホリン誘導体またはその塩
EP4171651A1 (de)	2020-06-24	2023-05-03	AstraZeneca UK Limited	Kombination aus antikörper-wirkstoff-konjugat und atm-inhibitor
CN112094210A (zh) *	2020-09-24	2020-12-18	江苏扬农化工股份有限公司	一种取代的亚磺酸盐的制备方法
JPWO2024214685A1 (de)	2023-04-10	2024-10-17

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4282155A (en) *	1980-02-04	1981-08-04	Merck & Co., Inc.	Antihypercholesterolemic compounds
DE68914495T2 (de) *	1988-03-02	1994-10-27	Merck & Co Inc	Antihypercholesterolemisches Mittel.
ATE128128T1 (de) *	1990-06-29	1995-10-15	Upjohn Co	Antiatherosclerotische und antithrombotische 2- amino-6-phenyl-4h-pyran-4-one.
IL129871A (en) *	1994-05-06	2003-11-23	Pharmacia & Upjohn Inc	Process for preparing 4-phenyl-substituted octanoyl-oxazolidin-2-one intermediates that are useful for preparing pyran-2-ones useful for treating retroviral infections
JP3851661B2 (ja) *	1996-05-14	2006-11-29	第一製薬株式会社	新規生理活性物質及びその製造方法
FR2765579A1 (fr) *	1997-07-01	1999-01-08	Lipha	Nouveaux derives de 4-hydroxy-2h-1-(thio)pyran-2-ones leurs preparations et leurs utilisations comme rodonticides
CN1205198C (zh) *	1997-09-26	2005-06-08	东丽株式会社	环酮衍生物及其医药用途
AU756965B2 (en) *	1998-03-12	2003-01-30	Microbial Chemistry Research Foundation	Benzofurylpyrone derivatives

2003
- 2003-02-24 AT AT03742608T patent/ATE451365T1/de not_active IP Right Cessation
- 2003-02-24 CN CNB038045478A patent/CN100358891C/zh not_active Expired - Fee Related
- 2003-02-24 CA CA002473100A patent/CA2473100A1/en not_active Abandoned
- 2003-02-24 AU AU2003209990A patent/AU2003209990B8/en not_active Ceased
- 2003-02-24 ES ES03742608T patent/ES2336206T3/es not_active Expired - Lifetime
- 2003-02-24 BR BR0307944-9A patent/BR0307944A/pt not_active IP Right Cessation
- 2003-02-24 PT PT03742608T patent/PT1485377E/pt unknown
- 2003-02-24 DE DE60330442T patent/DE60330442D1/de not_active Expired - Lifetime
- 2003-02-24 DK DK03742608.7T patent/DK1485377T5/da active
- 2003-02-24 SI SI200331759T patent/SI1485377T1/sl unknown
- 2003-02-24 EP EP03742608A patent/EP1485377B9/de not_active Expired - Lifetime
- 2003-02-24 NZ NZ534821A patent/NZ534821A/en not_active IP Right Cessation
- 2003-02-24 PL PL03370074A patent/PL370074A1/xx not_active Application Discontinuation
- 2003-02-24 EP EP09014921A patent/EP2174939A1/de not_active Withdrawn
- 2003-02-24 JP JP2003569633A patent/JP2005521689A/ja active Pending
- 2003-02-24 MX MXPA04007809A patent/MXPA04007809A/es active IP Right Grant
- 2003-02-24 WO PCT/GB2003/000770 patent/WO2003070726A1/en not_active Ceased
- 2003-02-24 GB GB0419534A patent/GB2401606B/en not_active Expired - Fee Related
2004
- 2004-09-24 NO NO20044063A patent/NO329806B1/no not_active IP Right Cessation
2010
- 2010-02-18 CY CY20101100162T patent/CY1109835T1/el unknown

Also Published As

Publication number	Publication date
CN100358891C (zh)	2008-01-02
AU2003209990A1 (en)	2003-09-09
NZ534821A (en)	2006-07-28
EP1485377B1 (de)	2009-12-09
BR0307944A (pt)	2005-02-01
DK1485377T5 (da)	2010-12-06
MXPA04007809A (es)	2004-10-15
EP1485377A1 (de)	2004-12-15
ES2336206T3 (es)	2010-04-09
NO20044063L (no)	2004-09-24
ES2336206T9 (es)	2011-03-24
JP2005521689A (ja)	2005-07-21
EP1485377B9 (de)	2010-10-06
WO2003070726A1 (en)	2003-08-28
EP1485377B8 (de)	2010-02-24
EP2174939A1 (de)	2010-04-14
CN1639154A (zh)	2005-07-13
NO329806B1 (no)	2010-12-20
PT1485377E (pt)	2010-03-12
AU2003209990B8 (en)	2008-10-30
HK1069827A1 (zh)	2005-06-03
GB0419534D0 (en)	2004-10-06
AU2003209990B2 (en)	2008-10-09
DK1485377T3 (da)	2010-04-19
SI1485377T1 (sl)	2010-04-30
CY1109835T1 (el)	2014-09-10
DE60330442D1 (de)	2010-01-21
GB2401606B (en)	2005-08-31
PL370074A1 (en)	2005-05-16
CA2473100A1 (en)	2003-08-28
GB2401606A (en)	2004-11-17

Legal Events

Date

Code

Title

Description

2010-06-15

UEP

Publication of translation of european patent specification

Ref document number: 1485377

Country of ref document: EP

2011-11-15

REN

Ceased due to non-payment of the annual fee

Publication	Publication Date	Title
DE60330442D1 (de)	2010-01-21	Als atm-inhibitoren geeignete pyranone
ATE461193T1 (de)	2010-04-15	Aminopyrone und ihre verwendung als atm inhibitoren
BR0316241A (pt)	2005-10-04	Pirrolobenzodiazepinas
MEP61208A (bs)	2011-05-10	Nova jedinjenja koja imaju inhibitorno dejstvo na transporter glukoze zavistan od natrijuma
UY26727A1 (es)	2001-12-28	Derivados de tropano útiles en terapia
DK156588A (da)	1988-09-27	Acetylener disubstitueret med en phenylgruppe og en heterobicyklisk gruppe, og som har retinoidagtig virkning
WO2005037785A3 (fr)	2005-07-14	Derives de n-[phenyl(pyrrolidin-2-yl)methyl]benzamide, et n-[azepan-2-yl) phenylmethyl]benzamide, leur preparation et leur application en therapeutique
DK1044967T3 (da)	2004-11-22	2-pyridinylguanidinurokinaseinhibitor
TW200638938A (en)	2006-11-16	ATM inhibitors
EA200000400A1 (ru)	2000-10-30	Галогензамещенные тетрациклические производные тетрагидрофурана
CO5580821A2 (es)	2005-11-30	4-cetolactamas y -lactonas 3-fenil-3-substituidas, espirociclicas
AR056049A1 (es)	2007-09-12	2-(2,6-dimetil-morfolin-4-il-n-[5-(6-morfolin-4-il-4-oxo-4h-piran-2-il)-9h-tioxanten-2-il]-acetamida,como inhibidor de la quinasa atm
ATE374750T1 (de)	2007-10-15	Serotoninwiederaufnahme-inhibitoren
ATE550332T1 (de)	2012-04-15	4-imidazolin-2-onverbindungen als p38-map- kinaseinhibitors
EA200500984A1 (ru)	2005-12-29	Производные 3-замещённого-4-пиримидона
FI930264A0 (fi)	1993-01-22	4-aryl-3-(heteroarylureido)-1,2-dihydro-2-oxokinolinderivat saosom antihyperkolesterolemiska och antiaterosklerotiska medel
FI912888A0 (fi)	1991-06-14	2-(aminoalkyl)-5-(arylalkyl)-1,3 -dioxanderivat, deras framstaellning och terapeutiska tillaempning.
GB0116312D0 (en)	2001-08-29	"Compositions containing N-acyl homoserine lactones"
ATE500243T1 (de)	2011-03-15	Carbonsäureamidverbindung und deren verwendung
ECSP014089A (es)	2003-01-13	Derivados de tropano utiles en terapia
IL178548A (en)	2010-12-30	Derivatives of 14,15-dihydro 20,21-dinoreburnamenin-14-ol and applications thereof
ATE275542T1 (de)	2004-09-15	Arthropodische carboxanilide