ATE461193T1 - Aminopyrone und ihre verwendung als atm inhibitoren - Google Patents
Aminopyrone und ihre verwendung als atm inhibitorenInfo
- Publication number
- ATE461193T1 ATE461193T1 AT04768070T AT04768070T ATE461193T1 AT E461193 T1 ATE461193 T1 AT E461193T1 AT 04768070 T AT04768070 T AT 04768070T AT 04768070 T AT04768070 T AT 04768070T AT E461193 T1 ATE461193 T1 AT E461193T1
- Authority
- AT
- Austria
- Prior art keywords
- group
- optionally substituted
- aminopyrones
- atm inhibitors
- prodrugs
- Prior art date
Links
- 239000012827 ATM inhibitor Substances 0.000 title 1
- 125000000623 heterocyclic group Chemical group 0.000 abstract 2
- 125000006701 (C1-C7) alkyl group Chemical group 0.000 abstract 1
- 125000002252 acyl group Chemical group 0.000 abstract 1
- 125000003368 amide group Chemical group 0.000 abstract 1
- 125000003118 aryl group Chemical group 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 125000004185 ester group Chemical group 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 125000004435 hydrogen atom Chemical class [H]* 0.000 abstract 1
- 229910052757 nitrogen Inorganic materials 0.000 abstract 1
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 1
- 229940002612 prodrug Drugs 0.000 abstract 1
- 239000000651 prodrug Substances 0.000 abstract 1
- 125000006413 ring segment Chemical group 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 239000012453 solvate Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Virology (AREA)
- Oncology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Neurology (AREA)
- Communicable Diseases (AREA)
- Pain & Pain Management (AREA)
- Molecular Biology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Hematology (AREA)
- AIDS & HIV (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Pyrrole Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US49477603P | 2003-08-13 | 2003-08-13 | |
| PCT/GB2004/003507 WO2005016919A1 (en) | 2003-08-13 | 2004-08-13 | Aminopyrones and their use as atm inhibitors |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE461193T1 true ATE461193T1 (de) | 2010-04-15 |
Family
ID=34193236
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT04768070T ATE461193T1 (de) | 2003-08-13 | 2004-08-13 | Aminopyrone und ihre verwendung als atm inhibitoren |
Country Status (18)
| Country | Link |
|---|---|
| US (2) | US7429660B2 (de) |
| EP (1) | EP1654257B1 (de) |
| JP (1) | JP2007501836A (de) |
| KR (1) | KR20060066722A (de) |
| CN (1) | CN1867566B (de) |
| AT (1) | ATE461193T1 (de) |
| AU (1) | AU2004265149A1 (de) |
| BR (1) | BRPI0413467A (de) |
| CA (1) | CA2534300A1 (de) |
| DE (1) | DE602004026071D1 (de) |
| ES (1) | ES2341342T3 (de) |
| GB (1) | GB2420781B (de) |
| MX (1) | MXPA06001599A (de) |
| NO (1) | NO20061126L (de) |
| NZ (1) | NZ545919A (de) |
| TW (1) | TW200524924A (de) |
| WO (1) | WO2005016919A1 (de) |
| ZA (1) | ZA200601595B (de) |
Families Citing this family (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0119865D0 (en) * | 2001-08-14 | 2001-10-10 | Cancer Res Campaign Tech | DNA-PK inhibitors |
| BRPI0413467A (pt) * | 2003-08-13 | 2006-10-17 | Kudos Pharm Ltd | aminopironas e seu uso como inibidoras da atm |
| US7402607B2 (en) | 2004-09-20 | 2008-07-22 | Kudos Pharmaceuticals Limited | DNA-PK inhibitors |
| JP2008529995A (ja) * | 2005-02-09 | 2008-08-07 | クドス ファーマシューティカルズ リミテッド | Ａｔｍ阻害剤 |
| AR053358A1 (es) * | 2005-04-15 | 2007-05-02 | Cancer Rec Tech Ltd | Inhibidores de adn - pk |
| UY29774A1 (es) * | 2005-08-31 | 2007-03-30 | Kudos Pharm Ltd | Inhibidor de atm |
| WO2007075655A2 (en) | 2005-12-19 | 2007-07-05 | Northwestern University | Compositions and methods for altering rnai |
| US20080279866A1 (en) * | 2006-08-25 | 2008-11-13 | The Brigham And Women's Hospital, Inc. | Induction of immunosuppression by inhibition of ATM |
| JP2010514839A (ja) | 2007-01-03 | 2010-05-06 | バーナム インスティテュート フォー メディカル リサーチ | クロット結合化合物に関連する方法および組成物 |
| WO2008080398A1 (en) * | 2007-01-05 | 2008-07-10 | Bkg Pharma Aps | Anti - infective agents such as phenothiazine and thioxanthene derivates to treat infectious diseases |
| UY31232A1 (es) * | 2007-07-19 | 2009-03-02 | Compuestos derivados de dibenzotifenilamino-cromen-4-onas activas sustituidas y sus isomeros y aplicaciones | |
| WO2011075725A1 (en) | 2009-12-18 | 2011-06-23 | Sanford-Burnham Medical Research Institute | Methods and compositions related to clot-binding compounds |
| CN103765212A (zh) | 2011-06-27 | 2014-04-30 | 杰克逊实验室 | 治疗癌症和自体免疫性疾病的方法和组合物 |
| US9187439B2 (en) | 2011-09-21 | 2015-11-17 | Inception Orion, Inc. | Tricyclic compounds useful as neurogenic and neuroprotective agents |
| JP6074043B2 (ja) * | 2013-08-29 | 2017-02-01 | 富士フイルム株式会社 | 新規なモルホリン誘導体またはその塩 |
| KR20160049435A (ko) | 2014-10-27 | 2016-05-09 | 삼성전자주식회사 | Atm 저해제를 포함하는 세포의 노화를 감소시키기 위한 조성물 및 그의 용도 |
| WO2018153365A1 (zh) * | 2017-02-27 | 2018-08-30 | 上海瑛派药业有限公司 | 取代的稠合杂芳三环化合物作为激酶抑制剂及其应用 |
| CN109045042A (zh) * | 2018-09-21 | 2018-12-21 | 上海交通大学医学院附属上海儿童医学中心 | Atm抑制剂在制备抑制急性淋巴细胞性白血病复发的药物中的应用 |
| US20200355997A1 (en) * | 2019-05-08 | 2020-11-12 | Facebook Technologies, Llc | Thianthrene derivatized monomers and polymers for volume bragg gratings |
| US11718580B2 (en) | 2019-05-08 | 2023-08-08 | Meta Platforms Technologies, Llc | Fluorene derivatized monomers and polymers for volume Bragg gratings |
| US11780819B2 (en) | 2019-11-27 | 2023-10-10 | Meta Platforms Technologies, Llc | Aromatic substituted alkane-core monomers and polymers thereof for volume Bragg gratings |
| EP4171651A1 (de) | 2020-06-24 | 2023-05-03 | AstraZeneca UK Limited | Kombination aus antikörper-wirkstoff-konjugat und atm-inhibitor |
| US11879024B1 (en) | 2020-07-14 | 2024-01-23 | Meta Platforms Technologies, Llc | Soft mold formulations for surface relief grating fabrication with imprinting lithography |
| JPWO2024214685A1 (de) | 2023-04-10 | 2024-10-17 |
Family Cites Families (45)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1303724A (de) | 1969-05-14 | 1973-01-17 | ||
| JPH0753725B2 (ja) | 1987-10-08 | 1995-06-07 | 富山化学工業株式会社 | ４ｈ―１―ベンゾピラン―４―オン誘導体およびその塩、それらの製造法並びにそれらを含有する抗炎症剤 |
| US5284856A (en) | 1988-10-28 | 1994-02-08 | Hoechst Aktiengesellschaft | Oncogene-encoded kinases inhibition using 4-H-1-benzopyran-4-one derivatives |
| HUT58310A (en) | 1988-12-21 | 1992-02-28 | Upjohn Co | Anti-atherosclerotic and anti-thrombotic 1-benzopyran-4-one- and 2-amino-1,3-benzoxazin-4-one derivatives, process for producing them and pharmaceutical compositions containing them |
| US5703075A (en) | 1988-12-21 | 1997-12-30 | Pharmacia & Upjohn Company | Antiatherosclerotic and antithrombotic 1-benzopyran-4-ones and 2-amino-1,3-benzoxazine-4-ones |
| JPH03215423A (ja) | 1990-01-18 | 1991-09-20 | Kyowa Hakko Kogyo Co Ltd | 血管拡張剤 |
| EP0525123B1 (de) | 1990-06-20 | 1997-09-17 | PHARMACIA & UPJOHN COMPANY | Antiatherosklerotische und antithrombotische 1-benzopyran-4-on- und 2-amino-1,3-benzoxazin-4-on-derivate |
| ATE128128T1 (de) * | 1990-06-29 | 1995-10-15 | Upjohn Co | Antiatherosclerotische und antithrombotische 2- amino-6-phenyl-4h-pyran-4-one. |
| US5252735A (en) | 1990-06-29 | 1993-10-12 | The Upjohn Company | Antiatherosclerotic and antithrombotic 2-amino-6-phenyl-4H-pyran-4-ones |
| US5302613A (en) | 1990-06-29 | 1994-04-12 | The Upjohn Company | Antiatheroscleroic and antithrombotic 2-amino-6-phenyl-4H-pyran-4-ones |
| DE69327153T2 (de) | 1992-09-02 | 2000-05-25 | Kyowa Hakko Kogyo Co., Ltd. | Anti-hiv-medikament |
| EP0695547B1 (de) | 1993-04-09 | 2001-08-08 | Toyama Chemical Co., Ltd. | Immunomodulator, zelladhäsionsinhibitor und mittel zur behandlung und vorbeugung von autoimmunerkrankungen |
| US5378725A (en) | 1993-07-19 | 1995-01-03 | The Arizona Board Of Regents | Inhibition of phosphatidylinositol 3-kinase with wortmannin and analogs thereof |
| US5441947A (en) | 1993-08-25 | 1995-08-15 | Eli Lilly And Company | Methods of inhibiting vascular restenosis |
| US5468773A (en) | 1993-08-25 | 1995-11-21 | Eli Lilly And Company | Methods for inhibiting bone loss and cartilage degradation using wortmannin and its analogs |
| US5504103A (en) | 1993-08-25 | 1996-04-02 | Eli Lilly And Company | Inhibition of phosphatidylinositol 3-kinase with 17 β-hydroxywortmannin and analogs thereof |
| CA2133815A1 (en) | 1993-10-12 | 1995-04-13 | Jeffrey Alan Dodge | Inhibition of phosphatidylinositol 3-kinase with viridin, demethoxyviridin, viridiol, demethoxyviridiol, virone, wortmannolone, and analogs thereof |
| US6632789B1 (en) | 1994-04-29 | 2003-10-14 | The United States Of America As Represented By The Secretary Of The Navy | Methods for modulating T cell responses by manipulating intracellular signal transduction |
| US5480906A (en) | 1994-07-01 | 1996-01-02 | Eli Lilly And Company | Stereochemical Wortmannin derivatives |
| GB9521987D0 (en) | 1995-10-26 | 1996-01-03 | Ludwig Inst Cancer Res | Phosphoinositide 3-kinase modulators |
| US5733920A (en) | 1995-10-31 | 1998-03-31 | Mitotix, Inc. | Inhibitors of cyclin dependent kinases |
| PL322876A1 (en) | 1995-11-16 | 1998-03-02 | Icos Corp | Pik type kinase of cellular cycle control point: materials and methods |
| GB2302021A (en) | 1996-10-16 | 1997-01-08 | Lilly Co Eli | Inhibiting bone loss or resorption |
| CA2292540A1 (en) | 1997-06-06 | 1998-12-10 | Jann N. Sarkaria | Screening for phosphatidylinositol related-kinase inhibitors |
| AU8068198A (en) | 1997-06-13 | 1998-12-30 | President And Fellows Of Harvard College | Methods for treating human cancers |
| FR2776291B1 (fr) | 1998-03-18 | 2000-06-16 | Pf Medicament | Nouveaux derives bis-benzamides, leur procede de fabrication, les compositions pharmaceutiques les contenant et leur utilisation comme medicament |
| US6387640B1 (en) | 1999-02-10 | 2002-05-14 | St. Jude Children's Research Hospital | ATM kinase modulation for screening and therapies |
| US6348311B1 (en) | 1999-02-10 | 2002-02-19 | St. Jude Childre's Research Hospital | ATM kinase modulation for screening and therapies |
| US6333180B1 (en) * | 1999-12-21 | 2001-12-25 | International Flavors & Fragrances Inc. | Bioprocess for the high-yield production of food flavor-acceptable jasmonic acid and methyl jasmonate |
| EP1857443B1 (de) | 2000-01-24 | 2012-03-28 | AstraZeneca AB | Therapeutische Morpholino-substituierte Verbindungen |
| IL153688A0 (en) * | 2000-06-28 | 2003-07-06 | Teva Pharma | Carvedilol |
| EP1351946A2 (de) | 2000-09-01 | 2003-10-15 | Icos Corporation | Materialien und methoden für krebs-therapie |
| EP1353693B1 (de) | 2001-01-16 | 2005-03-16 | Glaxo Group Limited | Pharmazeutische mischung gegen krebs, die ein 4-chinazolinamin in kombination mit paclitaxel, carboplatin or vinorelbine enthält |
| GB0119865D0 (en) | 2001-08-14 | 2001-10-10 | Cancer Res Campaign Tech | DNA-PK inhibitors |
| GB0119863D0 (en) * | 2001-08-14 | 2001-10-10 | Cancer Res Campaign Tech | DNA-PK inhibitors |
| WO2003034997A2 (en) | 2001-10-24 | 2003-05-01 | Iconix Pharmaceuticals, Inc. | Modulators of phosphoinositide 3-kinase |
| AU2002349912A1 (en) | 2001-10-24 | 2003-05-06 | Iconix Pharmaceuticals, Inc. | Modulators of phosphoinositide 3-kinase |
| ATE451365T1 (de) * | 2002-02-25 | 2009-12-15 | Kudos Pharm Ltd | Als atm-inhibitoren geeignete pyranone |
| US7049313B2 (en) | 2002-02-25 | 2006-05-23 | Kudos Pharmaceuticals Ltd. | ATM inhibitors |
| US7196085B2 (en) | 2002-04-30 | 2007-03-27 | Kudos Pharmaceuticals Limited | Phthalazinone derivatives |
| BRPI0413467A (pt) * | 2003-08-13 | 2006-10-17 | Kudos Pharm Ltd | aminopironas e seu uso como inibidoras da atm |
| US7402607B2 (en) * | 2004-09-20 | 2008-07-22 | Kudos Pharmaceuticals Limited | DNA-PK inhibitors |
| JP2008529995A (ja) | 2005-02-09 | 2008-08-07 | クドス ファーマシューティカルズ リミテッド | Ａｔｍ阻害剤 |
| AR053358A1 (es) * | 2005-04-15 | 2007-05-02 | Cancer Rec Tech Ltd | Inhibidores de adn - pk |
| UY31232A1 (es) * | 2007-07-19 | 2009-03-02 | Compuestos derivados de dibenzotifenilamino-cromen-4-onas activas sustituidas y sus isomeros y aplicaciones |
-
2004
- 2004-08-13 BR BRPI0413467-2A patent/BRPI0413467A/pt not_active IP Right Cessation
- 2004-08-13 CA CA002534300A patent/CA2534300A1/en not_active Abandoned
- 2004-08-13 DE DE602004026071T patent/DE602004026071D1/de not_active Expired - Lifetime
- 2004-08-13 EP EP04768070A patent/EP1654257B1/de not_active Expired - Lifetime
- 2004-08-13 ES ES04768070T patent/ES2341342T3/es not_active Expired - Lifetime
- 2004-08-13 KR KR1020067002998A patent/KR20060066722A/ko not_active Ceased
- 2004-08-13 AT AT04768070T patent/ATE461193T1/de not_active IP Right Cessation
- 2004-08-13 MX MXPA06001599A patent/MXPA06001599A/es active IP Right Grant
- 2004-08-13 CN CN2004800299408A patent/CN1867566B/zh not_active Expired - Fee Related
- 2004-08-13 US US10/918,180 patent/US7429660B2/en not_active Expired - Fee Related
- 2004-08-13 NZ NZ545919A patent/NZ545919A/en unknown
- 2004-08-13 WO PCT/GB2004/003507 patent/WO2005016919A1/en not_active Ceased
- 2004-08-13 TW TW093124420A patent/TW200524924A/zh unknown
- 2004-08-13 JP JP2006523057A patent/JP2007501836A/ja active Pending
- 2004-08-13 AU AU2004265149A patent/AU2004265149A1/en not_active Abandoned
- 2004-08-13 GB GB0604321A patent/GB2420781B/en not_active Expired - Fee Related
-
2006
- 2006-02-23 ZA ZA200601595A patent/ZA200601595B/xx unknown
- 2006-03-08 NO NO20061126A patent/NO20061126L/no not_active Application Discontinuation
-
2008
- 2008-09-19 US US12/233,736 patent/US20090043091A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| TW200524924A (en) | 2005-08-01 |
| BRPI0413467A (pt) | 2006-10-17 |
| EP1654257A1 (de) | 2006-05-10 |
| GB0604321D0 (en) | 2006-04-12 |
| US20090043091A1 (en) | 2009-02-12 |
| DE602004026071D1 (de) | 2010-04-29 |
| CN1867566B (zh) | 2010-06-16 |
| GB2420781B (en) | 2008-07-09 |
| NO20061126L (no) | 2006-05-09 |
| US20050054657A1 (en) | 2005-03-10 |
| ES2341342T3 (es) | 2010-06-18 |
| MXPA06001599A (es) | 2006-05-19 |
| KR20060066722A (ko) | 2006-06-16 |
| AU2004265149A1 (en) | 2005-02-24 |
| EP1654257B1 (de) | 2010-03-17 |
| US7429660B2 (en) | 2008-09-30 |
| ZA200601595B (en) | 2007-03-28 |
| CA2534300A1 (en) | 2005-02-24 |
| HK1097273A1 (zh) | 2007-06-22 |
| CN1867566A (zh) | 2006-11-22 |
| WO2005016919A1 (en) | 2005-02-24 |
| GB2420781A (en) | 2006-06-07 |
| JP2007501836A (ja) | 2007-02-01 |
| NZ545919A (en) | 2009-07-31 |
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