ATE451367T1 - Verfahren zur herstellung von ziprasidon - Google Patents
Verfahren zur herstellung von ziprasidonInfo
- Publication number
- ATE451367T1 ATE451367T1 AT05708625T AT05708625T ATE451367T1 AT E451367 T1 ATE451367 T1 AT E451367T1 AT 05708625 T AT05708625 T AT 05708625T AT 05708625 T AT05708625 T AT 05708625T AT E451367 T1 ATE451367 T1 AT E451367T1
- Authority
- AT
- Austria
- Prior art keywords
- ziprasidone
- relates
- preparation
- substantially pure
- producing
- Prior art date
Links
- 229960000607 ziprasidone Drugs 0.000 title abstract 5
- MVWVFYHBGMAFLY-UHFFFAOYSA-N ziprasidone Chemical compound C1=CC=C2C(N3CCN(CC3)CCC3=CC=4CC(=O)NC=4C=C3Cl)=NSC2=C1 MVWVFYHBGMAFLY-UHFFFAOYSA-N 0.000 title abstract 5
- 238000004519 manufacturing process Methods 0.000 title 1
- QCQCHGYLTSGIGX-GHXANHINSA-N 4-[[(3ar,5ar,5br,7ar,9s,11ar,11br,13as)-5a,5b,8,8,11a-pentamethyl-3a-[(5-methylpyridine-3-carbonyl)amino]-2-oxo-1-propan-2-yl-4,5,6,7,7a,9,10,11,11b,12,13,13a-dodecahydro-3h-cyclopenta[a]chrysen-9-yl]oxy]-2,2-dimethyl-4-oxobutanoic acid Chemical compound N([C@@]12CC[C@@]3(C)[C@]4(C)CC[C@H]5C(C)(C)[C@@H](OC(=O)CC(C)(C)C(O)=O)CC[C@]5(C)[C@H]4CC[C@@H]3C1=C(C(C2)=O)C(C)C)C(=O)C1=CN=CC(C)=C1 QCQCHGYLTSGIGX-GHXANHINSA-N 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 201000000980 schizophrenia Diseases 0.000 abstract 1
- 229960003474 ziprasidone hydrochloride Drugs 0.000 abstract 1
- ZCBZSCBNOOIHFP-UHFFFAOYSA-N ziprasidone hydrochloride hydrate Chemical compound [H+].O.[Cl-].C1=CC=C2C(N3CCN(CC3)CCC3=CC=4CC(=O)NC=4C=C3Cl)=NSC2=C1 ZCBZSCBNOOIHFP-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Psychiatry (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Cephalosporin Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IN307DE2004 | 2004-02-27 | ||
| IN1395DE2004 | 2004-07-28 | ||
| PCT/IB2005/000512 WO2005085240A2 (en) | 2004-02-27 | 2005-02-28 | Process for the preparation of ziprasidone |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE451367T1 true ATE451367T1 (de) | 2009-12-15 |
Family
ID=34921521
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT05708625T ATE451367T1 (de) | 2004-02-27 | 2005-02-28 | Verfahren zur herstellung von ziprasidon |
Country Status (7)
| Country | Link |
|---|---|
| US (2) | US20080312254A1 (de) |
| EP (1) | EP1720867B1 (de) |
| AT (1) | ATE451367T1 (de) |
| DE (1) | DE602005018171D1 (de) |
| ES (1) | ES2334800T3 (de) |
| PT (1) | PT1720867E (de) |
| WO (1) | WO2005085240A2 (de) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2250000B1 (es) * | 2004-09-29 | 2007-06-01 | Medichem, S.A. | Procedimiento para la preparacion de ziprasidona. |
| HU230479B1 (hu) * | 2006-05-02 | 2016-07-28 | Richter Gedeon Nyrt. | Eljárás 5-{2-[4-(1,2-benzizotiazol-3-il)-1-piperazinil]-etil}-6-klór-1,3-dihidro-2H-indol-2-on (Ziprasidon) előállítására |
| WO2010010566A1 (en) * | 2008-07-25 | 2010-01-28 | Lupin Limited | Improved process for the manufacture of ziprasidone |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4831031A (en) * | 1988-01-22 | 1989-05-16 | Pfizer Inc. | Aryl piperazinyl-(C2 or C4) alkylene heterocyclic compounds having neuroleptic activity |
| US5206366A (en) * | 1992-08-26 | 1993-04-27 | Pfizer Inc. | Process for preparing aryl piperazinyl-heterocyclic compounds |
| US5312925A (en) * | 1992-09-01 | 1994-05-17 | Pfizer Inc. | Monohydrate of 5-(2-(4-(1,2-benzisothiazol-3-yl)-1-piperazinyl)-ethyl)-6-chloro-1,3-dihydro-2H-indol-2-one-hydrochloride |
| US5338846A (en) * | 1992-08-26 | 1994-08-16 | Pfizer Inc. | Process for preparing aryl piperazinyl-heterocyclic compounds with a piperazine salt |
| CA2252895C (en) * | 1996-05-07 | 2002-08-20 | Pfizer Inc. | Mesylate trihydrate salt of 5-(2-(4-(1,2-benzisothiazol-3-yl)-1-piperazinyl)ethyl)-6-chloro-1,3-dihydro-2(1h)-indol-2-one (=ziprasidone), its preparation and its use as dopamine d2 antagonist |
| US6150366A (en) * | 1998-06-15 | 2000-11-21 | Pfizer Inc. | Ziprasidone formulations |
| UY27668A1 (es) * | 2002-02-20 | 2003-10-31 | Pfizer Prod Inc | Composición de ziprasidona y controles sintéticos |
| WO2004050655A1 (en) * | 2002-12-04 | 2004-06-17 | Dr. Reddy's Laboratories Limited | Polymorphic forms of ziprasidone and its hydrochloride |
| AU2003245027A1 (en) * | 2003-04-11 | 2004-11-01 | Hetero Drugs Limited | Novel crystalline forms of ziprasidone hydrochloride |
| KR20080022595A (ko) * | 2003-06-03 | 2008-03-11 | 테바 파마슈티컬 인더스트리즈 리미티드 | 지프라시돈 ＨＣｌ의 다형 형태 및 그 제조 방법 |
| US20050049295A1 (en) * | 2003-06-12 | 2005-03-03 | Dr. Reddy's Laboratories Limited | Process for the preparation of 5-(2-(4-(1,2-benzisothiazol-3-yl)-1piperazinyl) ethyl)-6-chloro-1, 3-dihydro-2h-indol-2-one hydrochloride (ziprasidone hydrochloride) and its intermediate |
| EP1628973A2 (de) * | 2003-10-24 | 2006-03-01 | Teva Pharmaceutical Industries Ltd. | Verfahren zurherstellung von ziprasidon |
-
2005
- 2005-02-28 EP EP05708625A patent/EP1720867B1/de not_active Expired - Lifetime
- 2005-02-28 AT AT05708625T patent/ATE451367T1/de not_active IP Right Cessation
- 2005-02-28 DE DE602005018171T patent/DE602005018171D1/de not_active Expired - Lifetime
- 2005-02-28 PT PT05708625T patent/PT1720867E/pt unknown
- 2005-02-28 ES ES05708625T patent/ES2334800T3/es not_active Expired - Lifetime
- 2005-02-28 WO PCT/IB2005/000512 patent/WO2005085240A2/en not_active Ceased
- 2005-02-28 US US10/598,370 patent/US20080312254A1/en not_active Abandoned
-
2011
- 2011-05-04 US US13/100,833 patent/US8178674B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| US8178674B2 (en) | 2012-05-15 |
| DE602005018171D1 (de) | 2010-01-21 |
| PT1720867E (pt) | 2010-01-28 |
| US20110207933A1 (en) | 2011-08-25 |
| WO2005085240A3 (en) | 2005-12-01 |
| EP1720867A2 (de) | 2006-11-15 |
| US20080312254A1 (en) | 2008-12-18 |
| EP1720867B1 (de) | 2009-12-09 |
| ES2334800T3 (es) | 2010-03-16 |
| WO2005085240A2 (en) | 2005-09-15 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |