ATE451368T1 - Azabicyclische verbindungen zur linderung von schmerzen und zur behandlung von erkrankungen des zentralen nervensystems - Google Patents

Azabicyclische verbindungen zur linderung von schmerzen und zur behandlung von erkrankungen des zentralen nervensystems

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Publication number
ATE451368T1
ATE451368T1 AT04795238T AT04795238T ATE451368T1 AT E451368 T1 ATE451368 T1 AT E451368T1 AT 04795238 T AT04795238 T AT 04795238T AT 04795238 T AT04795238 T AT 04795238T AT E451368 T1 ATE451368 T1 AT E451368T1
Authority
AT
Austria
Prior art keywords
nervous system
central nervous
compounds
relieving pain
system diseases
Prior art date
Application number
AT04795238T
Other languages
English (en)
Inventor
Scott R Breining
Balwinder S Bhatti
Gregory D Hawkins
Lan Miao
Anatoly Mazurov
Teresa Y Phillips
Craig H Miller
Original Assignee
Targacept Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Targacept Inc filed Critical Targacept Inc
Application granted granted Critical
Publication of ATE451368T1 publication Critical patent/ATE451368T1/de

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
    • C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
    • C07D221/22—Bridged ring systems
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
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    • A—HUMAN NECESSITIES
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond

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  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Psychiatry (AREA)
  • Addiction (AREA)
  • Oncology (AREA)
  • Pain & Pain Management (AREA)
  • Communicable Diseases (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Virology (AREA)
  • Pulmonology (AREA)
  • Hematology (AREA)
  • Rheumatology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Dermatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Diabetes (AREA)
  • Immunology (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Psychology (AREA)
  • Hospice & Palliative Care (AREA)
  • Obesity (AREA)
  • Tropical Medicine & Parasitology (AREA)
AT04795238T 2003-10-15 2004-10-15 Azabicyclische verbindungen zur linderung von schmerzen und zur behandlung von erkrankungen des zentralen nervensystems ATE451368T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US51169703P 2003-10-15 2003-10-15
PCT/US2004/034051 WO2005037832A2 (en) 2003-10-15 2004-10-15 Azabicycyclic compounds for relieving pain and treating central nervous system disorders

Publications (1)

Publication Number Publication Date
ATE451368T1 true ATE451368T1 (de) 2009-12-15

Family

ID=34465266

Family Applications (1)

Application Number Title Priority Date Filing Date
AT04795238T ATE451368T1 (de) 2003-10-15 2004-10-15 Azabicyclische verbindungen zur linderung von schmerzen und zur behandlung von erkrankungen des zentralen nervensystems

Country Status (13)

Country Link
US (4) US7402592B2 (de)
EP (1) EP1678172B1 (de)
JP (1) JP2007533641A (de)
AT (1) ATE451368T1 (de)
AU (1) AU2004282201A1 (de)
CA (1) CA2539811A1 (de)
DE (1) DE602004024565D1 (de)
DK (1) DK1678172T3 (de)
ES (1) ES2356356T3 (de)
PL (1) PL1678172T3 (de)
PT (1) PT1678172E (de)
SI (1) SI1678172T1 (de)
WO (1) WO2005037832A2 (de)

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US8697722B2 (en) * 2007-11-02 2014-04-15 Sri International Nicotinic acetylcholine receptor modulators
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CN103415519B (zh) 2011-03-01 2016-03-02 詹森药业有限公司 作为β-分泌酶(BACE)抑制剂有用的6，7-二氢-吡唑[1，5-a]吡嗪-4-基胺衍生物
AU2012224632B2 (en) 2011-03-09 2016-06-16 Janssen Pharmaceutica Nv 3,4-dihydro-pyrrolo[1,2-a]pyrazin-1-ylamine derivatives useful as inhibitors of beta-secretase (BACE)
MX368326B (es) 2013-06-12 2019-09-27 Janssen Pharmaceutica Nv Derivados de 4-amino-6-fenil-5,6-dihidroimidazo[1,5-a]pirazin-3(2h )-ona como inhibidores de beta-secretasa (bace).
KR102243134B1 (ko) 2013-06-12 2021-04-22 얀센 파마슈티카 엔.브이. 베타-세크레타제(bace) 저해제로서의 4-아미노-6-페닐-5,6-디하이드로이미다조[1,5-a]피라진 유도체
BR112015030597A2 (pt) 2013-06-12 2017-07-25 Janssen Pharmaceutica Nv derivados 4-amino-6-fenil-6,7-di-hidro[1,2,3]triazolo[1,5-a]pirazina como inibidores de beta-secretase (bace)
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CA2539811A1 (en) 2005-04-28
WO2005037832A2 (en) 2005-04-28
US7897611B2 (en) 2011-03-01
AU2004282201A1 (en) 2005-04-28
DE602004024565D1 (de) 2010-01-21
PT1678172E (pt) 2010-03-03
EP1678172A2 (de) 2006-07-12
EP1678172B1 (de) 2009-12-09
WO2005037832B1 (en) 2005-09-15
US20100179183A1 (en) 2010-07-15
US20100152228A1 (en) 2010-06-17
US20050282823A1 (en) 2005-12-22
US7402592B2 (en) 2008-07-22
WO2005037832A3 (en) 2005-06-16
ES2356356T3 (es) 2011-04-07
SI1678172T1 (sl) 2010-04-30
US20080242693A1 (en) 2008-10-02
JP2007533641A (ja) 2007-11-22

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