ATE45157T1 - Hydroxy-4-indol-derivate, verfahren zur herstellung und ihre anwendung. - Google Patents
Hydroxy-4-indol-derivate, verfahren zur herstellung und ihre anwendung.Info
- Publication number
- ATE45157T1 ATE45157T1 AT86870165T AT86870165T ATE45157T1 AT E45157 T1 ATE45157 T1 AT E45157T1 AT 86870165 T AT86870165 T AT 86870165T AT 86870165 T AT86870165 T AT 86870165T AT E45157 T1 ATE45157 T1 AT E45157T1
- Authority
- AT
- Austria
- Prior art keywords
- radical
- alkyl
- see diagramm
- alkoxy
- branched
- Prior art date
Links
- 229940054051 antipsychotic indole derivative Drugs 0.000 title 1
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 4
- 229910052739 hydrogen Inorganic materials 0.000 abstract 4
- 239000001257 hydrogen Substances 0.000 abstract 4
- NLMQHXUGJIAKTH-UHFFFAOYSA-N 4-hydroxyindole Chemical class OC1=CC=CC2=C1C=CN2 NLMQHXUGJIAKTH-UHFFFAOYSA-N 0.000 abstract 2
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 2
- CIUQDSCDWFSTQR-UHFFFAOYSA-N [C]1=CC=CC=C1 Chemical group [C]1=CC=CC=C1 CIUQDSCDWFSTQR-UHFFFAOYSA-N 0.000 abstract 2
- 125000004432 carbon atom Chemical group C* 0.000 abstract 2
- JEVCWSUVFOYBFI-UHFFFAOYSA-N cyanyl Chemical compound N#[C] JEVCWSUVFOYBFI-UHFFFAOYSA-N 0.000 abstract 2
- 125000005843 halogen group Chemical group 0.000 abstract 2
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 2
- 125000006239 protecting group Chemical group 0.000 abstract 2
- BRLQWZUYTZBJKN-UHFFFAOYSA-N Epichlorohydrin Chemical compound ClCC1CO1 BRLQWZUYTZBJKN-UHFFFAOYSA-N 0.000 abstract 1
- -1 N-protected indole Chemical class 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- GKIPXFAANLTWBM-UHFFFAOYSA-N epibromohydrin Chemical compound BrCC1CO1 GKIPXFAANLTWBM-UHFFFAOYSA-N 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 239000003444 phase transfer catalyst Substances 0.000 abstract 1
- 238000010992 reflux Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/08—Indoles; Hydrogenated indoles with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to carbon atoms of the hetero ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Indole Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR8516676A FR2589863B1 (fr) | 1985-11-12 | 1985-11-12 | Derives d'hydroxy-4 indole, leur procede de preparation et leur utilisation |
| EP86870165A EP0228356B1 (de) | 1985-11-12 | 1986-11-06 | Hydroxy-4-indol-Derivate, Verfahren zur Herstellung und ihre Anwendung |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE45157T1 true ATE45157T1 (de) | 1989-08-15 |
Family
ID=9324703
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT86870165T ATE45157T1 (de) | 1985-11-12 | 1986-11-06 | Hydroxy-4-indol-derivate, verfahren zur herstellung und ihre anwendung. |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US4977274A (de) |
| EP (1) | EP0228356B1 (de) |
| JP (1) | JPS62114960A (de) |
| AT (1) | ATE45157T1 (de) |
| DE (1) | DE3664771D1 (de) |
| ES (1) | ES2009807B3 (de) |
| FR (1) | FR2589863B1 (de) |
| GR (1) | GR3000120T3 (de) |
| PT (1) | PT83693B (de) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1569638B1 (de) * | 2002-12-03 | 2007-09-05 | F. Hoffmann-La Roche Ag | Aminoalkoxyindol-derivate als 5-ht6-rezeptorliganden zur bekämpfung von zns-krankheiten |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3471515A (en) * | 1965-02-01 | 1969-10-07 | Sandoz Ag | (2-hydroxy-3-substituted aminopropoxy)indoles |
| US4235695A (en) * | 1977-12-09 | 1980-11-25 | Diamond Shamrock Technologies S.A. | Novel electrodes and their use |
| EP0005828B1 (de) * | 1978-06-06 | 1981-03-11 | Hoechst Aktiengesellschaft | Neue substituierte Phenylpiperazinderivate, diese enthaltende Arzneimittel und Verfahren zu deren Herstellung |
| EP0013878A1 (de) * | 1979-01-18 | 1980-08-06 | Sandoz Ag | 3-Aminopropoxyaryl-Derivate, ihre Herstellung und sie enthaltende pharmazeutische Zusammensetzungen |
| FR2459792A1 (fr) * | 1979-06-27 | 1981-01-16 | Rhone Poulenc Ind | Procede de preparation de derives benzeniques par reaction d'un halogenobenzene active avec un reactif organique anionique oxygene ou soufre |
| EP0025111B1 (de) * | 1979-08-10 | 1984-07-25 | Sandoz Ag | 3-Aminopropoxyaryl-Derivate, ihre Herstellung und diese enthaltende pharmazeutische Zusammensetzungen |
| FR2463765A1 (fr) * | 1979-08-17 | 1981-02-27 | Clin Midy | Nouveaux derives de l'indole actifs sur le systeme cardiovasculaire |
| JPS57142969A (en) * | 1981-02-27 | 1982-09-03 | Nissan Chem Ind Ltd | Substituted indole |
-
1985
- 1985-11-12 FR FR8516676A patent/FR2589863B1/fr not_active Expired
-
1986
- 1986-11-06 DE DE8686870165T patent/DE3664771D1/de not_active Expired
- 1986-11-06 EP EP86870165A patent/EP0228356B1/de not_active Expired
- 1986-11-06 ES ES86870165T patent/ES2009807B3/es not_active Expired
- 1986-11-06 AT AT86870165T patent/ATE45157T1/de not_active IP Right Cessation
- 1986-11-07 PT PT83693A patent/PT83693B/pt not_active IP Right Cessation
- 1986-11-11 JP JP61269484A patent/JPS62114960A/ja active Pending
-
1989
- 1989-08-03 GR GR89400206T patent/GR3000120T3/el unknown
- 1989-08-28 US US07/398,922 patent/US4977274A/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| ES2009807B3 (es) | 1989-10-16 |
| PT83693A (en) | 1986-12-01 |
| US4977274A (en) | 1990-12-11 |
| DE3664771D1 (en) | 1989-09-07 |
| FR2589863B1 (fr) | 1988-07-29 |
| EP0228356B1 (de) | 1989-08-02 |
| JPS62114960A (ja) | 1987-05-26 |
| FR2589863A1 (fr) | 1987-05-15 |
| PT83693B (pt) | 1989-06-30 |
| GR3000120T3 (en) | 1990-11-29 |
| EP0228356A1 (de) | 1987-07-08 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| DK135791D0 (da) | 1h-imidazooe4,5-caaquinolin-4-amin, farmaceutisk praeparat indeholdende en saadan forbindelse og fremga ngsmaade til fremstilling af forbindelsen | |
| EP0259255A3 (en) | Phenolic corrosion inhibitors for paints | |
| DK369384A (da) | 1,6-naphthyridinonderivater, fremgangsmaade til fremstilling heraf og deres anvendelse til bekaempelse af karsygdomme | |
| DE69111925D1 (de) | Aromatische Vinyletherverbindungen und -zusammensetzungen und Verfahren zu deren Herstellung. | |
| ATE9794T1 (de) | Indolderivate und verfahren zu ihrer herstellung. | |
| DK605484A (da) | Imidazo-(1,2-a)-pyrimidiner og fremgangsmaade til fremstilling deraf | |
| DE3664771D1 (en) | Hydroxy-4-indole derivatives, process for their preparation and their use | |
| DK153547C (da) | Analogifremgangsmaade til fremstilling af aminoalkoxypyrazoler eller salte deraf | |
| ATE18559T1 (de) | Vinyl-3-cephalosporinverbindungen und ihre herstellung. | |
| DK392579A (da) | Fremgangsmaade til fremstilling af 4,5-methano-bufadienolid-rhamnosider | |
| BG102429A (en) | Derivatives of 5-naphthalen-1-yl-1,3-dioxan, their preparation and usage as therapeutical means | |
| ATE8633T1 (de) | Vinyl-3-cephalosporinverbindungen und ihre herstellung. | |
| ATE878T1 (de) | Imidazo und pyrimido-pyrido-indole, ihre herstellung und sie enthaltende arzneimittel. | |
| ATE31404T1 (de) | Verfahren zur herstellung von cycklopropanabkoemmlingen. | |
| DK452984A (da) | Fremgangsmaade til fremstilling af quinolin-4-oner |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification | ||
| REN | Ceased due to non-payment of the annual fee |