ES2009807B3 - Procedimiento para la preparacion de derivados del hidroxi-4 indol. - Google Patents

Procedimiento para la preparacion de derivados del hidroxi-4 indol.

Info

Publication number
ES2009807B3
ES2009807B3 ES86870165T ES86870165T ES2009807B3 ES 2009807 B3 ES2009807 B3 ES 2009807B3 ES 86870165 T ES86870165 T ES 86870165T ES 86870165 T ES86870165 T ES 86870165T ES 2009807 B3 ES2009807 B3 ES 2009807B3
Authority
ES
Spain
Prior art keywords
radical
alkyl
see diagramm
alkoxy
branched
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES86870165T
Other languages
English (en)
Inventor
Walter Verstraeten
Marcel Descamps
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sanofi SA
Original Assignee
Sanofi SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi SA filed Critical Sanofi SA
Application granted granted Critical
Publication of ES2009807B3 publication Critical patent/ES2009807B3/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/08—Indoles; Hydrogenated indoles with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to carbon atoms of the hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Indole Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

LA INVENCION SE REFIERE A NUEVOS DERIVADOS DE HIDROXI-4INDOLE DE FORMULA GENERAL (I) EN LA QUE R REPRESENTA UN AGRUPAMIENTO PROTECTOR LABIL Y R1 PUEDE REPRESENTAR HIDROGENO, UN RADICAL ALQUILO, LINEAL O RAMIFICADO, HABIENDO DE 1 A 6 ATOMOS DE CARBONO, UN RADICAL CICLOALQUILO HABIENDO DE 3 A 6 ATOMOS DE CARBONO, UN RADICAL ALCOXI INFERIOR, UN RADICAL HIDROXIALQUILO INFERIOR, UN RADICAL (ALCOXI INFERIOR), ALQUILO INFERIOR, UN RADICAL FENIL, EVENTUALMENTE SUSTITUIDO POR UN ATOMO DE HALOGENO O POR UN RADICAL ALQUILO INFERIOR O ALCOXI INFERIOR, UN RADICAL CIANO, UN RADICAL DE FORMULA (II) EN EL QUE: R2 Y R3, IDENTICOS O DIFERENTES, REPRESENTAN CADA UNO HIDROGENO O UN RADICAL ALQUILO INFERIOR, R4 REPRESENTA HIDROXI, UN RADICAL ALQUILO INFERIOR O ALCOXI INFERIOR O UN RADICAL EN EL QUE R2 Y R3 TIENEN EL MISMO SIGNIFICADO QUE ANTERIORMENTE, R5 REPRESENTA UN RADICAL ALQUILO INFERIOR, ALK REPRESENTA UN ENLACE SIMPLE O UN RADICAL ALQUILENO, LINEAL O RAMIFICADO, HABIENDO DE 1 A 4 ATOMOS DE CARBONO. LOS DERIVADOS DE HIDROXI-4INDOLE SON UTILES COMO INTERMEDIARIOS DE SINTESIS PARTICULARMENTE PARA LA PREPARACION DE DERIVADOS DE (AMINO -3 HIDROXI-2 PROPOXI)-4INDOLE.
ES86870165T 1985-11-12 1986-11-06 Procedimiento para la preparacion de derivados del hidroxi-4 indol. Expired ES2009807B3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR8516676A FR2589863B1 (fr) 1985-11-12 1985-11-12 Derives d'hydroxy-4 indole, leur procede de preparation et leur utilisation

Publications (1)

Publication Number Publication Date
ES2009807B3 true ES2009807B3 (es) 1989-10-16

Family

ID=9324703

Family Applications (1)

Application Number Title Priority Date Filing Date
ES86870165T Expired ES2009807B3 (es) 1985-11-12 1986-11-06 Procedimiento para la preparacion de derivados del hidroxi-4 indol.

Country Status (9)

Country Link
US (1) US4977274A (es)
EP (1) EP0228356B1 (es)
JP (1) JPS62114960A (es)
AT (1) ATE45157T1 (es)
DE (1) DE3664771D1 (es)
ES (1) ES2009807B3 (es)
FR (1) FR2589863B1 (es)
GR (1) GR3000120T3 (es)
PT (1) PT83693B (es)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1569638B1 (en) * 2002-12-03 2007-09-05 F. Hoffmann-La Roche Ag Aminoalkoxyindoles as 5-ht6-receptor ligands for the treatment of cns-disorders

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3471515A (en) * 1965-02-01 1969-10-07 Sandoz Ag (2-hydroxy-3-substituted aminopropoxy)indoles
US4235695A (en) * 1977-12-09 1980-11-25 Diamond Shamrock Technologies S.A. Novel electrodes and their use
EP0005828B1 (de) * 1978-06-06 1981-03-11 Hoechst Aktiengesellschaft Neue substituierte Phenylpiperazinderivate, diese enthaltende Arzneimittel und Verfahren zu deren Herstellung
EP0013878A1 (en) * 1979-01-18 1980-08-06 Sandoz Ag 3-Aminopropoxyaryl derivatives, their preparation and pharmaceutical compositions containing them
FR2459792A1 (fr) * 1979-06-27 1981-01-16 Rhone Poulenc Ind Procede de preparation de derives benzeniques par reaction d'un halogenobenzene active avec un reactif organique anionique oxygene ou soufre
EP0025111B1 (en) * 1979-08-10 1984-07-25 Sandoz Ag 3-aminopropoxyaryl derivatives, their preparation and pharmaceutical compositions containing them
FR2463765A1 (fr) * 1979-08-17 1981-02-27 Clin Midy Nouveaux derives de l'indole actifs sur le systeme cardiovasculaire
JPS57142969A (en) * 1981-02-27 1982-09-03 Nissan Chem Ind Ltd Substituted indole

Also Published As

Publication number Publication date
PT83693A (en) 1986-12-01
US4977274A (en) 1990-12-11
DE3664771D1 (en) 1989-09-07
FR2589863B1 (fr) 1988-07-29
EP0228356B1 (fr) 1989-08-02
JPS62114960A (ja) 1987-05-26
FR2589863A1 (fr) 1987-05-15
ATE45157T1 (de) 1989-08-15
PT83693B (pt) 1989-06-30
GR3000120T3 (en) 1990-11-29
EP0228356A1 (fr) 1987-07-08

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