ATE452145T1 - Verfahren zur herstellung von peptidderivaten - Google Patents

Verfahren zur herstellung von peptidderivaten

Info

Publication number: ATE452145T1
Authority: AT; Austria
Prior art keywords: peptide derivatives; producing peptide; relates; phase synthesis; leuprolide
Prior art date: 2005-05-03

Application number

AT06759010T

Other languages

English (en)

Inventor

Alexander Ivchenko

Hagi Alon

Shai Elster

Shimon Shushan

Chaim Eidelman

Avi Tovi

Tehila Gadi

Leah Bar-Oz

Eleonora Alterman

Gil Zaovi

Gabriel-Marcus Butilca

Original Assignee

Novetide Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2005-05-03

Filing date

2006-05-02

Publication date

2010-01-15

2006-05-02 Application filed by Novetide Ltd filed Critical Novetide Ltd

2010-01-15 Application granted granted Critical

2010-01-15 Publication of ATE452145T1 publication Critical patent/ATE452145T1/de

Links

238000004519 manufacturing process Methods 0.000 title 1
108090000765 processed proteins & peptides Proteins 0.000 title 1
108010000817 Leuprolide Proteins 0.000 abstract 2
GFIJNRVAKGFPGQ-LIJARHBVSA-N leuprolide Chemical compound CCNC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@H](CO)NC(=O)[C@H](CC=1C2=CC=CC=C2NC=1)NC(=O)[C@H](CC=1N=CNC=1)NC(=O)[C@H]1NC(=O)CC1)CC1=CC=C(O)C=C1 GFIJNRVAKGFPGQ-LIJARHBVSA-N 0.000 abstract 2
229960004338 leuprorelin Drugs 0.000 abstract 2
230000015572 biosynthetic process Effects 0.000 abstract 1
238000000034 method Methods 0.000 abstract 1
239000012071 phase Substances 0.000 abstract 1
238000002360 preparation method Methods 0.000 abstract 1
238000010532 solid phase synthesis reaction Methods 0.000 abstract 1
238000003786 synthesis reaction Methods 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/08—Drugs for disorders of the urinary system of the prostate
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/10—Drugs for disorders of the endocrine system of the posterior pituitary hormones, e.g. oxytocin, ADH
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/003—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by transforming the C-terminal amino acid to amides
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/585—Calcitonins
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/645—Secretins
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/655—Somatostatins
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/18—Kallidins; Bradykinins; Related peptides
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/23—Luteinising hormone-releasing hormone [LHRH]; Related peptides
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2740/00—Reverse transcribing RNA viruses
- C12N2740/00011—Details
- C12N2740/10011—Retroviridae
- C12N2740/16011—Human Immunodeficiency Virus, HIV
- C12N2740/16111—Human Immunodeficiency Virus, HIV concerning HIV env
- C12N2740/16122—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Biophysics (AREA)
Biochemistry (AREA)
Genetics & Genomics (AREA)
Molecular Biology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Endocrinology (AREA)
Gastroenterology & Hepatology (AREA)
Toxicology (AREA)
Zoology (AREA)
Veterinary Medicine (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Reproductive Health (AREA)
Analytical Chemistry (AREA)
Virology (AREA)
Diabetes (AREA)
Gynecology & Obstetrics (AREA)
Pregnancy & Childbirth (AREA)
Urology & Nephrology (AREA)
Peptides Or Proteins (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

AT06759010T 2005-05-03 2006-05-02 Verfahren zur herstellung von peptidderivaten ATE452145T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US67758205P	2005-05-03	2005-05-03
PCT/US2006/017044 WO2006119388A2 (en)	2005-05-03	2006-05-02	Methods for the production of peptide having a c-terminal amide

Publications (1)

Publication Number	Publication Date
ATE452145T1 true ATE452145T1 (de)	2010-01-15

Family

ID=37199222

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT06759010T ATE452145T1 (de)	2005-05-03	2006-05-02	Verfahren zur herstellung von peptidderivaten

Country Status (9)

Country	Link
US (1)	US20060276626A1 (de)
EP (3)	EP2119724A1 (de)
JP (1)	JP2008534628A (de)
AT (1)	ATE452145T1 (de)
DE (1)	DE602006011099D1 (de)
DK (1)	DK1773870T3 (de)
ES (1)	ES2336826T3 (de)
IL (1)	IL185493A0 (de)
WO (1)	WO2006119388A2 (de)

Families Citing this family (44)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US8829157B2 (en) *	2004-06-14	2014-09-09	Usv, Ltd.	Process for the synthesis of cyclic heptapeptide
ATE480561T1 (de)	2004-10-19	2010-09-15	Lonza Ag	Verfahren zur festphasen-peptidsynthese
NL2000126C2 (nl) *	2005-07-15	2008-01-29	Solvay	Werkwijze voor de vervaardiging van eptifibatide.
KR101046846B1 (ko)	2006-10-12	2011-07-06	동국제약 주식회사	고체상 합성법을 이용한 펩타이드의 제조방법
IE20060841A1 (en) *	2006-11-21	2008-05-28	Ipsen Mfg Ireland Ltd	Boc and fmoc solid phase peptide synthesis
EP2057183A2 (de) *	2007-03-01	2009-05-13	Novetide Ltd.	Peptide von hoher reinheit
CN101372505B (zh) *	2007-08-22	2011-03-30	深圳翰宇药业股份有限公司	一种制备醋酸去氨加压素的方法
US20100204131A1 (en) *	2007-09-11	2010-08-12	Dorian Bevec	Use of a peptide as a therapeutic agent
WO2009046833A1 (en) *	2007-09-11	2009-04-16	Mondobiotech Laboratories Ag	Use of a peptide as a therapeutic agent
WO2009046877A2 (en) *	2007-09-11	2009-04-16	Mondobiotech Laboratories Ag	Use of a histrelin and leuprolide as therapeutic agents
AU2008303928A1 (en)	2007-09-11	2009-04-02	Mondobiotech Laboratories Ag	Use of NF-KAPPAB inhibitor SN50 and optionally angiotensin III as therapeutic agents in the treatment of EG HBV infection
JP2011505335A (ja) *	2007-09-11	2011-02-24	モンドバイオテックラボラトリーズアクチエンゲゼルシャフト	治療剤としてのＴＲＰ−６−トリプトレリンおよびＤ−Ｌｅｕ６−ロイプロリドの使用
EP2062909A1 (de) *	2007-11-21	2009-05-27	SOLVAY (Société Anonyme)	Herstellung von Peptiden und Reinigungsverfahren
US9051349B2 (en)	2007-11-21	2015-06-09	Alba Therapeutics Corporation	Larazotide acetate compositions
RU2461564C2 (ru) *	2008-02-06	2012-09-20	Байокон Лимитид	Способ очистки циклического или нециклического пептида
WO2011006644A2 (en)	2009-07-15	2011-01-20	Lonza Ltd	Process for the production of exenatide and of an exenatide analogue
PL2464655T3 (pl) *	2009-08-11	2017-08-31	Biocon Limited	Procesy chromatograficzne
EP2566883A1 (de) *	2010-05-07	2013-03-13	Mylan Laboratories, Limited	Neuartiges verfahren zur herstellung von leuprolid und pharmazeutisch zulässigen salzen davon
CN102127146B (zh) *	2010-12-24	2013-04-24	深圳翰宇药业股份有限公司	一种制备醋酸阿托西班的方法
CN103163258B (zh) *	2011-12-09	2015-09-23	山东绿叶制药有限公司	一种测定痕量曲普瑞林的方法
CN102702320B (zh) *	2012-06-01	2013-08-21	深圳翰宇药业股份有限公司	一种制备爱啡肽的方法
CN102702325B (zh) *	2012-06-19	2015-09-23	深圳翰宇药业股份有限公司	一种抗凝血多肽的制备方法
US9637517B2 (en) *	2012-10-31	2017-05-02	Hybio Pharmaceutical Co., Ltd.	Method for preparing exenatide
KR101454892B1 (ko)	2012-10-31	2014-11-04	애니젠 주식회사	엑세나타이드의 제조방법
US9150615B2 (en)	2013-12-18	2015-10-06	Scinopharm Taiwan, Ltd.	Process for the preparation of leuprolide and its pharmaceutically acceptable salts
CN104910257B (zh) *	2015-01-07	2018-04-03	苏州天马医药集团天吉生物制药有限公司	戈舍瑞林的固相合成方法
CN106146360B (zh) *	2015-03-31	2020-05-15	深圳翰宇药业股份有限公司	一种制备酪氨酸-o-磺酸盐的方法
WO2017178950A1 (en) *	2016-04-11	2017-10-19	Emcure Pharmaceuticals Limited	Process for preparation of lanreotide acetate
CN107540727B (zh) *	2016-06-28	2021-03-16	深圳翰宇药业股份有限公司	布舍瑞林或戈舍瑞林的制备方法
CN106967155B (zh) *	2017-03-17	2018-05-15	兰州凯博药业股份有限公司	一种多肽液相合成缩宫素的方法
CN107602668A (zh) *	2017-10-10	2018-01-19	合肥师范学院	一种液相全合成制备布舍瑞林的方法
CN108892711A (zh) *	2018-06-29	2018-11-27	江苏吉泰肽业科技有限公司	一种纯化布舍瑞林的方法
EP3590526A1 (de) *	2018-07-05	2020-01-08	Antev Limited	Lyophilisierungsverfahren und dadurch hergestelltes teverelix-tfa-lyophilisat
EP3628683A1 (de) *	2018-09-28	2020-04-01	Zealand Pharma A/S	Formulierungen von analoga des glucagon-like-peptid-2 (glp-2)
WO2020170185A1 (en) *	2019-02-21	2020-08-27	Dr. Reddy’S Laboratories Limited	Substantially pure lanreotide or its salt & process thereof
CN111825742B (zh) *	2019-04-18	2024-01-30	陈铭	Ctpa作为特种偶合剂用于氨基酸离子液体的多肽固相合成
CN110128505A (zh) *	2019-05-21	2019-08-16	梯尔希（南京）药物研发有限公司	一种戈舍瑞林杂质的合成方法
US20230399360A1 (en) *	2019-12-20	2023-12-14	Northwestern University	Terlipressin-octadecanedioic acid conjugate for vasoconstrictive therapy
CN114685616B (zh) *	2020-12-31	2024-03-29	哈尔滨三联药业股份有限公司	醋酸曲普瑞林的合成方法
CN114716515A (zh) *	2022-03-31	2022-07-08	深圳深创生物药业有限公司	一种多肽类似物及其制备方法和应用
CN115417923B (zh) *	2022-07-29	2025-10-28	海南双成药业股份有限公司	一种无菌兰瑞肽原料药的制备方法
WO2024112250A1 (en) *	2022-11-23	2024-05-30	Polypeptide Laboratories Holding (Ppl) Ab	Method of preparing vasopressin
CN116675741B (zh) *	2023-07-31	2023-10-31	杭州湃肽生化科技有限公司	一种中间体在制备戈舍瑞林中的用途
CN121779506B (zh) *	2026-01-05	2026-07-31	天津市药品检验研究院	一种特利加压素与甘露醇的酯化杂质及应用

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CS180644B2 (en)	1973-09-29	1978-01-31	Takeda Chemical Industries Ltd	Process for preparing nonapeptides
US4005063A (en)	1973-10-11	1977-01-25	Abbott Laboratories	[Des-gly]10 -GnRH nonapeptide anide analogs in position 6 having ovulation-inducing activity
US4002738A (en)	1975-05-30	1977-01-11	Abbott Laboratories	Treatment of specified neoplasias
GB1524747A (en) *	1976-05-11	1978-09-13	Ici Ltd	Polypeptide
GB9112859D0 (en)	1991-06-14	1991-07-31	Ici Plc	Peptide process
GB9112825D0 (en)	1991-06-14	1991-07-31	Ici Plc	Process for making peptides
DE69332377T2 (de) *	1992-07-13	2003-07-03	Bionebraska, Inc.	Verfahren zur modifizierung rekombinanter polypeptide
RU2074191C1 (ru)	1994-06-08	1997-02-27	Российско-германское совместное предприятие "Константа"	Способ синтеза дез-гли 10, /d-лей 6/ lh-rh-этиламида
EP1008656A4 (de)	1996-06-13	2000-09-20	Itoham Foods Inc	Verfahren zur herstellung von lh-rh derivaten
US6211333B1 (en)	1996-06-21	2001-04-03	Takeda Chemical Industries, Ltd.	Method for producing peptides and their salts which have an agonist activity of luteinizing hormone releasing hormones secreted from the hypothalamus
JP3759821B2 (ja) *	1996-06-21	2006-03-29	武田薬品工業株式会社	ペプチドの製造法
US6140315A (en) *	1997-06-09	2000-10-31	Weisman; Kenneth M.	Therapeutic uses of goserelin acetate
ES2154590B1 (es)	1999-05-20	2001-11-01	Lipotec Sa	Procedimiento de sintesis de peptidos en fase solida
JP4678619B2 (ja) *	1999-06-30	2011-04-27	武田薬品工業株式会社	Ｌｈ−ｒｈ誘導体の精製方法
CA2376763C (en) *	1999-06-30	2009-12-22	Takeda Chemical Industries, Ltd.	Process for preparing lh-rh derivatives
US7332474B2 (en) *	2001-10-11	2008-02-19	Amgen Inc.	Peptides and related compounds having thrombopoietic activity
DE60309019T2 (de) *	2002-05-03	2007-05-16	Avecia Ltd., Blackley	Verfahren zur herstellung von peptidamiden durch seitenkettenanknüpfung an einer festphase
GB0210183D0 (en) *	2002-05-03	2002-06-12	Avecia Ltd	Process

2006
- 2006-05-02 EP EP09010808A patent/EP2119724A1/de not_active Withdrawn
- 2006-05-02 DE DE602006011099T patent/DE602006011099D1/de not_active Expired - Fee Related
- 2006-05-02 ES ES06759010T patent/ES2336826T3/es not_active Expired - Lifetime
- 2006-05-02 WO PCT/US2006/017044 patent/WO2006119388A2/en not_active Ceased
- 2006-05-02 DK DK06759010.9T patent/DK1773870T3/da active
- 2006-05-02 AT AT06759010T patent/ATE452145T1/de not_active IP Right Cessation
- 2006-05-02 JP JP2008504545A patent/JP2008534628A/ja active Pending
- 2006-05-02 US US11/416,856 patent/US20060276626A1/en not_active Abandoned
- 2006-05-02 EP EP06759010A patent/EP1773870B1/de not_active Expired - Lifetime
- 2006-05-02 EP EP09010809A patent/EP2119725A1/de not_active Withdrawn
2007
- 2007-08-23 IL IL185493A patent/IL185493A0/en unknown

Also Published As

Publication number	Publication date
DE602006011099D1 (de)	2010-01-28
WO2006119388A3 (en)	2007-06-28
DK1773870T3 (da)	2010-04-12
IL185493A0 (en)	2008-01-06
WO2006119388A2 (en)	2006-11-09
JP2008534628A (ja)	2008-08-28
ES2336826T3 (es)	2010-04-16
EP1773870A2 (de)	2007-04-18
EP2119725A1 (de)	2009-11-18
EP2119724A1 (de)	2009-11-18
US20060276626A1 (en)	2006-12-07
WO2006119388A8 (en)	2008-04-17
EP1773870B1 (de)	2009-12-16

Legal Events

Date	Code	Title	Description
2010-06-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties

Publication	Publication Date	Title
DE602006011099D1 (de)	2010-01-28	Verfahren zur herstellung von peptidderivaten
DE602004031907D1 (de)	2011-05-05	Verfahren zur Herstellung von Nanopartikeln durch grössenspezifische Photoätzung
DK1511761T3 (da)	2006-11-27	Fremgangsmåde til fremstilling af cykliske peptider
NI201300130A (es)	2014-12-22	Composiciones que contienen, metodos que involucran, y usos de derivados de dolastatina unidos a aminoácidos no naturales
BRPI0516385A (pt)	2007-11-27	composições contendo aminoácidos não naturais e polipeptìdeos, métodos envolvendo os mesmos e usos dos mesmos
WO2015061720A3 (en)	2015-06-11	Prostacyclin compounds, compositions and methods of use thereof
ATE473224T1 (de)	2010-07-15	Verfahren zur herstellung von nebivolol
DE60123509D1 (de)	2006-11-16	Verfahren zur Herstellung von leichten Iso-Paraffinen aus Synthesegas
ATE486857T1 (de)	2010-11-15	Verfahren zur herstellung von telmisartan
ATE480561T1 (de)	2010-09-15	Verfahren zur festphasen-peptidsynthese
ATE354583T1 (de)	2007-03-15	Verfahren zur herstellung c-7 substituierter 5- androstene
DE50306876D1 (de)	2007-05-03	Verfahren zur herstellung von alkylarylsulfonaten mittels modifizierter, dimerisierter olefine
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WO2006126100A3 (en)	2007-03-01	Modulation of plant growth by altering amino acid uptake
DE602004001646D1 (de)	2006-09-07	Verfahren zur Herstellung von Pyran
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